FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2743, 1139 aa 1>>>pF1KE2743 1139 - 1139 aa - 1139 aa Library: /omim/omim.rfq.tfa 65951994 residues in 93482 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4858+/-0.000409; mu= 21.6878+/- 0.026 mean_var=72.0124+/-14.380, 0's: 0 Z-trim(110.8): 29 B-trim: 1112 in 2/53 Lambda= 0.151137 statistics sampled from 20083 (20098) to 20083 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.564), E-opt: 0.2 (0.215), width: 16 Scan time: 7.220 The best scores are: opt bits E(93482) NP_653273 (OMIM: 607038,607039) otoancorin isoform (1139) 7439 1632.2 0 NP_001155155 (OMIM: 607038,607039) otoancorin isof (1060) 6868 1507.7 0 NP_733764 (OMIM: 607038,607039) otoancorin isoform ( 815) 5327 1171.7 0 XP_011544050 (OMIM: 607038,607039) otoancorin isof ( 798) 4999 1100.1 0 XP_016878440 (OMIM: 607038,607039) otoancorin isof ( 597) 3745 826.6 0 NP_714544 (OMIM: 603720,606440,611102,612997) ster (1775) 397 96.9 1.3e-18 NP_037536 (OMIM: 601051) mesothelin isoform 2 prep ( 630) 221 58.3 2e-07 NP_001170826 (OMIM: 601051) mesothelin isoform 1 p ( 622) 198 53.2 6.3e-06 NP_005814 (OMIM: 601051) mesothelin isoform 1 prep ( 622) 198 53.2 6.3e-06 >>NP_653273 (OMIM: 607038,607039) otoancorin isoform 1 p (1139 aa) initn: 7439 init1: 7439 opt: 7439 Z-score: 8757.1 bits: 1632.2 E(93482): 0 Smith-Waterman score: 7439; 99.9% identity (99.9% similar) in 1139 aa overlap (1-1139:1-1139) 10 20 30 40 50 60 pF1KE2 MSQEPTTYSLFLFLFLSHGVSSYTVPNSRQDLHPLLQNMAEEIIDGSYLNALLDLIQFQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 MSQEPTTYSLFLFLFLSHGVSSYTVPNSRQDLHPLLQNMAEEIIDGSYLNALLDLIQFQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQFRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 SHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQFRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 AMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 AMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVEIL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 GKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGILQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 TSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVYDI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSHLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 TPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSHLR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 GFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLNQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 GFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLNQV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 SGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAVSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 SGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAVSQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 YVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 YVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKELG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 RSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 RSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 YQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 YQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 KTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 KTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLN 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 PEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 PEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 RTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 RTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRC 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 MEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 MEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 LEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 LEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAIN 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 ITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 ITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 LTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPL :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 LTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KE2 QLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 QLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW 1090 1100 1110 1120 1130 >>NP_001155155 (OMIM: 607038,607039) otoancorin isoform (1060 aa) initn: 6868 init1: 6868 opt: 6868 Z-score: 8084.7 bits: 1507.7 E(93482): 0 Smith-Waterman score: 6868; 99.9% identity (99.9% similar) in 1051 aa overlap (89-1139:10-1060) 60 70 80 90 100 110 pF1KE2 QSSHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQF :::::::::::::::::::::::::::::: NP_001 MGNSITYRDQAAVENHLEQRLHQPQKLLEDLRKTDAQQF 10 20 30 120 130 140 150 160 170 pF1KE2 RTAMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTAMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVE 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE2 ILGKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGI 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE2 LQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVY 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE2 DITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSH 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE2 LRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLN 280 290 300 310 320 330 420 430 440 450 460 470 pF1KE2 QVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAV 340 350 360 370 380 390 480 490 500 510 520 530 pF1KE2 SQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKE 400 410 420 430 440 450 540 550 560 570 580 590 pF1KE2 LGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALL 460 470 480 490 500 510 600 610 620 630 640 650 pF1KE2 SPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDS 520 530 540 550 560 570 660 670 680 690 700 710 pF1KE2 HKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPD 580 590 600 610 620 630 720 730 740 750 760 770 pF1KE2 LNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASK 640 650 660 670 680 690 780 790 800 810 820 830 pF1KE2 MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDL 700 710 720 730 740 750 840 850 860 870 880 890 pF1KE2 RCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNE 760 770 780 790 800 810 900 910 920 930 940 950 pF1KE2 SELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCA 820 830 840 850 860 870 960 970 980 990 1000 1010 pF1KE2 INITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIA 880 890 900 910 920 930 1020 1030 1040 1050 1060 1070 pF1KE2 AGLTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLS :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLS 940 950 960 970 980 990 1080 1090 1100 1110 1120 1130 pF1KE2 PLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLL 1000 1010 1020 1030 1040 1050 pF1KE2 W : NP_001 W 1060 >>NP_733764 (OMIM: 607038,607039) otoancorin isoform 2 [ (815 aa) initn: 5327 init1: 5327 opt: 5327 Z-score: 6270.5 bits: 1171.7 E(93482): 0 Smith-Waterman score: 5327; 99.6% identity (99.8% similar) in 815 aa overlap (325-1139:1-815) 300 310 320 330 340 350 pF1KE2 DMVYDITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMI . :::::::::::::::::::::::::::: NP_733 MFRLGLLVCFYNDLELLDATVAQVLLYQMI 10 20 30 360 370 380 390 400 410 pF1KE2 KCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 KCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAI 40 50 60 70 80 90 420 430 440 450 460 470 pF1KE2 STLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 STLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVL 100 110 120 130 140 150 480 490 500 510 520 530 pF1KE2 RSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 RSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVL 160 170 180 190 200 210 540 550 560 570 580 590 pF1KE2 KDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 KDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNN 220 230 240 250 260 270 600 610 620 630 640 650 pF1KE2 FALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 FALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSL 280 290 300 310 320 330 660 670 680 690 700 710 pF1KE2 VLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 VLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLR 340 350 360 370 380 390 720 730 740 750 760 770 pF1KE2 DCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 DCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQ 400 410 420 430 440 450 780 790 800 810 820 830 pF1KE2 AASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 AASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWA 460 470 480 490 500 510 840 850 860 870 880 890 pF1KE2 LEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 LEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIAL 520 530 540 550 560 570 900 910 920 930 940 950 pF1KE2 ALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGA 580 590 600 610 620 630 960 970 980 990 1000 1010 pF1KE2 TLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 TLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQEL 640 650 660 670 680 690 1020 1030 1040 1050 1060 1070 pF1KE2 GTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQR :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GTIAAGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQR 700 710 720 730 740 750 1080 1090 1100 1110 1120 1130 pF1KE2 RRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 RRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLM 760 770 780 790 800 810 pF1KE2 AKLLW ::::: NP_733 AKLLW >>XP_011544050 (OMIM: 607038,607039) otoancorin isoform (798 aa) initn: 4999 init1: 4999 opt: 4999 Z-score: 5884.1 bits: 1100.1 E(93482): 0 Smith-Waterman score: 4999; 99.9% identity (99.9% similar) in 762 aa overlap (378-1139:1-762) 350 360 370 380 390 400 pF1KE2 VLLYQMIKCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSP :::::::::::::::::::::::::::::: XP_011 MENQTLNETLGSLSDAVVGLTYSQLESLSP 10 20 30 410 420 430 440 450 460 pF1KE2 EAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKR 40 50 60 70 80 90 470 480 490 500 510 520 pF1KE2 KDISQVLRSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDISQVLRSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQP 100 110 120 130 140 150 530 540 550 560 570 580 pF1KE2 GFNSTVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFNSTVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAH 160 170 180 190 200 210 590 600 610 620 630 640 pF1KE2 FQDFQNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQDFQNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLG 220 230 240 250 260 270 650 660 670 680 690 700 pF1KE2 KSWLDSLVLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSWLDSLVLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWA 280 290 300 310 320 330 710 720 730 740 750 760 pF1KE2 TALHGLRDCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TALHGLRDCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATK 340 350 360 370 380 390 770 780 790 800 810 820 pF1KE2 FPEILLQAASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FPEILLQAASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLA 400 410 420 430 440 450 830 840 850 860 870 880 pF1KE2 EANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIV 460 470 480 490 500 510 890 900 910 920 930 940 pF1KE2 SLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSF 520 530 540 550 560 570 950 960 970 980 990 1000 pF1KE2 HLVGLGATLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLVGLGATLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWT 580 590 600 610 620 630 1010 1020 1030 1040 1050 1060 pF1KE2 SSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAA ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_011 SSVLQELGTIAAGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAA 640 650 660 670 680 690 1070 1080 1090 1100 1110 1120 pF1KE2 AVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLG 700 710 720 730 740 750 1130 pF1KE2 CPLLVLMAKLLW :::::::::::: XP_011 CPLLVLMAKLLWCLPFPWDSAEWMAVKLSLNSQNIPCFWWRWWWLFWF 760 770 780 790 >>XP_016878440 (OMIM: 607038,607039) otoancorin isoform (597 aa) initn: 3745 init1: 3745 opt: 3745 Z-score: 4408.3 bits: 826.6 E(93482): 0 Smith-Waterman score: 3745; 99.8% identity (99.8% similar) in 561 aa overlap (579-1139:1-561) 550 560 570 580 590 600 pF1KE2 ELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSPYQVNCLAW :::::::::::::::::::::::::::::: XP_016 MSTDFFLAHFQDFQNNFALLSPYQVNCLAW 10 20 30 610 620 630 640 650 660 pF1KE2 KYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHKKTSVLRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHKKTSVLRKV 40 50 60 70 80 90 670 680 690 700 710 720 pF1KE2 QQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLNPEQKAAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLNPEQKAAVR 100 110 120 130 140 150 730 740 750 760 770 780 pF1KE2 LKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMARTLPTKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMARTLPTKEF 160 170 180 190 200 210 790 800 810 820 830 840 pF1KE2 LWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRCMEEDTFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRCMEEDTFIR 220 230 240 250 260 270 850 860 870 880 890 900 pF1KE2 TVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSS 280 290 300 310 320 330 910 920 930 940 950 960 pF1KE2 IDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIK 340 350 360 370 380 390 970 980 990 1000 1010 1020 pF1KE2 ISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAGLTKAALRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_016 ISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAGLTKAELRM 400 410 420 430 440 450 1030 1040 1050 1060 1070 1080 pF1KE2 LDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQA 460 470 480 490 500 510 1090 1100 1110 1120 1130 pF1KE2 LDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLWCLPFPWDSA 520 530 540 550 560 570 XP_016 EWMAVKLSLNSQNIPCFWWRWWWLFWF 580 590 >>NP_714544 (OMIM: 603720,606440,611102,612997) stereoci (1775 aa) initn: 384 init1: 206 opt: 397 Z-score: 455.9 bits: 96.9 E(93482): 1.3e-18 Smith-Waterman score: 462; 23.7% identity (51.1% similar) in 947 aa overlap (251-1122:861-1757) 230 240 250 260 270 280 pF1KE2 DKTSAHSQRALYSWMTGILQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIE .: : ::.. . :: .:.. ..:: . NP_714 IRDYSPGMRPEQKEALAKRLLAPELFGEVPAW-PQELLWAVLPLLPHLPLENFLQLSPHQ 840 850 860 870 880 290 300 310 320 330 pF1KE2 I-GLFISYDNATKQLDMVYDITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLE : .: :. : . : :. :. . ... . . ..::: :.:: . : NP_714 IQALEDSWPAA--------GLGPGHARHVLRSLVNQSVQ-DGEEQVRRLGPLACFLSPEE 890 900 910 920 930 940 340 350 360 370 380 390 pF1KE2 L-----LDATVAQVLLYQMIKCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAV : :. .. : ...:. : . .. ::: . .. . .:. : NP_714 LQSLVPLSDPTGPVE-RGLLECAA-NGTLSPEGRVAYELLGVL--RSSGGAVLSPRELRV 950 960 970 980 990 400 410 420 430 440 pF1KE2 VGLTYSQL-----ESLSPEAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQ . .::: . :: ... . .: : .. . .:...: .. : .. ::. .. . NP_714 WAPLFSQLGLRFLQELSEPQLRAMLPVL-QGTSVTPAQAVLLLGRLLPRHD-LSLEELCS 1000 1010 1020 1030 1040 1050 450 460 470 480 490 500 pF1KE2 MGALLAGVSTQAFCSMKRKDISQVLRSAVSQYVSDLS--PAQQQGILSKMVQAED----- . :: :.: :.. .. :. :: .: : . .:: : : . : . ...: NP_714 LHLLLPGLSPQTLQAIPRR----VLVGACSCLAPELSRLSACQTAALLQTFRVKDGVKNM 1060 1070 1080 1090 1100 1110 510 520 530 540 pF1KE2 --TAPG-IVEIQGAFFKE------VSLFDLRRQPGFNSTVLKDK----ELGRS--QALFL :. : : : : . . :. :. . ..: .. :: : :: :: NP_714 GTTGAGPAVCIPGQPIPTTWPDCLLPLLPLKLLQLDSLALLANRRRYWELPWSEQQAQFL 1120 1130 1140 1150 1160 1170 550 560 570 580 590 600 pF1KE2 YE-LLLKTTRRPEELLSAGQLVKGVTCSHIDAMST--DFFLAHFQDFQNNFALLSPYQVN .. . . :. ..: . : :. :..: .. ... ::. . . .: . . .. NP_714 WKKMQVPTNLTLRNLQALGTLAGGMSCEFLQQINSMVDFLEVVHMIYQLPTRVRGSLRA- 1180 1190 1200 1210 1220 610 620 630 640 650 pF1KE2 CLAWKYWEVSRLSMP-PFL------LAALPARYLASVP-------ASQCVPFLISLGKSW :. : . :..:: : : .: .. : ..: ... . ... : . NP_714 CI-WAELQ-RRMAMPEPEWTTVGPELNGLDSKLLLDLPIQLMDRLSNESIMLVVELVQRA 1230 1240 1250 1260 1270 1280 660 670 680 690 700 pF1KE2 LDSLV-LDSHKKTSVLRKVQQCL---DDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAW ..:. : ..... ... : : . .. : ... .: :. : . : : . NP_714 PEQLLALTPLHQAALAERALQNLAPKETPVSGE-VLETLGPLVGFLGTEST-RQIPLQIL 1290 1300 1310 1320 1330 1340 710 720 730 740 750 760 pF1KE2 ATALHGLRD-CPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIA . : :. : . . . : . : :. :. . ... : .. .: . .: : NP_714 LSHLSQLQGFCLGETFATELGWLLLQESVLGKPELWSQDEVEQAGRLVFTLSTEAISLIP 1350 1360 1370 1380 1390 1400 770 780 790 800 810 pF1KE2 TKF--PEILL-----QAASKMART--LPTKEFLWA-----VFQSVRNSSDKIPSYDPMPG . :: : : . ...:. : . : : : :: ... .: .:.:. NP_714 REALGPETLERLLEKQQSWEQSRVGQLCREPQLAAKKAALVAGVVRPAAEDLP--EPVPN 1410 1420 1430 1440 1450 1460 820 830 840 850 860 870 pF1KE2 CHGVVAPSSDDIFKLAEANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKA : : . : : :. .. :: . : . :... :.. .: . :: NP_714 CADVRG-----TFP-----AAWSATQIAEMELSDFEDCLTLFAGDPGLGPEELRAAMGKA 1470 1480 1490 1500 1510 880 890 900 910 920 930 pF1KE2 IQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQ :.: : .: ..:..:::. ..:.. ::..: : . ....:. :. : . ... NP_714 KQLWGPPRGFRPEQILQLGRLLIGLGDRELQELILVDWGVLSTLGQIDGWSTTQLRIVVS 1520 1530 1540 1550 1560 1570 940 950 960 970 980 pF1KE2 GYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL--LCSTHVL ..: .:: .. : ::..:: :::.. :. :. :: .. .::: :: . : NP_714 SFLRQSGRHVSHLDFVHLTALGYTLCGLRPEELQHISSWEFSQAALFLGTLHLQCSEEQL 1580 1590 1600 1610 1620 1630 990 1000 1010 1020 1030 1040 pF1KE2 AEFKRKAEVV---FGDPTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLP : . :. :: ..: .. :.::::::. :: : . . : ::. .: NP_714 -EVLAHLLVLPGGFGPISNWGPEIFTEIGTIAAGIPDLALSALLRGQIQGVTPLAISVIP 1640 1650 1660 1670 1680 1690 1050 1060 1070 1080 1090 1100 pF1KE2 DEIFKEL-SAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAG : . : :..:: .:.::: : ::: : ... : : ...: . : NP_714 PPKFAVVFSPIQLSSLTSAQAVAVTPEQMAFLSPEQRRAVAWA-----QHEGKESPEQQG 1700 1710 1720 1730 1740 1110 1120 1130 pF1KE2 PTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW :: : .::.: NP_714 -------RSTAWGLQDWSRPSWSLVLTISFLGHLL 1750 1760 1770 >>NP_037536 (OMIM: 601051) mesothelin isoform 2 prepropr (630 aa) initn: 79 init1: 51 opt: 221 Z-score: 255.2 bits: 58.3 E(93482): 2e-07 Smith-Waterman score: 259; 22.9% identity (47.8% similar) in 558 aa overlap (562-1090:61-580) 540 550 560 570 580 590 pF1KE2 TVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDF :: ::. : :......::. . NP_037 VQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLL-GFPCAEVSGLSTERVRELAVAL 40 50 60 70 80 600 610 620 630 640 pF1KE2 QNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYL------ASVPASQCVPFLIS .. . :: :. ::: ::: :: : ::: : : . :. :. NP_037 AQKNVKLSTEQLRCLA------HRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSR 90 100 110 120 130 140 650 660 670 680 690 700 pF1KE2 LGKSWLDSLVLDSHKKTSVLRKVQQC--LDDSIADEYTVDIMGNLLCHLPAAIIDRGISP . :. .: : . .. .: . : . :. .: : .:.: : ::. : .. NP_037 ITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPG----RFVAE 150 160 170 180 190 710 720 730 740 750 pF1KE2 RAWATALHGLRDCPD-LNPEQKAAVRLKLLG---QYGLPQHWTAETTKDLGPFLVLFSGD : . : : .:: :. .:. :.: : : :: :. :.. : : .: ... NP_037 SA-EVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQP 200 210 220 230 240 250 760 770 780 790 800 810 pF1KE2 ELSSIATKFPEILLQAASK-MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAP . :: . : .:. . : . .: : : .: .: : NP_037 IIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRF---RREVEKT-------AC-----P 260 270 280 290 300 820 830 840 850 860 870 pF1KE2 SSDDIFKLAEA---NACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVW :. .. :. : :: :.. . .. ..:. :. :: .::.: ... NP_037 SGKKAREIDESLIFYKKWELEA--CVDAALLATQMDRVNAIP-FTYEQLDVLKHKLDELY 310 320 330 340 350 360 880 890 900 910 920 pF1KE2 DMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASL---------SWQTEWTP-GQ :. . : : :: . : .. .... ...:..:. .: : :. : : NP_037 --PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQ 370 380 390 400 410 930 940 950 960 970 980 pF1KE2 AESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL-LC . .... .. : .: . . . ::... :. . : . .: : : : NP_037 VATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAV--RPQDLDTC 420 430 440 450 460 470 990 1000 1010 1020 1030 1040 pF1KE2 STHVLAEFKRKAEVVFGD--PTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAI . . : . ::...: . .:. .. . :: : :. :... . . . . NP_037 DPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLG----GAPTEDLKALSQQNVSMDLATFM 480 490 500 510 520 530 1050 1060 1070 1080 1090 1100 pF1KE2 KCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPA : : .. :: :::. . .. ..: . :.. :. :: NP_037 KLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPN 540 550 560 570 580 590 1110 1120 1130 pF1KE2 SAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW NP_037 GYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA 600 610 620 630 >>NP_001170826 (OMIM: 601051) mesothelin isoform 1 prepr (622 aa) initn: 79 init1: 51 opt: 198 Z-score: 228.2 bits: 53.2 E(93482): 6.3e-06 Smith-Waterman score: 271; 23.0% identity (48.5% similar) in 551 aa overlap (562-1090:61-572) 540 550 560 570 580 590 pF1KE2 TVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDF :: ::. : :......::. . NP_001 VQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLL-GFPCAEVSGLSTERVRELAVAL 40 50 60 70 80 600 610 620 630 640 pF1KE2 QNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYL------ASVPASQCVPFLIS .. . :: :. ::: ::: :: : ::: : : . :. :. NP_001 AQKNVKLSTEQLRCLA------HRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSR 90 100 110 120 130 140 650 660 670 680 690 700 pF1KE2 LGKSWLDSLVLDSHKKTSVLRKVQQC--LDDSIADEYTVDIMGNLLCHLPAAIIDRGISP . :. .: : . .. .: . : . :. .: : .:.: : ::. : .. NP_001 ITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPG----RFVAE 150 160 170 180 190 710 720 730 740 750 pF1KE2 RAWATALHGLRDCPD-LNPEQKAAVRLKLLG---QYGLPQHWTAETTKDLGPFLVLFSGD : . : : .:: :. .:. :.: : : :: :. :.. : : .: ... NP_001 SA-EVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQP 200 210 220 230 240 250 760 770 780 790 800 810 pF1KE2 ELSSIATKFPEILLQAASK-MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAP . :: . : .:. . : . .: : : .: .: : NP_001 IIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRF---RREVEKT-------AC-----P 260 270 280 290 300 820 830 840 850 860 870 pF1KE2 SSDDIFKLAEA---NACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVW :. .. :. : :: :.. . .. ..:. :. :: .::.: ... NP_001 SGKKAREIDESLIFYKKWELEA--CVDAALLATQMDRVNAIP-FTYEQLDVLKHKLDELY 310 320 330 340 350 360 880 890 900 910 920 930 pF1KE2 DMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASL---SWQTEWTPGQAESILQG :. . : : :: . : .. .... ...:..:. .: . : .: :. .... NP_001 --PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSP-QVATLIDR 370 380 390 400 410 940 950 960 970 980 990 pF1KE2 YLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL-LCSTHVLAE .. : .: . . . ::... :. . : . .: : : :. . : NP_001 FVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAV--RPQDLDTCDPRQLDV 420 430 440 450 460 470 1000 1010 1020 1030 1040 pF1KE2 FKRKAEVVFGD--PTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEI . ::...: . .:. .. . :: : :. :... . . . .: : . NP_001 LYPKARLAFQNMNGSEYFVKIQSFLG----GAPTEDLKALSQQNVSMDLATFMKLRTDAV 480 490 500 510 520 530 1050 1060 1070 1080 1090 1100 pF1KE2 FKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRT . :: :::. . .. ..: . :.. :. :: NP_001 LPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDL 540 550 560 570 580 590 1110 1120 1130 pF1KE2 SSSRSPAGALQSWGLWLGCPLLVLMAKLLW NP_001 SMQEALSGTPCLLGPGPVLTVLALLLASTLA 600 610 620 >>NP_005814 (OMIM: 601051) mesothelin isoform 1 prepropr (622 aa) initn: 79 init1: 51 opt: 198 Z-score: 228.2 bits: 53.2 E(93482): 6.3e-06 Smith-Waterman score: 271; 23.0% identity (48.5% similar) in 551 aa overlap (562-1090:61-572) 540 550 560 570 580 590 pF1KE2 TVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDF :: ::. : :......::. . NP_005 VQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLL-GFPCAEVSGLSTERVRELAVAL 40 50 60 70 80 600 610 620 630 640 pF1KE2 QNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYL------ASVPASQCVPFLIS .. . :: :. ::: ::: :: : ::: : : . :. :. NP_005 AQKNVKLSTEQLRCLA------HRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSR 90 100 110 120 130 140 650 660 670 680 690 700 pF1KE2 LGKSWLDSLVLDSHKKTSVLRKVQQC--LDDSIADEYTVDIMGNLLCHLPAAIIDRGISP . :. .: : . .. .: . : . :. .: : .:.: : ::. : .. NP_005 ITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPG----RFVAE 150 160 170 180 190 710 720 730 740 750 pF1KE2 RAWATALHGLRDCPD-LNPEQKAAVRLKLLG---QYGLPQHWTAETTKDLGPFLVLFSGD : . : : .:: :. .:. :.: : : :: :. :.. : : .: ... NP_005 SA-EVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQP 200 210 220 230 240 250 760 770 780 790 800 810 pF1KE2 ELSSIATKFPEILLQAASK-MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAP . :: . : .:. . : . .: : : .: .: : NP_005 IIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRF---RREVEKT-------AC-----P 260 270 280 290 300 820 830 840 850 860 870 pF1KE2 SSDDIFKLAEA---NACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVW :. .. :. : :: :.. . .. ..:. :. :: .::.: ... NP_005 SGKKAREIDESLIFYKKWELEA--CVDAALLATQMDRVNAIP-FTYEQLDVLKHKLDELY 310 320 330 340 350 360 880 890 900 910 920 930 pF1KE2 DMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASL---SWQTEWTPGQAESILQG :. . : : :: . : .. .... ...:..:. .: . : .: :. .... NP_005 --PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSP-QVATLIDR 370 380 390 400 410 940 950 960 970 980 990 pF1KE2 YLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL-LCSTHVLAE .. : .: . . . ::... :. . : . .: : : :. . : NP_005 FVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAV--RPQDLDTCDPRQLDV 420 430 440 450 460 470 1000 1010 1020 1030 1040 pF1KE2 FKRKAEVVFGD--PTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEI . ::...: . .:. .. . :: : :. :... . . . .: : . NP_005 LYPKARLAFQNMNGSEYFVKIQSFLG----GAPTEDLKALSQQNVSMDLATFMKLRTDAV 480 490 500 510 520 530 1050 1060 1070 1080 1090 1100 pF1KE2 FKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRT . :: :::. . .. ..: . :.. :. :: NP_005 LPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDL 540 550 560 570 580 590 1110 1120 1130 pF1KE2 SSSRSPAGALQSWGLWLGCPLLVLMAKLLW NP_005 SMQEALSGTPCLLGPGPVLTVLALLLASTLA 600 610 620 1139 residues in 1 query sequences 65951994 residues in 93482 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Jun 21 11:08:40 2019 done: Fri Jun 21 11:08:41 2019 Total Scan time: 7.220 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]