Result of FASTA (omim) for
pFN21AB8480
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8480, 854 aa
1>>>pF1KB8480 854 - 854 aa - 854 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6881+/-0.00045; mu= 1.0471+/- 0.028
mean_var=265.8997+/-52.835, 0's: 0 Z-trim(118.7): 13 B-trim: 1122 in 1/54
Lambda= 0.078653
statistics sampled from 31846 (31859) to 31846 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.374), width: 16
Scan time: 12.710
The best scores are: opt bits E(85289)
NP_001017963 (OMIM: 140571) heat shock protein HSP ( 854) 5588 648.3 4.4e-185
XP_011535020 (OMIM: 140571) PREDICTED: heat shock ( 853) 5571 646.3 1.7e-184
NP_005339 (OMIM: 140571) heat shock protein HSP 90 ( 732) 4718 549.5 2e-155
NP_001258899 (OMIM: 140572) heat shock protein HSP ( 724) 4122 481.9 4.6e-135
NP_031381 (OMIM: 140572) heat shock protein HSP 90 ( 724) 4122 481.9 4.6e-135
NP_001258898 (OMIM: 140572) heat shock protein HSP ( 724) 4122 481.9 4.6e-135
NP_001258900 (OMIM: 140572) heat shock protein HSP ( 676) 3462 407.0 1.5e-112
NP_001258901 (OMIM: 140572) heat shock protein HSP ( 714) 3424 402.7 3.2e-111
NP_003290 (OMIM: 191175) endoplasmin precursor [Ho ( 803) 1463 180.2 3.4e-44
XP_011520647 (OMIM: 606219) PREDICTED: heat shock ( 564) 626 85.1 1e-15
NP_001258978 (OMIM: 606219) heat shock protein 75 ( 651) 626 85.1 1.1e-15
NP_057376 (OMIM: 606219) heat shock protein 75 kDa ( 704) 626 85.2 1.2e-15
XP_016878340 (OMIM: 606219) PREDICTED: heat shock ( 405) 590 80.9 1.3e-14
>>NP_001017963 (OMIM: 140571) heat shock protein HSP 90- (854 aa)
initn: 5588 init1: 5588 opt: 5588 Z-score: 3443.8 bits: 648.3 E(85289): 4.4e-185
Smith-Waterman score: 5588; 99.9% identity (100.0% similar) in 854 aa overlap (1-854:1-854)
10 20 30 40 50 60
pF1KB8 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLRSRAPVNWYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLRSRAPVNWYQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EKAQVFLWHLLVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAQVFLWHLMVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
790 800 810 820 830 840
850
pF1KB8 LEGDDDTSRMEEVD
::::::::::::::
NP_001 LEGDDDTSRMEEVD
850
>>XP_011535020 (OMIM: 140571) PREDICTED: heat shock prot (853 aa)
initn: 5569 init1: 5198 opt: 5571 Z-score: 3433.4 bits: 646.3 E(85289): 1.7e-184
Smith-Waterman score: 5571; 99.8% identity (99.9% similar) in 854 aa overlap (1-854:1-853)
10 20 30 40 50 60
pF1KB8 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLRSRAPVNWYQ
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 MPPCSGGDGSTPPGPSLRDRDCPAQSAEYPRDRLDPRPGSPSEASSPPFLR-RAPVNWYQ
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 EKAQVFLWHLLVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKAQVFLWHLMVSGSTTLLCLWKQPFHVSAFPVTASLAFRQSQGAGQHLYKDLQPFILLR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDK
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAF
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB8 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEK
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB8 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWT
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB8 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKK
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB8 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVK
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB8 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB8 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB8 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC
660 670 680 690 700 710
730 740 750 760 770 780
pF1KB8 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKS
720 730 740 750 760 770
790 800 810 820 830 840
pF1KB8 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPP
780 790 800 810 820 830
850
pF1KB8 LEGDDDTSRMEEVD
::::::::::::::
XP_011 LEGDDDTSRMEEVD
840 850
>>NP_005339 (OMIM: 140571) heat shock protein HSP 90-alp (732 aa)
initn: 4718 init1: 4718 opt: 4718 Z-score: 2911.2 bits: 549.5 E(85289): 2e-155
Smith-Waterman score: 4718; 100.0% identity (100.0% similar) in 732 aa overlap (123-854:1-732)
100 110 120 130 140 150
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
::::::::::::::::::::::::::::::
NP_005 MPEETQTQDQPMEEEEVETFAFQAEIAQLM
10 20 30
160 170 180 190 200 210
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
400 410 420 430 440 450
580 590 600 610 620 630
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
460 470 480 490 500 510
640 650 660 670 680 690
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
520 530 540 550 560 570
700 710 720 730 740 750
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
580 590 600 610 620 630
760 770 780 790 800 810
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
640 650 660 670 680 690
820 830 840 850
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
::::::::::::::::::::::::::::::::::::::::::
NP_005 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
700 710 720 730
>>NP_001258899 (OMIM: 140572) heat shock protein HSP 90- (724 aa)
initn: 2811 init1: 2811 opt: 4122 Z-score: 2545.8 bits: 481.9 E(85289): 4.6e-135
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (123-854:1-724)
100 110 120 130 140 150
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
::::.. :::::::::::::::::
NP_001 MPEEVH-----HGEEEVETFAFQAEIAQLM
10 20
160 170 180 190 200 210
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
:::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
30 40 50 60 70 80
220 230 240 250 260 270
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_001 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
90 100 110 120 130 140
280 290 300 310 320 330
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
:::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
150 160 170 180 190 200
340 350 360 370 380 390
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
::::::::::..::::.::.:::::::.. :::.:.:..:.::.:::::::::...
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
210 220 230 240 250 260
400 410 420 430 440 450
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
270 280 290 300 310 320
460 470 480 490 500 510
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
330 340 350 360 370 380
520 530 540 550 560 570
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
:::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
390 400 410 420 430 440
580 590 600 610 620 630
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
450 460 470 480 490 500
640 650 660 670 680 690
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
.::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
510 520 530 540 550 560
700 710 720 730 740 750
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
:::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
570 580 590 600 610 620
760 770 780 790 800 810
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
:::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
630 640 650 660 670 680
820 830 840 850
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
:::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
690 700 710 720
>>NP_031381 (OMIM: 140572) heat shock protein HSP 90-bet (724 aa)
initn: 2811 init1: 2811 opt: 4122 Z-score: 2545.8 bits: 481.9 E(85289): 4.6e-135
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (123-854:1-724)
100 110 120 130 140 150
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
::::.. :::::::::::::::::
NP_031 MPEEVH-----HGEEEVETFAFQAEIAQLM
10 20
160 170 180 190 200 210
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
:::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_031 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
30 40 50 60 70 80
220 230 240 250 260 270
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_031 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
90 100 110 120 130 140
280 290 300 310 320 330
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
:::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_031 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
150 160 170 180 190 200
340 350 360 370 380 390
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
::::::::::..::::.::.:::::::.. :::.:.:..:.::.:::::::::...
NP_031 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
210 220 230 240 250 260
400 410 420 430 440 450
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_031 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
270 280 290 300 310 320
460 470 480 490 500 510
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_031 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
330 340 350 360 370 380
520 530 540 550 560 570
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
:::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_031 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
390 400 410 420 430 440
580 590 600 610 620 630
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_031 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
450 460 470 480 490 500
640 650 660 670 680 690
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
.::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_031 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
510 520 530 540 550 560
700 710 720 730 740 750
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
:::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_031 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
570 580 590 600 610 620
760 770 780 790 800 810
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
:::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_031 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
630 640 650 660 670 680
820 830 840 850
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
:::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_031 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
690 700 710 720
>>NP_001258898 (OMIM: 140572) heat shock protein HSP 90- (724 aa)
initn: 2811 init1: 2811 opt: 4122 Z-score: 2545.8 bits: 481.9 E(85289): 4.6e-135
Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (123-854:1-724)
100 110 120 130 140 150
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
::::.. :::::::::::::::::
NP_001 MPEEVH-----HGEEEVETFAFQAEIAQLM
10 20
160 170 180 190 200 210
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
:::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
30 40 50 60 70 80
220 230 240 250 260 270
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_001 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV
90 100 110 120 130 140
280 290 300 310 320 330
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
:::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
150 160 170 180 190 200
340 350 360 370 380 390
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
::::::::::..::::.::.:::::::.. :::.:.:..:.::.:::::::::...
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
210 220 230 240 250 260
400 410 420 430 440 450
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
270 280 290 300 310 320
460 470 480 490 500 510
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
330 340 350 360 370 380
520 530 540 550 560 570
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
:::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
390 400 410 420 430 440
580 590 600 610 620 630
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
450 460 470 480 490 500
640 650 660 670 680 690
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
.::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
510 520 530 540 550 560
700 710 720 730 740 750
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
:::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
570 580 590 600 610 620
760 770 780 790 800 810
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
:::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
630 640 650 660 670 680
820 830 840 850
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
:::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
690 700 710 720
>>NP_001258900 (OMIM: 140572) heat shock protein HSP 90- (676 aa)
initn: 3184 init1: 2811 opt: 3462 Z-score: 2141.4 bits: 407.0 E(85289): 1.5e-112
Smith-Waterman score: 3745; 79.9% identity (89.6% similar) in 732 aa overlap (123-854:1-676)
100 110 120 130 140 150
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
::::.. :::::::::::::::::
NP_001 MPEEVH-----HGEEEVETFAFQAEIAQLM
10 20
160 170 180 190 200 210
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
:::::::::::::::::::::.::::::::::::::::::::::::.:
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKI------------
30 40 50 60 70
220 230 240 250 260 270
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
::::::::::::::::::::::.:
NP_001 ------------------------------------DISMIGQFGVGFYSAYLVAEKVVV
80 90
280 290 300 310 320 330
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
:::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
100 110 120 130 140 150
340 350 360 370 380 390
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
::::::::::..::::.::.:::::::.. :::.:.:..:.::.:::::::::...
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
160 170 180 190 200 210
400 410 420 430 440 450
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
220 230 240 250 260 270
460 470 480 490 500 510
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
280 290 300 310 320 330
520 530 540 550 560 570
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
:::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
340 350 360 370 380 390
580 590 600 610 620 630
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
400 410 420 430 440 450
640 650 660 670 680 690
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
.::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
460 470 480 490 500 510
700 710 720 730 740 750
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
:::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
520 530 540 550 560 570
760 770 780 790 800 810
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
:::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
580 590 600 610 620 630
820 830 840 850
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
:::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
640 650 660 670
>>NP_001258901 (OMIM: 140572) heat shock protein HSP 90- (714 aa)
initn: 3438 init1: 2811 opt: 3424 Z-score: 2117.8 bits: 402.7 E(85289): 3.2e-111
Smith-Waterman score: 4029; 84.4% identity (94.7% similar) in 732 aa overlap (123-854:1-714)
100 110 120 130 140 150
pF1KB8 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM
::::.. :::::::::::::::::
NP_001 MPEEVH-----HGEEEVETFAFQAEIAQLM
10 20
160 170 180 190 200 210
pF1KB8 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT
:::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.::::
NP_001 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT
30 40 50 60 70 80
220 230 240 250 260 270
pF1KB8 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV
.:::::::::::::::::::::::::::::::: :::::::::::::::.:
NP_001 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ----------FGVGFYSAYLVAEKVVV
90 100 110 120 130
280 290 300 310 320 330
pF1KB8 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH
:::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.::::
NP_001 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH
140 150 160 170 180 190
340 350 360 370 380 390
pF1KB8 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK
::::::::::..::::.::.:::::::.. :::.:.:..:.::.:::::::::...
NP_001 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG
200 210 220 230 240 250
400 410 420 430 440 450
pF1KB8 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS
::: ::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_001 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS
260 270 280 290 300 310
460 470 480 490 500 510
pF1KB8 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD
::::::::::::.:::::::::::.:::::::::::::::::.:.:::::::::::::::
NP_001 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD
320 330 340 350 360 370
520 530 540 550 560 570
pF1KB8 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
:::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.:::::
NP_001 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH
380 390 400 410 420 430
580 590 600 610 620 630
pF1KB8 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER
::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.::::::::::
NP_001 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER
440 450 460 470 480 490
640 650 660 670 680 690
pF1KB8 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN
.::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.::::
NP_001 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN
500 510 520 530 540 550
700 710 720 730 740 750
pF1KB8 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA
:::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: :
NP_001 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA
560 570 580 590 600 610
760 770 780 790 800 810
pF1KB8 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR
:::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.:::::
NP_001 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
620 630 640 650 660 670
820 830 840 850
pF1KB8 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
:::::::::::. .:.. .::: .:.::::::.:.:::::::
NP_001 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
680 690 700 710
>>NP_003290 (OMIM: 191175) endoplasmin precursor [Homo s (803 aa)
initn: 1759 init1: 448 opt: 1463 Z-score: 914.5 bits: 180.2 E(85289): 3.4e-44
Smith-Waterman score: 2148; 47.8% identity (74.2% similar) in 730 aa overlap (137-854:71-783)
110 120 130 140 150 160
pF1KB8 QHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIF
:. : ::::::. ..:.::::..:.:::::
NP_003 GSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIF
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB8 LRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLI
:::::::.:::::::: :::: . :....:: ... .:. : ..:::.:::. .:.
NP_003 LRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELV
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB8 NNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFYSAYLVAEKVTVITKHNDDEQ
.::::::::::. :. :: . : . : .:::::::::::.:::.:: : .:::.: :
NP_003 KNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQ
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB8 YAWESSAGGSFTVRTDT-GEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPI
. :::... :.: .: :. .:::: . : :::. ..::: ::..:::.::::..::
NP_003 HIWESDSN-EFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPI
230 240 250 260 270
350 360 370 380 390 400
pF1KB8 TLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKK
.. : :. .. ::.: .:::: ::.:. .:. :::::: : :
NP_003 YVWSSKT---ETVEEPMEEEEAAKEEKE----ESDDEAAVEE----EEEEKKP----KTK
280 290 300 310 320
410 420 430 440 450 460
pF1KB8 KIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFR
:... : : .: :::: : .. ..:: ::::.... .: .: ::..::.. :.
NP_003 KVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFK
330 340 350 360 370 380
470 480 490 500 510
pF1KB8 ALLFVPRRAPFDLFENR--KKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPL
..:::: :: ::.. ::.. :::::::::: :. ....:.::::..:::::.::::
NP_003 SILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPL
390 400 410 420 430 440
520 530 540 550 560 570
pF1KB8 NISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNR
:.::: ::: :.::::::.::.: :... ..:.:: : :...:. :::::. :: .::
NP_003 NVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYN-DTFWKEFGTNIKLGVIEDHSNR
450 460 470 480 490 500
580 590 600 610 620 630
pF1KB8 KKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGL
.:..:::. .: ...:: .: ::::.: .::...: .. .. .: ::::: :.:
NP_003 TRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGY
510 520 530 540 550 560
640 650 660 670 680 690
pF1KB8 EVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMK
::::. ::.::::.: : ::.:: . .:.:::... :.:. :...: . .:: : . ::
NP_003 EVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMK
570 580 590 600 610 620
700 710 720 730 740 750
pF1KB8 D-ILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQAL---RDNSTMGYMAAKK
: :. :.::.:::.::. ::: .:.: :::..:::::::::: .: :: : . ::
NP_003 DKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKK
630 640 650 660 670 680
760 770 780 790 800 810
pF1KB8 HLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMI
.:::: : .:. . .. . :..::.: ::...:.::: : ::. : : .....:: ::.
NP_003 TFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERML
690 700 710 720 730 740
820 830 840 850
pF1KB8 KLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
.:.:.:: : . .. : : . .. ::.:
NP_003 RLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL
750 760 770 780 790 800
>>XP_011520647 (OMIM: 606219) PREDICTED: heat shock prot (564 aa)
initn: 913 init1: 306 opt: 626 Z-score: 403.3 bits: 85.1 E(85289): 1e-15
Smith-Waterman score: 955; 29.9% identity (61.7% similar) in 635 aa overlap (198-814:1-557)
170 180 190 200 210 220
pF1KB8 RELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLIN
..:.: : . :.:: :::::::. .:..
XP_011 MEIHLQTNAEKGTITIQDTGIGMTQEELVS
10 20 30
230 240 250 260 270 280
pF1KB8 NLGTIAKSGTKAFMEALQAGADIS--MIGQFGVGFYSAYLVAEKVTVITKHNDDEQ--YA
::::::.::.:::..::: :. : .:::::::::::..::..: : .. . :
XP_011 NLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQ
40 50 60 70 80 90
290 300 310 320 330 340
pF1KB8 WESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLF
: :...: : . .: . :::.:.::: : :. : :....: :.:.:...:.
XP_011 WLSDGSGVFEIAEASG--VRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPL---
100 110 120 130 140
350 360 370 380 390 400
pF1KB8 VEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIK
XP_011 ------------------------------------------------------------
410 420 430 440 450 460
pF1KB8 EKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL
:.. ...: . :: .: :. . .. :::. ... . . :..... :..:...
XP_011 --YLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIF
150 160 170 180 190 200
470 480 490 500 510 520
pF1KB8 FVPRRAPFDLFE-NRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISR
.:: : ..:. .:. ... :: :.:.:. . ...:..: ::::::::::.:::.::
XP_011 YVPDMKP-SMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSR
210 220 230 240 250 260
530 540 550 560 570
pF1KB8 EMLQQSKILKVIRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGI--HEDSQNRK
:.::.: ... .: : .. ...: . .. : :.: ::.:... .. :: ... ..
XP_011 ELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKE
270 280 290 300 310 320
580 590 600 610 620 630
pF1KB8 KLSELLRYYTSA--SGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHG
...:::: .:: :: ...::..: .::. . ..:::. . .. . .: . : ..:.
XP_011 DIAKLLRYESSALPSG-QLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKD
330 340 350 360 370 380
640 650 660 670 680
pF1KB8 LEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQE--------EKKTK
::.. .: .:: . .:.::. : :.:: . . . . .::: ... ::.:
XP_011 TEVLFCFEQFDELTLLHLREFDKKKLISVETD-IVVDHYKEEKFEDRSPAAECLSEKET-
390 400 410 420 430
690 700 710 720 730 740
pF1KB8 FENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGY
:.: :...: ..: .: :. :: : : ... .: ..... : : ..
XP_011 -EELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMG---AARHFLRMQQLAKTQEERA
440 450 460 470 480 490
750 760 770 780 790 800
pF1KB8 MAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANR
. . ::::: :..:. : : .. . .. :: .::.:....:. ..::.. ..:
XP_011 QLLQPTLEINPRHALIKKLNQLRASEPGLAQL--LVDQIYENAMIAAGL-VDDPRAMVGR
500 510 520 530 540 550
810 820 830 840 850
pF1KB8 IYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
. ...
XP_011 LNELLVKALERH
560
854 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 11:17:22 2016 done: Sun Nov 6 11:17:24 2016
Total Scan time: 12.710 Total Display time: 0.250
Function used was FASTA [36.3.4 Apr, 2011]