FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3965, 332 aa 1>>>pF1KE3965 332 - 332 aa - 332 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6011+/-0.000426; mu= 15.9445+/- 0.026 mean_var=103.9290+/-22.115, 0's: 0 Z-trim(113.7): 128 B-trim: 1089 in 1/49 Lambda= 0.125807 statistics sampled from 23050 (23193) to 23050 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.272), width: 16 Scan time: 7.260 The best scores are: opt bits E(85289) NP_006559 (OMIM: 606138) cell growth regulator wit ( 332) 2246 418.3 1.1e-116 XP_016876420 (OMIM: 606138) PREDICTED: cell growth ( 272) 1849 346.2 4.8e-95 XP_011534664 (OMIM: 606138) PREDICTED: cell growth ( 272) 1849 346.2 4.8e-95 XP_016876421 (OMIM: 606138) PREDICTED: cell growth ( 272) 1849 346.2 4.8e-95 NP_114404 (OMIM: 606130) RING finger protein 26 [H ( 433) 179 43.3 0.0012 XP_011520744 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 339) 166 40.8 0.005 XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 514) 168 41.3 0.0052 NP_001243787 (OMIM: 608299) E3 ubiquitin-protein l ( 180) 162 39.8 0.0053 XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 530) 168 41.4 0.0053 NP_001135763 (OMIM: 607559) E3 ubiquitin-protein l ( 530) 168 41.4 0.0053 XP_016878581 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 531) 168 41.4 0.0053 XP_011520743 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 539) 168 41.4 0.0054 NP_001135762 (OMIM: 607559) E3 ubiquitin-protein l ( 552) 168 41.4 0.0055 XP_005255277 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 552) 168 41.4 0.0055 XP_016878580 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 168 41.4 0.0055 XP_005255276 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 168 41.4 0.0055 NP_001135761 (OMIM: 607559) E3 ubiquitin-protein l ( 554) 168 41.4 0.0055 XP_005255275 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 555) 168 41.4 0.0055 NP_056061 (OMIM: 607559) E3 ubiquitin-protein liga ( 576) 168 41.4 0.0056 XP_005255274 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 577) 168 41.4 0.0057 NP_079402 (OMIM: 608299) E3 ubiquitin-protein liga ( 372) 162 40.1 0.0088 NP_919247 (OMIM: 608299) E3 ubiquitin-protein liga ( 373) 162 40.1 0.0088 >>NP_006559 (OMIM: 606138) cell growth regulator with RI (332 aa) initn: 2246 init1: 2246 opt: 2246 Z-score: 2215.8 bits: 418.3 E(85289): 1.1e-116 Smith-Waterman score: 2246; 99.7% identity (100.0% similar) in 332 aa overlap (1-332:1-332) 10 20 30 40 50 60 pF1KE3 MAAVFLVTLYEYSPLFYIAVVFTCFIVTTGLVLGWFGWDVPVILRNSEETQFSTRVFKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAAVFLVTLYEYSPLFYIAVVFTCFIVTTGLVLGWFGWDVPVILRNSEETQFSTRVFKKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 MRQVKNPFGLEITNPSSASITTGITLTTDCLEDSLLTCYWGCNVQKLYEALQKHVYCFRI ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_006 MRQVKNPFGLEITNPSSASITTGITLTTDCLEDSLLTCYWGCSVQKLYEALQKHVYCFRI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 STPQALEDALYSEYLYQEQYFIKKDSKEEIYCQLPRDTKIEDFGTVPRSRYPLVALLTLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 STPQALEDALYSEYLYQEQYFIKKDSKEEIYCQLPRDTKIEDFGTVPRSRYPLVALLTLA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DEDDREIYDIISMVSVIHIPDRTYKLSCRILYQYLLLAQGQFHDLKQLFMSANNNFTPSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DEDDREIYDIISMVSVIHIPDRTYKLSCRILYQYLLLAQGQFHDLKQLFMSANNNFTPSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 NSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDGCVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDGCVK 250 260 270 280 290 300 310 320 330 pF1KE3 YFQQCPMCRQFVQESFALCSQKEQDKDKPKTL :::::::::::::::::::::::::::::::: NP_006 YFQQCPMCRQFVQESFALCSQKEQDKDKPKTL 310 320 330 >>XP_016876420 (OMIM: 606138) PREDICTED: cell growth reg (272 aa) initn: 1849 init1: 1849 opt: 1849 Z-score: 1827.4 bits: 346.2 E(85289): 4.8e-95 Smith-Waterman score: 1849; 99.6% identity (100.0% similar) in 272 aa overlap (61-332:1-272) 40 50 60 70 80 90 pF1KE3 LVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDC :::::::::::::::::::::::::::::: XP_016 MRQVKNPFGLEITNPSSASITTGITLTTDC 10 20 30 100 110 120 130 140 150 pF1KE3 LEDSLLTCYWGCNVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK 220 230 240 250 260 270 pF1KE3 TL :: XP_016 TL >>XP_011534664 (OMIM: 606138) PREDICTED: cell growth reg (272 aa) initn: 1849 init1: 1849 opt: 1849 Z-score: 1827.4 bits: 346.2 E(85289): 4.8e-95 Smith-Waterman score: 1849; 99.6% identity (100.0% similar) in 272 aa overlap (61-332:1-272) 40 50 60 70 80 90 pF1KE3 LVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDC :::::::::::::::::::::::::::::: XP_011 MRQVKNPFGLEITNPSSASITTGITLTTDC 10 20 30 100 110 120 130 140 150 pF1KE3 LEDSLLTCYWGCNVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK 220 230 240 250 260 270 pF1KE3 TL :: XP_011 TL >>XP_016876421 (OMIM: 606138) PREDICTED: cell growth reg (272 aa) initn: 1849 init1: 1849 opt: 1849 Z-score: 1827.4 bits: 346.2 E(85289): 4.8e-95 Smith-Waterman score: 1849; 99.6% identity (100.0% similar) in 272 aa overlap (61-332:1-272) 40 50 60 70 80 90 pF1KE3 LVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDC :::::::::::::::::::::::::::::: XP_016 MRQVKNPFGLEITNPSSASITTGITLTTDC 10 20 30 100 110 120 130 140 150 pF1KE3 LEDSLLTCYWGCNVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK 220 230 240 250 260 270 pF1KE3 TL :: XP_016 TL >>NP_114404 (OMIM: 606130) RING finger protein 26 [Homo (433 aa) initn: 178 init1: 142 opt: 179 Z-score: 186.7 bits: 43.3 E(85289): 0.0012 Smith-Waterman score: 179; 37.5% identity (71.4% similar) in 56 aa overlap (268-316:374-429) 240 250 260 270 280 290 pF1KE3 PSNNSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDG .:. : ::.::. . . .:::::: :::.. NP_114 TIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQA 350 360 370 380 390 400 300 310 320 330 pF1KE3 CVK-------YFQQCPMCRQFVQESFALCSQKEQDKDKPKTL :.. : ..::.::. . ... NP_114 CTEILMRHPVYHRNCPLCRRGILQTLNVYL 410 420 430 >>XP_011520744 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (339 aa) initn: 167 init1: 136 opt: 166 Z-score: 175.3 bits: 40.8 E(85289): 0.005 Smith-Waterman score: 166; 41.5% identity (67.9% similar) in 53 aa overlap (265-309:28-80) 240 250 260 270 280 290 pF1KE3 NFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWVLLPCR :::.. ::..:::: . . ..:::: XP_011 MASGPRTTGAAPRGGSGAPGRASPQPREPSDDENSDNSNECVVCLSDLRDTLILPCR 10 20 30 40 50 300 310 320 330 pF1KE3 HTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL : ::: .:. .. .::.:: XP_011 HLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEH 60 70 80 90 100 110 >>XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (514 aa) initn: 167 init1: 136 opt: 168 Z-score: 175.0 bits: 41.3 E(85289): 0.0052 Smith-Waterman score: 168; 37.9% identity (70.7% similar) in 58 aa overlap (260-309:222-279) 230 240 250 260 270 280 pF1KE3 MSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWV ...:..::.. ::..:::: . . . XP_016 GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTL 200 210 220 230 240 250 290 300 310 320 330 pF1KE3 LLPCRHTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL .::::: ::: .:. .. .::.:: XP_016 ILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSL 260 270 280 290 300 310 >>NP_001243787 (OMIM: 608299) E3 ubiquitin-protein ligas (180 aa) initn: 177 init1: 158 opt: 162 Z-score: 174.9 bits: 39.8 E(85289): 0.0053 Smith-Waterman score: 162; 31.5% identity (67.1% similar) in 73 aa overlap (240-312:105-171) 210 220 230 240 250 260 pF1KE3 ILYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE : .:......: :.. :.. :: NP_001 MSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERLQLQD------EE 80 90 100 110 120 270 280 290 300 310 320 pF1KE3 NSKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKP ... : .:...... ::: : : : : : ...::.:::.: NP_001 DDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS 130 140 150 160 170 180 330 pF1KE3 KTL >>XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (530 aa) initn: 167 init1: 136 opt: 168 Z-score: 174.8 bits: 41.4 E(85289): 0.0053 Smith-Waterman score: 168; 37.9% identity (70.7% similar) in 58 aa overlap (260-309:260-317) 230 240 250 260 270 280 pF1KE3 MSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWV ...:..::.. ::..:::: . . . XP_005 GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTL 230 240 250 260 270 280 290 300 310 320 330 pF1KE3 LLPCRHTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL .::::: ::: .:. .. .::.:: XP_005 ILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSL 290 300 310 320 330 340 >>NP_001135763 (OMIM: 607559) E3 ubiquitin-protein ligas (530 aa) initn: 167 init1: 136 opt: 168 Z-score: 174.8 bits: 41.4 E(85289): 0.0053 Smith-Waterman score: 168; 37.9% identity (70.7% similar) in 58 aa overlap (260-309:260-317) 230 240 250 260 270 280 pF1KE3 MSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWV ...:..::.. ::..:::: . . . NP_001 GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTL 230 240 250 260 270 280 290 300 310 320 330 pF1KE3 LLPCRHTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL .::::: ::: .:. .. .::.:: NP_001 ILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSL 290 300 310 320 330 340 332 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:30:09 2016 done: Sun Nov 6 08:30:10 2016 Total Scan time: 7.260 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]