Result of FASTA (omim) for
pFN21AE6393
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6393, 438 aa
1>>>pF1KE6393 438 - 438 aa - 438 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2103+/-0.000327; mu= 14.0666+/- 0.020
mean_var=112.8216+/-22.949, 0's: 0 Z-trim(119.4): 16 B-trim: 996 in 1/51
Lambda= 0.120747
statistics sampled from 33328 (33344) to 33328 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.391), width: 16
Scan time: 6.610
The best scores are: opt bits E(85289)
NP_001305662 (OMIM: 603264) rhomboid-related prote ( 438) 3036 539.6 6.1e-153
NP_001265649 (OMIM: 603264) rhomboid-related prote ( 373) 2484 443.4 4.8e-124
XP_016879338 (OMIM: 603264) PREDICTED: rhomboid-re ( 469) 2040 366.1 1.1e-100
XP_016879339 (OMIM: 603264) PREDICTED: rhomboid-re ( 315) 2036 365.3 1.3e-100
NP_001265650 (OMIM: 603264) rhomboid-related prote ( 298) 1594 288.2 1.9e-77
NP_060291 (OMIM: 608962) rhomboid-related protein ( 303) 632 120.7 5.4e-27
NP_001291675 (OMIM: 608962) rhomboid-related prote ( 383) 632 120.8 6.4e-27
>>NP_001305662 (OMIM: 603264) rhomboid-related protein 1 (438 aa)
initn: 3036 init1: 3036 opt: 3036 Z-score: 2866.8 bits: 539.6 E(85289): 6.1e-153
Smith-Waterman score: 3036; 100.0% identity (100.0% similar) in 438 aa overlap (1-438:1-438)
10 20 30 40 50 60
pF1KE6 MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 WSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 EVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 ITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 FSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAV
370 380 390 400 410 420
430
pF1KE6 FWNVFAYDLLGAHIPPPP
::::::::::::::::::
NP_001 FWNVFAYDLLGAHIPPPP
430
>>NP_001265649 (OMIM: 603264) rhomboid-related protein 1 (373 aa)
initn: 2484 init1: 2484 opt: 2484 Z-score: 2348.1 bits: 443.4 E(85289): 4.8e-124
Smith-Waterman score: 2484; 100.0% identity (100.0% similar) in 361 aa overlap (78-438:13-373)
50 60 70 80 90 100
pF1KE6 PEPDAPSQPGPALWSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPA
::::::::::::::::::::::::::::::
NP_001 MDRSSLLQLIQEQQLDPENTGFIGADTFTGLVHSHELPLDPA
10 20 30 40
110 120 130 140 150 160
pF1KE6 KLDMLVALAQSNEQGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLDMLVALAQSNEQGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYK
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE6 RFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYH
110 120 130 140 150 160
230 240 250 260 270 280
pF1KE6 PEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLL
170 180 190 200 210 220
290 300 310 320 330 340
pF1KE6 YLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALV
230 240 250 260 270 280
350 360 370 380 390 400
pF1KE6 CMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWV
290 300 310 320 330 340
410 420 430
pF1KE6 VLLAYGTFLLFAVFWNVFAYDLLGAHIPPPP
:::::::::::::::::::::::::::::::
NP_001 VLLAYGTFLLFAVFWNVFAYDLLGAHIPPPP
350 360 370
>>XP_016879338 (OMIM: 603264) PREDICTED: rhomboid-relate (469 aa)
initn: 2036 init1: 2036 opt: 2040 Z-score: 1928.7 bits: 366.1 E(85289): 1.1e-100
Smith-Waterman score: 2047; 74.0% identity (80.0% similar) in 446 aa overlap (1-405:1-446)
10 20 30 40 50 60
pF1KE6 MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 WSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 EVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPG
190 200 210 220 230 240
250 260 270 280 290
pF1KE6 HRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLA----GS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAELGWDE
250 260 270 280 290 300
300 310 320 330 340
pF1KE6 LTVSITDMRA-----PVVGGSGGVYALCSA----------HLANVVMNWAGMRCPYKLLR
....... : . :: : : :: : : : . .: . : . .
XP_016 MSLQVAEDGAGLGVHELRGGPGRVAALLPAAARLGPTAQLHGAPGRRGGGGEHGPDHPAE
310 320 330 340 350 360
350 360 370 380
pF1KE6 MVLALVCMSSEVGRAVWLRFSPPL----------PASGPQP--SFMAHLA------GAVV
. : . :: :. :: : : ::. :.: .. ..: : ::
XP_016 LRGAPAGPVRLVGGAAGLRHLPALRRLLERLRLRPAGRPHPPTALTGYLRLHRPGLGHVV
370 380 390 400 410 420
390 400 410 420 430
pF1KE6 GVSMGLTILRSYEERLRDQ----CGWWVVLLAYGTFLLFAVFWNVFAYDLLGAHIPPPP
.. .: . : . ::: :::
XP_016 AAHQGPSRLPFVNGRLRAAVPLGCGWPQRRPCPSHPPPTPRTCGLSLFG
430 440 450 460
>>XP_016879339 (OMIM: 603264) PREDICTED: rhomboid-relate (315 aa)
initn: 2036 init1: 2036 opt: 2036 Z-score: 1927.3 bits: 365.3 E(85289): 1.3e-100
Smith-Waterman score: 2036; 100.0% identity (100.0% similar) in 294 aa overlap (1-294:1-294)
10 20 30 40 50 60
pF1KE6 MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 WSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 EVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAELGWDE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 ITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLR
XP_016 MSLQVAEDGAGLGVQ
310
>>NP_001265650 (OMIM: 603264) rhomboid-related protein 1 (298 aa)
initn: 1594 init1: 1594 opt: 1594 Z-score: 1511.5 bits: 288.2 E(85289): 1.9e-77
Smith-Waterman score: 1801; 79.2% identity (79.2% similar) in 361 aa overlap (78-438:13-298)
50 60 70 80 90 100
pF1KE6 PEPDAPSQPGPALWSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPA
::::::::::::::::::::::::::::::
NP_001 MDRSSLLQLIQEQQLDPENTGFIGADTFTGLVHSHELPLDPA
10 20 30 40
110 120 130 140 150 160
pF1KE6 KLDMLVALAQSNEQGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYK
::::::::::::::::::::::::::
NP_001 KLDMLVALAQSNEQGQVCYQELVDLI----------------------------------
50 60
170 180 190 200 210 220
pF1KE6 RFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYH
:::::::::::::::::::
NP_001 -----------------------------------------IVFLCYGARLNKWVLQTYH
70 80
230 240 250 260 270 280
pF1KE6 PEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLL
90 100 110 120 130 140
290 300 310 320 330 340
pF1KE6 YLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALV
150 160 170 180 190 200
350 360 370 380 390 400
pF1KE6 CMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWV
210 220 230 240 250 260
410 420 430
pF1KE6 VLLAYGTFLLFAVFWNVFAYDLLGAHIPPPP
:::::::::::::::::::::::::::::::
NP_001 VLLAYGTFLLFAVFWNVFAYDLLGAHIPPPP
270 280 290
>>NP_060291 (OMIM: 608962) rhomboid-related protein 2 is (303 aa)
initn: 589 init1: 453 opt: 632 Z-score: 605.7 bits: 120.7 E(85289): 5.4e-27
Smith-Waterman score: 632; 38.7% identity (70.5% similar) in 261 aa overlap (167-425:43-298)
140 150 160 170 180 190
pF1KE6 RSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPCEVDRRWYFYRHRSCPP
:. : :. .:: : .: :. : ::
NP_060 NLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLP-EKSRGTYLERANCFPP
20 30 40 50 60 70
200 210 220 230 240 250
pF1KE6 PVFMASVTLAQIIVFLCYGAR--LNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFM
:::. :..::.. ::. :.. ..:. : ..::..: : .: .::::..::..
NP_060 PVFIISISLAELAVFIYYAVWKPQKQWI--TLDTGILESPFIYSPEKREEAWRFISYMLV
80 90 100 110 120
260 270 280 290 300 310
pF1KE6 HVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGG
:.:.... : .::..:.:::::: ::..:.:::::.::::. :: : .::.:::
NP_060 HAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPLRYLVGASGG
130 140 150 160 170 180
320 330 340 350 360 370
pF1KE6 VYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSF
:::: .... ::..:. : . ..:... .. . ..: :.. :: .: .: ::
NP_060 VYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDMGFALYRRFF--VPEDGSPVSF
190 200 210 220 230 240
380 390 400 410 420 430
pF1KE6 MAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAVFWNVFAYDLLGAHI
::.::. .:.:.: :.. ... : . .:... :: . .:::::.:.:
NP_060 AAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYLACVLFAVFFNIFLSPAN
250 260 270 280 290 300
pF1KE6 PPPP
>>NP_001291675 (OMIM: 608962) rhomboid-related protein 2 (383 aa)
initn: 589 init1: 453 opt: 632 Z-score: 604.3 bits: 120.8 E(85289): 6.4e-27
Smith-Waterman score: 632; 38.7% identity (70.5% similar) in 261 aa overlap (167-425:123-378)
140 150 160 170 180 190
pF1KE6 RSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPCEVDRRWYFYRHRSCPP
:. : :. .:: : .: :. : ::
NP_001 NLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLP-EKSRGTYLERANCFPP
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE6 PVFMASVTLAQIIVFLCYGAR--LNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFM
:::. :..::.. ::. :.. ..:. : ..::..: : .: .::::..::..
NP_001 PVFIISISLAELAVFIYYAVWKPQKQWI--TLDTGILESPFIYSPEKREEAWRFISYMLV
160 170 180 190 200
260 270 280 290 300 310
pF1KE6 HVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGG
:.:.... : .::..:.:::::: ::..:.:::::.::::. :: : .::.:::
NP_001 HAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPLRYLVGASGG
210 220 230 240 250 260
320 330 340 350 360 370
pF1KE6 VYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSF
:::: .... ::..:. : . ..:... .. . ..: :.. :: .: .: ::
NP_001 VYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDMGFALYRRFF--VPEDGSPVSF
270 280 290 300 310 320
380 390 400 410 420 430
pF1KE6 MAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAVFWNVFAYDLLGAHI
::.::. .:.:.: :.. ... : . .:... :: . .:::::.:.:
NP_001 AAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYLACVLFAVFFNIFLSPAN
330 340 350 360 370 380
pF1KE6 PPPP
438 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:52:33 2016 done: Tue Nov 8 12:52:34 2016
Total Scan time: 6.610 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]