Result of FASTA (omim) for
pFN21AE5441
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5441, 317 aa
1>>>pF1KE5441 317 - 317 aa - 317 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9321+/-0.000299; mu= 18.2956+/- 0.019
mean_var=68.6890+/-13.838, 0's: 0 Z-trim(118.0): 314 B-trim: 64 in 1/55
Lambda= 0.154750
statistics sampled from 30149 (30494) to 30149 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.358), width: 16
Scan time: 7.430
The best scores are: opt bits E(85289)
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 2241 508.8 5.8e-144
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 2241 508.8 5.8e-144
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 995 230.6 3e-60
XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 855 199.3 7.4e-51
NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 855 199.3 7.4e-51
XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 855 199.3 7.4e-51
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 823 192.3 1.2e-48
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 778 182.2 1.2e-45
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 751 176.2 8.5e-44
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 751 176.2 8.5e-44
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 737 173.4 1.4e-42
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 737 173.4 1.4e-42
NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 725 170.4 4.4e-42
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 723 169.9 5.4e-42
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 725 170.6 7.4e-42
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 725 170.6 7.5e-42
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 725 170.6 7.6e-42
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 725 170.7 8.6e-42
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 725 170.7 8.7e-42
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 725 170.7 9.4e-42
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 725 170.7 9.5e-42
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 715 168.1 1.9e-41
NP_006790 (OMIM: 608159) testisin isoform 1 prepro ( 314) 712 167.5 3.3e-41
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 670 158.5 5.5e-38
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 670 158.5 5.7e-38
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 659 155.7 1.5e-37
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 659 155.8 1.6e-37
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 659 155.8 1.6e-37
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 656 155.0 2e-37
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 656 155.1 2.5e-37
XP_011520991 (OMIM: 608018) PREDICTED: serine prot ( 188) 650 153.4 3.3e-37
NP_001305324 (OMIM: 608018) serine protease 27 iso ( 188) 650 153.4 3.3e-37
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 650 153.7 6.2e-37
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 650 153.7 6.2e-37
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 650 153.9 8.3e-37
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 650 153.9 8.4e-37
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 650 153.9 8.4e-37
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 647 153.1 1.2e-36
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 647 153.2 1.3e-36
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 647 153.2 1.3e-36
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 647 153.2 1.3e-36
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 621 147.2 5.1e-35
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 621 147.2 5.3e-35
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 621 147.2 5.3e-35
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 621 147.2 5.3e-35
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 621 147.2 5.3e-35
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 621 147.2 5.3e-35
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 617 146.3 9.3e-35
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 617 146.4 1.1e-34
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 617 146.4 1.1e-34
>>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa)
initn: 2241 init1: 2241 opt: 2241 Z-score: 2705.6 bits: 508.8 E(85289): 5.8e-144
Smith-Waterman score: 2241; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317)
10 20 30 40 50 60
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG
250 260 270 280 290 300
310
pF1KE5 GGALRAPSQGSGAAARS
:::::::::::::::::
XP_005 GGALRAPSQGSGAAARS
310
>>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa)
initn: 2241 init1: 2241 opt: 2241 Z-score: 2705.6 bits: 508.8 E(85289): 5.8e-144
Smith-Waterman score: 2241; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317)
10 20 30 40 50 60
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG
250 260 270 280 290 300
310
pF1KE5 GGALRAPSQGSGAAARS
:::::::::::::::::
NP_071 GGALRAPSQGSGAAARS
310
>>NP_114154 (OMIM: 608018) serine protease 27 isoform 1 (290 aa)
initn: 978 init1: 374 opt: 995 Z-score: 1202.8 bits: 230.6 E(85289): 3e-60
Smith-Waterman score: 995; 49.1% identity (75.4% similar) in 285 aa overlap (21-301:10-288)
10 20 30 40 50 60
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
:::: ... : . :::.:..:::.:::.:. ..:
NP_114 MRRPAAVPLLLLLC----FGSQRAKAATACGRPRMLNRMVGGQDTQEGE
10 20 30 40
70 80 90 100 110 120
pF1KE5 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
::: ::::.::.: :.:::.. .::.::::::. : .. :..::::: :: .:: ...
NP_114 WPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFR-NTSETSLYQVLLGARQLVQPGPHAMY
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
. : :: .:.:. .. ::.:::.:: . :.. .::.:::: :. . . .::..::
NP_114 ARVRQVESNPLYQ-GTASSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGW
110 120 130 140 150 160
190 200 210 220 230
pF1KE5 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGA--GQGP--ITEDMLCAGYLEGERD
:: .. ::.:. :::: :::::. :. :: . . : : : .::::::. ::..:
NP_114 GSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKD
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 ACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRG
:: :::::::.: : .:: ::.::::::::..::::::: ..::..:...:. .:..
NP_114 ACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPKLQFQP
230 240 250 260 270 280
300 310
pF1KE5 RAQGGGALRAPSQGSGAAARS
::
NP_114 ARLGGQK
290
>>XP_011520754 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 856 init1: 298 opt: 855 Z-score: 1034.0 bits: 199.3 E(85289): 7.4e-51
Smith-Waterman score: 855; 45.9% identity (71.9% similar) in 281 aa overlap (11-286:3-275)
10 20 30 40 50 60
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
: .:: . ::::. : . .: . :::.:.. .:.:::.:. :.:
XP_011 MRGVSCLQV---LLLLVLGAAGTQGRKSA--ACGQPRMSSRIVGGRDGRDGE
10 20 30 40
70 80 90 100 110 120
pF1KE5 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
::: .:::. :.: :.:::.. .::.:::::: : . : ::: .::. . :. .
XP_011 WPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRR-ALPAEYRVRLGALRLGSTSPRTLS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
: : : : :: ..:: .:.::..:.: . .: :: :.::: . . ::.: : ..::
XP_011 VPVRRVLLPPDYS-EDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGW
110 120 130 140 150 160
190 200 210 220 230
pF1KE5 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDM-----LCAGYLEGER
::.. :::::. . :: ..::..::..:. :: :: . : .: . ::::: .:..
XP_011 GSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGA-DVPQAERIVLPGSLCAGYPQGHK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR
::: ::::::: : .:.:.:.:..:::.::: :::::: :.... :..
XP_011 DACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
230 240 250 260 270 280
300 310
pF1KE5 GRAQGGGALRAPSQGSGAAARS
>>NP_690851 (OMIM: 613797) serine protease 33 precursor (280 aa)
initn: 856 init1: 298 opt: 855 Z-score: 1034.0 bits: 199.3 E(85289): 7.4e-51
Smith-Waterman score: 855; 45.9% identity (71.9% similar) in 281 aa overlap (11-286:3-275)
10 20 30 40 50 60
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
: .:: . ::::. : . .: . :::.:.. .:.:::.:. :.:
NP_690 MRGVSCLQV---LLLLVLGAAGTQGRKSA--ACGQPRMSSRIVGGRDGRDGE
10 20 30 40
70 80 90 100 110 120
pF1KE5 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
::: .:::. :.: :.:::.. .::.:::::: : . : ::: .::. . :. .
NP_690 WPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRR-ALPAEYRVRLGALRLGSTSPRTLS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
: : : : :: ..:: .:.::..:.: . .: :: :.::: . . ::.: : ..::
NP_690 VPVRRVLLPPDYS-EDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGW
110 120 130 140 150 160
190 200 210 220 230
pF1KE5 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDM-----LCAGYLEGER
::.. :::::. . :: ..::..::..:. :: :: . : .: . ::::: .:..
NP_690 GSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGA-DVPQAERIVLPGSLCAGYPQGHK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR
::: ::::::: : .:.:.:.:..:::.::: :::::: :.... :..
NP_690 DACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
230 240 250 260 270 280
300 310
pF1KE5 GRAQGGGALRAPSQGSGAAARS
>>XP_011520753 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 856 init1: 298 opt: 855 Z-score: 1034.0 bits: 199.3 E(85289): 7.4e-51
Smith-Waterman score: 855; 45.9% identity (71.9% similar) in 281 aa overlap (11-286:3-275)
10 20 30 40 50 60
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
: .:: . ::::. : . .: . :::.:.. .:.:::.:. :.:
XP_011 MRGVSCLQV---LLLLVLGAAGTQGRKSA--ACGQPRMSSRIVGGRDGRDGE
10 20 30 40
70 80 90 100 110 120
pF1KE5 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
::: .:::. :.: :.:::.. .::.:::::: : . : ::: .::. . :. .
XP_011 WPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRR-ALPAEYRVRLGALRLGSTSPRTLS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE5 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
: : : : :: ..:: .:.::..:.: . .: :: :.::: . . ::.: : ..::
XP_011 VPVRRVLLPPDYS-EDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGW
110 120 130 140 150 160
190 200 210 220 230
pF1KE5 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDM-----LCAGYLEGER
::.. :::::. . :: ..::..::..:. :: :: . : .: . ::::: .:..
XP_011 GSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGA-DVPQAERIVLPGSLCAGYPQGHK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLR
::: ::::::: : .:.:.:.:..:::.::: :::::: :.... :..
XP_011 DACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
230 240 250 260 270 280
300 310
pF1KE5 GRAQGGGALRAPSQGSGAAARS
>>NP_002764 (OMIM: 600823) prostasin preproprotein [Homo (343 aa)
initn: 841 init1: 335 opt: 823 Z-score: 994.2 bits: 192.3 E(85289): 1.2e-48
Smith-Waterman score: 823; 43.9% identity (67.8% similar) in 289 aa overlap (10-295:7-291)
10 20 30 40 50 60
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
:: : ::. . :: :. ..:. : :: : :..:: ... ..
NP_002 MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAP-CGVAPQ-ARITGGSSAVAGQ
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
::: ::: .:.: :.:::.. .::..::::: .. .: . : ::: :: . . ..
NP_002 WPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEA-YEVKLGAHQLDSYSEDAKV
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
. . ::: : .::. .::::..: : : ::. . ::::: :. .: . :: ..::
NP_002 STLKDIIPHPSY-LQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGW
120 130 140 150 160 170
190 200 210 220 230
pF1KE5 GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAG-QGP--ITEDMLCAGYLEGERDA
: . .: : :. ::.:.::.:. :.:. :: : . : . :::.::::.:: .::
NP_002 GHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 CLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGR
: ::::::: : :.: : :.::.:::..:. ::::::: :.. ::... : .: :
NP_002 CQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVV
240 250 260 270 280 290
300 310
pF1KE5 AQGGGALRAPSQGSGAAARS
NP_002 PQTQESQPDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
300 310 320 330 340
>>NP_036599 (OMIM: 609341) tryptase gamma preproprotein (321 aa)
initn: 717 init1: 266 opt: 778 Z-score: 940.3 bits: 182.2 E(85289): 1.2e-45
Smith-Waterman score: 778; 42.8% identity (67.4% similar) in 276 aa overlap (15-287:3-267)
10 20 30 40 50
pF1KE5 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLN---RVVGGEDST
::. ::::: .. . : . :.::.:: . :.:::. .
NP_036 MALGACGLLLLLAVPGV--SLRT-LQPGCGRPQVSDAGGRIVGGHAAP
10 20 30 40
60 70 80 90 100 110
pF1KE5 DSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSR
. ::: .:.. .: :.::::. .::.::::::. .::. ..: :: ..
NP_036 AGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSD-YQVHLGELEITLSPHF
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE5 SQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWI
: : . : : . :. .:::::.: . .: :.::.:::.:: . :. .::.
NP_036 ST---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE5 SGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDA
.::: ..: ::: : .:...:: ..:.:.: . : : : . . ::::: .: ::
NP_036 TGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDY-PGPGGSILQPDMLCA---RGPGDA
170 180 190 200 210
240 250 260 270 280 290
pF1KE5 CLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGR
: ::::::.:::.:::. :::.::::::.. :::::: . :. .:...
NP_036 CQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSES
220 230 240 250 260 270
300 310
pF1KE5 AQGGGALRAPSQGSGAAARS
NP_036 GYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
280 290 300 310 320
>>XP_011520749 (OMIM: 609341) PREDICTED: tryptase gamma (346 aa)
initn: 738 init1: 266 opt: 751 Z-score: 907.3 bits: 176.2 E(85289): 8.5e-44
Smith-Waterman score: 751; 43.2% identity (68.0% similar) in 250 aa overlap (41-287:51-292)
20 30 40 50 60
pF1KE5 GGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLN---RVVGGEDSTDSEWPWIVSI
::.:: . :.:::. . . ::: .:.
XP_011 GRCGQGRLHGGSAVGFLGSPPGTPSSFDLGCGRPQVSDAGGRIVGGHAAPAGAWPWQASL
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE5 QKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVE
. .: :.::::. .::.::::::. .::. ..: :: .. : : .
XP_011 RLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSD-YQVHLGELEITLSPHFST---VRQII
90 100 110 120 130
130 140 150 160 170 180
pF1KE5 PHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGV
: : . :. .:::::.: . .: :.::.:::.:: . :. .::..::: ..:
XP_011 LHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGE
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE5 PLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLM
::: : .:...:: ..:.:.: . : : : . . ::::: .: ::: ::::::.
XP_011 PLPPPYSLREVKVSVVDTETCRRDY-PGPGGSILQPDMLCA---RGPGDACQDDSGGPLV
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE5 CQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQGGGALRAP
:::.:::. :: .::::::.. :::::: . :. .:...
XP_011 CQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAG
260 270 280 290 300 310
310
pF1KE5 SQGSGAAARS
XP_011 FFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
320 330 340
>>XP_011520748 (OMIM: 609341) PREDICTED: tryptase gamma (346 aa)
initn: 738 init1: 266 opt: 751 Z-score: 907.3 bits: 176.2 E(85289): 8.5e-44
Smith-Waterman score: 751; 43.2% identity (68.0% similar) in 250 aa overlap (41-287:51-292)
20 30 40 50 60
pF1KE5 GGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLN---RVVGGEDSTDSEWPWIVSI
::.:: . :.:::. . . ::: .:.
XP_011 GRCGQGRLHGGSAVGFLGSPPGTPSSFDLGCGRPQVSDAGGRIVGGHAAPAGAWPWQASL
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE5 QKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVE
. .: :.::::. .::.::::::. .::. ..: :: .. : : .
XP_011 RLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSD-YQVHLGELEITLSPHFST---VRQII
90 100 110 120 130
130 140 150 160 170 180
pF1KE5 PHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGV
: : . :. .:::::.: . .: :.::.:::.:: . :. .::..::: ..:
XP_011 LHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGE
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE5 PLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLM
::: : .:...:: ..:.:.: . : : : . . ::::: .: ::: ::::::.
XP_011 PLPPPYSLREVKVSVVDTETCRRDY-PGPGGSILQPDMLCA---RGPGDACQDDSGGPLV
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE5 CQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQGGGALRAP
:::.:::. :: .::::::.. :::::: . :. .:...
XP_011 CQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAG
260 270 280 290 300 310
310
pF1KE5 SQGSGAAARS
XP_011 FFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
320 330 340
317 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 00:47:40 2016 done: Tue Nov 8 00:47:41 2016
Total Scan time: 7.430 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]