FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4365, 383 aa 1>>>pF1KE4365 383 - 383 aa - 383 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0483+/-0.000496; mu= 9.5896+/- 0.030 mean_var=243.2952+/-48.362, 0's: 0 Z-trim(117.4): 521 B-trim: 24 in 1/53 Lambda= 0.082226 statistics sampled from 28767 (29378) to 28767 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.344), width: 16 Scan time: 8.750 The best scores are: opt bits E(85289) NP_003827 (OMIM: 176290) protein delta homolog 1 i ( 383) 2788 344.2 3.1e-94 NP_001304101 (OMIM: 176290) protein delta homolog ( 310) 1778 224.2 3.2e-58 XP_005266991 (OMIM: 606582) PREDICTED: delta-like ( 524) 832 112.3 2.7e-24 NP_005609 (OMIM: 606582) delta-like protein 1 prec ( 723) 832 112.5 3.2e-24 NP_061947 (OMIM: 605185,616589) delta-like protein ( 685) 800 108.7 4.3e-23 XP_016883196 (OMIM: 118450,187500,601920) PREDICTE (1059) 750 103.0 3.4e-21 NP_000205 (OMIM: 118450,187500,601920) protein jag (1218) 750 103.1 3.7e-21 NP_660142 (OMIM: 602570) protein jagged-2 isoform (1200) 742 102.1 7e-21 NP_002217 (OMIM: 602570) protein jagged-2 isoform (1238) 733 101.1 1.5e-20 NP_001186930 (OMIM: 102500,600275,610205) neurogen (1235) 627 88.5 9.1e-17 XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432) 627 88.9 1.4e-16 XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432) 627 88.9 1.4e-16 XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432) 627 88.9 1.4e-16 XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455) 627 88.9 1.4e-16 XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467) 627 88.9 1.4e-16 NP_077719 (OMIM: 102500,600275,610205) neurogenic (2471) 627 88.9 1.4e-16 XP_011517019 (OMIM: 109730,190198,616028) PREDICTE (2314) 622 88.3 2e-16 NP_060087 (OMIM: 109730,190198,616028) neurogenic (2555) 622 88.4 2.1e-16 XP_005259981 (OMIM: 125310,130720,600276,615293) P (2269) 592 84.7 2.3e-15 NP_000426 (OMIM: 125310,130720,600276,615293) neur (2321) 592 84.7 2.3e-15 NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 543 78.8 1.2e-13 NP_982353 (OMIM: 277300,602768) delta-like protein ( 587) 530 76.6 1.7e-13 NP_058637 (OMIM: 277300,602768) delta-like protein ( 618) 530 76.6 1.8e-13 NP_001136272 (OMIM: 602772,612424) protein eyes sh (3144) 505 74.6 3.6e-12 NP_001278938 (OMIM: 602772,612424) protein eyes sh (3165) 505 74.6 3.6e-12 NP_001244895 (OMIM: 172870,600105,604210,613835) p ( 870) 495 72.6 3.9e-12 XP_011507669 (OMIM: 172870,600105,604210,613835) P (1297) 495 72.9 4.9e-12 XP_011507667 (OMIM: 172870,600105,604210,613835) P (1349) 495 72.9 5e-12 NP_957705 (OMIM: 172870,600105,604210,613835) prot (1406) 495 72.9 5.1e-12 XP_016856341 (OMIM: 172870,600105,604210,613835) P (1451) 495 73.0 5.2e-12 NP_001180569 (OMIM: 172870,600105,604210,613835) p (1294) 485 71.7 1.1e-11 NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 469 69.9 4.5e-11 NP_001244894 (OMIM: 172870,600105,604210,613835) p (1382) 465 69.4 6e-11 XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 459 68.5 8.8e-11 XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 460 68.8 9.3e-11 NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 460 68.8 9.5e-11 XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 459 68.7 1e-10 XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 459 68.7 1e-10 XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 459 68.7 1e-10 NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 459 68.7 1e-10 NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 459 68.7 1e-10 NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 459 68.7 1e-10 XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 459 68.7 1e-10 NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534) 455 68.2 1.4e-10 NP_620711 (OMIM: 607299) delta and Notch-like epid ( 737) 443 66.4 2.5e-10 XP_005247007 (OMIM: 607299) PREDICTED: delta and N ( 696) 437 65.6 4e-10 NP_938024 (OMIM: 602772,612424) protein eyes shut ( 594) 412 62.6 2.8e-09 NP_001136273 (OMIM: 602772,612424) protein eyes sh ( 619) 412 62.6 2.9e-09 XP_005252032 (OMIM: 187380,615629) PREDICTED: tena (1564) 413 63.3 4.6e-09 XP_005252031 (OMIM: 187380,615629) PREDICTED: tena (1655) 413 63.3 4.8e-09 >>NP_003827 (OMIM: 176290) protein delta homolog 1 isofo (383 aa) initn: 2788 init1: 2788 opt: 2788 Z-score: 1812.7 bits: 344.2 E(85289): 3.1e-94 Smith-Waterman score: 2788; 99.7% identity (100.0% similar) in 383 aa overlap (1-383:1-383) 10 20 30 40 50 60 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_003 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 310 320 330 340 350 360 370 380 pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI ::::::::::::::::::::::: NP_003 VNIIFPEKIDMTTFSKEAGDEEI 370 380 >>NP_001304101 (OMIM: 176290) protein delta homolog 1 is (310 aa) initn: 1774 init1: 1774 opt: 1778 Z-score: 1166.1 bits: 224.2 E(85289): 3.2e-58 Smith-Waterman score: 2145; 80.9% identity (80.9% similar) in 383 aa overlap (1-383:1-310) 10 20 30 40 50 60 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQ------------ 190 200 210 220 250 260 270 280 290 300 pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT NP_001 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -GQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 230 240 250 260 270 280 370 380 pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI ::::::::::::::::::::::: NP_001 VNIIFPEKIDMTTFSKEAGDEEI 290 300 310 >>XP_005266991 (OMIM: 606582) PREDICTED: delta-like prot (524 aa) initn: 797 init1: 345 opt: 832 Z-score: 557.3 bits: 112.3 E(85289): 2.7e-24 Smith-Waterman score: 832; 43.4% identity (67.0% similar) in 221 aa overlap (26-244:226-440) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD :.:.:. :.:::. . :.:. :::: :: XP_005 DDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD 200 210 220 230 240 250 60 70 80 90 100 110 pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS .:. :::::: : .: :: : .:: : .:..:. :. :: :..::.. .: : :: XP_005 ECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC : :::.: :. : . :::..::.:.: : . :: ::::: :..::. : .: XP_005 CRPGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTC 320 330 340 350 360 370 180 190 200 210 220 230 pF1KE4 TPNPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC . .:: : : :.: : . ::::.:. .: . . :.::::.::. :.. . .: : XP_005 ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLC 380 390 400 410 420 240 250 260 270 280 290 pF1KE4 LCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELN :. :.: : XP_005 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSSGEASE 430 440 450 460 470 480 >>NP_005609 (OMIM: 606582) delta-like protein 1 precurso (723 aa) initn: 742 init1: 345 opt: 832 Z-score: 555.8 bits: 112.5 E(85289): 3.2e-24 Smith-Waterman score: 832; 43.4% identity (67.0% similar) in 221 aa overlap (26-244:226-440) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD :.:.:. :.:::. . :.:. :::: :: NP_005 DDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD 200 210 220 230 240 250 60 70 80 90 100 110 pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS .:. :::::: : .: :: : .:: : .:..:. :. :: :..::.. .: : :: NP_005 ECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC : :::.: :. : . :::..::.:.: : . :: ::::: :..::. : .: NP_005 CRPGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTC 320 330 340 350 360 370 180 190 200 210 220 230 pF1KE4 TPNPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC . .:: : : :.: : . ::::.:. .: . . :.::::.::. :.. . .: : NP_005 ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLC 380 390 400 410 420 240 250 260 270 280 290 pF1KE4 LCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELN :. :.: : NP_005 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP 430 440 450 460 470 480 >>NP_061947 (OMIM: 605185,616589) delta-like protein 4 p (685 aa) initn: 794 init1: 329 opt: 800 Z-score: 535.5 bits: 108.7 E(85289): 4.3e-23 Smith-Waterman score: 801; 36.3% identity (60.1% similar) in 311 aa overlap (26-331:222-518) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD :. .:. :::.: : :.::::: ::. NP_061 NDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCN 200 210 220 230 240 250 60 70 80 90 100 110 pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS .:. :: :: :. : :: : .:: : .::.:. :. .:: :..:: . . : :. NP_061 ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC : :::.: ::. . . : ...::..::.: :.: . : ::::::. : :: . :: NP_061 CRPGYTGVDCELELSEC--DSNPCRNGGSCKDQED-GYH--CLCPPGYYGLHCEHSTLSC 320 330 340 350 360 180 190 200 210 220 230 pF1KE4 TPNPCENDGVCTD--IGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE . .:: : : : . :... :.:: .: ..: . : :.:.:: ::: ::.. : NP_061 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP-SRM 370 380 390 400 410 420 240 250 260 270 280 290 pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYG-LAYRLTPGVH-ELPVQQPEHRILKVSMK : :.: ::: : : .. .: : ..: . : :. :. .: . NP_061 CRCRPGFTGTYC----ELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSI 430 440 450 460 470 480 300 310 320 330 340 350 pF1KE4 ELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLL . ..: . ..: :.: :.. ..: :.: ..:: NP_061 DACASSPCF--NRATCYTDLST-DTFVCNCPYGFVG-SRCEFPVGLPPSFPWVAVSLGVG 490 500 510 520 530 360 370 380 pF1KE4 LQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI NP_061 LAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVD 540 550 560 570 580 590 >>XP_016883196 (OMIM: 118450,187500,601920) PREDICTED: p (1059 aa) initn: 972 init1: 297 opt: 750 Z-score: 501.5 bits: 103.0 E(85289): 3.4e-21 Smith-Waterman score: 750; 39.2% identity (64.4% similar) in 222 aa overlap (24-244:73-288) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPL : : .:.:..: :. . :::: :::: XP_016 PRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLY 50 60 70 80 90 100 60 70 80 90 100 110 pF1KE4 CDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYE ::.:. :::.::.:.:: ::.: .: :.:::.:. :.. :: :.::: . :. XP_016 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ 110 120 130 140 150 160 120 130 140 150 160 170 pF1KE4 CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVAN ::: :::: .:. . :. ..::.. :.: . . : : ::..: : . XP_016 CSCPEGYSGPNCEIAEHACL--SDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNID 170 180 190 200 210 180 190 200 210 220 230 pF1KE4 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE .:.:: : . :.: :. . :.: :: . :::. ...: ..:: :. .: .. .:: XP_016 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSC-KNLIASYY 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKEL : : : . : .: XP_016 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP 280 290 300 310 320 330 >-- initn: 736 init1: 265 opt: 521 Z-score: 354.7 bits: 75.8 E(85289): 5.1e-13 Smith-Waterman score: 624; 37.7% identity (64.0% similar) in 228 aa overlap (30-244:440-658) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN----VCRCQPGWQGPLC- :.:. : :.... .: :. :. : : XP_016 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH-GKCKSQSGGKFTCDCNKGFTGTYCH 410 420 430 440 450 460 60 70 80 90 100 pF1KE4 ---DQCVTSPGCLHG-LCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD ..: ..: : .: : . .:::.:::.: :. .. ::. :: :.::: .: XP_016 ENINDCESNP-CRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 470 480 490 500 510 520 110 120 130 140 150 160 pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC . .: :.: :..:: :...:. : . . :..:::: : :: : .:.:: :. :. : XP_016 NDFY-CDCKNGWKGKTCHSRDSQC--DEATCNNGGTCYD-EGDAF--KCMCPGGWEGTTC 530 540 550 560 570 580 170 180 190 200 210 220 pF1KE4 EIVANS-CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH .:. :: : ::::.: :.:. : .: : : :. :.. ...:. :: :.:::.. XP_016 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG 590 600 610 620 630 640 230 240 250 260 270 280 pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK . :.: : : :.: : XP_016 DNW-YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS 650 660 670 680 690 700 >-- initn: 257 init1: 257 opt: 411 Z-score: 284.2 bits: 62.8 E(85289): 4.3e-09 Smith-Waterman score: 411; 37.0% identity (63.8% similar) in 138 aa overlap (86-223:289-419) 60 70 80 90 100 110 pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSC : .. : . : :...: .: .: :.: : XP_016 AKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG-YRCIC 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE4 APGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT :::.: :.. :. : :: .:: : .. .: .:::: :::::.:.. . : XP_016 PPGYAGDHCERDIDECASN--PCLNGGHCQNEINRF---QCLCPTGFSGNLCQLDIDYCE 320 330 340 350 360 370 180 190 200 210 220 230 pF1KE4 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC ::::.: . : . ..:. :.:: . :.::. .: ..::. .: XP_016 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG 380 390 400 410 420 430 240 250 260 270 280 290 pF1KE4 KPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK XP_016 VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS 440 450 460 470 480 490 >>NP_000205 (OMIM: 118450,187500,601920) protein jagged- (1218 aa) initn: 972 init1: 297 opt: 750 Z-score: 500.9 bits: 103.1 E(85289): 3.7e-21 Smith-Waterman score: 750; 39.2% identity (64.4% similar) in 222 aa overlap (24-244:232-447) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPL : : .:.:..: :. . :::: :::: NP_000 PRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLY 210 220 230 240 250 260 60 70 80 90 100 110 pF1KE4 CDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYE ::.:. :::.::.:.:: ::.: .: :.:::.:. :.. :: :.::: . :. NP_000 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ 270 280 290 300 310 320 120 130 140 150 160 170 pF1KE4 CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVAN ::: :::: .:. . :. ..::.. :.: . . : : ::..: : . NP_000 CSCPEGYSGPNCEIAEHACL--SDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNID 330 340 350 360 370 180 190 200 210 220 230 pF1KE4 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE .:.:: : . :.: :. . :.: :: . :::. ...: ..:: :. .: .. .:: NP_000 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSC-KNLIASYY 380 390 400 410 420 430 240 250 260 270 280 290 pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKEL : : : . : .: NP_000 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP 440 450 460 470 480 490 >-- initn: 736 init1: 265 opt: 521 Z-score: 354.1 bits: 75.9 E(85289): 5.5e-13 Smith-Waterman score: 624; 37.7% identity (64.0% similar) in 228 aa overlap (30-244:599-817) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN----VCRCQPGWQGPLC- :.:. : :.... .: :. :. : : NP_000 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH-GKCKSQSGGKFTCDCNKGFTGTYCH 570 580 590 600 610 620 60 70 80 90 100 pF1KE4 ---DQCVTSPGCLHG-LCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD ..: ..: : .: : . .:::.:::.: :. .. ::. :: :.::: .: NP_000 ENINDCESNP-CRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 630 640 650 660 670 680 110 120 130 140 150 160 pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC . .: :.: :..:: :...:. : . . :..:::: : :: : .:.:: :. :. : NP_000 NDFY-CDCKNGWKGKTCHSRDSQC--DEATCNNGGTCYD-EGDAF--KCMCPGGWEGTTC 690 700 710 720 730 740 170 180 190 200 210 220 pF1KE4 EIVANS-CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH .:. :: : ::::.: :.:. : .: : : :. :.. ...:. :: :.:::.. NP_000 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG 750 760 770 780 790 800 230 240 250 260 270 280 pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK . :.: : : :.: : NP_000 DNW-YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS 810 820 830 840 850 >-- initn: 257 init1: 257 opt: 411 Z-score: 283.6 bits: 62.9 E(85289): 4.7e-09 Smith-Waterman score: 411; 37.0% identity (63.8% similar) in 138 aa overlap (86-223:448-578) 60 70 80 90 100 110 pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSC : .. : . : :...: .: .: :.: : NP_000 AKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG-YRCIC 420 430 440 450 460 470 120 130 140 150 160 170 pF1KE4 APGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT :::.: :.. :. : :: .:: : .. .: .:::: :::::.:.. . : NP_000 PPGYAGDHCERDIDECASN--PCLNGGHCQNEINRF---QCLCPTGFSGNLCQLDIDYCE 480 490 500 510 520 530 180 190 200 210 220 230 pF1KE4 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC ::::.: . : . ..:. :.:: . :.::. .: ..::. .: NP_000 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG 540 550 560 570 580 590 240 250 260 270 280 290 pF1KE4 KPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK NP_000 VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS 600 610 620 630 640 650 >>NP_660142 (OMIM: 602570) protein jagged-2 isoform b pr (1200 aa) initn: 1053 init1: 302 opt: 742 Z-score: 495.8 bits: 102.1 E(85289): 7e-21 Smith-Waterman score: 748; 37.2% identity (57.7% similar) in 298 aa overlap (18-311:237-518) 10 20 30 40 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP :. : : .:: .: : . :::. NP_660 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY 210 220 230 240 250 260 50 60 70 80 90 100 pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL :::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::.. NP_660 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 270 280 290 300 310 320 110 120 130 140 150 160 pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF . :.:.: ::::..:.: . :. : :: .::.: . : : :: :.:: NP_660 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT 330 340 350 360 370 380 170 180 190 200 210 220 pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH : . . :. ::: :.:.: :.: :: .. ::. :..: . ::.:::: . NP_660 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTC-KD 390 400 410 420 430 230 240 250 260 270 280 pF1KE4 TQVSYECLCKPEFTGLTCVKKR---ALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR .:.:.: : : : .: : :: . .: :: :. : : : NP_660 LVNGYQCVCPRGFGGRHCELERDECASSPCH-----SG-GLCEDLADGFHCHCPQGFSGP 440 450 460 470 480 490 290 300 310 320 330 340 pF1KE4 ILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHML . .:.. .: . .: .. : :... : NP_660 LCEVDV-DLCEPSP--CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDG 500 510 520 530 540 550 >-- initn: 604 init1: 256 opt: 477 Z-score: 325.9 bits: 70.7 E(85289): 2e-11 Smith-Waterman score: 591; 36.4% identity (55.6% similar) in 239 aa overlap (21-244:593-824) 10 20 30 40 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQ----NGFCEDDN---VC :: : . : : .: : :. : NP_660 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 570 580 590 600 610 620 50 60 70 80 90 pF1KE4 RCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSAP : ::.: ::: .:. .: .: : . : : ::: :. : :.. NP_660 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 630 640 650 660 670 680 100 110 120 130 140 150 pF1KE4 CANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRASHAS :.:.::: . : ..:.: ::..:. : :.. :. : :: .::::: : .. : NP_660 CSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSGASFS 690 700 710 720 730 160 170 180 190 200 210 pF1KE4 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS :.: :. : : .:.:.: :: : :.:.: . :::.: :: : . .: :: NP_660 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 740 750 760 770 780 790 220 230 240 250 260 270 pF1KE4 PCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHEL :: :.::... . .:.: : : .: : NP_660 PCAYGATCVDEIN-GYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCR 800 810 820 830 840 850 >>NP_002217 (OMIM: 602570) protein jagged-2 isoform a pr (1238 aa) initn: 1253 init1: 302 opt: 733 Z-score: 489.9 bits: 101.1 E(85289): 1.5e-20 Smith-Waterman score: 733; 39.9% identity (61.8% similar) in 228 aa overlap (18-244:237-458) 10 20 30 40 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP :. : : .:: .: : . :::. NP_002 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY 210 220 230 240 250 260 50 60 70 80 90 100 pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL :::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::.. NP_002 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 270 280 290 300 310 320 110 120 130 140 150 160 pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF . :.:.: ::::..:.: . :. : :: .::.: . : : :: :.:: NP_002 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT 330 340 350 360 370 380 170 180 190 200 210 220 pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH : . . :. ::: :.:.: :.: :: .. ::. ...: ..:: :. .: .. NP_002 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSC-KN 390 400 410 420 430 440 230 240 250 260 270 280 pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK .: : : : . :..: NP_002 LIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD 450 460 470 480 490 500 >-- initn: 638 init1: 266 opt: 376 Z-score: 261.0 bits: 58.7 E(85289): 8.4e-08 Smith-Waterman score: 526; 33.6% identity (55.5% similar) in 247 aa overlap (25-237:501-740) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCED--DNV-CRCQPGWQG :: . ..:.::: :. :.: :..: NP_002 HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSG 480 490 500 510 520 530 60 70 80 90 pF1KE4 PLC----DQCVTSPGCLHGL-CGE-PGQ--CICTDGWDGELCD-----------RDVRAC ::: : : :: : .: : . :. : : : . :. :. : . .: NP_002 PLCEVDVDLCEPSP-CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC 540 550 560 570 580 100 110 120 130 140 pF1KE4 SS--AP----------CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH .: .: :. .: ::: : . : : :..: :... :. :.::.. NP_002 GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL--GQPCRN 590 600 610 620 630 640 150 160 170 180 190 200 pF1KE4 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGF ::::.:. .. :.:: :. :..:. :.: :.::.. : : :. .:: : : :. NP_002 GGTCIDE---VDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW 650 660 670 680 690 700 210 220 230 240 250 260 pF1KE4 IDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPN ::: .: . :.::::: . . ...: : : NP_002 KGKTCHSREFQCDAYTCSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPNPCVNG 710 720 730 740 750 760 270 280 290 300 310 320 pF1KE4 GYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLG NP_002 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD 770 780 790 800 810 820 >-- initn: 249 init1: 249 opt: 361 Z-score: 251.4 bits: 57.0 E(85289): 2.9e-07 Smith-Waterman score: 433; 32.1% identity (55.0% similar) in 280 aa overlap (48-306:741-992) 20 30 40 50 60 pF1KE4 GHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLC-----DQCVTSPGCLHG-LC--- ::.: : ..:. .: :..: : NP_002 SREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNP-CVNGGTCVGS 720 730 740 750 760 70 80 90 100 110 120 pF1KE4 GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQK : .::: :::.:. : ... :. :: :.: :: ::. ..: ::::..: ::. NP_002 GASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV---DGVNWFRCECAPGFAGPDCRI 770 780 790 800 810 820 130 140 150 160 170 pF1KE4 KDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC-EIVA--NSC----TPNPC . : ..::: .:.::::. . : :::: .: : :... :: :: : NP_002 NIDEC--QSSPCAYGATCVDE---INGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH 830 840 850 860 870 880 180 190 200 210 220 230 pF1KE4 ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEF .. : : .. ::: : : ::. . :. .:: .: : .: .: : NP_002 GSSWV-EDCNS---CRCLDGRRD--CSK--VWCGWKPCLLAG---QPEALSAQC---P-- 890 900 910 920 240 250 260 270 280 290 pF1KE4 TGLTCVKKRALSPQQVTRLP-NGYG-LAYRLTPGVHELPVQ-QPEHRILKVSMKELNKKT : :..: .: : : : ...: . . :.. :: . . .. ..... .. NP_002 LGQRCLEK---APGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHV 930 940 950 960 970 980 300 310 320 330 340 350 pF1KE4 PLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSG : : ::: NP_002 PQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLI 990 1000 1010 1020 1030 1040 >>NP_001186930 (OMIM: 102500,600275,610205) neurogenic l (1235 aa) initn: 1105 init1: 309 opt: 627 Z-score: 422.0 bits: 88.5 E(85289): 9.1e-17 Smith-Waterman score: 633; 39.4% identity (59.3% similar) in 236 aa overlap (25-244:341-567) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAEC-FPACNPQNGFCEDDNV---CRCQPGWQ .: : .:.: .. : : . : : : NP_001 NGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP-GSTCIDRVASFSCMCPEGKA 320 330 340 350 360 60 70 80 90 pF1KE4 GPLC---DQCVTSPGCLHG-LCG-EP--GQ--CICTDGWDGELCDRDVRACS---SAPCA : :: : :...: : .: :: .: :: : : .:. : : .:: :. : :: NP_001 GLLCHLDDACISNP-CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCE 370 380 390 400 410 420 100 110 120 130 140 150 pF1KE4 NNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLC . : ::. : : ..: : ::.: :. . : ...:::. .::.: : .::: NP_001 HAGKCVNTD-GAFHCECLKGYAGPRCEMDINEC--HSDPCQNDATCLDKIG---GFTCLC 430 440 450 460 470 480 160 170 180 190 200 210 pF1KE4 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ :::.: ::. : : ::: :.: :.: . :.: :: :: .:. . .:.:.:: NP_001 MPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCL 490 500 510 520 530 540 220 230 240 250 260 270 pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ ::. :..: . .::: : :::. : NP_001 NGAKCIDHPN-GYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMG 550 560 570 580 590 600 >-- initn: 1105 init1: 309 opt: 627 Z-score: 422.0 bits: 88.5 E(85289): 9.1e-17 Smith-Waterman score: 627; 38.5% identity (61.9% similar) in 231 aa overlap (25-244:876-1098) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN---VCRCQPGWQG ::. ..:.:.. . .:.: ::..: NP_001 AVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSG 850 860 870 880 890 900 60 70 80 90 100 pF1KE4 PLC----DQCVTSPGCLHGLCGEPG----QCICTDGWDGELCDRDVRACSSAPCANNGTC : :.:...: : .: : .:.: :. :. :. :. : : :: :.::: NP_001 MDCEEDIDDCLANP-CQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTC 910 920 930 940 950 960 110 120 130 140 150 160 pF1KE4 VSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS . .. : :.: :..: :... . :. : : .:::::: : : ::::: ::. NP_001 SDYVNS-YTCKCQAGFDGVHCENNINECT--ESSCFNGGTCVD--GINSF-SCLCPVGFT 970 980 990 1000 1010 170 180 190 200 210 220 pF1KE4 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC :.:: : :. .:: :.:.:.: : .:: :: :. :.:. :. :. :::.: ::: NP_001 GSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTC 1020 1030 1040 1050 1060 1070 230 240 250 260 270 280 pF1KE4 LQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR .:. : .::: ..: : NP_001 VQKKAES-QCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQC 1080 1090 1100 1110 1120 1130 >-- initn: 262 init1: 262 opt: 589 Z-score: 397.6 bits: 84.0 E(85289): 2.1e-15 Smith-Waterman score: 589; 34.9% identity (59.2% similar) in 238 aa overlap (25-252:610-836) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCED---DNVCRCQPGWQG ::. . ..: : : : :::: .: NP_001 HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG 580 590 600 610 620 630 60 70 80 90 100 pF1KE4 PLC----DQCVTSPGCLHGLCGEP---GQCICTDGWDGELCDRDVRACSSAPCANNGTCV : :.:...: :.::.: . .:.:. :. :. :. :. :.: :: ...::. NP_001 VNCEINFDDCASNP-CIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCI 640 650 660 670 680 690 110 120 130 140 150 160 pF1KE4 SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSG . .: ..: : : .: .. . :. : :: ::. :. : : .::: :. : NP_001 NGVNG-FRCICPEGPHHPSCYSQVNECLSN--PCIHGN-CT---GGLSGYKCLCDAGWVG 700 710 720 730 740 750 170 180 190 200 210 220 pF1KE4 NFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL ::. : : :::.: :.: .. . .:: : :: .:. . .:::.:: : :::. NP_001 INCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCF 760 770 780 790 800 810 230 240 250 260 270 280 pF1KE4 QHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRI . . .: : : .:: .: . .:.: NP_001 DDIS-GYTCHCVLPYTGKNC--QTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQ 820 830 840 850 860 >-- initn: 491 init1: 263 opt: 587 Z-score: 396.3 bits: 83.8 E(85289): 2.5e-15 Smith-Waterman score: 587; 34.7% identity (58.5% similar) in 277 aa overlap (6-261:7-272) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLL-LAFGHSTYGAECFPACNP--QNGFC----EDDNVCRCQPGWQGP ::: .:: : : . ... .: . .: ..:.: . . :.: :. : NP_001 MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE 10 20 30 40 50 60 60 70 80 90 pF1KE4 LCDQCVTSPGCLHGLCGEPGQCI-----------CTDGWDGELCDRDV-RAC-SSAPCAN :.. .: : .. : . : :. :..:. :: :. .. . : : :: : NP_001 YCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLN 70 80 90 100 110 100 110 120 130 140 150 pF1KE4 NGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCP .::: :. :::.: :..::.:: :. :. . :: .:.::. :.. :: : NP_001 GGTCHMLSRDTYECTCQVGFTGKECQWTDA-CL--SHPCANGSTCTT---VANQFSCKCL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE4 PGFSGNFCEIVANSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ ::.:. :: .: : :. :.. :.: .. :...:.:: :: . :. . :: ::: NP_001 TGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCV 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ ::::: : . ..:: : : : : :: .. :.. : :: NP_001 NGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNH--RCQNGGVCVDGVNTYNCRCPPQ 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 QPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLR NP_001 WTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP 290 300 310 320 330 340 >-- initn: 433 init1: 265 opt: 340 Z-score: 238.0 bits: 54.5 E(85289): 1.6e-06 Smith-Waterman score: 340; 37.1% identity (67.6% similar) in 105 aa overlap (138-242:1120-1220) 110 120 130 140 150 160 pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC :::.:.:.. : . . : :: :..:..: NP_001 PSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCIN-AGNTHY--CQCPLGYTGSYC 1090 1100 1110 1120 1130 1140 170 180 190 200 210 220 pF1KE4 EIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHT : . :. :::.. ..:.:. : .::.: :. .: : .: ..::::::::.. . NP_001 EEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLV 1150 1160 1170 1180 1190 1200 230 240 250 260 270 280 pF1KE4 QVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKV . ..: : : :. NP_001 N-HFKCSCPPGTRGMKSSLSIFHPGHCLKL 1210 1220 1230 383 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 02:02:44 2016 done: Sun Nov 6 02:02:46 2016 Total Scan time: 8.750 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]