FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1660, 177 aa 1>>>pF1KE1660 177 - 177 aa - 177 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7251+/-0.000255; mu= 11.6656+/- 0.016 mean_var=83.7404+/-16.459, 0's: 0 Z-trim(121.7): 15 B-trim: 0 in 0/58 Lambda= 0.140154 statistics sampled from 38615 (38635) to 38615 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.797), E-opt: 0.2 (0.453), width: 16 Scan time: 5.660 The best scores are: opt bits E(85289) NP_073626 (OMIM: 605658) interleukin-25 isoform 1 ( 177) 1285 268.4 4.3e-72 NP_758525 (OMIM: 605658) interleukin-25 isoform 2 ( 161) 1171 245.3 3.5e-65 NP_037410 (OMIM: 604628) interleukin-17C precursor ( 197) 223 53.7 2.1e-07 NP_612141 (OMIM: 607587) interleukin-17D precursor ( 202) 181 45.2 7.6e-05 XP_005266478 (OMIM: 607587) PREDICTED: interleukin ( 209) 181 45.2 7.8e-05 XP_016864837 (OMIM: 604627) PREDICTED: interleukin ( 128) 177 44.3 9.2e-05 XP_011535924 (OMIM: 604627) PREDICTED: interleukin ( 128) 177 44.3 9.2e-05 NP_001304916 (OMIM: 604627) interleukin-17B isofor ( 128) 177 44.3 9.2e-05 XP_016864836 (OMIM: 604627) PREDICTED: interleukin ( 128) 177 44.3 9.2e-05 NP_055258 (OMIM: 604627) interleukin-17B isoform 1 ( 180) 177 44.4 0.00012 XP_016864835 (OMIM: 604627) PREDICTED: interleukin ( 245) 177 44.4 0.00015 XP_011512578 (OMIM: 606496,613956) PREDICTED: inte ( 163) 159 40.7 0.0014 NP_443104 (OMIM: 606496,613956) interleukin-17F pr ( 163) 159 40.7 0.0014 >>NP_073626 (OMIM: 605658) interleukin-25 isoform 1 prec (177 aa) initn: 1285 init1: 1285 opt: 1285 Z-score: 1415.3 bits: 268.4 E(85289): 4.3e-72 Smith-Waterman score: 1285; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KE1 MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 PLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQT 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 GSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 GSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG 130 140 150 160 170 >>NP_758525 (OMIM: 605658) interleukin-25 isoform 2 prec (161 aa) initn: 1171 init1: 1171 opt: 1171 Z-score: 1291.3 bits: 245.3 E(85289): 3.5e-65 Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 159 aa overlap (19-177:3-161) 10 20 30 40 50 60 pF1KE1 MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVP :::::::::::::::::::::::::::::::::::::::::: NP_758 MYQVVAFLAMVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVP 10 20 30 40 70 80 90 100 110 120 pF1KE1 PLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 PLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQT 50 60 70 80 90 100 130 140 150 160 170 pF1KE1 GSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 GSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG 110 120 130 140 150 160 >>NP_037410 (OMIM: 604628) interleukin-17C precursor [Ho (197 aa) initn: 199 init1: 159 opt: 223 Z-score: 254.1 bits: 53.7 E(85289): 2.1e-07 Smith-Waterman score: 230; 32.9% identity (54.7% similar) in 170 aa overlap (31-174:27-195) 10 20 30 40 50 pF1KE1 MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHW-PSCCPSK----GQDTSEELLR-- : .:: : : .. :: . : : NP_037 MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGA 10 20 30 40 50 60 70 80 90 pF1KE1 -WS-TVPVP---PLEPARP-NRH--PES---C---RASE--DGPLNSRAISPWRYELDRD :. ..:: :: : .:: : . : : : .. ..:.::::::..: : NP_037 KWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTD 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 LNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKG---THKG .: :: : :.::: :.. .:: . :: : .. :. :::: . . : . NP_037 EDRYPQKLAFAECLCRGCIDARTGRETAAL-NSVRLLQSLLVLRRRPCSRDGSGLPTPGA 120 130 140 150 160 170 160 170 pF1KE1 YCLERRLYRVSLACVCVRPRVMG . .. .. .: ..:.:: :: NP_037 FAFHTEFIHVPVGCTCVLPRSV 180 190 >>NP_612141 (OMIM: 607587) interleukin-17D precursor [Ho (202 aa) initn: 134 init1: 116 opt: 181 Z-score: 208.0 bits: 45.2 E(85289): 7.6e-05 Smith-Waterman score: 181; 30.0% identity (52.5% similar) in 120 aa overlap (56-171:57-170) 30 40 50 60 70 80 pF1KE1 MVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVPPLEPARPNRHPESCRASED---GPL :. . : : :: : . : .. : NP_612 RPRGCADRPEELLEQLYGRLAAGVLSAFHHTLQLGPREQARNASCPAGGRPADRRFRPPT 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE1 NSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYR : :..::: :... : : :. : .: ::: :.. : . : : : .: .:. : NP_612 NLRSVSPWAYRISYDPARYPRYLPEAYCLCRGCLTGLFGEE-DVRFRSAPVYMPTVVLRR 90 100 110 120 130 140 150 160 170 pF1KE1 RP-CHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG : : : .... . . ..:.:: NP_612 TPACAGGRSVYT-----EAYVTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPA 150 160 170 180 190 200 >>XP_005266478 (OMIM: 607587) PREDICTED: interleukin-17D (209 aa) initn: 134 init1: 116 opt: 181 Z-score: 207.8 bits: 45.2 E(85289): 7.8e-05 Smith-Waterman score: 181; 30.0% identity (52.5% similar) in 120 aa overlap (56-171:64-177) 30 40 50 60 70 80 pF1KE1 MVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVPPLEPARPNRHPESCRASED---GPL :. . : : :: : . : .. : XP_005 RPRGCADRPEELLEQLYGRLAAGVLSAFHHTLQLGPREQARNASCPAGGRPADRRFRPPT 40 50 60 70 80 90 90 100 110 120 130 140 pF1KE1 NSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYR : :..::: :... : : :. : .: ::: :.. : . : : : .: .:. : XP_005 NLRSVSPWAYRISYDPARYPRYLPEAYCLCRGCLTGLFGEE-DVRFRSAPVYMPTVVLRR 100 110 120 130 140 150 150 160 170 pF1KE1 RP-CHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG : : : .... . . ..:.:: XP_005 TPACAGGRSVYT-----EAYVTIPVGCTCVPEPEKDADSINSSIDKQGAKLLLGPNDAPA 160 170 180 190 200 >>XP_016864837 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 125 init1: 125 opt: 177 Z-score: 206.5 bits: 44.3 E(85289): 9.2e-05 Smith-Waterman score: 177; 33.3% identity (62.2% similar) in 90 aa overlap (83-171:42-127) 60 70 80 90 100 110 pF1KE1 RWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLC :.:..::: : ...: .:.: :: .::::: XP_016 RNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLC 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE1 PHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYR-VSLACVCV ::. : .. :. . .:. :: : : : : .: ... ....:.:. XP_016 LGCVNPFT--MQEDRSMVSVPVFSQVPVRRRLCPPPPRT--GPCRQRAVMETIAVGCTCI 80 90 100 110 120 pF1KE1 RPRVMG XP_016 F >>XP_011535924 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 125 init1: 125 opt: 177 Z-score: 206.5 bits: 44.3 E(85289): 9.2e-05 Smith-Waterman score: 177; 33.3% identity (62.2% similar) in 90 aa overlap (83-171:42-127) 60 70 80 90 100 110 pF1KE1 RWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLC :.:..::: : ...: .:.: :: .::::: XP_011 RNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLC 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE1 PHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYR-VSLACVCV ::. : .. :. . .:. :: : : : : .: ... ....:.:. XP_011 LGCVNPFT--MQEDRSMVSVPVFSQVPVRRRLCPPPPRT--GPCRQRAVMETIAVGCTCI 80 90 100 110 120 pF1KE1 RPRVMG XP_011 F >>NP_001304916 (OMIM: 604627) interleukin-17B isoform 2 (128 aa) initn: 125 init1: 125 opt: 177 Z-score: 206.5 bits: 44.3 E(85289): 9.2e-05 Smith-Waterman score: 177; 33.3% identity (62.2% similar) in 90 aa overlap (83-171:42-127) 60 70 80 90 100 110 pF1KE1 RWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLC :.:..::: : ...: .:.: :: .::::: NP_001 RNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLC 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE1 PHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYR-VSLACVCV ::. : .. :. . .:. :: : : : : .: ... ....:.:. NP_001 LGCVNPFT--MQEDRSMVSVPVFSQVPVRRRLCPPPPRT--GPCRQRAVMETIAVGCTCI 80 90 100 110 120 pF1KE1 RPRVMG NP_001 F >>XP_016864836 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 125 init1: 125 opt: 177 Z-score: 206.5 bits: 44.3 E(85289): 9.2e-05 Smith-Waterman score: 177; 33.3% identity (62.2% similar) in 90 aa overlap (83-171:42-127) 60 70 80 90 100 110 pF1KE1 RWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLC :.:..::: : ...: .:.: :: .::::: XP_016 RNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLC 20 30 40 50 60 70 120 130 140 150 160 170 pF1KE1 PHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYR-VSLACVCV ::. : .. :. . .:. :: : : : : .: ... ....:.:. XP_016 LGCVNPFT--MQEDRSMVSVPVFSQVPVRRRLCPPPPRT--GPCRQRAVMETIAVGCTCI 80 90 100 110 120 pF1KE1 RPRVMG XP_016 F >>NP_055258 (OMIM: 604627) interleukin-17B isoform 1 pre (180 aa) initn: 125 init1: 125 opt: 177 Z-score: 204.4 bits: 44.4 E(85289): 0.00012 Smith-Waterman score: 177; 33.3% identity (62.2% similar) in 90 aa overlap (83-171:94-179) 60 70 80 90 100 110 pF1KE1 RWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLC :.:..::: : ...: .:.: :: .::::: NP_055 RNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 PHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYR-VSLACVCV ::. : .. :. . .:. :: : : : : .: ... ....:.:. NP_055 LGCVNPFT--MQEDRSMVSVPVFSQVPVRRRLCPPPPRT--GPCRQRAVMETIAVGCTCI 130 140 150 160 170 pF1KE1 RPRVMG NP_055 F 180 177 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:30:20 2016 done: Sun Nov 6 14:30:21 2016 Total Scan time: 5.660 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]