FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5249, 182 aa 1>>>pF1KE5249 182 - 182 aa - 182 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.1511+/-0.000382; mu= 19.3103+/- 0.024 mean_var=62.8775+/-12.970, 0's: 0 Z-trim(112.6): 62 B-trim: 0 in 0/56 Lambda= 0.161743 statistics sampled from 21497 (21559) to 21497 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.253), width: 16 Scan time: 5.570 The best scores are: opt bits E(85289) NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens ( 182) 1190 286.0 2.3e-77 NP_849199 (OMIM: 607891) CKLF-like MARVEL transmem ( 173) 419 106.0 3.2e-23 XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like M ( 196) 374 95.6 5.1e-20 XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like M ( 130) 366 93.5 1.4e-19 XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like M ( 100) 250 66.3 1.7e-11 NP_005425 (OMIM: 602022) MAL-like protein [Homo sa ( 153) 201 55.1 6.1e-08 NP_002362 (OMIM: 188860) myelin and lymphocyte pro ( 153) 198 54.4 1e-07 XP_011510111 (OMIM: 602022) PREDICTED: MAL-like pr ( 149) 192 53.0 2.6e-07 NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 184 51.3 1.2e-06 XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 184 51.3 1.2e-06 NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 184 51.3 1.3e-06 NP_113672 (OMIM: 616970) MARVEL domain-containing ( 173) 179 50.0 2.3e-06 NP_443118 (OMIM: 609684) protein MAL2 [Homo sapien ( 176) 177 49.6 3.3e-06 NP_001277121 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001018656 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001277123 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001018655 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001018654 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001018657 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001277118 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001277120 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_612382 (OMIM: 609959) myeloid-associated differ ( 322) 164 46.8 4e-05 NP_001277122 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001277119 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_001277117 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05 NP_071883 (OMIM: 188860) myelin and lymphocyte pro ( 111) 159 45.2 4.4e-05 NP_001307237 (OMIM: 607891) CKLF-like MARVEL trans ( 115) 148 42.6 0.00027 NP_612419 (OMIM: 607890) CKLF-like MARVEL transmem ( 175) 144 41.9 0.00068 XP_011531621 (OMIM: 607890) PREDICTED: CKLF-like M ( 151) 138 40.4 0.0016 XP_016861135 (OMIM: 607890) PREDICTED: CKLF-like M ( 179) 138 40.5 0.0018 XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like M ( 179) 135 39.8 0.0029 XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 37.8 0.0098 XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 37.8 0.0098 NP_612469 (OMIM: 607888) CKLF-like MARVEL transmem ( 156) 127 37.8 0.0098 >>NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens] (182 aa) initn: 1190 init1: 1190 opt: 1190 Z-score: 1509.8 bits: 286.0 E(85289): 2.3e-77 Smith-Waterman score: 1190; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KE5 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 HLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGG 130 140 150 160 170 180 pF1KE5 YA :: NP_057 YA >>NP_849199 (OMIM: 607891) CKLF-like MARVEL transmembran (173 aa) initn: 270 init1: 270 opt: 419 Z-score: 537.8 bits: 106.0 E(85289): 3.2e-23 Smith-Waterman score: 419; 42.8% identity (71.7% similar) in 159 aa overlap (8-166:12-168) 10 20 30 40 50 pF1KE5 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIA :.: .:: :.. .: :.. : :.:. : :.. ..:::::::.::: NP_849 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 DTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYI : : ::.::::::::: :..:. .. .:. . . .. .::: : . :: :: :::. NP_849 GTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 TAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQ .: .. ...: . : .. .:. ::.:::: :: : :. ...::. ::: NP_849 SAAVVDASSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ 130 140 150 160 170 180 pF1KE5 MAGGYA >>XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like MARVE (196 aa) initn: 278 init1: 278 opt: 374 Z-score: 480.4 bits: 95.6 E(85289): 5.1e-20 Smith-Waterman score: 374; 45.1% identity (71.4% similar) in 133 aa overlap (34-166:61-191) 10 20 30 40 50 60 pF1KE5 FPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLY :: :.. ::::::::.::: : : XP_011 AYDREFLRTLPGFLIVAEILISLPITDPLHRSALSTTARDILVLGLLVWTLIAGTEYFRV 40 50 60 70 80 90 70 80 90 100 110 120 pF1KE5 PAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFIACS ::.::::::::: :..:. .. .:. . . .. .::: : . :: :: :::..: .. . XP_011 PAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDA 100 110 120 130 140 150 130 140 150 160 170 180 pF1KE5 AAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA ..: . : .. .:. ::.:::: :: : :. ...::. ::: XP_011 SSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ 160 170 180 190 >>XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like MARVE (130 aa) initn: 282 init1: 270 opt: 366 Z-score: 472.5 bits: 93.5 E(85289): 1.4e-19 Smith-Waterman score: 366; 46.3% identity (73.6% similar) in 121 aa overlap (46-166:7-125) 20 30 40 50 60 70 pF1KE5 AQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVF :::::::.::: : : ::.::::::::: XP_016 MFRRIQVLGLLVWTLIAGTEYFRVPAFGWVMFVAVF 10 20 30 80 90 100 110 120 130 pF1KE5 LWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFIACSAAVDLTSLRGTR :..:. .. .:. . . .. .::: : . :: :: :::..: .. ...: . : .. XP_016 YWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSV--SPERDSH 40 50 60 70 80 90 140 150 160 170 180 pF1KE5 PYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA .:. ::.:::: :: : :. ...::. ::: XP_016 NFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ 100 110 120 130 >>XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like MARVE (100 aa) initn: 166 init1: 154 opt: 250 Z-score: 327.5 bits: 66.3 E(85289): 1.7e-11 Smith-Waterman score: 250; 40.2% identity (72.2% similar) in 97 aa overlap (70-166:1-95) 40 50 60 70 80 90 pF1KE5 LMLLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVP :::::: :..:. .. .:. . . .. .:: XP_016 MFVAVFYWVLTVFFLIIYITMTYTRIPQVP 10 20 30 100 110 120 130 140 150 pF1KE5 WPLVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAF : : . :: :: :::..: .. ...: . : .. .:. ::.:::: :: : :. ... XP_016 WTTVGLCFNGSAFVLYLSAAVVDASSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTY 40 50 60 70 80 160 170 180 pF1KE5 FSYQAWRGVGSNAATSQMAGGYA ::. ::: XP_016 FSFIAWRSRTIQ 90 100 >>NP_005425 (OMIM: 602022) MAL-like protein [Homo sapien (153 aa) initn: 164 init1: 125 opt: 201 Z-score: 263.5 bits: 55.1 E(85289): 6.1e-08 Smith-Waterman score: 201; 30.2% identity (65.1% similar) in 126 aa overlap (39-162:29-151) 10 20 30 40 50 60 pF1KE5 STRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAY-G :..: .:..:.:::...: : . .:: : NP_005 MASPDPPATSYAPSDVPSGVALFLTIPFAFFLPELIFGFLVWTMVAAT-HIVYPLLQG 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI-ACSAAV :::.:.. .:...... ::: .. .. : .. ... .. .::..: . :.. NP_005 WVMYVSLTSFLISLMFLLSYLFGFYKRFE--SWRVLDSLYHGTTGILYMSAAVLQVHATI 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 DLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA .: : : .:::::: .. . : . :: : NP_005 VSEKLLDPRIYYINSAASFFAFIATLLYILHAFSIYYH 120 130 140 150 >>NP_002362 (OMIM: 188860) myelin and lymphocyte protein (153 aa) initn: 146 init1: 132 opt: 198 Z-score: 259.7 bits: 54.4 E(85289): 1e-07 Smith-Waterman score: 198; 29.4% identity (60.8% similar) in 153 aa overlap (19-166:4-151) 10 20 30 40 50 pF1KE5 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGF-VRSRLGALMLL-QLVLGLLVWALIADT : :. .. :. :: : . : :... ....: ::: :.:.. NP_002 MAPAAATGGSTLPS-GFSVFTTLPDLLFIFEFIFGGLVWILVASS 10 20 30 40 60 70 80 90 100 110 pF1KE5 --PYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYI :. : . ::::::.:: ...: .:. ::.. : . : . .. .:...:. NP_002 LVPWPL--VQGWVMFVSVFCFVATTTLIILYIIGAHGG--ETSWVTLDAAYHCTAALFYL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 TAFIACS-AAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATS .: . . :.. . . : :.. :: :. .. . : : : :: :. NP_002 SASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS 110 120 130 140 150 180 pF1KE5 QMAGGYA >>XP_011510111 (OMIM: 602022) PREDICTED: MAL-like protei (149 aa) initn: 155 init1: 116 opt: 192 Z-score: 252.3 bits: 53.0 E(85289): 2.6e-07 Smith-Waterman score: 192; 30.0% identity (64.2% similar) in 120 aa overlap (45-162:31-147) 20 30 40 50 60 70 pF1KE5 PAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAY-GWVMFVA :..:.:::...: : . .:: ::::.:. XP_011 MEKLTEDSRKKKKGAGIFGKETRIQNTTKLLIFGFLVWTMVAAT-HIVYPLLQGWVMYVS 10 20 30 40 50 80 90 100 110 120 130 pF1KE5 VFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI-ACSAAVDLTSLR . .:...... ::: .. .. : .. ... .. .::..: . :.. .: XP_011 LTSFLISLMFLLSYLFGFYKRFE--SWRVLDSLYHGTTGILYMSAAVLQVHATIVSEKLL 60 70 80 90 100 110 140 150 160 170 180 pF1KE5 GTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA : : .:::::: .. . : . :: : XP_011 DPRIYYINSAASFFAFIATLLYILHAFSIYYH 120 130 140 >>NP_852662 (OMIM: 607887) CKLF-like MARVEL transmembran (208 aa) initn: 154 init1: 76 opt: 184 Z-score: 240.5 bits: 51.3 E(85289): 1.2e-06 Smith-Waterman score: 185; 30.7% identity (59.0% similar) in 166 aa overlap (13-166:24-176) 10 20 30 40 pF1KE5 MAEFPSKVSTRTSSPAQGAEASVS------ALRPDLGFVRSRLGALMLL ::: : . :: .:: : ..:. :: : . NP_852 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 QLVLGLLVWALIADTPYHLYPAYG--WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWP :..:.:... : .: . : : . ::. ..:: ::. .. ..:::.. .. : NP_852 QVILALIAFICI-ETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWN 70 80 90 100 110 110 120 130 140 150 pF1KE5 LVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRA----AASFFACLVMIAYGVS :. .. : . ..::. :.. :..: :.:: :: .:. :. ::.:. NP_852 LTDLV-NTG-----LSAFLFFIASIVLAAL------NHRAGAEIAAVIFGFLATAAYAVN 120 130 140 150 160 160 170 180 pF1KE5 AFFSYQAWRGVGSNAATSQMAGGYA .:.. : :: NP_852 TFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT 170 180 190 200 >>XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like MARVE (221 aa) initn: 154 init1: 76 opt: 184 Z-score: 240.2 bits: 51.3 E(85289): 1.2e-06 Smith-Waterman score: 185; 30.7% identity (59.0% similar) in 166 aa overlap (13-166:24-176) 10 20 30 40 pF1KE5 MAEFPSKVSTRTSSPAQGAEASVS------ALRPDLGFVRSRLGALMLL ::: : . :: .:: : ..:. :: : . XP_016 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 QLVLGLLVWALIADTPYHLYPAYG--WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWP :..:.:... : .: . : : . ::. ..:: ::. .. ..:::.. .. : XP_016 QVILALIAFICI-ETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWN 70 80 90 100 110 110 120 130 140 150 pF1KE5 LVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRA----AASFFACLVMIAYGVS :. .. : . ..::. :.. :..: :.:: :: .:. :. ::.:. XP_016 LTDLV-NTG-----LSAFLFFIASIVLAAL------NHRAGAEIAAVIFGFLATAAYAVN 120 130 140 150 160 160 170 180 pF1KE5 AFFSYQAWRGVGSNAATSQMAGGYA .:.. : :: XP_016 TFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTLNWKPNGHQQVKG 170 180 190 200 210 220 182 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:52:23 2016 done: Mon Nov 7 22:52:24 2016 Total Scan time: 5.570 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]