FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3959, 507 aa 1>>>pF1KE3959 507 - 507 aa - 507 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9472+/-0.000334; mu= 13.5072+/- 0.021 mean_var=186.2543+/-37.829, 0's: 0 Z-trim(121.6): 9 B-trim: 97 in 1/53 Lambda= 0.093977 statistics sampled from 38370 (38380) to 38370 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.45), width: 16 Scan time: 10.930 The best scores are: opt bits E(85289) NP_005655 (OMIM: 176270,603856,615346) probable E3 ( 507) 3585 498.3 2.2e-140 NP_038474 (OMIM: 607754) E3 ubiquitin-protein liga ( 482) 1441 207.6 6.7e-53 XP_011514300 (OMIM: 607754) PREDICTED: E3 ubiquiti ( 418) 1405 202.7 1.8e-51 XP_011514299 (OMIM: 607754) PREDICTED: E3 ubiquiti ( 418) 1405 202.7 1.8e-51 XP_011514298 (OMIM: 607754) PREDICTED: E3 ubiquiti ( 439) 1405 202.7 1.8e-51 NP_001138597 (OMIM: 607754) E3 ubiquitin-protein l ( 329) 925 137.5 6e-32 NP_001258636 (OMIM: 608426) probable E3 ubiquitin- ( 373) 903 134.5 5.1e-31 NP_054879 (OMIM: 608426) probable E3 ubiquitin-pro ( 416) 900 134.2 7.3e-31 NP_001278592 (OMIM: 607754) E3 ubiquitin-protein l ( 265) 889 132.5 1.5e-30 >>NP_005655 (OMIM: 176270,603856,615346) probable E3 ubi (507 aa) initn: 3585 init1: 3585 opt: 3585 Z-score: 2641.5 bits: 498.3 E(85289): 2.2e-140 Smith-Waterman score: 3585; 100.0% identity (100.0% similar) in 507 aa overlap (1-507:1-507) 10 20 30 40 50 60 pF1KE3 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 APVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 APVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSSETERKQMAVGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSSETERKQMAVGSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 FAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 CPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 EYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLS 430 440 450 460 470 480 490 500 pF1KE3 LRDELPFSEDQWDLLHYELEEYFNLIL ::::::::::::::::::::::::::: NP_005 LRDELPFSEDQWDLLHYELEEYFNLIL 490 500 >>NP_038474 (OMIM: 607754) E3 ubiquitin-protein ligase m (482 aa) initn: 1572 init1: 1126 opt: 1441 Z-score: 1070.8 bits: 207.6 E(85289): 6.7e-53 Smith-Waterman score: 1619; 51.5% identity (71.1% similar) in 505 aa overlap (20-507:2-482) 10 20 30 40 50 60 pF1KE3 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPV :::: :... :: .:: .: :: . .:.:. NP_038 MAEAATPGTTATT------SGAGAAAATA---AAASPTPIPT 10 20 30 70 80 90 100 110 120 pF1KE3 APVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHD . .:. : :: .:::. . :.: ::::. :::..:: ::::.::::::: NP_038 VTAPS-LGAGG------GGGGS------DGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHD 40 50 60 70 80 130 140 150 160 170 pF1KE3 LSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPP--------AASSLSLPVIG :: ... : : : .: :: : : :.:::: ..: NP_038 LSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLS-SIVG 90 100 110 120 130 180 190 200 210 220 pF1KE3 SAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS---- .: . ::: :.. :. ::: :.:..:::::::::: :: . : :::::.: NP_038 PLVEMNTGEAESRNSNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKE 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE3 ETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRA :.:..: :: . ..: ::. : : ::.:.::::: :::::::.::::::::: .:... NP_038 ESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKS 200 210 220 230 240 250 290 300 310 320 330 340 pF1KE3 CIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWR :::::::::::::::::. : :::::::::::::::..:::::::::::..:..:::.:: NP_038 CIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWR 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE3 SARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRG ::.:::..:.::::.::.::..:::::.::::.::::::: .::::::::::::: :::: NP_038 SAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRG 320 330 340 350 360 370 410 420 430 440 450 460 pF1KE3 NCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQ----LVEPVRMGEGNMLYKSIKKE .:::: .::::: ::.: .:: :. : : : . : .. :.. . . ..: NP_038 SCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEE 380 390 400 410 420 430 470 480 490 500 pF1KE3 LVVLRLASLLFKRFLSL-RDELPFSEDQWDLLHYELEEYFNLIL .:...:. .:. . . ::: :::.:::.: :::....: : NP_038 VVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL 440 450 460 470 480 >>XP_011514300 (OMIM: 607754) PREDICTED: E3 ubiquitin-pr (418 aa) initn: 1343 init1: 1126 opt: 1405 Z-score: 1045.1 bits: 202.7 E(85289): 1.8e-51 Smith-Waterman score: 1511; 54.8% identity (74.0% similar) in 420 aa overlap (105-507:1-418) 80 90 100 110 120 130 pF1KE3 APASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSP .:: ::::.::::::::: ... XP_011 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ 10 20 30 140 150 160 170 180 pF1KE3 PGASAGGGPSTAAHIEPPTQEVAEAPP--------AASSLSLPVIGSAAERGFFEAERDN : : : .: :: : : :.:::: ..: .: . ::: : XP_011 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLS-SIVGPLVEMNTGEAESRN 40 50 60 70 80 190 200 210 220 230 240 pF1KE3 ADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS----ETERKQMAVGSGLR .. :. ::: :.:..:::::::::: :: . : :::::.: :.:..: :: . . XP_011 SNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQ 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE3 FCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFA .: ::. : : ::.:.::::: :::::::.::::::::: .:...:::::::::::::: XP_011 LCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFA 150 160 170 180 190 200 310 320 330 340 350 360 pF1KE3 VQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCP :::. : :::::::::::::::..:::::::::::..:..:::.::::.:::..:.:::: XP_011 VQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCP 210 220 230 240 250 260 370 380 390 400 410 420 pF1KE3 QCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEY .::.::..:::::.::::.::::::: .::::::::::::: ::::.:::: .::::: : XP_011 ECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAY 270 280 290 300 310 320 430 440 450 460 470 pF1KE3 PEGWGDEPPGPGGGSFSAYWHQ----LVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRF :.: .:: :. : : : . : .. :.. . . ..:.:...:. .:. . XP_011 PDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLL 330 340 350 360 370 380 480 490 500 pF1KE3 LSL-RDELPFSEDQWDLLHYELEEYFNLIL . ::: :::.:::.: :::....: : XP_011 AAGGDDELTDSEDEWDLFHDELEDFYDLDL 390 400 410 >>XP_011514299 (OMIM: 607754) PREDICTED: E3 ubiquitin-pr (418 aa) initn: 1343 init1: 1126 opt: 1405 Z-score: 1045.1 bits: 202.7 E(85289): 1.8e-51 Smith-Waterman score: 1511; 54.8% identity (74.0% similar) in 420 aa overlap (105-507:1-418) 80 90 100 110 120 130 pF1KE3 APASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSP .:: ::::.::::::::: ... XP_011 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ 10 20 30 140 150 160 170 180 pF1KE3 PGASAGGGPSTAAHIEPPTQEVAEAPP--------AASSLSLPVIGSAAERGFFEAERDN : : : .: :: : : :.:::: ..: .: . ::: : XP_011 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLS-SIVGPLVEMNTGEAESRN 40 50 60 70 80 190 200 210 220 230 240 pF1KE3 ADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS----ETERKQMAVGSGLR .. :. ::: :.:..:::::::::: :: . : :::::.: :.:..: :: . . XP_011 SNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQ 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE3 FCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFA .: ::. : : ::.:.::::: :::::::.::::::::: .:...:::::::::::::: XP_011 LCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFA 150 160 170 180 190 200 310 320 330 340 350 360 pF1KE3 VQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCP :::. : :::::::::::::::..:::::::::::..:..:::.::::.:::..:.:::: XP_011 VQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCP 210 220 230 240 250 260 370 380 390 400 410 420 pF1KE3 QCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEY .::.::..:::::.::::.::::::: .::::::::::::: ::::.:::: .::::: : XP_011 ECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAY 270 280 290 300 310 320 430 440 450 460 470 pF1KE3 PEGWGDEPPGPGGGSFSAYWHQ----LVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRF :.: .:: :. : : : . : .. :.. . . ..:.:...:. .:. . XP_011 PDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLL 330 340 350 360 370 380 480 490 500 pF1KE3 LSL-RDELPFSEDQWDLLHYELEEYFNLIL . ::: :::.:::.: :::....: : XP_011 AAGGDDELTDSEDEWDLFHDELEDFYDLDL 390 400 410 >>XP_011514298 (OMIM: 607754) PREDICTED: E3 ubiquitin-pr (439 aa) initn: 1428 init1: 1126 opt: 1405 Z-score: 1044.8 bits: 202.7 E(85289): 1.8e-51 Smith-Waterman score: 1430; 48.3% identity (69.6% similar) in 497 aa overlap (20-507:2-439) 10 20 30 40 50 60 pF1KE3 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPV :::: :... :: .:: .: :: . .:.:. XP_011 MAEAATPGTTATT------SGAGAAAATA---AAASPTPIPT 10 20 30 70 80 90 100 110 120 pF1KE3 APVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHD . .:. : :: .:::. . :.: ::::. ::: :.. . : . XP_011 VTAPS-LGAGG------GGGGS------DGSGGGWTKQVTCRYE-HSKPLKQE------E 40 50 60 70 130 140 150 160 170 180 pF1KE3 LSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFF .. ...:..... :.:::: ..: .: . XP_011 ATATELTTKSSLA----------------------------ASSSLS-SIVGPLVEMNTG 80 90 100 190 200 210 220 230 pF1KE3 EAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS----ETERKQMA ::: :.. :. ::: :.:..:::::::::: :: . : :::::.: :.:..: : XP_011 EAESRNSNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTA 110 120 130 140 150 160 240 250 260 270 280 290 pF1KE3 VGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKD : . ..: ::. : : ::.:.::::: :::::::.::::::::: .:...:::::::: XP_011 VETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKD 170 180 190 200 210 220 300 310 320 330 340 350 pF1KE3 MELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENR :::::::::. : :::::::::::::::..:::::::::::..:..:::.::::.:::.. XP_011 MELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESK 230 240 250 260 270 280 360 370 380 390 400 410 pF1KE3 IVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTC :.::::.::.::..:::::.::::.::::::: .::::::::::::: ::::.:::: .: XP_011 IIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNC 290 300 310 320 330 340 420 430 440 450 460 470 pF1KE3 FYKHEYPEGWGDEPPGPGGGSFSAYWHQ----LVEPVRMGEGNMLYKSIKKELVVLRLAS :::: ::.: .:: :. : : : . : .. :.. . . ..:.:...:. XP_011 FYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGE 350 360 370 380 390 400 480 490 500 pF1KE3 LLFKRFLSL-RDELPFSEDQWDLLHYELEEYFNLIL .:. . . ::: :::.:::.: :::....: : XP_011 MLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL 410 420 430 >>NP_001138597 (OMIM: 607754) E3 ubiquitin-protein ligas (329 aa) initn: 1042 init1: 687 opt: 925 Z-score: 694.6 bits: 137.5 E(85289): 6e-32 Smith-Waterman score: 1103; 51.4% identity (69.3% similar) in 352 aa overlap (20-359:2-329) 10 20 30 40 50 60 pF1KE3 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPV :::: :... :: .:: .: :: . .:.:. NP_001 MAEAATPGTTATT------SGAGAAAATA---AAASPTPIPT 10 20 30 70 80 90 100 110 120 pF1KE3 APVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHD . .:. : :: .:::. . :.: ::::. :::..:: ::::.::::::: NP_001 VTAPS-LGAGG------GGGGS------DGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHD 40 50 60 70 80 130 140 150 160 170 pF1KE3 LSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPP--------AASSLSLPVIG :: ... : : : .: :: : : :.:::: ..: NP_001 LSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLS-SIVG 90 100 110 120 130 180 190 200 210 220 pF1KE3 SAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS---- .: . ::: :.. :. ::: :.:..:::::::::: :: . : :::::.: NP_001 PLVEMNTGEAESRNSNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKE 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE3 ETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRA :.:..: :: . ..: ::. : : ::.:.::::: :::::::.::::::::: .:... NP_001 ESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKS 200 210 220 230 240 250 290 300 310 320 330 340 pF1KE3 CIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWR :::::::::::::::::. : :::::::::::::::..:::::::::::..:..:::.:: NP_001 CIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWR 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE3 SARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRG ::.:::..:.: NP_001 SAKQFESKIIK 320 >>NP_001258636 (OMIM: 608426) probable E3 ubiquitin-prot (373 aa) initn: 956 init1: 864 opt: 903 Z-score: 677.8 bits: 134.5 E(85289): 5.1e-31 Smith-Waterman score: 903; 41.6% identity (69.4% similar) in 320 aa overlap (121-433:1-317) 100 110 120 130 140 150 pF1KE3 SSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSPPGASAGGGPSTAAHIE .: .... . . :.:.:::. .: :: NP_001 MSTKQITCRYDHTRPSAAAGGAVGTMAHSV 10 20 30 160 170 180 190 200 pF1KE3 PPTQEVAEAPPAASSLSLPVIGSAAERGFFEAERDNA--DRGAAGGAGVESWADAIEFVP : . ::. . :. : .. : : : .: . ::. .: : .. . . : NP_001 PSPAFHSPHPPSEVTASI-VKTNSHEPGKRE-KRTLVLRDRNLSGMAERKTQPSMVS-NP 40 50 60 70 80 210 220 230 240 250 260 pF1KE3 G-----QPYRGRWVASAPEAPLQSSETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHG : :: : .: .. . . . . .. ..: ::. : : :..:.:::: NP_001 GSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHG 90 100 110 120 130 140 270 280 290 300 310 320 pF1KE3 DICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKAN ..:..: ::.:::.: ::. : . :. . :..:: .:: : ..::::.:::::. :::. NP_001 EVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKAS 150 160 170 180 190 200 330 340 350 360 370 380 pF1KE3 PNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEE ..:::::::::::..:. :::.:: :.:::: :.::::.::: ::.:::: .:::.... NP_001 ASERRFGILSNCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNK 210 220 230 240 250 260 390 400 410 420 430 440 pF1KE3 KQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWH :..::. .:..:..:::.:: .:.:.::::. :.:.: ::.: :: : NP_001 KNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTV 270 280 290 300 310 320 450 460 470 480 490 500 pF1KE3 QLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLSLRDELPFSEDQWDLLHYELEEYF NP_001 RFFNSVRLWDFIENRESRHVPNNEDVDMTELGDLFMHLSGVESSEP 330 340 350 360 370 >>NP_054879 (OMIM: 608426) probable E3 ubiquitin-protein (416 aa) initn: 1057 init1: 864 opt: 900 Z-score: 675.1 bits: 134.2 E(85289): 7.3e-31 Smith-Waterman score: 1005; 42.1% identity (67.6% similar) in 361 aa overlap (96-433:3-360) 70 80 90 100 110 120 pF1KE3 HLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRK :::: :::..:: :.:: .: .::::.. : NP_054 MSTKQITCRYFMHGVCREGSQCLFSHDLANSK 10 20 30 130 140 150 160 pF1KE3 MAT-----EGGV-----------SPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLP .: . : . :.:.:::. .: :: : . ::. . :. NP_054 PSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASI- 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE3 VIGSAAERGFFEAERDNA--DRGAAGGAGVESWADAIEFVPG-----QPYRGRWVASAPE : .. : : : .: . ::. .: : .. . . :: :: : . NP_054 VKTNSHEPGKRE-KRTLVLRDRNLSGMAERKTQPSMVS-NPGSCSDPQPSPEMKPHSYLD 100 110 120 130 140 230 240 250 260 270 280 pF1KE3 APLQSSETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQR : .. . . . . .. ..: ::. : : :..:.::::..:..: ::.:::.: :: NP_054 AIRSGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQVLHPFDPEQR 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE3 EEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIR . : . :. . :..:: .:: : ..::::.:::::. :::. ..:::::::::::..:. NP_054 KAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLS 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE3 CIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRY :::.:: :.:::: :.::::.::: ::.:::: .:::....:..::. .:..:..:::.: NP_054 CIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKY 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE3 FAEGRGNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIK : .:.:.::::. :.:.: ::.: :: : NP_054 FEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWDFIENRESRH 330 340 350 360 370 380 470 480 490 500 pF1KE3 KELVVLRLASLLFKRFLSLRDELPFSEDQWDLLHYELEEYFNLIL NP_054 VPNNEDVDMTELGDLFMHLSGVESSEP 390 400 410 >>NP_001278592 (OMIM: 607754) E3 ubiquitin-protein ligas (265 aa) initn: 1001 init1: 687 opt: 889 Z-score: 669.3 bits: 132.5 E(85289): 1.5e-30 Smith-Waterman score: 995; 56.6% identity (73.4% similar) in 267 aa overlap (105-359:1-265) 80 90 100 110 120 130 pF1KE3 APASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSP .:: ::::.::::::::: ... NP_001 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ 10 20 30 140 150 160 170 180 pF1KE3 PGASAGGGPSTAAHIEPPTQEVAEAPP--------AASSLSLPVIGSAAERGFFEAERDN : : : .: :: : : :.:::: ..: .: . ::: : NP_001 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLS-SIVGPLVEMNTGEAESRN 40 50 60 70 80 190 200 210 220 230 240 pF1KE3 ADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS----ETERKQMAVGSGLR .. :. ::: :.:..:::::::::: :: . : :::::.: :.:..: :: . . NP_001 SNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQ 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE3 FCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFA .: ::. : : ::.:.::::: :::::::.::::::::: .:...:::::::::::::: NP_001 LCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFA 150 160 170 180 190 200 310 320 330 340 350 360 pF1KE3 VQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCP :::. : :::::::::::::::..:::::::::::..:..:::.::::.:::..:.: NP_001 VQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIK 210 220 230 240 250 260 370 380 390 400 410 420 pF1KE3 QCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEY 507 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:33:19 2016 done: Sun Nov 6 08:33:20 2016 Total Scan time: 10.930 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]