FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2482, 468 aa 1>>>pF1KE2482 468 - 468 aa - 468 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5471+/-0.000954; mu= 12.7106+/- 0.058 mean_var=100.3500+/-19.813, 0's: 0 Z-trim(107.6): 124 B-trim: 3 in 1/50 Lambda= 0.128031 statistics sampled from 9522 (9648) to 9522 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.296), width: 16 Scan time: 2.340 The best scores are: opt bits E(32554) CCDS45271.1 RORA gene_id:6095|Hs108|chr15 ( 468) 3180 597.9 7.3e-171 CCDS10178.1 RORA gene_id:6095|Hs108|chr15 ( 548) 3129 588.5 5.7e-168 CCDS10179.1 RORA gene_id:6095|Hs108|chr15 ( 556) 3124 587.6 1.1e-167 CCDS10177.1 RORA gene_id:6095|Hs108|chr15 ( 523) 3113 585.6 4.2e-167 CCDS6646.1 RORB gene_id:6096|Hs108|chr9 ( 459) 1971 374.6 1.2e-103 CCDS30856.1 RORC gene_id:6097|Hs108|chr1 ( 497) 950 186.0 7.5e-47 CCDS1004.1 RORC gene_id:6097|Hs108|chr1 ( 518) 950 186.0 7.8e-47 CCDS11361.1 NR1D1 gene_id:9572|Hs108|chr17 ( 614) 438 91.5 2.7e-18 CCDS33718.1 NR1D2 gene_id:9975|Hs108|chr3 ( 579) 428 89.7 9.1e-18 CCDS6856.1 NR5A1 gene_id:2516|Hs108|chr9 ( 461) 419 87.9 2.4e-17 CCDS2642.1 RARB gene_id:5915|Hs108|chr3 ( 448) 417 87.6 3e-17 CCDS58236.1 RARG gene_id:5916|Hs108|chr12 ( 382) 415 87.2 3.4e-17 CCDS41790.1 RARG gene_id:5916|Hs108|chr12 ( 443) 415 87.2 3.8e-17 CCDS8850.1 RARG gene_id:5916|Hs108|chr12 ( 454) 415 87.2 3.9e-17 CCDS42317.1 RARA gene_id:5914|Hs108|chr17 ( 457) 407 85.7 1.1e-16 CCDS11366.1 RARA gene_id:5914|Hs108|chr17 ( 462) 407 85.7 1.1e-16 CCDS41821.1 NR2C1 gene_id:7181|Hs108|chr12 ( 467) 399 84.2 3.1e-16 CCDS44953.1 NR2C1 gene_id:7181|Hs108|chr12 ( 483) 399 84.3 3.2e-16 CCDS9051.1 NR2C1 gene_id:7181|Hs108|chr12 ( 603) 399 84.3 3.8e-16 CCDS35172.1 RXRA gene_id:6256|Hs108|chr9 ( 462) 397 83.9 4e-16 CCDS2610.2 PPARG gene_id:5468|Hs108|chr3 ( 477) 389 82.4 1.1e-15 CCDS2609.1 PPARG gene_id:5468|Hs108|chr3 ( 505) 389 82.4 1.2e-15 CCDS72970.1 RXRG gene_id:6258|Hs108|chr1 ( 340) 385 81.6 1.4e-15 CCDS1248.1 RXRG gene_id:6258|Hs108|chr1 ( 463) 385 81.7 1.9e-15 CCDS4768.1 RXRB gene_id:6257|Hs108|chr6 ( 533) 385 81.7 2.1e-15 CCDS59007.1 RXRB gene_id:6257|Hs108|chr6 ( 537) 385 81.7 2.1e-15 CCDS60383.1 NR5A2 gene_id:2494|Hs108|chr1 ( 469) 380 80.7 3.6e-15 CCDS1400.1 NR5A2 gene_id:2494|Hs108|chr1 ( 495) 380 80.7 3.7e-15 CCDS1401.1 NR5A2 gene_id:2494|Hs108|chr1 ( 541) 380 80.8 4e-15 CCDS10375.1 NR2F2 gene_id:7026|Hs108|chr15 ( 414) 378 80.3 4.1e-15 CCDS4068.1 NR2F1 gene_id:7025|Hs108|chr5 ( 423) 378 80.3 4.2e-15 CCDS33669.1 PPARA gene_id:5465|Hs108|chr22 ( 468) 377 80.2 5.2e-15 CCDS6743.1 NR4A3 gene_id:8013|Hs108|chr9 ( 626) 374 79.7 9.8e-15 CCDS6742.1 NR4A3 gene_id:8013|Hs108|chr9 ( 637) 374 79.7 9.9e-15 CCDS4804.1 PPARD gene_id:5467|Hs108|chr6 ( 361) 369 78.6 1.2e-14 CCDS54994.1 PPARD gene_id:5467|Hs108|chr6 ( 402) 369 78.7 1.3e-14 CCDS4803.1 PPARD gene_id:5467|Hs108|chr6 ( 441) 369 78.7 1.4e-14 CCDS6744.1 NR4A3 gene_id:8013|Hs108|chr9 ( 443) 363 77.6 3e-14 CCDS12352.1 NR2F6 gene_id:2063|Hs108|chr19 ( 404) 362 77.4 3.1e-14 CCDS42316.1 THRA gene_id:7067|Hs108|chr17 ( 410) 361 77.2 3.6e-14 CCDS58546.1 THRA gene_id:7067|Hs108|chr17 ( 451) 361 77.2 3.9e-14 CCDS55340.1 NR6A1 gene_id:2649|Hs108|chr9 ( 475) 361 77.2 4.1e-14 CCDS65127.1 NR6A1 gene_id:2649|Hs108|chr9 ( 476) 361 77.2 4.1e-14 CCDS35137.1 NR6A1 gene_id:2649|Hs108|chr9 ( 480) 361 77.2 4.1e-14 CCDS11360.1 THRA gene_id:7067|Hs108|chr17 ( 490) 361 77.2 4.2e-14 CCDS5063.1 NR2E1 gene_id:7101|Hs108|chr6 ( 385) 355 76.1 7.4e-14 CCDS2641.1 THRB gene_id:7068|Hs108|chr3 ( 461) 354 75.9 9.8e-14 CCDS69165.1 NR2E1 gene_id:7101|Hs108|chr6 ( 422) 353 75.7 1e-13 CCDS2201.1 NR4A2 gene_id:4929|Hs108|chr2 ( 598) 351 75.4 1.8e-13 CCDS74905.1 NR2C2 gene_id:7182|Hs108|chr3 ( 596) 349 75.1 2.3e-13 >>CCDS45271.1 RORA gene_id:6095|Hs108|chr15 (468 aa) initn: 3180 init1: 3180 opt: 3180 Z-score: 3181.1 bits: 597.9 E(32554): 7.3e-171 Smith-Waterman score: 3180; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468) 10 20 30 40 50 60 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 INGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVS 370 380 390 400 410 420 430 440 450 460 pF1KE2 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG :::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 430 440 450 460 >>CCDS10178.1 RORA gene_id:6095|Hs108|chr15 (548 aa) initn: 3127 init1: 3127 opt: 3129 Z-score: 3129.1 bits: 588.5 E(32554): 5.7e-168 Smith-Waterman score: 3129; 98.9% identity (99.6% similar) in 466 aa overlap (4-468:83-548) 10 20 30 pF1KE2 MMYFVIAAM-KAQIEIIPCKICGDKSSGIHYGV :.. :. ::::::::::::::::::::::: CCDS10 LSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGIHYGV 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE2 ITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE2 MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGH 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE2 TPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPT 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE2 VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE2 TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE2 PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE2 KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY 480 490 500 510 520 530 460 pF1KE2 KELFTSEFEPAMQIDG :::::::::::::::: CCDS10 KELFTSEFEPAMQIDG 540 >>CCDS10179.1 RORA gene_id:6095|Hs108|chr15 (556 aa) initn: 3124 init1: 3124 opt: 3124 Z-score: 3124.0 bits: 587.6 E(32554): 1.1e-167 Smith-Waterman score: 3124; 99.8% identity (100.0% similar) in 460 aa overlap (9-468:97-556) 10 20 30 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGC :.:::::::::::::::::::::::::::: CCDS10 FVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGC 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE2 KGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 KGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQR 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE2 DSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSK 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE2 ADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAEL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE2 EHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 EHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQY 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE2 VVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKS 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE2 LGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLAL 430 440 450 460 470 480 400 410 420 430 440 450 pF1KE2 QHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTS 490 500 510 520 530 540 460 pF1KE2 EFEPAMQIDG :::::::::: CCDS10 EFEPAMQIDG 550 >>CCDS10177.1 RORA gene_id:6095|Hs108|chr15 (523 aa) initn: 3113 init1: 3113 opt: 3113 Z-score: 3113.4 bits: 585.6 E(32554): 4.2e-167 Smith-Waterman score: 3113; 99.8% identity (100.0% similar) in 458 aa overlap (11-468:66-523) 10 20 30 40 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKG .::::::::::::::::::::::::::::: CCDS10 ARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKG 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE2 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE2 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKAD 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE2 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 SAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEH 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE2 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVV 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE2 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 EFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLG 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE2 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 CEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQH 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE2 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEF 460 470 480 490 500 510 pF1KE2 EPAMQIDG :::::::: CCDS10 EPAMQIDG 520 >>CCDS6646.1 RORB gene_id:6096|Hs108|chr9 (459 aa) initn: 1833 init1: 1137 opt: 1971 Z-score: 1974.3 bits: 374.6 E(32554): 1.2e-103 Smith-Waterman score: 1971; 63.9% identity (85.1% similar) in 457 aa overlap (9-459:1-453) 10 20 30 40 50 60 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC :.::::.::::::::::::::::::::::::::::::::.::.::::::.:: CCDS66 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNC 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ :::::.::::::::::::::.:::::::::::::::::::::::::::. :. :...::: CCDS66 LIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQ-QRLQEQRQQQ 60 70 80 90 100 110 130 140 150 160 170 pF1KE2 PGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGSKADSAVSSFYLDI-QPSPDQS :::: :. .:. : .:::..:... :. : .::. . :... . .: ::::::: CCDS66 SGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGY---YNVDSGQPSPDQS 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 GLDINGIKP---EPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQ :::..::: ::: : : . ..: : ::.::. .: ..:.:....:::: :::::::: CCDS66 GLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQ 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 YLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQ : :::.:..::: :::. ::.:.::..:: :::.::.:::::::::::: ::::::: CCDS66 YTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQ 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 NDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKS ::::.:::.: ::::..::::::. :::: :.:::.. ..::.:: .:... .:.:.:. CCDS66 NDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKN 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE2 LCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTK :::..:::.::::::. ::.: ::.:: : :..:::.:: .:::::.:::: .: :.: CCDS66 LCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAK 350 360 370 380 390 400 420 430 440 450 460 pF1KE2 LICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG :: :. :. :.:. : :::..:: .:.:: :::::::::. . CCDS66 LIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK 410 420 430 440 450 >>CCDS30856.1 RORC gene_id:6097|Hs108|chr1 (497 aa) initn: 1634 init1: 785 opt: 950 Z-score: 954.6 bits: 186.0 E(32554): 7.5e-47 Smith-Waterman score: 1539; 49.6% identity (73.0% similar) in 492 aa overlap (9-461:1-490) 10 20 30 40 50 60 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC :..:::.:::::::::::::::::::::::::::::::. ::.::: ::.:: CCDS30 MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNC 10 20 30 40 50 70 80 90 100 110 pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQ-- :::::::::::::::::::.::::::::::::::::::::.:::::. .:.::.... CCDS30 PIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPV 60 70 80 90 100 110 120 130 140 pF1KE2 -----------------------QQPGEAEPLTPTYNISANGLTELHDDLSNY------- : : . : : . :: . . .: CCDS30 VKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKA 120 130 140 150 160 170 150 160 170 180 190 200 pF1KE2 -IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPY ..: ..:: .::.. : . : .::. :: .. . . . . . CCDS30 GLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGS 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE2 CSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQR :: . .: .:..:.:::.:.. ::. :::: :.: . . : .::. .:: :. CCDS30 PSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE2 EVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQN ::. :: ..:::::::::::::..:::::::::::::::::..:::..:::::....: CCDS30 WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADN 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE2 NTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWL ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::..:.::..: : : CCDS30 RTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGL 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE2 QEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYP ::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::..:.:.:. :. ..: CCDS30 QEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQHVERLQIFQHLHP 420 430 440 450 460 470 450 460 pF1KE2 DIVRLHFPPLYKELFTSEFEPAMQIDG .:. :::::::::..: : CCDS30 IVVQAAFPPLYKELFSTETESPVGLSK 480 490 >>CCDS1004.1 RORC gene_id:6097|Hs108|chr1 (518 aa) initn: 1625 init1: 785 opt: 950 Z-score: 954.3 bits: 186.0 E(32554): 7.8e-47 Smith-Waterman score: 1530; 49.6% identity (72.9% similar) in 490 aa overlap (11-461:24-511) 10 20 30 40 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQ .:::.:::::::::::::::::::::::::::::::. CCDS10 MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 SNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQK ::.::: ::.:: :::::::::::::::::::.::::::::::::::::::::.::::: CCDS10 CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK 70 80 90 100 110 120 110 120 130 140 pF1KE2 HRMQQQQRDHQ-------------------------QQPGEAEPLTPTYNISANGLTELH . .:.::.... : : . : : . :: . CCDS10 QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS 130 140 150 160 170 180 150 160 170 180 pF1KE2 DDLSNY--------IDG------HTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEP . .: ..: ..:: .::.. : . : .::. :: .. . CCDS10 GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG 190 200 210 220 230 240 190 200 210 220 230 240 pF1KE2 ICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTF . . . . :: . .: .:..:.:::.:.. ::. :::: :.: . . : CCDS10 LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF 250 260 270 280 290 300 250 260 270 280 290 300 pF1KE2 LQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEV .::. .:: :. ::. :: ..:::::::::::::..:::::::::::::::::..:: CCDS10 SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV 310 320 330 340 350 360 310 320 330 340 350 360 pF1KE2 VFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALF :..:::::....: ::.:.:::.. ..:..::: ..:: .:.:..:: ..:..::::::. CCDS10 VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY 370 380 390 400 410 420 370 380 390 400 410 420 pF1KE2 SAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGR .:.::..: : :::: :.:.:: ...::..: : :.::.. ::.:: : . ::.::.. CCDS10 TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQS-ILAKLPPK-GKLRSLCSQ 430 440 450 460 470 430 440 450 460 pF1KE2 HTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG :.:.:. :. ..: .:. :::::::::..: : CCDS10 HVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK 480 490 500 510 >>CCDS11361.1 NR1D1 gene_id:9572|Hs108|chr17 (614 aa) initn: 650 init1: 265 opt: 438 Z-score: 442.1 bits: 91.5 E(32554): 2.7e-18 Smith-Waterman score: 762; 33.0% identity (61.1% similar) in 491 aa overlap (15-437:129-610) 10 20 30 40 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRR .. ::.::: .::.:::: .:::::::::: CCDS11 PPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRR 100 110 120 130 140 150 50 60 70 80 90 100 pF1KE2 SQQSNATYS-CPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYA : :.: :. : ...:: : : .:::::.::..:::.::::::::.:::. :.... . : CCDS11 SIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLA 160 170 180 190 200 210 110 120 130 pF1KE2 EVQK-HRMQQQQRDHQ--------QQP-----GEAEP-----------------LTPTYN :.:. . ..: . : :.: : . : ::: . CCDS11 EMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRS 220 230 240 250 260 270 140 150 160 170 pF1KE2 ISANGLTE--------LHDDLSNYID---GHTPEGSKADSAVSS------FYLDIQ---P : . .: : .. .: : .: . .:. : .: . : : CCDS11 PSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPP 280 290 300 310 320 330 180 190 200 210 pF1KE2 SPDQSGL--------DINGIKPEPICDYTPASGFFPY---C--SFTNGET-SPTVSMAEL .:.... .::.. : .: :. : : : .::. :: .: CCDS11 APNDNNTLAAQRHNEALNGLRQAP-SSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAP 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE2 EHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQY : : : . .. ... .. .. ... . .:. ....: :.. CCDS11 EGKAPANSPRQGNS--------KNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVRE 400 410 420 430 440 280 290 300 310 320 330 pF1KE2 VVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYA-SPDVFK ::::::.: :: .: :.::..:::::..::...:. :. ...::.: .. . : . . CCDS11 VVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELG 450 460 470 480 490 500 340 350 360 370 380 390 pF1KE2 SLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLA ..: :..: .:.:...: :. :::.:..::.: ::.::::: .......:.::. . : CCDS11 AMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRA 510 520 530 540 550 560 400 410 420 430 440 450 pF1KE2 LQHVLQKNHR-EDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELF :. .. ::. : . .:::. :. ::.: . :.:::..:. CCDS11 LRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ 570 580 590 600 610 460 pF1KE2 TSEFEPAMQIDG >>CCDS33718.1 NR1D2 gene_id:9975|Hs108|chr3 (579 aa) initn: 544 init1: 248 opt: 428 Z-score: 432.5 bits: 89.7 E(32554): 9.1e-18 Smith-Waterman score: 823; 34.0% identity (63.2% similar) in 486 aa overlap (15-441:100-579) 10 20 30 40 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRR .. ::.::: .::.:::: .:::::::::: CCDS33 DRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRR 70 80 90 100 110 120 50 60 70 80 90 100 pF1KE2 SQQSNATYS-CPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYA : :.: :. : ...:: : : .:::::.::..:::.::::::::.:::. :.... . CCDS33 SIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLI 130 140 150 160 170 180 110 120 130 pF1KE2 EVQ---KHRMQQQ-----QRD----HQQQ---PGEAE----PLTPTYNISANG------- :.: : :..: : : :..: :.. . : ::.... CCDS33 EMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFA 190 200 210 220 230 240 140 150 160 170 pF1KE2 -------LTELHDDL--------SNYIDGHTPE-GSKADSAVSSFYLDIQPSPD------ .:. : : : .. :. : . . . .. :. . . CCDS33 KEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHF 250 260 270 280 290 300 180 190 200 210 220 pF1KE2 ---QSGLDING-IKPEPICDYTPASGFF---PYC-SFTNGETSPTVSMAELEHLAQNISK .: .:: .: . : : . .. .: .:.:. :. . . . .. ..:: .: CCDS33 PCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENK 310 320 330 340 350 360 230 240 250 260 270 280 pF1KE2 SHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRID . .:: . .. ... .:. . .:. ....: :.. :::::::: CCDS33 N-----SYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIP 370 380 390 400 410 420 290 300 310 320 330 340 pF1KE2 GFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYF-DGKYASPDVFKSLGCEDFIS :: .: :.::. :::::..::...:. ::... :: : .:: : : ..:.: :... CCDS33 GFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLN 430 440 450 460 470 480 350 360 370 380 390 400 pF1KE2 FVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNH .:::...: ...:...:..::.: ::.::::: ... ..: ::. . ::. ...::: CCDS33 SMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 490 500 510 520 530 540 410 420 430 440 450 460 pF1KE2 -REDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQ : .:.:::. :. ::.: . :.:.:.::: ..: CCDS33 PNEASIFTKLLLKLPDLRSLNNMHSEELLAFK-VHP 550 560 570 pF1KE2 IDG >>CCDS6856.1 NR5A1 gene_id:2516|Hs108|chr9 (461 aa) initn: 382 init1: 352 opt: 419 Z-score: 425.0 bits: 87.9 E(32554): 2.4e-17 Smith-Waterman score: 440; 26.8% identity (53.8% similar) in 444 aa overlap (18-433:13-437) 10 20 30 40 50 60 pF1KE2 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC : .:::: :: :::..:::.:::::.:. :.: :.: ....: CCDS68 MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSC 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ ::.:.:.:: ::.::::.::: .::. :: . :... .. : .::. : . CCDS68 KIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRM-RGGRNKFGPMYKRDRALKQQKKAQIR 60 70 80 90 100 110 130 140 150 160 170 pF1KE2 ---------PGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQ : . : : . :: . . . : : .: .. .. . . CCDS68 ANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVP 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 PS---------PDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLA . : : :.. ::: .: . .:: : : . . CCDS68 GAHGPLAGYLYPAFPGRAIKSEYPEPYA--SPPQPGLPY-----GYPEPFSG-------G 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 QNISKSHLETCQYLREELQQITWQTF--LQEEIENYQNKQREVMWQLCAIKITEAIQYVV :. . :. : :. . .:. . . ::: .. . : .. :: . :. .: CCDS68 PNVPELILQLLQ-LEPDEDQVRARILGCLQEPTKSRPD-QPAAFGLLCRMADQTFIS-IV 230 240 250 260 270 290 300 310 320 330 pF1KE2 EFAKRIDGFMELCQNDQIVLLKAGSLEV-VFIRMCRAFD--SQNNTVYFDGKYASPDVFK ..:.: : :: ::..::. :. :: .. : . .... . :. . . CCDS68 DWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVA 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE2 SLGCEDFISFVF---EFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKI . . . :.:. :. .: ...: ..:.. .. ..:.: : ..:.... .. :.: CCDS68 TQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKA 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE2 QLAL-QHVL-QKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY . :: ...: . : : . :.: : .::: . : : CCDS68 NAALLDYTLCHYPHCGDKFQQLLLCLVE-VRALSMQAKEYLYHKHLGNEMPRNNLLIEML 400 410 420 430 440 450 460 pF1KE2 KELFTSEFEPAMQIDG CCDS68 QAKQT 460 468 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:45:24 2016 done: Mon Nov 7 20:45:24 2016 Total Scan time: 2.340 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]