FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4436, 453 aa 1>>>pF1KE4436 453 - 453 aa - 453 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.2984+/-0.000447; mu= -12.6489+/- 0.028 mean_var=407.7331+/-82.362, 0's: 0 Z-trim(121.7): 23 B-trim: 151 in 1/58 Lambda= 0.063516 statistics sampled from 38672 (38695) to 38672 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.454), width: 16 Scan time: 10.390 The best scores are: opt bits E(85289) NP_001924 (OMIM: 126063) dihydrolipoyllysine-resid ( 453) 2963 285.4 2.1e-76 NP_001231812 (OMIM: 126063) dihydrolipoyllysine-re ( 166) 971 102.5 8.7e-22 XP_011518692 (OMIM: 245349,608769) PREDICTED: pyru ( 441) 452 55.3 3.8e-07 NP_001128496 (OMIM: 245349,608769) pyruvate dehydr ( 486) 452 55.3 4.2e-07 NP_003468 (OMIM: 245349,608769) pyruvate dehydroge ( 501) 452 55.3 4.3e-07 XP_005270602 (OMIM: 248600,248610) PREDICTED: lipo ( 301) 436 53.7 7.9e-07 XP_016855958 (OMIM: 248600,248610) PREDICTED: lipo ( 301) 436 53.7 7.9e-07 XP_016855957 (OMIM: 248600,248610) PREDICTED: lipo ( 301) 436 53.7 7.9e-07 NP_001909 (OMIM: 248600,248610) lipoamide acyltran ( 482) 435 53.8 1.2e-06 XP_011540949 (OMIM: 245348,608770) PREDICTED: dihy ( 611) 412 51.7 6.3e-06 NP_001922 (OMIM: 245348,608770) dihydrolipoyllysin ( 647) 395 50.2 1.9e-05 NP_001159630 (OMIM: 245349,608769) pyruvate dehydr ( 274) 321 43.1 0.0011 >>NP_001924 (OMIM: 126063) dihydrolipoyllysine-residue s (453 aa) initn: 2963 init1: 2963 opt: 2963 Z-score: 1492.6 bits: 285.4 E(85289): 2.1e-76 Smith-Waterman score: 2963; 100.0% identity (100.0% similar) in 453 aa overlap (1-453:1-453) 10 20 30 40 50 60 pF1KE4 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 AQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 IEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVAL 370 380 390 400 410 420 430 440 450 pF1KE4 TYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL ::::::::::::::::::::::::::::::::: NP_001 TYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL 430 440 450 >>NP_001231812 (OMIM: 126063) dihydrolipoyllysine-residu (166 aa) initn: 971 init1: 971 opt: 971 Z-score: 512.2 bits: 102.5 E(85289): 8.7e-22 Smith-Waterman score: 971; 100.0% identity (100.0% similar) in 147 aa overlap (1-147:1-147) 10 20 30 40 50 60 pF1KE4 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI ::::::::::::::::::::::::::: NP_001 GVIEALLVPDGGKVEGGTPLFTLRKTGGKEVLLVVKVSSVPSWDWD 130 140 150 160 >>XP_011518692 (OMIM: 245349,608769) PREDICTED: pyruvate (441 aa) initn: 503 init1: 239 opt: 452 Z-score: 249.2 bits: 55.3 E(85289): 3.8e-07 Smith-Waterman score: 510; 28.3% identity (54.0% similar) in 448 aa overlap (76-446:2-437) 50 60 70 80 90 100 pF1KE4 RKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGD-VRWEKAVGDTVAEDEVVC :... .. ::. :.: : :..:. ...: XP_011 MPSLSPTMEEGNIVKWLKKEGEAVSAGDALC 10 20 30 110 120 130 140 150 pF1KE4 EIETDKTSVQVPSPANGVIEALLVPDGGK-----------VEGGTPLFTL---RKTGAAP ::::::. : . . .:.. ..: .:.: :: : . . .: : XP_011 EIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIPKDVGPPP 40 50 60 70 80 90 160 170 pF1KE4 AKAKPAEAPAAAAPKAE-PTAAAVPP--------PAA----------------------- .::.: . :. :. : ::: XP_011 PVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIF 100 110 120 130 140 150 180 190 200 210 pF1KE4 -----------------------PIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGA : :: : .::: : .: : : .: : ::.. :: XP_011 TKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAG-P-SYPRP-VIPPVSTPGQ 160 170 180 190 200 220 230 240 250 260 270 pF1KE4 GKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHN ... . . . .:. ::.:: :...: . . :.. . ..: : : . XP_011 PNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQD-----LVKDD 210 220 230 240 250 260 280 290 300 310 320 330 pF1KE4 LKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNV .:.. . ..::.: .:...: ::. : . . .::::::::: .::..:.:... XP_011 IKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQL--PFIDISVAVATDKGLLTPIIKDA 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE4 EAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILG : .. .: .. :..::: ..: :...::.:.::: :.:: : .:::::. ::. XP_011 AAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPPQACILA 330 340 350 360 370 380 400 410 420 430 440 pF1KE4 MHGIFDRPVAI-------GGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRV . : : ::: ..:.. : .. :... : :..: . :. ::...:: .:.: XP_011 V-GRF-RPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLENPIR 390 400 410 420 430 450 pF1KE4 LLLDL XP_011 LA 440 >>NP_001128496 (OMIM: 245349,608769) pyruvate dehydrogen (486 aa) initn: 503 init1: 239 opt: 452 Z-score: 248.6 bits: 55.3 E(85289): 4.2e-07 Smith-Waterman score: 517; 27.9% identity (54.1% similar) in 455 aa overlap (69-446:40-482) 40 50 60 70 80 90 pF1KE4 GPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGD-VRWEKAVGDTV : . . :... .. ::. :.: : :..: NP_001 PGAGRTGRGPGSGKAPPAEISSGAPDFPGGDPIKILMPSLSPTMEEGNIVKWLKKEGEAV 10 20 30 40 50 60 100 110 120 130 140 pF1KE4 AEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGK-----------VEGGTPLFTL--- . ...:::::::. : . . .:.. ..: .:.: :: : . NP_001 SAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIP 70 80 90 100 110 120 150 160 170 pF1KE4 RKTGAAPAKAKPAEAPAAAAPKAE-PTAAAVPP--------PAA---------------- . .: : .::.: . :. :. : ::: NP_001 KDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTA 130 140 150 160 170 180 180 190 200 pF1KE4 ------------------------------PIPTQMPPVPSPSQPPSGKPVSAVKPTVAP : :: : .::: : .: : : .:.. : NP_001 TGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAG-P-SYPRPVI-P 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 PLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKE :.. :: ... . . . .:. ::.:: :...: . . :.. . ..: NP_001 PVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQD--- 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE4 AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLV : : ..:.. . ..::.: .:...: ::. : . . .::::::::: .::. NP_001 --LVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQL--PFIDISVAVATDKGLL 310 320 330 340 350 330 340 350 360 370 380 pF1KE4 VPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINP .:.:... : .. .: .. :..::: ..: :...::.:.::: :.:: : .::: NP_001 TPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINP 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE4 PQSAILGMHGIFDRPVAI-------GGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKA ::. ::.. : : ::: ..:.. : .. :... : :..: . :. ::...:: NP_001 PQACILAV-GRF-RPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKA 420 430 440 450 460 470 450 pF1KE4 AVEDPRVLLLDL .:.: NP_001 NLENPIRLA 480 >>NP_003468 (OMIM: 245349,608769) pyruvate dehydrogenase (501 aa) initn: 503 init1: 239 opt: 452 Z-score: 248.4 bits: 55.3 E(85289): 4.3e-07 Smith-Waterman score: 543; 28.3% identity (53.6% similar) in 498 aa overlap (27-446:22-497) 10 20 30 40 50 pF1KE4 MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGP-GYPNSRKVVINNSVFSVRF :::: :.: .: :. :: . . :. NP_003 MAASWRLGCDPRLLRYLVGFPGRRS---VGLVKGALGWSVSRGA-------NWRW 10 20 30 40 60 70 80 90 100 110 pF1KE4 FRTTAVCKDDLVTVKTPAFAESVTEGD-VRWEKAVGDTVAEDEVVCEIETDKTSVQVPSP :..: . : . . :... .. ::. :.: : :..:. ...:::::::. : . . NP_003 FHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDAS 50 60 70 80 90 100 120 130 140 150 160 pF1KE4 ANGVIEALLVPDGGK-----------VEGGTPLFTL---RKTGAAPAKAKPAEAPAAAAP .:.. ..: .:.: :: : . . .: : .::.: . : NP_003 DDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEP 110 120 130 140 150 160 170 pF1KE4 KAE-PTAAAVPP--------PAA------------------------------------- . :. : ::: NP_003 QISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQT 170 180 190 200 210 220 180 190 200 210 220 pF1KE4 ---------PIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNR : :: : .::: : .: : : .: : ::.. :: ... . . . NP_003 GKITESRPTPAPTATPTAPSPLQATAG-P-SYPRP-VIPPVSTPGQPNAVGTFTEIPASN 230 240 250 260 270 280 230 240 250 260 270 280 pF1KE4 MRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASA .:. ::.:: :...: . . :.. . ..: : : ..:.. . ..::.: NP_003 IRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQD-----LVKDDIKVSVNDFIIKAAA 290 300 310 320 330 290 300 310 320 330 340 pF1KE4 FALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITE .:...: ::. : . . .::::::::: .::..:.:... : .. .: .. NP_003 VTLKQMPDVNVSWDGEGPKQL--PFIDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKA 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE4 LGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAI--- :..::: ..: :...::.:.::: :.:: : .:::::. ::.. : : ::: NP_003 LSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPPQACILAV-GRF-RPVLKLTE 400 410 420 430 440 450 410 420 430 440 450 pF1KE4 ----GGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL ..:.. : .. :... : :..: . :. ::...:: .:.: NP_003 DEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLENPIRLA 460 470 480 490 500 >>XP_005270602 (OMIM: 248600,248610) PREDICTED: lipoamid (301 aa) initn: 438 init1: 297 opt: 436 Z-score: 243.6 bits: 53.7 E(85289): 7.9e-07 Smith-Waterman score: 441; 30.4% identity (61.6% similar) in 289 aa overlap (167-453:29-300) 140 150 160 170 180 190 pF1KE4 GTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSG : ..:. ::. : ::: :.:.. XP_005 MENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPS-PKVEIMPPPPKPKDMTV- 10 20 30 40 50 200 210 220 230 240 250 pF1KE4 KPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDM :. . :: : .:: .. : .. ... ... .. : . . .:::. XP_005 -PILVSKPPVF-------TGK----DKTEPIKGFQKAMVKTMSAALKI-PHFGYCDEIDL 60 70 80 90 100 260 270 280 290 300 310 pF1KE4 SNIQEMRARHKE-AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI ... ..: . : :: . ..::.:: :.::....: . :..:: .:.. ....:. XP_005 TELVKLREELKPIAFAR--GIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASH 110 120 130 140 150 160 320 330 340 350 360 370 pF1KE4 DISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGG .:..:. : .::.:: ..::. .. :: ...: . . ..:. :. :::::.:: : XP_005 NIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTDLTGGTFTLSNIG 170 180 190 200 210 220 380 390 400 410 420 430 pF1KE4 VFGSLFGTPIINPPQSAILGMHGIFDRP-VAIGGKVEVRPMMYVALTYDHRLIDGREAVT .:. :. :.: ::. :: .. .: : :.: .: :. . :::.::: XP_005 SIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSR 230 240 250 260 270 280 440 450 pF1KE4 FLRKIKAAVEDPRVLLLDL : :. .:.: .:::: XP_005 FSNLWKSYLENPAFMLLDLK 290 300 >>XP_016855958 (OMIM: 248600,248610) PREDICTED: lipoamid (301 aa) initn: 438 init1: 297 opt: 436 Z-score: 243.6 bits: 53.7 E(85289): 7.9e-07 Smith-Waterman score: 441; 30.4% identity (61.6% similar) in 289 aa overlap (167-453:29-300) 140 150 160 170 180 190 pF1KE4 GTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSG : ..:. ::. : ::: :.:.. XP_016 MENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPS-PKVEIMPPPPKPKDMTV- 10 20 30 40 50 200 210 220 230 240 250 pF1KE4 KPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDM :. . :: : .:: .. : .. ... ... .. : . . .:::. XP_016 -PILVSKPPVF-------TGK----DKTEPIKGFQKAMVKTMSAALKI-PHFGYCDEIDL 60 70 80 90 100 260 270 280 290 300 310 pF1KE4 SNIQEMRARHKE-AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI ... ..: . : :: . ..::.:: :.::....: . :..:: .:.. ....:. XP_016 TELVKLREELKPIAFAR--GIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASH 110 120 130 140 150 160 320 330 340 350 360 370 pF1KE4 DISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGG .:..:. : .::.:: ..::. .. :: ...: . . ..:. :. :::::.:: : XP_016 NIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTDLTGGTFTLSNIG 170 180 190 200 210 220 380 390 400 410 420 430 pF1KE4 VFGSLFGTPIINPPQSAILGMHGIFDRP-VAIGGKVEVRPMMYVALTYDHRLIDGREAVT .:. :. :.: ::. :: .. .: : :.: .: :. . :::.::: XP_016 SIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSR 230 240 250 260 270 280 440 450 pF1KE4 FLRKIKAAVEDPRVLLLDL : :. .:.: .:::: XP_016 FSNLWKSYLENPAFMLLDLK 290 300 >>XP_016855957 (OMIM: 248600,248610) PREDICTED: lipoamid (301 aa) initn: 438 init1: 297 opt: 436 Z-score: 243.6 bits: 53.7 E(85289): 7.9e-07 Smith-Waterman score: 441; 30.4% identity (61.6% similar) in 289 aa overlap (167-453:29-300) 140 150 160 170 180 190 pF1KE4 GTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSG : ..:. ::. : ::: :.:.. XP_016 MENNIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPS-PKVEIMPPPPKPKDMTV- 10 20 30 40 50 200 210 220 230 240 250 pF1KE4 KPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDM :. . :: : .:: .. : .. ... ... .. : . . .:::. XP_016 -PILVSKPPVF-------TGK----DKTEPIKGFQKAMVKTMSAALKI-PHFGYCDEIDL 60 70 80 90 100 260 270 280 290 300 310 pF1KE4 SNIQEMRARHKE-AFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI ... ..: . : :: . ..::.:: :.::....: . :..:: .:.. ....:. XP_016 TELVKLREELKPIAFAR--GIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASH 110 120 130 140 150 160 320 330 340 350 360 370 pF1KE4 DISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGG .:..:. : .::.:: ..::. .. :: ...: . . ..:. :. :::::.:: : XP_016 NIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTDLTGGTFTLSNIG 170 180 190 200 210 220 380 390 400 410 420 430 pF1KE4 VFGSLFGTPIINPPQSAILGMHGIFDRP-VAIGGKVEVRPMMYVALTYDHRLIDGREAVT .:. :. :.: ::. :: .. .: : :.: .: :. . :::.::: XP_016 SIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVIDGATMSR 230 240 250 260 270 280 440 450 pF1KE4 FLRKIKAAVEDPRVLLLDL : :. .:.: .:::: XP_016 FSNLWKSYLENPAFMLLDLK 290 300 >>NP_001909 (OMIM: 248600,248610) lipoamide acyltransfer (482 aa) initn: 545 init1: 296 opt: 435 Z-score: 240.2 bits: 53.8 E(85289): 1.2e-06 Smith-Waterman score: 509; 27.8% identity (56.0% similar) in 439 aa overlap (59-453:53-481) 30 40 50 60 70 80 pF1KE4 RSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVR :..:::. . ..: : ..:.. : :. NP_001 FQTCGNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAALRGQVVQFKLSDIGEGIREVTVK 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE4 -WEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTG : ::::.. . .::...::.:: . : .:::. : . : :: .. . NP_001 EWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAYVGKPLVDIETEA 90 100 110 120 130 140 150 160 170 180 pF1KE4 AAPAKAKPAEAPAAAAP-------KAEPTAA--AVPPPAAPIPTQMPPV----------- .. .:.::.. :.. : : :: : .. : NP_001 LKDSEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRLAMENNIKLSEVVGSGKDGRILK 150 160 170 180 190 200 190 200 210 220 pF1KE4 ----------------PSPS---QPPSGKPVSAVKPTVA--PPLAEPGAGKGLRSEHREK :::. .:: :: . . : .. ::. .:: .. : NP_001 EDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPILVSKPPVF---TGK----DKTEP 210 220 230 240 250 230 240 250 260 270 280 pF1KE4 MNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKE-AFLKKHNLKLGFMSAFV .. ... ... .. : . . .:::.... ..: . : :: . ..::.:: :. NP_001 IKGFQKAMVKTMSAALKI-PHFGYCDEIDLTELVKLREELKPIAFAR--GIKLSFMPFFL 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE4 KASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIER ::....: . :..:: .:.. ....:. .:..:. : .::.:: ..::. .. :: NP_001 KAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIAT 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE4 TITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRP-V ...: . . ..:. :. :::::.:: : .:. :. :.: ::. :: .. .: : NP_001 ELNRLQKLGSVGQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRF 380 390 400 410 420 430 410 420 430 440 450 pF1KE4 AIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL :.: .: :. . :::.::: : :. .:.: .:::: NP_001 NQKGEVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLDLK 440 450 460 470 480 >>XP_011540949 (OMIM: 245348,608770) PREDICTED: dihydrol (611 aa) initn: 537 init1: 234 opt: 412 Z-score: 227.4 bits: 51.7 E(85289): 6.3e-06 Smith-Waterman score: 559; 31.6% identity (58.5% similar) in 405 aa overlap (73-451:221-611) 50 60 70 80 90 100 pF1KE4 PNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDV-RWEKAVGDTVAEDE : ::.. ..: : : :::: ::. ..: . XP_011 AAPAPTPAATASPPTPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGD 200 210 220 230 240 250 110 120 130 140 150 pF1KE4 VVCEIETDKTSVQVPSPANGVIEALLVPDGGK-VEGGTPLFTLRKTGA---APAKAKPAE .. ::::::... .: . .:::.: . : :::: . . : : : .:.: XP_011 LLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADYRPTE 260 270 280 290 300 310 160 170 180 190 200 210 pF1KE4 AP---AAAAPKAEPTAAAVPPPAAPI-PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEP . . : . : .::::: :. :: : .: :. : . : :.: . .: XP_011 VTDLKPQVPPPTPPPVAAVPPTPQPLAPT--PSAPCPATPAGPKGRVFVSPLAKKLAVEK 320 330 340 350 360 220 230 240 250 pF1KE4 GAG----KGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLT----------TFNEIDMSNI : :: . : . . . . ... : . . : .:..: .::: XP_011 GIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVFTDIPISNI 370 380 390 400 410 420 260 270 280 290 300 310 pF1KE4 QEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYI-DIS ... :. .. :.. . ..::::.: . : .:. :: :. .... :.: XP_011 RRI--------LEGRS-KISVNDFIIKASALACLKVPEANSSWMDT---VIRQNHVVDVS 430 440 450 460 470 320 330 340 350 360 370 pF1KE4 VAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFG :::.:: ::..:.. :.. . : .. :. :::...: ....:::::::: :.:: XP_011 VAVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFG 480 490 500 510 520 530 380 390 400 410 420 430 pF1KE4 SLFGTPIINPPQSAILGMHGIFDRPVAIGGK--VEVRPMMYVALTYDHRLIDGREAVTFL . ::::::. ::.. . :. : .. .: :: :.:. :::..:: .. .: XP_011 IKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWL 540 550 560 570 580 590 440 450 pF1KE4 RKIKAAVEDPRVLLLDL ... .: : ..:: XP_011 AEFRKYLEKPITMLL 600 610 453 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:08:33 2016 done: Sun Nov 6 01:08:34 2016 Total Scan time: 10.390 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]