Result of FASTA (omim) for
pFN21AB9733
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9733, 483 aa
1>>>pF1KB9733 483 - 483 aa - 483 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.6544+/-0.000435; mu= -11.1257+/- 0.027
mean_var=642.6664+/-132.296, 0's: 0 Z-trim(125.9): 41 B-trim: 923 in 1/61
Lambda= 0.050592
statistics sampled from 50715 (50775) to 50715 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.837), E-opt: 0.2 (0.595), width: 16
Scan time: 10.840
The best scores are: opt bits E(85289)
NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 3386 261.7 3.4e-69
NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 3366 260.2 9.4e-69
XP_011521111 (OMIM: 606195,611174) PREDICTED: iroq ( 413) 2856 222.9 1.4e-57
NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 1134 97.3 1e-19
NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 1134 97.3 1e-19
XP_011512281 (OMIM: 606198) PREDICTED: iroquois-cl ( 471) 1134 97.3 1e-19
NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 802 73.1 2.1e-12
XP_005256196 (OMIM: 612985) PREDICTED: iroquois-cl ( 529) 802 73.1 2.2e-12
NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 705 66.0 2.9e-10
NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 705 66.0 2.9e-10
NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 705 66.0 2.9e-10
XP_016865334 (OMIM: 606197) PREDICTED: iroquois-cl ( 449) 604 58.6 4.3e-08
NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 604 58.6 4.5e-08
NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 604 58.7 4.9e-08
NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 604 58.7 4.9e-08
XP_005256194 (OMIM: 606196) PREDICTED: iroquois-cl ( 445) 503 51.2 7.1e-06
NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 503 51.2 7.2e-06
>>NP_005844 (OMIM: 606195,611174) iroquois-class homeodo (483 aa)
initn: 3386 init1: 3386 opt: 3386 Z-score: 1363.2 bits: 261.7 E(85289): 3.4e-69
Smith-Waterman score: 3386; 99.8% identity (99.8% similar) in 483 aa overlap (1-483:1-483)
10 20 30 40 50 60
pF1KB9 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 YNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 TRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAASGCERLQGPPTPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAASGCERLQGPPTPAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 KETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGP
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_005 KETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 HPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 PCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGM
430 440 450 460 470 480
pF1KB9 SDI
:::
NP_005 SDI
>>NP_001239126 (OMIM: 606195,611174) iroquois-class home (482 aa)
initn: 1908 init1: 1908 opt: 3366 Z-score: 1355.4 bits: 260.2 E(85289): 9.4e-69
Smith-Waterman score: 3366; 99.6% identity (99.6% similar) in 483 aa overlap (1-483:1-482)
10 20 30 40 50 60
pF1KB9 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 YNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 TRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 PRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAASGCERLQGPPTPAG
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
NP_001 PRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAG-AEQKAASGCERLQGPPTPAG
190 200 210 220 230
250 260 270 280 290 300
pF1KB9 KETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGP
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
NP_001 KETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB9 HPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB9 PCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGH
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB9 LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGM
420 430 440 450 460 470
pF1KB9 SDI
:::
NP_001 SDI
480
>>XP_011521111 (OMIM: 606195,611174) PREDICTED: iroquois (413 aa)
initn: 2856 init1: 2856 opt: 2856 Z-score: 1155.0 bits: 222.9 E(85289): 1.4e-57
Smith-Waterman score: 2856; 98.5% identity (99.3% similar) in 409 aa overlap (75-483:5-413)
50 60 70 80 90 100
pF1KB9 FSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAA
::.: :.. :::::::::::::::::::::
XP_011 MEGRAAVARSAHGGSPYDHTPGMAGSLGYHPYAA
10 20 30
110 120 130 140 150 160
pF1KB9 PLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWF
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB9 ANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQK
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB9 AASGCERLQGPPTPAGKETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAARLA
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_011 AASGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLA
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB9 EDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSS
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB9 DKVKDGGGGNEGSPCPPCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKVKDGGGGNEGSPCPPCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYY
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB9 TAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQS
340 350 360 370 380 390
470 480
pF1KB9 QLDLCKDSPYELKKGMSDI
:::::::::::::::::::
XP_011 QLDLCKDSPYELKKGMSDI
400 410
>>NP_001127694 (OMIM: 606198) iroquois-class homeodomain (471 aa)
initn: 970 init1: 655 opt: 1134 Z-score: 475.0 bits: 97.3 E(85289): 1e-19
Smith-Waterman score: 1246; 51.5% identity (69.8% similar) in 443 aa overlap (1-424:1-405)
10 20 30 40 50
pF1KB9 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSP-
:::::::::: .::::::::::..:....::..::.::.:::::::: ::.:::: .
NP_001 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 GYNSHLQYGADPAAAAAAAFSSYVGSPYD-HTPGMAGSLGYHPYAAPLGSYPY--GDPAY
:..: :::.:: ::::::.: ::.:.::: :: ::.:...::::.. ..::: .::::
NP_001 GFGSPLQYSAD-AAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGS--AAYPYQLNDPAY
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK
120 130 140 150 160 170
180 190 200 210 220
pF1KB9 MTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQ---------KAAS
:::.:::.::::.:.:. : .. .. :.: .. . . . : . . .: :
NP_001 MTWAPRNKSEDEDEDEG-DATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAES
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 GCERLQ---GPPT-PAGKETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAARL
:.: : : .:.: . . .: . : .: .: .::. :: : :
NP_001 DGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPVTSSPLTGLEAPL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB9 AEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATS
: : .:: : ..: : .. : :::: .:::::::::::::
NP_001 LSPP----PEAAPRGG-----RKTPQGS------RTSPGAPPPA--SKPKLWSLAEIATS
300 310 320 330
350 360 370 380 390 400
pF1KB9 SDKVKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPL
. : . : : : : :: : :. ::: . .: . :.:.. .:.:::
NP_001 DLKQPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGSPYPASPLLGRPL
340 350 360 370 380
410 420 430 440 450 460
pF1KB9 YYTAPFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLR
:::.::: .:::::... :.:.
NP_001 YYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESH
390 400 410 420 430 440
>>NP_150366 (OMIM: 606198) iroquois-class homeodomain pr (471 aa)
initn: 970 init1: 655 opt: 1134 Z-score: 475.0 bits: 97.3 E(85289): 1e-19
Smith-Waterman score: 1246; 51.5% identity (69.8% similar) in 443 aa overlap (1-424:1-405)
10 20 30 40 50
pF1KB9 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSP-
:::::::::: .::::::::::..:....::..::.::.:::::::: ::.:::: .
NP_150 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 GYNSHLQYGADPAAAAAAAFSSYVGSPYD-HTPGMAGSLGYHPYAAPLGSYPY--GDPAY
:..: :::.:: ::::::.: ::.:.::: :: ::.:...::::.. ..::: .::::
NP_150 GFGSPLQYSAD-AAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGS--AAYPYQLNDPAY
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK
120 130 140 150 160 170
180 190 200 210 220
pF1KB9 MTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQ---------KAAS
:::.:::.::::.:.:. : .. .. :.: .. . . . : . . .: :
NP_150 MTWAPRNKSEDEDEDEG-DATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAES
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 GCERLQ---GPPT-PAGKETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAARL
:.: : : .:.: . . .: . : .: .: .::. :: : :
NP_150 DGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPVTSSPLTGLEAPL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB9 AEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATS
: : .:: : ..: : .. : :::: .:::::::::::::
NP_150 LSPP----PEAAPRGG-----RKTPQGS------RTSPGAPPPA--SKPKLWSLAEIATS
300 310 320 330
350 360 370 380 390 400
pF1KB9 SDKVKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPL
. : . : : : : :: : :. ::: . .: . :.:.. .:.:::
NP_150 DLKQPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGSPYPASPLLGRPL
340 350 360 370 380
410 420 430 440 450 460
pF1KB9 YYTAPFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLR
:::.::: .:::::... :.:.
NP_150 YYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESH
390 400 410 420 430 440
>>XP_011512281 (OMIM: 606198) PREDICTED: iroquois-class (471 aa)
initn: 970 init1: 655 opt: 1134 Z-score: 475.0 bits: 97.3 E(85289): 1e-19
Smith-Waterman score: 1246; 51.5% identity (69.8% similar) in 443 aa overlap (1-424:1-405)
10 20 30 40 50
pF1KB9 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSP-
:::::::::: .::::::::::..:....::..::.::.:::::::: ::.:::: .
XP_011 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 GYNSHLQYGADPAAAAAAAFSSYVGSPYD-HTPGMAGSLGYHPYAAPLGSYPY--GDPAY
:..: :::.:: ::::::.: ::.:.::: :: ::.:...::::.. ..::: .::::
XP_011 GFGSPLQYSAD-AAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGS--AAYPYQLNDPAY
70 80 90 100 110
120 130 140 150 160 170
pF1KB9 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK
120 130 140 150 160 170
180 190 200 210 220
pF1KB9 MTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQ---------KAAS
:::.:::.::::.:.:. : .. .. :.: .. . . . : . . .: :
XP_011 MTWAPRNKSEDEDEDEG-DATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAES
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 GCERLQ---GPPT-PAGKETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAARL
:.: : : .:.: . . .: . : .: .: .::. :: : :
XP_011 DGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPVTSSPLTGLEAPL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB9 AEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATS
: : .:: : ..: : .. : :::: .:::::::::::::
XP_011 LSPP----PEAAPRGG-----RKTPQGS------RTSPGAPPPA--SKPKLWSLAEIATS
300 310 320 330
350 360 370 380 390 400
pF1KB9 SDKVKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPL
. : . : : : : :: : :. ::: . .: . :.:.. .:.:::
XP_011 DLKQPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGSPYPASPLLGRPL
340 350 360 370 380
410 420 430 440 450 460
pF1KB9 YYTAPFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLR
:::.::: .:::::... :.:.
XP_011 YYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESH
390 400 410 420 430 440
>>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa)
initn: 730 init1: 522 opt: 802 Z-score: 343.8 bits: 73.1 E(85289): 2.1e-12
Smith-Waterman score: 811; 38.4% identity (56.3% similar) in 497 aa overlap (1-465:1-479)
10 20 30 40
pF1KB9 MSYPQ-GYLY----QPSASLALYSCPAYSTSVISG--PRTDELGRSSSGSAF------SP
::.:: :: : :: . . . :... .: ..::. :.: : .:
NP_077 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 YAGSTAFTAPSPGYNSHLQYGAD-PAAAAAAAFSSYVGSPYDHTPGMAGSLGY-HPYAAP
::...: .: . ::.. : :.:. : .: :: . :. :... . :: :
NP_077 YAAAAA-AAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYP
70 80 90 100 110
110 120 130 140 150 160
pF1KB9 LGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
:.: .:::. :::::..:.:::::::::::::::::::::::::::::::::::::::
NP_077 YGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 NARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPED---KGDPEGPEAGGAE
::::::::::::::.::.:.. :: . :...::: . :: . . : : :: :
NP_077 NARRRLKKENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEE
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 QKAASGCERLQGPPTPAGKETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAAR
. .: : : .. : .: . : : : .: : : : :: .
NP_077 ED--TGGEGLADD----DEDEEIDLENLDGAATEPE---LSLAGAARRDGDLGLGPISDS
240 250 260 270 280
290 300 310 320 330
pF1KB9 LAEDPAPH--------YPAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPK
: :. . ::.: :.: : :. : :. : : : ..: :::
NP_077 KNSDSEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPK
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB9 LWSLAEIATSSDKVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-P
.::::: ::: :. . . : ::: :: .: .:: : :. : : : ::
NP_077 IWSLAETATSPDNPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGK
350 360 370 380 390 400
400 410 420 430 440
pF1KB9 FPGGTVLSRPLYYTAP---FYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLN
::. : .::. : ..: .. :: : :: . :... . . . .
NP_077 FPAWT--NRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTD
410 420 430 440 450 460
450 460 470 480
pF1KB9 RADALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI
: .:: . :.:.. :
NP_077 RCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
470 480 490 500
>>XP_005256196 (OMIM: 612985) PREDICTED: iroquois-class (529 aa)
initn: 730 init1: 522 opt: 802 Z-score: 343.5 bits: 73.1 E(85289): 2.2e-12
Smith-Waterman score: 811; 38.4% identity (56.3% similar) in 497 aa overlap (1-465:1-479)
10 20 30 40
pF1KB9 MSYPQ-GYLY----QPSASLALYSCPAYSTSVISG--PRTDELGRSSSGSAF------SP
::.:: :: : :: . . . :... .: ..::. :.: : .:
XP_005 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 YAGSTAFTAPSPGYNSHLQYGAD-PAAAAAAAFSSYVGSPYDHTPGMAGSLGY-HPYAAP
::...: .: . ::.. : :.:. : .: :: . :. :... . :: :
XP_005 YAAAAA-AAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYP
70 80 90 100 110
110 120 130 140 150 160
pF1KB9 LGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
:.: .:::. :::::..:.:::::::::::::::::::::::::::::::::::::::
XP_005 YGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 NARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPED---KGDPEGPEAGGAE
::::::::::::::.::.:.. :: . :...::: . :: . . : : :: :
XP_005 NARRRLKKENKMTWAPRSRTD--EEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEE
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB9 QKAASGCERLQGPPTPAGKETEGSLSDSDFKETPSEGRLDALQGPPRTGGPSPAGPAAAR
. .: : : .. : .: . : : : .: : : : :: .
XP_005 ED--TGGEGLADD----DEDEEIDLENLDGAATEPE---LSLAGAARRDGDLGLGPISDS
240 250 260 270 280
290 300 310 320 330
pF1KB9 LAEDPAPH--------YPAGAPAPGPHPAAGEVPPGPGGP-SVIHSPPPPPPPAVLAKPK
: :. . ::.: :.: : :. : :. : : : ..: :::
XP_005 KNSDSEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPK
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB9 LWSLAEIATSSDKVKDGGGGNEGSPCPPCPGP-IAGQALGGSRASPAPAPSRSPSAQC-P
.::::: ::: :. . . : ::: :: .: .:: : :. : : : ::
XP_005 IWSLAETATSPDNPRRSPPGAGGSP----PGAAVAPSALQLSPAAAAAAAHRLVSAPLGK
350 360 370 380 390 400
400 410 420 430 440
pF1KB9 FPGGTVLSRPLYYTAP---FYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLN
::. : .::. : ..: .. :: : :: . :... . . . .
XP_005 FPAWT--NRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTD
410 420 430 440 450 460
450 460 470 480
pF1KB9 RADALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI
: .:: . :.:.. :
XP_005 RCSALEVEKKLLKTAFQPVPRRPRPRVLTPRAHPTVKPQHTHLQLDIILHCDTFLTIGPN
470 480 490 500 510 520
>>NP_001265561 (OMIM: 606199) iroquois-class homeodomain (519 aa)
initn: 562 init1: 451 opt: 705 Z-score: 305.3 bits: 66.0 E(85289): 2.9e-10
Smith-Waterman score: 705; 38.7% identity (59.6% similar) in 406 aa overlap (11-394:39-422)
10 20 30
pF1KB9 MSYPQGYLYQPSASL-ALYSCPAYSTSVISGPRTDELGRS
:.:: : ::.: . ... : . . .
NP_001 PYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 SSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAA-AAAAAFSSYVGSPYDHTPGMA-GSL
. : .::.:: ::.... ::.. .: . .:.: :: : :.: ..
NP_001 ALGVYGGPYGGS-------QGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHG-GLAPAAA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 GYHPYAAPLGSYPYG------DPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAI
.:.:: ::.::: . . ::::::..:.::::::.::::::::::::::::::
NP_001 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
130 140 150 160 170 180
160 170 180 190 200
pF1KB9 ITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDE-----EEEENIDLEKNDEDEPQK
:::::::::::::::::::::::::::: :::. :: : ::. :.. ..:: :
NP_001 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB9 PEDKGDPEGPEAGGAEQKAASGCERLQG-PPTPAGKETEGSLSDSDFKETPS--EGRLDA
...: : : : . . . :.. ::. : :: :. ....:. .: .
NP_001 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSL-DGGLERVPAAPDGPVKE
250 260 270 280 290
270 280 290 300 310 320
pF1KB9 LQGPPRTGGPSPAGPAAARLAED-PAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSP--
.: : : :. ..: : :: . . : ::.: .: . :::.: ..
NP_001 ASGALRM---SLAAGGGAALDEDLERARSCLRSAAAGPEP----LPGAEGGPQVCEAKLG
300 310 320 330 340 350
330 340 350 360 370
pF1KB9 --PPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPGPIAGQALGGSRASP
: .. :::..::::. ::.. . . . .: : : : : . :.
NP_001 FVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTE---FPSCMLKRQGPA---APAAV
360 370 380 390 400
380 390 400 410 420 430
pF1KB9 APAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSH
. ::. :::. : :
NP_001 SSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLD
410 420 430 440 450 460
>>NP_001265563 (OMIM: 606199) iroquois-class homeodomain (519 aa)
initn: 562 init1: 451 opt: 705 Z-score: 305.3 bits: 66.0 E(85289): 2.9e-10
Smith-Waterman score: 705; 38.7% identity (59.6% similar) in 406 aa overlap (11-394:39-422)
10 20 30
pF1KB9 MSYPQGYLYQPSASL-ALYSCPAYSTSVISGPRTDELGRS
:.:: : ::.: . ... : . . .
NP_001 PYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 SSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAA-AAAAAFSSYVGSPYDHTPGMA-GSL
. : .::.:: ::.... ::.. .: . .:.: :: : :.: ..
NP_001 ALGVYGGPYGGS-------QGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHG-GLAPAAA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 GYHPYAAPLGSYPYG------DPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAI
.:.:: ::.::: . . ::::::..:.::::::.::::::::::::::::::
NP_001 AYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAI
130 140 150 160 170 180
160 170 180 190 200
pF1KB9 ITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDE-----EEEENIDLEKNDEDEPQK
:::::::::::::::::::::::::::: :::. :: : ::. :.. ..:: :
NP_001 ITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLK
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB9 PEDKGDPEGPEAGGAEQKAASGCERLQG-PPTPAGKETEGSLSDSDFKETPS--EGRLDA
...: : : : . . . :.. ::. : :: :. ....:. .: .
NP_001 SSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSL-DGGLERVPAAPDGPVKE
250 260 270 280 290
270 280 290 300 310 320
pF1KB9 LQGPPRTGGPSPAGPAAARLAED-PAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSP--
.: : : :. ..: : :: . . : ::.: .: . :::.: ..
NP_001 ASGALRM---SLAAGGGAALDEDLERARSCLRSAAAGPEP----LPGAEGGPQVCEAKLG
300 310 320 330 340 350
330 340 350 360 370
pF1KB9 --PPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPGPIAGQALGGSRASP
: .. :::..::::. ::.. . . . .: : : : : . :.
NP_001 FVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTE---FPSCMLKRQGPA---APAAV
360 370 380 390 400
380 390 400 410 420 430
pF1KB9 APAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSH
. ::. :::. : :
NP_001 SSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLD
410 420 430 440 450 460
483 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:32:17 2016 done: Sun Nov 6 04:32:18 2016
Total Scan time: 10.840 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]