FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3045, 184 aa 1>>>pF1KE3045 184 - 184 aa - 184 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3437+/-0.00027; mu= 9.6531+/- 0.017 mean_var=101.8004+/-20.343, 0's: 0 Z-trim(122.9): 21 B-trim: 949 in 1/55 Lambda= 0.127116 statistics sampled from 41641 (41662) to 41641 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.818), E-opt: 0.2 (0.488), width: 16 Scan time: 6.650 The best scores are: opt bits E(85289) NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precu ( 184) 1275 242.9 2.2e-64 XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 i ( 221) 1275 242.9 2.5e-64 XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 i ( 240) 1275 243.0 2.7e-64 NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 pr ( 143) 763 148.9 3.3e-36 NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [H ( 114) 754 147.2 8.6e-36 XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 i ( 168) 622 123.1 2.3e-28 NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo ( 168) 622 123.1 2.3e-28 XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 i ( 186) 622 123.1 2.5e-28 NP_005445 (OMIM: 603777) cerberus precursor [Homo ( 267) 242 53.6 3.2e-07 NP_001191014 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06 NP_001191013 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06 NP_005371 (OMIM: 600613) neuroblastoma suppressor ( 181) 219 49.2 4.3e-06 NP_001265093 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06 NP_001265095 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06 NP_001265094 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06 NP_001191015 (OMIM: 600613) neuroblastoma suppress ( 215) 219 49.3 4.9e-06 NP_877421 (OMIM: 600613) neuroblastoma suppressor ( 216) 219 49.3 4.9e-06 NP_689867 (OMIM: 609068) DAN domain family member ( 189) 159 38.2 0.0091 >>NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precursor (184 aa) initn: 1275 init1: 1275 opt: 1275 Z-score: 1276.9 bits: 242.9 E(85289): 2.2e-64 Smith-Waterman score: 1275; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184) 10 20 30 40 50 60 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS 130 140 150 160 170 180 pF1KE3 IDLD :::: NP_037 IDLD >>XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 isofo (221 aa) initn: 1275 init1: 1275 opt: 1275 Z-score: 1275.8 bits: 242.9 E(85289): 2.5e-64 Smith-Waterman score: 1275; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:38-221) 10 20 30 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ :::::::::::::::::::::::::::::: XP_016 GSGGVLGRPLESAGWSIRRIHDVCICRSPSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT 130 140 150 160 170 180 160 170 180 pF1KE3 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD :::::::::::::::::::::::::::::::::: XP_016 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD 190 200 210 220 >>XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 isofo (240 aa) initn: 1275 init1: 1275 opt: 1275 Z-score: 1275.2 bits: 243.0 E(85289): 2.7e-64 Smith-Waterman score: 1275; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:57-240) 10 20 30 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ :::::::::::::::::::::::::::::: XP_005 PAPSPGGSGRGRTQRHASKAQAPRTRRTDSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE3 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE3 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT 150 160 170 180 190 200 160 170 180 pF1KE3 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD :::::::::::::::::::::::::::::::::: XP_005 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD 210 220 230 240 >>NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 precur (143 aa) initn: 777 init1: 755 opt: 763 Z-score: 771.0 bits: 148.9 E(85289): 3.3e-36 Smith-Waterman score: 904; 77.7% identity (77.7% similar) in 184 aa overlap (1-184:1-143) 10 20 30 40 50 60 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR ::::::::::::::::::::::::::::::::::::::: NP_001 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKA--------------------- 10 20 30 70 80 90 100 110 120 pF1KE3 GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG :::::::::::::::::::::::::::::::::::::::: NP_001 --------------------LHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG 40 50 60 70 130 140 150 160 170 180 pF1KE3 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS 80 90 100 110 120 130 pF1KE3 IDLD :::: NP_001 IDLD 140 >>NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [Homo (114 aa) initn: 754 init1: 754 opt: 754 Z-score: 763.5 bits: 147.2 E(85289): 8.6e-36 Smith-Waterman score: 754; 100.0% identity (100.0% similar) in 105 aa overlap (80-184:10-114) 50 60 70 80 90 100 pF1KE3 PQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCN :::::::::::::::::::::::::::::: NP_001 MSRTAYTVGALHVTERKYLKRDWCKTQPLKQTIHEEGCN 10 20 30 110 120 130 140 150 160 pF1KE3 SRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKR 40 50 60 70 80 90 170 180 pF1KE3 VTRVKQCRCISIDLD ::::::::::::::: NP_001 VTRVKQCRCISIDLD 100 110 >>XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 isofo (168 aa) initn: 675 init1: 614 opt: 622 Z-score: 630.3 bits: 123.1 E(85289): 2.3e-28 Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (12-183:9-162) 10 20 30 40 50 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDSEQTQSPQQPGSRNRG :.:...:. .::..:. :::: : : .. :.::. : . XP_011 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIK------- 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY ::: :::::: :::::::: ::::::::.::. :::: ::::.::::: XP_011 ------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY 60 70 80 90 120 130 140 150 160 170 pF1KE3 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCI :::::::::::..::: :::::.::::.. :...: :.:: :.:: . :.. .::::::. XP_011 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCM 100 110 120 130 140 150 180 pF1KE3 SIDLD :..: XP_011 SVNLSDSDKQ 160 >>NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo sap (168 aa) initn: 675 init1: 614 opt: 622 Z-score: 630.3 bits: 123.1 E(85289): 2.3e-28 Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (12-183:9-162) 10 20 30 40 50 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDSEQTQSPQQPGSRNRG :.:...:. .::..:. :::: : : .. :.::. : . NP_071 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIK------- 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY ::: :::::: :::::::: ::::::::.::. :::: ::::.::::: NP_071 ------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY 60 70 80 90 120 130 140 150 160 170 pF1KE3 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCI :::::::::::..::: :::::.::::.. :...: :.:: :.:: . :.. .::::::. NP_071 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCM 100 110 120 130 140 150 180 pF1KE3 SIDLD :..: NP_071 SVNLSDSDKQ 160 >>XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 isofo (186 aa) initn: 675 init1: 614 opt: 622 Z-score: 629.6 bits: 123.1 E(85289): 2.5e-28 Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (12-183:27-180) 10 20 30 40 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDS :.:...:. .::..:. :::: : : .. :.: XP_005 MRALRAESTSGSRQTPCRMFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 EQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIH :. : . ::: :::::: :::::::: ::::::::.::. XP_005 ERWQHQIK-------------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVS 70 80 90 100 110 120 130 140 150 160 pF1KE3 EEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPP :::: ::::.::::::::::::::::..::: :::::.::::.. :...: :.:: :.:: XP_005 EEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPP 110 120 130 140 150 160 170 180 pF1KE3 TKKKRVTRVKQCRCISIDLD . :.. .::::::.:..: XP_005 FRLKKIQKVKQCRCMSVNLSDSDKQ 170 180 >>NP_005445 (OMIM: 603777) cerberus precursor [Homo sapi (267 aa) initn: 289 init1: 132 opt: 242 Z-score: 250.7 bits: 53.6 E(85289): 3.2e-07 Smith-Waterman score: 252; 28.9% identity (53.9% similar) in 180 aa overlap (20-178:68-241) 10 20 30 40 pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPDKAQHND ::.::... . : . :.. .: . NP_005 NQRELPTGNHEEAEEKPDLFVAVPHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPS 40 50 60 70 80 90 50 60 70 80 90 pF1KE3 SEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VTERKYLK .. . : ::... . : : . : ... : . : . NP_005 RDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHE 100 110 120 130 140 150 100 110 120 130 140 pF1KE3 RDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKK : :.: :..::: .:::.. .. : .:.:.:.: ..: .. : ::: : : : NP_005 VHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQH---SHTSCSHCLPAK 160 170 180 190 200 210 150 160 170 180 pF1KE3 FTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD :::: . ::: ::. . : : :..:.: NP_005 FTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA 220 230 240 250 260 >>NP_001191014 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 213 init1: 193 opt: 219 Z-score: 230.4 bits: 49.2 E(85289): 4.3e-06 Smith-Waterman score: 219; 32.2% identity (58.9% similar) in 90 aa overlap (90-178:31-120) 60 70 80 90 100 110 pF1KE3 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY : ::... . : . . ::....: :: : NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 120 130 140 150 160 170 pF1KE3 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCP-ELQPPTKKKRVTRVKQCRC ::: :. .: . . :. :. : : . .:::.:: . . : : : .. .: : NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 180 pF1KE3 ISIDLD NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 184 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:55:11 2016 done: Sun Nov 6 04:55:12 2016 Total Scan time: 6.650 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]