FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4140, 557 aa 1>>>pF1KE4140 557 - 557 aa - 557 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6231+/-0.000423; mu= 5.3443+/- 0.027 mean_var=263.3897+/-52.845, 0's: 0 Z-trim(120.0): 102 B-trim: 57 in 1/52 Lambda= 0.079027 statistics sampled from 34608 (34714) to 34608 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.407), width: 16 Scan time: 9.750 The best scores are: opt bits E(85289) NP_005735 (OMIM: 605624) E3 ubiquitin-protein liga ( 557) 4005 470.2 7.7e-132 XP_011519741 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 465) 3130 370.3 7.4e-102 XP_011519740 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 498) 2980 353.3 1.1e-96 XP_016861020 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 493) 1135 142.9 2.3e-33 NP_001304262 (OMIM: 605615) E3 ubiquitin-protein l ( 493) 1135 142.9 2.3e-33 XP_016861021 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 493) 1135 142.9 2.3e-33 NP_006312 (OMIM: 605615) E3 ubiquitin-protein liga ( 493) 1135 142.9 2.3e-33 XP_016861030 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 409) 1110 140.0 1.4e-32 XP_016861029 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 409) 1110 140.0 1.4e-32 XP_016861026 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32 XP_016861028 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32 XP_011531577 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32 XP_016861025 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32 XP_016861027 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32 NP_001304263 (OMIM: 605615) E3 ubiquitin-protein l ( 351) 1039 131.8 3.5e-30 XP_011531567 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17 XP_011531568 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17 XP_011531570 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17 XP_011531569 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17 XP_011531575 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 432) 651 87.7 8.4e-17 XP_016861022 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17 XP_011531573 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17 XP_016861024 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17 XP_011531572 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17 XP_016861023 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17 XP_011512731 (OMIM: 607489) PREDICTED: cullin-9 is (1834) 517 73.0 9e-12 XP_016866079 (OMIM: 607489) PREDICTED: cullin-9 is (1909) 517 73.1 9.2e-12 XP_011512729 (OMIM: 607489) PREDICTED: cullin-9 is (2095) 517 73.1 9.8e-12 XP_011512727 (OMIM: 607489) PREDICTED: cullin-9 is (2456) 517 73.2 1.1e-11 NP_055904 (OMIM: 607489) cullin-9 [Homo sapiens] (2517) 517 73.2 1.1e-11 XP_011512726 (OMIM: 607489) PREDICTED: cullin-9 is (2539) 517 73.2 1.1e-11 XP_011512725 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 517 73.2 1.1e-11 XP_011512724 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 517 73.2 1.1e-11 XP_016866078 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 517 73.2 1.1e-11 XP_011512728 (OMIM: 607489) PREDICTED: cullin-9 is (2339) 493 70.4 7.1e-11 XP_011531578 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 254) 286 45.8 0.0002 NP_001120833 (OMIM: 610872) E3 ubiquitin-protein l ( 587) 262 43.4 0.0023 XP_016868793 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 263 43.7 0.0026 XP_011515258 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 263 43.7 0.0026 NP_001287755 (OMIM: 610872) E3 ubiquitin-protein l ( 731) 262 43.5 0.0027 XP_006710421 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 588) 260 43.2 0.0027 NP_056250 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 263 43.7 0.0027 NP_904355 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 263 43.7 0.0027 NP_001267468 (OMIM: 607119) E3 ubiquitin-protein l ( 838) 263 43.7 0.0027 XP_016868791 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 263 43.7 0.0027 XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 263 43.7 0.0027 XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 263 43.7 0.0027 XP_006710420 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 688) 260 43.3 0.003 XP_006710419 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 732) 260 43.3 0.0032 NP_699172 (OMIM: 610872) E3 ubiquitin-protein liga ( 732) 260 43.3 0.0032 >>NP_005735 (OMIM: 605624) E3 ubiquitin-protein ligase A (557 aa) initn: 4005 init1: 4005 opt: 4005 Z-score: 2487.9 bits: 470.2 E(85289): 7.7e-132 Smith-Waterman score: 4005; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 DDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 YMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 YLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLL 490 500 510 520 530 540 550 pF1KE4 QHVHEGYEKDLWEYIED ::::::::::::::::: NP_005 QHVHEGYEKDLWEYIED 550 >>XP_011519741 (OMIM: 605624) PREDICTED: E3 ubiquitin-pr (465 aa) initn: 3130 init1: 3130 opt: 3130 Z-score: 1949.7 bits: 370.3 E(85289): 7.4e-102 Smith-Waterman score: 3130; 99.8% identity (100.0% similar) in 433 aa overlap (125-557:33-465) 100 110 120 130 140 150 pF1KE4 QEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNL .::::::::::::::::::::::::::::: XP_011 PGGQRGHPVHIGYFQKYEFSDAKDRRAAAAKNPATITRILLSHFNWDKEKLMERYFDGNL 10 20 30 40 50 60 160 170 180 190 200 210 pF1KE4 EKLFAECHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKLFAECHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSE 70 80 90 100 110 120 220 230 240 250 260 270 pF1KE4 YLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK 130 140 150 160 170 180 280 290 300 310 320 330 pF1KE4 WCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETS 190 200 210 220 230 240 340 350 360 370 380 390 pF1KE4 NWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNE 250 260 270 280 290 300 400 410 420 430 440 450 pF1KE4 DDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIE 310 320 330 340 350 360 460 470 480 490 500 510 pF1KE4 VQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDIS 370 380 390 400 410 420 520 530 540 550 pF1KE4 QDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED ::::::::::::::::::::::::::::::::::::::::::: XP_011 QDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED 430 440 450 460 >>XP_011519740 (OMIM: 605624) PREDICTED: E3 ubiquitin-pr (498 aa) initn: 2980 init1: 2980 opt: 2980 Z-score: 1856.9 bits: 353.3 E(85289): 1.1e-96 Smith-Waterman score: 2980; 100.0% identity (100.0% similar) in 410 aa overlap (148-557:89-498) 120 130 140 150 160 170 pF1KE4 REVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNT :::::::::::::::::::::::::::::: XP_011 RRRITATRCSRPSRFYNTWWNVSGRSTRSSRYFDGNLEKLFAECHVINPSKKSRTRQMNT 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE4 RSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCD 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE4 ILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE4 KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGC 240 250 260 270 280 290 360 370 380 390 400 410 pF1KE4 NHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFY 300 310 320 330 340 350 420 430 440 450 460 470 pF1KE4 CNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYV 360 370 380 390 400 410 480 490 500 510 520 530 pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR 420 430 440 450 460 470 540 550 pF1KE4 VLLQHVHEGYEKDLWEYIED :::::::::::::::::::: XP_011 VLLQHVHEGYEKDLWEYIED 480 490 >>XP_016861020 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (493 aa) initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33 Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492) 10 20 30 40 50 60 pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG : .:: . : . ::::.:..:.: :..: :.. :..: XP_016 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV ..:. : :.:.. :: .. . : . . XP_016 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL 60 70 80 130 140 150 160 170 pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS :.. ......: .:.:. ....:: .: .:..: .: :::: .. . XP_016 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT 90 100 110 120 130 180 190 200 210 220 230 pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL : : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : . XP_016 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K . .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: . XP_016 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN :.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.:::: XP_016 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC :: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..:::: XP_016 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF 320 330 340 350 360 420 430 440 450 460 470 pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV .:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.::: XP_016 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP 370 380 390 400 410 420 480 490 500 510 520 530 pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR .:.:.... .. .:: .::.:: : :: .:: : : . ...... :.::: XP_016 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR 430 440 450 460 470 480 540 550 pF1KE4 VLLQHVHEGYEKDLWEYIED .::. :. XP_016 TLLKDFHDT 490 >>NP_001304262 (OMIM: 605615) E3 ubiquitin-protein ligas (493 aa) initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33 Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492) 10 20 30 40 50 60 pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG : .:: . : . ::::.:..:.: :..: :.. :..: NP_001 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV ..:. : :.:.. :: .. . : . . NP_001 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL 60 70 80 130 140 150 160 170 pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS :.. ......: .:.:. ....:: .: .:..: .: :::: .. . NP_001 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT 90 100 110 120 130 180 190 200 210 220 230 pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL : : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : . NP_001 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K . .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: . NP_001 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN :.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.:::: NP_001 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC :: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..:::: NP_001 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF 320 330 340 350 360 420 430 440 450 460 470 pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV .:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.::: NP_001 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP 370 380 390 400 410 420 480 490 500 510 520 530 pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR .:.:.... .. .:: .::.:: : :: .:: : : . ...... :.::: NP_001 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR 430 440 450 460 470 480 540 550 pF1KE4 VLLQHVHEGYEKDLWEYIED .::. :. NP_001 TLLKDFHDT 490 >>XP_016861021 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (493 aa) initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33 Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492) 10 20 30 40 50 60 pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG : .:: . : . ::::.:..:.: :..: :.. :..: XP_016 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV ..:. : :.:.. :: .. . : . . XP_016 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL 60 70 80 130 140 150 160 170 pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS :.. ......: .:.:. ....:: .: .:..: .: :::: .. . XP_016 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT 90 100 110 120 130 180 190 200 210 220 230 pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL : : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : . XP_016 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K . .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: . XP_016 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN :.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.:::: XP_016 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC :: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..:::: XP_016 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF 320 330 340 350 360 420 430 440 450 460 470 pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV .:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.::: XP_016 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP 370 380 390 400 410 420 480 490 500 510 520 530 pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR .:.:.... .. .:: .::.:: : :: .:: : : . ...... :.::: XP_016 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR 430 440 450 460 470 480 540 550 pF1KE4 VLLQHVHEGYEKDLWEYIED .::. :. XP_016 TLLKDFHDT 490 >>NP_006312 (OMIM: 605615) E3 ubiquitin-protein ligase A (493 aa) initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33 Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492) 10 20 30 40 50 60 pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG : .:: . : . ::::.:..:.: :..: :.. :..: NP_006 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV ..:. : :.:.. :: .. . : . . NP_006 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL 60 70 80 130 140 150 160 170 pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS :.. ......: .:.:. ....:: .: .:..: .: :::: .. . NP_006 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT 90 100 110 120 130 180 190 200 210 220 230 pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL : : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : . NP_006 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K . .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: . NP_006 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN :.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.:::: NP_006 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC :: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..:::: NP_006 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF 320 330 340 350 360 420 430 440 450 460 470 pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV .:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.::: NP_006 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP 370 380 390 400 410 420 480 490 500 510 520 530 pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR .:.:.... .. .:: .::.:: : :: .:: : : . ...... :.::: NP_006 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR 430 440 450 460 470 480 540 550 pF1KE4 VLLQHVHEGYEKDLWEYIED .::. :. NP_006 TLLKDFHDT 490 >>XP_016861030 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (409 aa) initn: 927 init1: 319 opt: 1110 Z-score: 705.7 bits: 140.0 E(85289): 1.4e-32 Smith-Waterman score: 1110; 36.7% identity (70.2% similar) in 420 aa overlap (129-545:5-408) 100 110 120 130 140 150 pF1KE4 YRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLF ......: .:.:. ....:: .: .:. XP_016 MVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLL 10 20 30 160 170 180 190 200 210 pF1KE4 AECHVI-NPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLT .: .: ::::. : : : .:. . . .: : :.:: .:: .. . XP_016 VEARVQPNPSKHVPT-------SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCS 40 50 60 70 80 220 230 240 250 260 270 pF1KE4 TKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCP . ....:.: .:: :. : . . .. :. :. . ... ::.. . ..:: . :. :: XP_016 V-LVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCP 90 100 110 120 130 140 280 290 300 310 320 330 pF1KE4 APDCHHVVKVQYPDAKPVRC-KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNW . :: :..:: : :. :.: .:.. :::.: . .: :. : ..::. :: :::::.:. XP_016 GADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANY 150 160 170 180 190 200 340 350 360 370 380 390 pF1KE4 IAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDD :.:.::.::::.. :::.:::::: : ..:: .:::.::: :. ::: .:.:.::.:. XP_016 ISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENP 210 220 230 240 250 260 400 410 420 430 440 450 pF1KE4 AKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEV . .. : ..: ::..:::: .:. :: .::..: . : ....:..: ..:. .::. XP_016 DIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDW 270 280 290 300 310 320 460 470 480 490 500 510 pF1KE4 QFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQ :.:..:. .: .:: ::.::: .:.:.... .. .:: .::.:: : :: .:: : XP_016 QYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSY 330 340 350 360 370 380 520 530 540 550 pF1KE4 DSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED : . ...... :.:::.::. :. XP_016 D-----RGDLENQMHIAEQRRRTLLKDFHDT 390 400 >>XP_016861029 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (409 aa) initn: 927 init1: 319 opt: 1110 Z-score: 705.7 bits: 140.0 E(85289): 1.4e-32 Smith-Waterman score: 1110; 36.7% identity (70.2% similar) in 420 aa overlap (129-545:5-408) 100 110 120 130 140 150 pF1KE4 YRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLF ......: .:.:. ....:: .: .:. XP_016 MVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLL 10 20 30 160 170 180 190 200 210 pF1KE4 AECHVI-NPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLT .: .: ::::. : : : .:. . . .: : :.:: .:: .. . XP_016 VEARVQPNPSKHVPT-------SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCS 40 50 60 70 80 220 230 240 250 260 270 pF1KE4 TKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCP . ....:.: .:: :. : . . .. :. :. . ... ::.. . ..:: . :. :: XP_016 V-LVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCP 90 100 110 120 130 140 280 290 300 310 320 330 pF1KE4 APDCHHVVKVQYPDAKPVRC-KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNW . :: :..:: : :. :.: .:.. :::.: . .: :. : ..::. :: :::::.:. XP_016 GADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANY 150 160 170 180 190 200 340 350 360 370 380 390 pF1KE4 IAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDD :.:.::.::::.. :::.:::::: : ..:: .:::.::: :. ::: .:.:.::.:. XP_016 ISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENP 210 220 230 240 250 260 400 410 420 430 440 450 pF1KE4 AKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEV . .. : ..: ::..:::: .:. :: .::..: . : ....:..: ..:. .::. XP_016 DIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDW 270 280 290 300 310 320 460 470 480 490 500 510 pF1KE4 QFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQ :.:..:. .: .:: ::.::: .:.:.... .. .:: .::.:: : :: .:: : XP_016 QYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSY 330 340 350 360 370 380 520 530 540 550 pF1KE4 DSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED : . ...... :.:::.::. :. XP_016 D-----RGDLENQMHIAEQRRRTLLKDFHDT 390 400 >>XP_016861026 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (421 aa) initn: 927 init1: 319 opt: 1110 Z-score: 705.6 bits: 140.0 E(85289): 1.5e-32 Smith-Waterman score: 1111; 36.1% identity (69.2% similar) in 435 aa overlap (114-545:5-420) 90 100 110 120 130 140 pF1KE4 GGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKE . :: . : . ......: .:.:. XP_016 MLTAISCILPMALVSH---SVAKLILVNFHWQVS 10 20 30 150 160 170 180 190 200 pF1KE4 KLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLE ....:: .: .:..: .: ::::. : : : .:. . . .: XP_016 EILDRY-KSNSAQLLVEARVQPNPSKHVPT-------SHPPHHCAVCMQFVRKENLLSLA 40 50 60 70 80 210 220 230 240 250 260 pF1KE4 CGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLI : :.:: .:: .. .. ....:.: .:: :. : . . .. :. :. . ... ::.. . XP_016 CQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYL 90 100 110 120 130 140 270 280 290 300 310 320 pF1KE4 TNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-KCGRQFCFNCGENWHDPVKCKWLK ..:: . :. ::. :: :..:: : :. :.: .:.. :::.: . .: :. : .. XP_016 FRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIR 150 160 170 180 190 200 330 340 350 360 370 380 pF1KE4 KWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEP ::. :: :::::.:.:.:.::.::::.. :::.:::::: : ..:: .:::.::: :. XP_016 KWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGDWKT 210 220 230 240 250 260 390 400 410 420 430 440 pF1KE4 HGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQK ::: .:.:.::.:. . .. : ..: ::..:::: .:. :: .::..: . : ....: XP_016 HGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEK 270 280 290 300 310 320 450 460 470 480 490 500 pF1KE4 MEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLEN ..: ..:. .::. :.:..:. .: .:: ::.::: .:.:.... .. .:: .::.:: XP_016 IQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEA 330 340 350 360 370 380 510 520 530 540 550 pF1KE4 ATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED : :: .:: : : . ...... :.:::.::. :. XP_016 EIENLSWKVERADSYD-----RGDLENQMHIAEQRRRTLLKDFHDT 390 400 410 420 557 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:50:28 2016 done: Sun Nov 6 01:50:29 2016 Total Scan time: 9.750 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]