FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5729, 640 aa 1>>>pF1KE5729 640 - 640 aa - 640 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5326+/-0.000391; mu= 14.8155+/- 0.025 mean_var=114.5845+/-23.414, 0's: 0 Z-trim(115.3): 45 B-trim: 0 in 0/51 Lambda= 0.119815 statistics sampled from 25574 (25619) to 25574 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.3), width: 16 Scan time: 8.460 The best scores are: opt bits E(85289) NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 4436 778.1 0 XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 4436 778.1 0 XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 4436 778.2 0 XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 4436 778.2 0 XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 2388 424.1 7.2e-118 NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 1301 236.2 2.7e-61 NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 1207 220.0 2.2e-56 NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 1207 220.0 2.2e-56 NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 1207 220.0 2.3e-56 XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 858 159.7 3e-38 XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 858 159.7 3e-38 XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 858 159.7 3.2e-38 XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 858 159.7 3.2e-38 XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 858 159.7 3.3e-38 XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 858 159.7 3.4e-38 XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 858 159.7 3.4e-38 XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 858 159.7 3.4e-38 XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 858 159.7 3.4e-38 XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 858 159.7 3.5e-38 XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 858 159.7 3.6e-38 NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 858 159.7 3.6e-38 XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 858 159.7 3.6e-38 XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 858 159.7 3.6e-38 XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 858 159.7 3.7e-38 XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 858 159.8 3.7e-38 XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 858 159.8 3.8e-38 XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 858 159.8 3.8e-38 XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 858 159.8 3.9e-38 XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 858 159.8 3.9e-38 NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 381 77.2 1.8e-13 NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 376 76.3 3.2e-13 NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 367 74.7 9.4e-13 NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 366 74.6 1e-12 XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 304 63.8 1.6e-09 NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 304 63.8 1.7e-09 NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 227 50.5 1.7e-05 NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 227 50.6 1.9e-05 NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 208 47.2 0.00017 XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 208 47.2 0.00017 XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 208 47.3 0.00018 XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 208 47.3 0.00018 NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 208 47.3 0.00018 NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 208 47.3 0.0002 XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 194 44.7 0.00062 NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 196 45.2 0.00087 >>NP_000327 (OMIM: 177200,211400,264350,600760) amilorid (640 aa) initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.2 bits: 778.1 E(85289): 0 Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:1-640) 10 20 30 40 50 60 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPKKKAMWFLLTLLFA :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_000 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 EKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 QSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 GEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN 550 560 570 580 590 600 610 620 630 640 pF1KE5 TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI :::::::::::::::::::::::::::::::::::::::: NP_000 TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI 610 620 630 640 >>XP_011544216 (OMIM: 177200,211400,264350,600760) PREDI (646 aa) initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.1 bits: 778.1 E(85289): 0 Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:7-646) 10 20 30 40 50 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPKKKAMWFL :::::::::::::::::::::::::::::::::::::::: ::::::::::::: XP_011 MTVGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 LTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 LDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 TSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 LVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 LKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRM 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 GEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKY 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 CNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 LSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE5 LCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDT 550 560 570 580 590 600 600 610 620 630 640 pF1KE5 APRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI :::::::::::::::::::::::::::::::::::::::::::::: XP_011 APRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI 610 620 630 640 >>XP_011544215 (OMIM: 177200,211400,264350,600760) PREDI (651 aa) initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.1 bits: 778.2 E(85289): 0 Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:12-651) 10 20 30 40 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPKKK :::::::::::::::::::::::::::::::::::::::: :::::::: XP_011 MGKPGHREGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 AMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 HLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGD 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE5 NHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE5 VPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANP 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE5 GTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVD 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE5 KLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLP 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE5 RGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASED 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE5 WIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFW 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE5 MGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFG 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE5 FQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI 610 620 630 640 650 >>XP_016879014 (OMIM: 177200,211400,264350,600760) PREDI (659 aa) initn: 4436 init1: 4436 opt: 4436 Z-score: 4150.0 bits: 778.2 E(85289): 0 Smith-Waterman score: 4436; 99.8% identity (99.8% similar) in 640 aa overlap (1-640:20-659) 10 20 30 40 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRT :::::::::::::::::::::::::::::::::::::::: XP_016 MVKQSWTQQHQETTLTGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE5 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE5 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE5 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE5 TSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNC 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE5 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE5 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE5 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE5 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI 610 620 630 640 650 >>XP_016879015 (OMIM: 177200,211400,264350,600760) PREDI (623 aa) initn: 4173 init1: 2387 opt: 2388 Z-score: 2237.1 bits: 424.1 E(85289): 7.2e-118 Smith-Waterman score: 4105; 94.2% identity (94.2% similar) in 640 aa overlap (1-640:20-623) 10 20 30 40 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRT :::::::::::::::::::::::::::::::::::::::: XP_016 MVKQSWTQQHQETTLTGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICEGPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNAS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE5 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE5 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTE 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE5 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE5 TSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNC ::::::: ::::::::::::::::: XP_016 TSIGVLV------------------------------------ACLRSCFQDHMIRNCNC 370 380 410 420 430 440 450 460 pF1KE5 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMAD 390 400 410 420 430 440 470 480 490 500 510 520 pF1KE5 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSN 450 460 470 480 490 500 530 540 550 560 570 580 pF1KE5 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAEL 510 520 530 540 550 560 590 600 610 620 630 640 pF1KE5 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI 570 580 590 600 610 620 >>NP_001030 (OMIM: 177200,264350,600761,613071) amilorid (649 aa) initn: 1191 init1: 546 opt: 1301 Z-score: 1221.4 bits: 236.2 E(85289): 2.7e-61 Smith-Waterman score: 1467; 36.5% identity (69.4% similar) in 627 aa overlap (17-626:19-633) 10 20 30 40 50 pF1KE5 MHVKKYLLKGLHRLQKGP-GYTYKELLVWYCDNTNTHGPKR-TICEGPKKKAMWFLLT :: . : :::. ::: :::::: .: .. .: .. .:. .: NP_001 MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 LLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLD : .::. :: .... .. . ::::..: :. .::::::::: .:.::: ..::: ::. NP_001 LTAVALILWQCALLVFSF--YTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLE 70 80 90 100 110 120 130 140 150 160 pF1KE5 ELMEAVLERILA-PELSHANATRNLNFSI-------WNHT-PLVLIDERNPHHPMVLDLF . . .:. . . :: . ... : :. ..: ::...:. .. . :.: NP_001 QETREALKSLYGFPESRKRREAESWN-SVSEGKQPRFSHRIPLLIFDQ--DEKGKARDFF 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 GDNHNGLTSS---SASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQAT . . .: .::. . ....::: . ..:. .:.:. .:. ::: :. NP_001 TGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYM 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 NIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKAL ::.:::: .. ..::: .:.....:.: . :. :::: . .: .:::: :: .: : NP_001 NIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETIL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE5 PSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSI .. :.:.::..:: :..:.: :::.:..:.....:.: :::..: : .. ::: NP_001 STSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSI 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE5 GVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHY :. . . ...:::: :: .::.::..:.: :..::.: ::.:::: .:...:.:..: NP_001 GMHLTESFKLSEPYSQCTEDGSDVPIRNIY---NAAYSLQICLHSCFQTKMVEKCGCAQY 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE5 LYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWP ::: . .::: .. :.: .:: .:. . .:.: : ..:::.:. .. .: :.:.:: NP_001 SQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWP 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE5 SEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLG : .:: :.. ::. .. ...: :.. ..:: :.....: :.: :: ::.: ::::.: NP_001 SVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFG 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE5 GQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPP-PTVAELV ::.:.::. ::.:.:: ::. .: .....: . . .. : .:: : . . NP_001 GQLGLWMSCSVVCVIE----IIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSP 540 550 560 570 580 590 600 610 620 630 640 pF1KE5 EAHTNFGFQ-PDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI ... : ... : : .. : . .::::::.:..:::. NP_001 QGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDE 590 600 610 620 630 640 NP_001 L >>NP_001029 (OMIM: 264350,600228,613021) amiloride-sensi (669 aa) initn: 1123 init1: 448 opt: 1207 Z-score: 1133.4 bits: 220.0 E(85289): 2.2e-56 Smith-Waterman score: 1227; 32.4% identity (65.6% similar) in 620 aa overlap (21-627:54-651) 10 20 30 40 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPK--K .:.::. ..:.::. :: : .: . : NP_001 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI :.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .: NP_001 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE5 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV :. :..::.. : .: . .. .. . . :.: .. : : : : : NP_001 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPP-- 150 160 170 180 190 170 180 190 200 210 220 pF1KE5 LDLFGDNHNGLTSSSASEKI--CNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL : . ..:: .. . . :....::. :...: .....:...:. ::: . NP_001 ---HGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE5 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT . ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: . NP_001 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE5 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT . :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :. NP_001 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE5 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN ::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:. NP_001 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG 380 390 400 410 420 430 410 420 430 440 450 pF1KE5 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM :.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... .. NP_001 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY 440 450 460 470 480 490 460 470 480 490 500 510 pF1KE5 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL . ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: :: NP_001 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL 500 510 520 530 540 520 530 540 550 560 570 pF1KE5 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV ::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: : NP_001 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE5 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG : . . : : : . :: :: : .::: : .: .: NP_001 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS 610 620 630 640 650 660 640 pF1KE5 DAI NP_001 STCPLGGP >>NP_001153047 (OMIM: 264350,600228,613021) amiloride-se (692 aa) initn: 1123 init1: 448 opt: 1207 Z-score: 1133.2 bits: 220.0 E(85289): 2.2e-56 Smith-Waterman score: 1227; 32.4% identity (65.6% similar) in 620 aa overlap (21-627:77-674) 10 20 30 40 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPK--K .:.::. ..:.::. :: : .: . : NP_001 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK 50 60 70 80 90 100 50 60 70 80 90 100 pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI :.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .: NP_001 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI 110 120 130 140 150 160 110 120 130 140 150 160 pF1KE5 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV :. :..::.. : .: . .. .. . . :.: .. : : : : : NP_001 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPP-- 170 180 190 200 210 220 170 180 190 200 210 220 pF1KE5 LDLFGDNHNGLTSSSASEKI--CNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL : . ..:: .. . . :....::. :...: .....:...:. ::: . NP_001 ---HGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF 230 240 250 260 270 230 240 250 260 270 280 pF1KE5 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT . ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: . NP_001 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE5 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT . :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :. NP_001 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE5 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN ::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:. NP_001 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG 400 410 420 430 440 450 410 420 430 440 450 pF1KE5 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM :.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... .. NP_001 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE5 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL . ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: :: NP_001 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE5 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV ::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: : NP_001 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV 580 590 600 610 620 580 590 600 610 620 630 pF1KE5 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG : . . : : : . :: :: : .::: : .: .: NP_001 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS 630 640 650 660 670 680 640 pF1KE5 DAI NP_001 STCPLGGP 690 >>NP_001153048 (OMIM: 264350,600228,613021) amiloride-se (728 aa) initn: 1123 init1: 448 opt: 1207 Z-score: 1132.9 bits: 220.0 E(85289): 2.3e-56 Smith-Waterman score: 1227; 32.4% identity (65.6% similar) in 620 aa overlap (21-627:113-710) 10 20 30 40 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTICEGPK--K .:.::. ..:.::. :: : .: . : NP_001 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI :.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .: NP_001 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE5 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV :. :..::.. : .: . .. .. . . :.: .. : : : : : NP_001 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPP-- 210 220 230 240 250 170 180 190 200 210 220 pF1KE5 LDLFGDNHNGLTSSSASEKI--CNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL : . ..:: .. . . :....::. :...: .....:...:. ::: . NP_001 ---HGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF 260 270 280 290 300 310 230 240 250 260 270 280 pF1KE5 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT . ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: . NP_001 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN 320 330 340 350 360 370 290 300 310 320 330 340 pF1KE5 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT . :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :. NP_001 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV 380 390 400 410 420 430 350 360 370 380 390 400 pF1KE5 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN ::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:. NP_001 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG 440 450 460 470 480 410 420 430 440 450 pF1KE5 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM :.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... .. NP_001 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY 490 500 510 520 530 540 460 470 480 490 500 510 pF1KE5 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL . ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: :: NP_001 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL 550 560 570 580 590 600 520 530 540 550 560 570 pF1KE5 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV ::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: : NP_001 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV 610 620 630 640 650 660 580 590 600 610 620 630 pF1KE5 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG : . . : : : . :: :: : .::: : .: .: NP_001 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS 670 680 690 700 710 720 640 pF1KE5 DAI NP_001 STCPLGGP >>XP_011540234 (OMIM: 601328) PREDICTED: amiloride-sensi (638 aa) initn: 920 init1: 346 opt: 858 Z-score: 807.7 bits: 159.7 E(85289): 3e-38 Smith-Waterman score: 1035; 29.9% identity (61.4% similar) in 606 aa overlap (21-614:55-616) 10 20 30 40 pF1KE5 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRTIC-EGPK-K ...:::...: :.. :: : .: .: . : XP_011 AQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLK 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE5 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI . : ::.: . .::: :.... . : ...:: . .: ::.:...: . : . XP_011 TTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPV 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE5 KHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFG . :. :::. . .. . .::.. :. :. .. : : .:.. . : XP_011 LRHLELLDEFARENIDSLYNVNLSKGRAA--LSATVPRHEPPFHLDRE-------IRLQR 150 160 170 180 190 170 180 190 200 210 220 pF1KE5 DNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFA .:.: .. ....:::. . .: .:..::.. :. .:: .. ..:.: XP_011 LSHSG-------SRV------RVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILA 200 210 220 230 240 230 240 250 260 270 280 pF1KE5 QVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSA .: : . : : ...:.: . . :. :.: .. .: ::.:: . : . XP_011 LLPAAWEDSHGSQDG-HFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQ----- 250 260 270 280 290 290 300 310 320 330 340 pF1KE5 NPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVL :: :. :.: . :. ..:.:.. ::.:.:.: . ::. ... . :::..:.. XP_011 RPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIR 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE5 VDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYP :...:.: ::. ::..: : :. . .::.:. :::: ::::. :...:.::.::.: XP_011 EDEVHRLGSPYGHCTAGGEGVEVELL---HNTSYTRQACLVSCFQQLMVETCSCGYYLHP 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE5 LPRGEKYCNNRDFPDWAHCYSDLQMSV-AQRETCIGMCKESCNDTQYKMTISMADWPSEA :: : .::.. : :.::. : ... ..: : . : . : .. .:.. . . ::: XP_011 LPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAK 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE5 SEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQF : : . .:. :. . .:....:.:: .::.:::..::. . .. ::: .:. XP_011 SAGWTLATLG-EQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLC 480 490 500 510 520 530 530 540 550 560 570 580 pF1KE5 GFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHT ..:.:.::: :.:. :...: . . :: .. : ::: :. : : XP_011 SLWFGASVLSLLELLELLLD---ASALTLVLGGR--RLRRAWFSWPRASP-------ASG 540 550 560 570 580 590 600 610 620 630 pF1KE5 NFGFQPDTAPRSPNTG-----PYPSEQALP---IPGTPPPNYDSLRLQPLDVIESDSEGD ...:... : .: : :: :: .:: XP_011 ASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT 590 600 610 620 630 640 pF1KE5 AI 640 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:08:52 2016 done: Tue Nov 8 06:08:53 2016 Total Scan time: 8.460 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]