FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4365, 383 aa 1>>>pF1KE4365 383 - 383 aa - 383 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1296+/-0.00125; mu= 15.0249+/- 0.075 mean_var=214.5187+/-40.073, 0's: 0 Z-trim(110.3): 229 B-trim: 7 in 1/52 Lambda= 0.087567 statistics sampled from 11277 (11522) to 11277 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.354), width: 16 Scan time: 2.740 The best scores are: opt bits E(32554) CCDS9963.1 DLK1 gene_id:8788|Hs108|chr14 ( 383) 2777 363.8 1.4e-100 CCDS81852.1 DLK1 gene_id:8788|Hs108|chr14 ( 310) 1767 236.1 3.3e-62 CCDS4897.1 DLK2 gene_id:65989|Hs108|chr6 ( 383) 904 127.2 2.5e-29 CCDS75461.1 DLK2 gene_id:65989|Hs108|chr6 ( 377) 850 120.4 2.8e-27 CCDS5313.1 DLL1 gene_id:28514|Hs108|chr6 ( 723) 832 118.5 1.9e-26 CCDS45232.1 DLL4 gene_id:54567|Hs108|chr15 ( 685) 800 114.4 3e-25 CCDS13112.1 JAG1 gene_id:182|Hs108|chr20 (1218) 750 108.5 3.3e-23 CCDS9999.1 JAG2 gene_id:3714|Hs108|chr14 (1200) 742 107.5 6.6e-23 CCDS9998.1 JAG2 gene_id:3714|Hs108|chr14 (1238) 733 106.4 1.5e-22 CCDS908.1 NOTCH2 gene_id:4853|Hs108|chr1 (2471) 627 93.4 2.3e-18 CCDS43905.1 NOTCH1 gene_id:4851|Hs108|chr9 (2555) 622 92.8 3.6e-18 CCDS12326.1 NOTCH3 gene_id:4854|Hs108|chr19 (2321) 592 89.0 4.7e-17 CCDS34420.1 NOTCH4 gene_id:4855|Hs108|chr6 (2003) 543 82.7 3.2e-15 CCDS12537.1 DLL3 gene_id:10683|Hs108|chr19 ( 587) 530 80.2 5.2e-15 CCDS12538.1 DLL3 gene_id:10683|Hs108|chr19 ( 618) 530 80.3 5.3e-15 CCDS47445.1 EYS gene_id:346007|Hs108|chr6 (3144) 505 78.2 1.1e-13 CCDS78156.1 EYS gene_id:346007|Hs108|chr6 (3165) 505 78.2 1.1e-13 CCDS58052.1 CRB1 gene_id:23418|Hs108|chr1 ( 870) 495 76.1 1.4e-13 CCDS1390.1 CRB1 gene_id:23418|Hs108|chr1 (1406) 495 76.4 1.8e-13 CCDS53454.1 CRB1 gene_id:23418|Hs108|chr1 (1294) 485 75.1 4.1e-13 CCDS72880.1 NOTCH2NL gene_id:388677|Hs108|chr1 ( 236) 474 72.5 4.3e-13 CCDS64311.1 SLIT3 gene_id:6586|Hs108|chr5 (1530) 469 73.2 1.8e-12 CCDS58053.1 CRB1 gene_id:23418|Hs108|chr1 (1382) 465 72.6 2.4e-12 CCDS4369.1 SLIT3 gene_id:6586|Hs108|chr5 (1523) 460 72.0 4e-12 CCDS75111.1 SLIT2 gene_id:9353|Hs108|chr4 (1521) 459 71.9 4.3e-12 CCDS75110.1 SLIT2 gene_id:9353|Hs108|chr4 (1525) 459 71.9 4.3e-12 CCDS3426.1 SLIT2 gene_id:9353|Hs108|chr4 (1529) 459 71.9 4.3e-12 CCDS7453.1 SLIT1 gene_id:6585|Hs108|chr10 (1534) 455 71.4 6.1e-12 CCDS33390.1 DNER gene_id:92737|Hs108|chr2 ( 737) 443 69.4 1.2e-11 >>CCDS9963.1 DLK1 gene_id:8788|Hs108|chr14 (383 aa) initn: 2777 init1: 2777 opt: 2777 Z-score: 1919.0 bits: 363.8 E(32554): 1.4e-100 Smith-Waterman score: 2777; 99.5% identity (99.7% similar) in 383 aa overlap (1-383:1-383) 10 20 30 40 50 60 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: CCDS99 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: CCDS99 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS99 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 310 320 330 340 350 360 370 380 pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI ::::::::::::::::::::::: CCDS99 VNIIFPEKIDMTTFSKEAGDEEI 370 380 >>CCDS81852.1 DLK1 gene_id:8788|Hs108|chr14 (310 aa) initn: 1763 init1: 1763 opt: 1767 Z-score: 1230.3 bits: 236.1 E(32554): 3.3e-62 Smith-Waterman score: 2134; 80.7% identity (80.7% similar) in 383 aa overlap (1-383:1-310) 10 20 30 40 50 60 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: CCDS81 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT :::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQ------------ 190 200 210 220 250 260 270 280 290 300 pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT CCDS81 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 -GQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 230 240 250 260 270 280 370 380 pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI ::::::::::::::::::::::: CCDS81 VNIIFPEKIDMTTFSKEAGDEEI 290 300 310 >>CCDS4897.1 DLK2 gene_id:65989|Hs108|chr6 (383 aa) initn: 513 init1: 492 opt: 904 Z-score: 640.2 bits: 127.2 E(32554): 2.5e-29 Smith-Waterman score: 904; 37.6% identity (63.3% similar) in 319 aa overlap (7-322:10-325) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQC :. .: .: : :. . . .: :. .: : :. :::.:::.: :..: CCDS48 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 VTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCA : ::: :: : .: :::: .:: :..::.: . :.. .:: :.: :. : :.: : CCDS48 VRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP ::. :.::..: ::: ::::..:: : ::.: : . .: : :: : ::. ...: CCDS48 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCK :: : ..: : . : : :: :: . :. . .::: ::: :. : .... ...::: CCDS48 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCP 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PEFTGLTCVKKRAL-SPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK . : :: . .: .. : : : ..:.. : .. .:..:.::. .. CCDS48 SGYGGKTCELVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRR 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 TPL-LTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYN : : . . ....:.::. .::.:: CCDS48 QEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQE 300 310 320 330 340 350 >>CCDS75461.1 DLK2 gene_id:65989|Hs108|chr6 (377 aa) initn: 730 init1: 492 opt: 850 Z-score: 603.4 bits: 120.4 E(32554): 2.8e-27 Smith-Waterman score: 850; 36.7% identity (61.8% similar) in 319 aa overlap (7-322:10-319) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQC :. .: .: : :. . . .: :. .: : :. :::.:::.: :..: CCDS75 MPSGCRCLHLVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 VTSPGCLHGLCGEPGQCICTDGW-DGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCA : ::: :: : .: :::: .:: : ..: ...:: :.: :. : :.: : CCDS75 VRMPGCQHGTCHQPWQCICHSGWADEHICT------TQSPCQNGGQCMYDGGGEYHCVCL 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP ::. :.::..: ::: ::::..:: : ::.: : . .: : :: : ::. ...: CCDS75 PGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCK :: : ..: : . : : :: :: . :. . .::: ::: :. : .... ...::: CCDS75 RPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PEFTGLTCVKKRAL-SPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK . : :: . .: .. : : : ..:.. : .. .:..:.::. .. CCDS75 SGYGGKTCELVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRR 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 TPL-LTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYN : : . . ....:.::. .::.:: CCDS75 QEAGLGEPSLVALVVFGALTAALVLATVLLTLRAWRRGVCPPGPCCYPAPHYAPACQDQE 300 310 320 330 340 350 >>CCDS5313.1 DLL1 gene_id:28514|Hs108|chr6 (723 aa) initn: 742 init1: 345 opt: 832 Z-score: 588.3 bits: 118.5 E(32554): 1.9e-26 Smith-Waterman score: 832; 43.4% identity (67.0% similar) in 221 aa overlap (26-244:226-440) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD :.:.:. :.:::. . :.:. :::: :: CCDS53 DDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD 200 210 220 230 240 250 60 70 80 90 100 110 pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS .:. :::::: : .: :: : .:: : .:..:. :. :: :..::.. .: : :: CCDS53 ECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC : :::.: :. : . :::..::.:.: : . :: ::::: :..::. : .: CCDS53 CRPGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTC 320 330 340 350 360 370 180 190 200 210 220 230 pF1KE4 TPNPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC . .:: : : :.: : . ::::.:. .: . . :.::::.::. :.. . .: : CCDS53 ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLC 380 390 400 410 420 240 250 260 270 280 290 pF1KE4 LCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELN :. :.: : CCDS53 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP 430 440 450 460 470 480 >>CCDS45232.1 DLL4 gene_id:54567|Hs108|chr15 (685 aa) initn: 794 init1: 329 opt: 800 Z-score: 566.7 bits: 114.4 E(32554): 3e-25 Smith-Waterman score: 801; 36.3% identity (60.1% similar) in 311 aa overlap (26-331:222-518) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD :. .:. :::.: : :.::::: ::. CCDS45 NDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCN 200 210 220 230 240 250 60 70 80 90 100 110 pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS .:. :: :: :. : :: : .:: : .::.:. :. .:: :..:: . . : :. CCDS45 ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC : :::.: ::. . . : ...::..::.: :.: . : ::::::. : :: . :: CCDS45 CRPGYTGVDCELELSEC--DSNPCRNGGSCKDQED-GYH--CLCPPGYYGLHCEHSTLSC 320 330 340 350 360 180 190 200 210 220 230 pF1KE4 TPNPCENDGVCTD--IGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE . .:: : : : . :... :.:: .: ..: . : :.:.:: ::: ::.. : CCDS45 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP-SRM 370 380 390 400 410 420 240 250 260 270 280 290 pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYG-LAYRLTPGVH-ELPVQQPEHRILKVSMK : :.: ::: : : .. .: : ..: . : :. :. .: . CCDS45 CRCRPGFTGTYC----ELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSI 430 440 450 460 470 480 300 310 320 330 340 350 pF1KE4 ELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLL . ..: . ..: :.: :.. ..: :.: ..:: CCDS45 DACASSPCF--NRATCYTDLST-DTFVCNCPYGFVG-SRCEFPVGLPPSFPWVAVSLGVG 490 500 510 520 530 360 370 380 pF1KE4 LQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI CCDS45 LAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVD 540 550 560 570 580 590 >>CCDS13112.1 JAG1 gene_id:182|Hs108|chr20 (1218 aa) initn: 972 init1: 297 opt: 750 Z-score: 530.2 bits: 108.5 E(32554): 3.3e-23 Smith-Waterman score: 750; 39.2% identity (64.4% similar) in 222 aa overlap (24-244:232-447) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPL : : .:.:..: :. . :::: :::: CCDS13 PRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLY 210 220 230 240 250 260 60 70 80 90 100 110 pF1KE4 CDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYE ::.:. :::.::.:.:: ::.: .: :.:::.:. :.. :: :.::: . :. CCDS13 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ 270 280 290 300 310 320 120 130 140 150 160 170 pF1KE4 CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVAN ::: :::: .:. . :. ..::.. :.: . . : : ::..: : . CCDS13 CSCPEGYSGPNCEIAEHACL--SDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNID 330 340 350 360 370 180 190 200 210 220 230 pF1KE4 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE .:.:: : . :.: :. . :.: :: . :::. ...: ..:: :. .: .. .:: CCDS13 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSC-KNLIASYY 380 390 400 410 420 430 240 250 260 270 280 290 pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKEL : : : . : .: CCDS13 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP 440 450 460 470 480 490 >-- initn: 736 init1: 265 opt: 521 Z-score: 373.8 bits: 79.6 E(32554): 1.7e-14 Smith-Waterman score: 624; 37.7% identity (64.0% similar) in 228 aa overlap (30-244:599-817) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN----VCRCQPGWQGPLC- :.:. : :.... .: :. :. : : CCDS13 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH-GKCKSQSGGKFTCDCNKGFTGTYCH 570 580 590 600 610 620 60 70 80 90 100 pF1KE4 ---DQCVTSPGCLHG-LCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD ..: ..: : .: : . .:::.:::.: :. .. ::. :: :.::: .: CCDS13 ENINDCESNP-CRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV 630 640 650 660 670 680 110 120 130 140 150 160 pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC . .: :.: :..:: :...:. : . . :..:::: : :: : .:.:: :. :. : CCDS13 NDFY-CDCKNGWKGKTCHSRDSQC--DEATCNNGGTCYD-EGDAF--KCMCPGGWEGTTC 690 700 710 720 730 740 170 180 190 200 210 220 pF1KE4 EIVANS-CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH .:. :: : ::::.: :.:. : .: : : :. :.. ...:. :: :.:::.. CCDS13 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG 750 760 770 780 790 800 230 240 250 260 270 280 pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK . :.: : : :.: : CCDS13 DNW-YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS 810 820 830 840 850 >>CCDS9999.1 JAG2 gene_id:3714|Hs108|chr14 (1200 aa) initn: 1053 init1: 302 opt: 742 Z-score: 524.8 bits: 107.5 E(32554): 6.6e-23 Smith-Waterman score: 748; 37.2% identity (57.7% similar) in 298 aa overlap (18-311:237-518) 10 20 30 40 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP :. : : .:: .: : . :::. CCDS99 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY 210 220 230 240 250 260 50 60 70 80 90 100 pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL :::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::.. CCDS99 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 270 280 290 300 310 320 110 120 130 140 150 160 pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF . :.:.: ::::..:.: . :. : :: .::.: . : : :: :.:: CCDS99 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT 330 340 350 360 370 380 170 180 190 200 210 220 pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH : . . :. ::: :.:.: :.: :: .. ::. :..: . ::.:::: . CCDS99 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTC-KD 390 400 410 420 430 230 240 250 260 270 280 pF1KE4 TQVSYECLCKPEFTGLTCVKKR---ALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR .:.:.: : : : .: : :: . .: :: :. : : : CCDS99 LVNGYQCVCPRGFGGRHCELERDECASSPCH-----SG-GLCEDLADGFHCHCPQGFSGP 440 450 460 470 480 490 290 300 310 320 330 340 pF1KE4 ILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHML . .:.. .: . .: .. : :... : CCDS99 LCEVDV-DLCEPSP--CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDG 500 510 520 530 540 550 >-- initn: 604 init1: 256 opt: 477 Z-score: 343.8 bits: 74.0 E(32554): 7.8e-13 Smith-Waterman score: 591; 36.4% identity (55.6% similar) in 239 aa overlap (21-244:593-824) 10 20 30 40 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQ----NGFCEDDN---VC :: : . : : .: : :. : CCDS99 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 570 580 590 600 610 620 50 60 70 80 90 pF1KE4 RCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSAP : ::.: ::: .:. .: .: : . : : ::: :. : :.. CCDS99 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 630 640 650 660 670 680 100 110 120 130 140 150 pF1KE4 CANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRASHAS :.:.::: . : ..:.: ::..:. : :.. :. : :: .::::: : .. : CCDS99 CSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSGASFS 690 700 710 720 730 160 170 180 190 200 210 pF1KE4 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS :.: :. : : .:.:.: :: : :.:.: . :::.: :: : . .: :: CCDS99 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 740 750 760 770 780 790 220 230 240 250 260 270 pF1KE4 PCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHEL :: :.::... . .:.: : : .: : CCDS99 PCAYGATCVDEIN-GYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCR 800 810 820 830 840 850 >>CCDS9998.1 JAG2 gene_id:3714|Hs108|chr14 (1238 aa) initn: 1253 init1: 302 opt: 733 Z-score: 518.5 bits: 106.4 E(32554): 1.5e-22 Smith-Waterman score: 733; 39.9% identity (61.8% similar) in 228 aa overlap (18-244:237-458) 10 20 30 40 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP :. : : .:: .: : . :::. CCDS99 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY 210 220 230 240 250 260 50 60 70 80 90 100 pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL :::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::.. CCDS99 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 270 280 290 300 310 320 110 120 130 140 150 160 pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF . :.:.: ::::..:.: . :. : :: .::.: . : : :: :.:: CCDS99 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT 330 340 350 360 370 380 170 180 190 200 210 220 pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH : . . :. ::: :.:.: :.: :: .. ::. ...: ..:: :. .: .. CCDS99 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSC-KN 390 400 410 420 430 440 230 240 250 260 270 280 pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK .: : : : . :..: CCDS99 LIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD 450 460 470 480 490 500 >>CCDS908.1 NOTCH2 gene_id:4853|Hs108|chr1 (2471 aa) initn: 1105 init1: 309 opt: 627 Z-score: 443.2 bits: 93.4 E(32554): 2.3e-18 Smith-Waterman score: 633; 39.4% identity (59.3% similar) in 236 aa overlap (25-244:341-567) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAEC-FPACNPQNGFCEDDNV---CRCQPGWQ .: : .:.: .. : : . : : : CCDS90 NGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP-GSTCIDRVASFSCMCPEGKA 320 330 340 350 360 60 70 80 90 pF1KE4 GPLC---DQCVTSPGCLHG-LCG-EP--GQ--CICTDGWDGELCDRDVRACS---SAPCA : :: : :...: : .: :: .: :: : : .:. : : .:: :. : :: CCDS90 GLLCHLDDACISNP-CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCE 370 380 390 400 410 420 100 110 120 130 140 150 pF1KE4 NNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLC . : ::. : : ..: : ::.: :. . : ...:::. .::.: : .::: CCDS90 HAGKCVNTD-GAFHCECLKGYAGPRCEMDINEC--HSDPCQNDATCLDKIG---GFTCLC 430 440 450 460 470 480 160 170 180 190 200 210 pF1KE4 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ :::.: ::. : : ::: :.: :.: . :.: :: :: .:. . .:.:.:: CCDS90 MPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCL 490 500 510 520 530 540 220 230 240 250 260 270 pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ ::. :..: . .::: : :::. : CCDS90 NGAKCIDHPN-GYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMG 550 560 570 580 590 600 >-- initn: 1105 init1: 309 opt: 627 Z-score: 443.2 bits: 93.4 E(32554): 2.3e-18 Smith-Waterman score: 627; 38.5% identity (61.9% similar) in 231 aa overlap (25-244:876-1098) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN---VCRCQPGWQG ::. ..:.:.. . .:.: ::..: CCDS90 AVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSG 850 860 870 880 890 900 60 70 80 90 100 pF1KE4 PLC----DQCVTSPGCLHGLCGEPG----QCICTDGWDGELCDRDVRACSSAPCANNGTC : :.:...: : .: : .:.: :. :. :. :. : : :: :.::: CCDS90 MDCEEDIDDCLANP-CQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTC 910 920 930 940 950 960 110 120 130 140 150 160 pF1KE4 VSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS . .. : :.: :..: :... . :. : : .:::::: : : ::::: ::. CCDS90 SDYVNS-YTCKCQAGFDGVHCENNINECT--ESSCFNGGTCVD--GINSF-SCLCPVGFT 970 980 990 1000 1010 170 180 190 200 210 220 pF1KE4 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC :.:: : :. .:: :.:.:.: : .:: :: :. :.:. :. :. :::.: ::: CCDS90 GSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTC 1020 1030 1040 1050 1060 1070 230 240 250 260 270 280 pF1KE4 LQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR .:. : .::: ..: : CCDS90 VQKKAES-QCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQC 1080 1090 1100 1110 1120 1130 >-- initn: 262 init1: 262 opt: 589 Z-score: 417.3 bits: 88.6 E(32554): 6.4e-17 Smith-Waterman score: 589; 34.9% identity (59.2% similar) in 238 aa overlap (25-252:610-836) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCED---DNVCRCQPGWQG ::. . ..: : : : :::: .: CCDS90 HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG 580 590 600 610 620 630 60 70 80 90 100 pF1KE4 PLC----DQCVTSPGCLHGLCGEP---GQCICTDGWDGELCDRDVRACSSAPCANNGTCV : :.:...: :.::.: . .:.:. :. :. :. :. :.: :: ...::. CCDS90 VNCEINFDDCASNP-CIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCI 640 650 660 670 680 690 110 120 130 140 150 160 pF1KE4 SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSG . .: ..: : : .: .. . :. : :: ::. :. : : .::: :. : CCDS90 NGVNG-FRCICPEGPHHPSCYSQVNECLSN--PCIHGN-CT---GGLSGYKCLCDAGWVG 700 710 720 730 740 750 170 180 190 200 210 220 pF1KE4 NFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL ::. : : :::.: :.: .. . .:: : :: .:. . .:::.:: : :::. CCDS90 INCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCF 760 770 780 790 800 810 230 240 250 260 270 280 pF1KE4 QHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRI . . .: : : .:: .: . .:.: CCDS90 DDIS-GYTCHCVLPYTGKNC--QTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQ 820 830 840 850 860 >-- initn: 491 init1: 263 opt: 587 Z-score: 415.9 bits: 88.4 E(32554): 7.6e-17 Smith-Waterman score: 587; 34.7% identity (58.5% similar) in 277 aa overlap (6-261:7-272) 10 20 30 40 50 pF1KE4 MTATEALLRVLLLL-LAFGHSTYGAECFPACNP--QNGFC----EDDNVCRCQPGWQGP ::: .:: : : . ... .: . .: ..:.: . . :.: :. : CCDS90 MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE 10 20 30 40 50 60 60 70 80 90 pF1KE4 LCDQCVTSPGCLHGLCGEPGQCI-----------CTDGWDGELCDRDV-RAC-SSAPCAN :.. .: : .. : . : :. :..:. :: :. .. . : : :: : CCDS90 YCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLN 70 80 90 100 110 100 110 120 130 140 150 pF1KE4 NGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCP .::: :. :::.: :..::.:: :. :. . :: .:.::. :.. :: : CCDS90 GGTCHMLSRDTYECTCQVGFTGKECQWTDA-CL--SHPCANGSTCTT---VANQFSCKCL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE4 PGFSGNFCEIVANSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ ::.:. :: .: : :. :.. :.: .. :...:.:: :: . :. . :: ::: CCDS90 TGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCV 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ ::::: : . ..:: : : : : :: .. :.. : :: CCDS90 NGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNH--RCQNGGVCVDGVNTYNCRCPPQ 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 QPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLR CCDS90 WTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP 290 300 310 320 330 340 383 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 02:02:44 2016 done: Sun Nov 6 02:02:44 2016 Total Scan time: 2.740 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]