FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6770, 555 aa 1>>>pF1KE6770 555 - 555 aa - 555 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4002+/-0.000353; mu= 18.7976+/- 0.022 mean_var=71.7706+/-14.393, 0's: 0 Z-trim(113.4): 31 B-trim: 0 in 0/54 Lambda= 0.151391 statistics sampled from 22688 (22716) to 22688 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.266), width: 16 Scan time: 5.180 The best scores are: opt bits E(85289) NP_005699 (OMIM: 258315,604404) glypican-6 precurs ( 555) 3741 826.5 0 XP_016875787 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207 XP_011519346 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207 XP_016875788 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207 XP_016875789 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207 XP_016875790 (OMIM: 258315,604404) PREDICTED: glyp ( 433) 2930 649.3 7.1e-186 NP_001439 (OMIM: 194070,300168,312870) glypican-4 ( 556) 2422 538.4 2.2e-152 XP_016875791 (OMIM: 258315,604404) PREDICTED: glyp ( 324) 1756 392.8 8.7e-109 NP_002072 (OMIM: 600395) glypican-1 precursor [Hom ( 558) 1320 297.7 6.3e-80 XP_011509278 (OMIM: 600395) PREDICTED: glypican-1 ( 486) 1048 238.3 4.3e-62 XP_016875924 (OMIM: 602446) PREDICTED: glypican-5 ( 565) 756 174.5 7.7e-43 NP_004457 (OMIM: 602446) glypican-5 precursor [Hom ( 572) 756 174.5 7.8e-43 XP_011519356 (OMIM: 602446) PREDICTED: glypican-5 ( 480) 745 172.1 3.6e-42 XP_011519362 (OMIM: 602446) PREDICTED: glypican-5 ( 443) 698 161.8 4.1e-39 XP_011519361 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39 XP_016875926 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39 XP_011519357 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39 XP_016875925 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39 XP_011519358 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39 XP_011519360 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39 XP_011519359 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39 NP_004475 (OMIM: 194070,300037,312870) glypican-3 ( 580) 687 159.5 2.7e-38 XP_016884902 (OMIM: 194070,300037,312870) PREDICTE ( 486) 640 149.2 2.9e-35 NP_001158089 (OMIM: 194070,300037,312870) glypican ( 603) 569 133.7 1.6e-30 NP_001158091 (OMIM: 194070,300037,312870) glypican ( 526) 558 131.3 7.6e-30 NP_001158090 (OMIM: 194070,300037,312870) glypican ( 564) 555 130.6 1.3e-29 >>NP_005699 (OMIM: 258315,604404) glypican-6 precursor [ (555 aa) initn: 3741 init1: 3741 opt: 3741 Z-score: 4413.7 bits: 826.5 E(85289): 0 Smith-Waterman score: 3741; 100.0% identity (100.0% similar) in 555 aa overlap (1-555:1-555) 10 20 30 40 50 60 pF1KE6 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRIC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 HFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 TPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 NTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 ECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 NDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLS 490 500 510 520 530 540 550 pF1KE6 WSLTCIVLALQRLCR ::::::::::::::: NP_005 WSLTCIVLALQRLCR 550 >>XP_016875787 (OMIM: 258315,604404) PREDICTED: glypican (485 aa) initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207 Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485) 50 60 70 80 90 100 pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS :::::::::::::::::::::::::::::: XP_016 MEDKLSQQSKLEFENLVEETSHFVRTTFVS 10 20 30 110 120 130 140 150 160 pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI 340 350 360 370 380 390 470 480 490 500 510 520 pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV 400 410 420 430 440 450 530 540 550 pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR ::::::::::::::::::::::::::::::::::: XP_016 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR 460 470 480 >>XP_011519346 (OMIM: 258315,604404) PREDICTED: glypican (485 aa) initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207 Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485) 50 60 70 80 90 100 pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS :::::::::::::::::::::::::::::: XP_011 MEDKLSQQSKLEFENLVEETSHFVRTTFVS 10 20 30 110 120 130 140 150 160 pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI 340 350 360 370 380 390 470 480 490 500 510 520 pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV 400 410 420 430 440 450 530 540 550 pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR ::::::::::::::::::::::::::::::::::: XP_011 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR 460 470 480 >>XP_016875788 (OMIM: 258315,604404) PREDICTED: glypican (485 aa) initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207 Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485) 50 60 70 80 90 100 pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS :::::::::::::::::::::::::::::: XP_016 MEDKLSQQSKLEFENLVEETSHFVRTTFVS 10 20 30 110 120 130 140 150 160 pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI 340 350 360 370 380 390 470 480 490 500 510 520 pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV 400 410 420 430 440 450 530 540 550 pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR ::::::::::::::::::::::::::::::::::: XP_016 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR 460 470 480 >>XP_016875789 (OMIM: 258315,604404) PREDICTED: glypican (485 aa) initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207 Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485) 50 60 70 80 90 100 pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS :::::::::::::::::::::::::::::: XP_016 MEDKLSQQSKLEFENLVEETSHFVRTTFVS 10 20 30 110 120 130 140 150 160 pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS 280 290 300 310 320 330 410 420 430 440 450 460 pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI 340 350 360 370 380 390 470 480 490 500 510 520 pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV 400 410 420 430 440 450 530 540 550 pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR ::::::::::::::::::::::::::::::::::: XP_016 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR 460 470 480 >>XP_016875790 (OMIM: 258315,604404) PREDICTED: glypican (433 aa) initn: 2930 init1: 2930 opt: 2930 Z-score: 3458.0 bits: 649.3 E(85289): 7.1e-186 Smith-Waterman score: 2930; 100.0% identity (100.0% similar) in 433 aa overlap (123-555:1-433) 100 110 120 130 140 150 pF1KE6 FVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTG :::::::::::::::::::::::::::::: XP_016 MFVRTYGMLYMQNSEVFQDLFTELKRYYTG 10 20 30 160 170 180 190 200 210 pF1KE6 GNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVT 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE6 RAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLN 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE6 VMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQ 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE6 VSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKL 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE6 KLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVD 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE6 ITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEF 340 350 360 370 380 390 520 530 540 550 pF1KE6 VTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR ::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR 400 410 420 430 >>NP_001439 (OMIM: 194070,300168,312870) glypican-4 prec (556 aa) initn: 2398 init1: 1676 opt: 2422 Z-score: 2856.7 bits: 538.4 E(85289): 2.2e-152 Smith-Waterman score: 2422; 64.5% identity (86.1% similar) in 546 aa overlap (9-552:9-553) 10 20 30 40 50 60 pF1KE6 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRIC .: :..: . .:..:..::.:::. : .:::. : : .:: :.::.:: NP_001 MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKIC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSL :: :::. :::.: : ::: .:...: : . ....:.::.:::::::.:::::::::: NP_001 PQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 NDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQY :::::.::: :::::::.:.:::.::::::. :::::::::::::::::::::.:.: :: NP_001 NDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 HFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSP ::...:::::::::.:::::::::::::.::::::.:::::.:::.:. .:...:: :.: NP_001 HFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 TPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAE : : .::.::.:: .:::: ::.:: ::: :.:.::::::.::: ::: ::::::.::: NP_001 TAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAE 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 RLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPEN- ::::::::::::::::::::.::::::.::.::: ::::::: ::: :: : .:: :. NP_001 RLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 FNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNE :..::::..:::::::::::::::::::.::::: .:: ::.:: ..:.:: ..::..:: NP_001 FSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE6 EECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYN ..::::..:.::: . ..::.:: :::::.:: ..:: .: .:::::::::.:.::::: NP_001 DDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYN 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE6 GNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLL ::::.: : :::::: :::::: . ::.::.. .:. . . ... .::.... : . NP_001 GNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEK-ADSAGVRPGAQAY 490 500 510 520 530 540 550 pF1KE6 SWSLTCIV-LALQRLCR .. ::. :..:: NP_001 LLTVFCILFLVMQREWR 540 550 >>XP_016875791 (OMIM: 258315,604404) PREDICTED: glypican (324 aa) initn: 1756 init1: 1756 opt: 1756 Z-score: 2074.0 bits: 392.8 E(85289): 8.7e-109 Smith-Waterman score: 1756; 100.0% identity (100.0% similar) in 263 aa overlap (293-555:62-324) 270 280 290 300 310 320 pF1KE6 VRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEA :::::::::::::::::::::::::::::: XP_016 QGLWGNSITGRRNSRCKAWRQDCIWLCPDPDAMLLVAERLEGPFNIESVMDPIDVKISEA 40 50 60 70 80 90 330 340 350 360 370 380 pF1KE6 IMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLD 100 110 120 130 140 150 390 400 410 420 430 440 pF1KE6 RLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTN 160 170 180 190 200 210 450 460 470 480 490 500 pF1KE6 QINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCM 220 230 240 250 260 270 510 520 530 540 550 pF1KE6 DDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR 280 290 300 310 320 >>NP_002072 (OMIM: 600395) glypican-1 precursor [Homo sa (558 aa) initn: 1719 init1: 1204 opt: 1320 Z-score: 1555.9 bits: 297.7 E(85289): 6.3e-80 Smith-Waterman score: 1766; 49.1% identity (80.3% similar) in 503 aa overlap (4-506:9-499) 10 20 30 40 50 pF1KE6 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGE :. . :.. . ::. :.:::::::: ::::::::.:.: ::.:: NP_002 MELRARGWWLLCAAAALVACARGDPAS---KSRSCGEVRQIYGAKGFSLSDVPQAEISGE 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 HLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLEN ::::::: :::::.:::..:...:. :.:. ....:. ... .... ..::. :..::.. NP_002 HLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLND 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 AEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQL .:..:. : ..: :: ::...:.::..::. :: :.:..::: : .::::::::.:. NP_002 SERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 INPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRV ..:: . .:::.:..: .. :.:::..::.:....::::.:::.::::: :. .:. .: NP_002 LHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 SKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAM ..: : : ::.::..:: .: :.: .::: .:: ::.:::::::::::.:: ..:.: NP_002 AQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSM 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 LLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARS .:..... : ..:::. . . ..::: .:.: ..:::.::::.:: : NP_002 VLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNP----QGP 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 APENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAG .::. : . :.::: . :: :..::.. : .:. . : .:: :.:. :... . NP_002 GPEEKRRRGK-LAPRERPPS--GT-LEKLVSEAKAQLRDVQDFWISLPGTLCS-EKMALS 360 370 380 390 400 420 430 440 450 460 470 pF1KE6 TSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLK :.....:::: ...:::::.:.:::.::::::::.::::.:: :::::: :..:::.:. NP_002 TASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLR 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE6 NAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRG .:::::::.:::.::..::::::.::.::.: NP_002 SAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQK 470 480 490 500 510 520 540 550 pF1KE6 HSLLSWSLTCIVLALQRLCR NP_002 TSAASCPQPPTFLLPLLLFLALTVARPRWR 530 540 550 >>XP_011509278 (OMIM: 600395) PREDICTED: glypican-1 isof (486 aa) initn: 1406 init1: 891 opt: 1048 Z-score: 1235.7 bits: 238.3 E(85289): 4.3e-62 Smith-Waterman score: 1494; 47.5% identity (81.0% similar) in 436 aa overlap (71-506:1-427) 50 60 70 80 90 100 pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS ::..:...:. :.:. ....:. ... ... XP_011 MEENLANRSHAELETALRDSSRVLQAMLAT 10 20 30 110 120 130 140 150 160 pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM . ..::. :..::...:..:. : ..: :: ::...:.::..::. :: :.:..::: XP_011 QLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEET 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART : .::::::::.:. ..:: . .:::.:..: .. :.:::..::.:....::::.:::. XP_011 LAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARS 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN ::::: :. .:. .:..: : : ::.::..:: .: :.: .::: .:: ::.:::::: XP_011 FVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLAN 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG :::::.:: ..:.:.:..... : ..:::. . . ..::: .:.: ..:::.:: XP_011 QADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS ::.:: : .::. : . :.::: . :: :..::.. : .:. . : XP_011 CGNPKVNPQ----GPGPEEKRRRGK-LAPRERPPS--GT-LEKLVSEAKAQLRDVQDFWI 280 290 300 310 320 410 420 430 440 450 460 pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI .:: :.:. :... .:.....:::: ...:::::.:.:::.::::::::.::::.:: : XP_011 SLPGTLCS-EKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTI 330 340 350 360 370 380 470 480 490 500 510 520 pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV ::::: :..:::.:..:::::::.:::.::..::::::.::.::.: XP_011 RQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTP 390 400 410 420 430 440 530 540 550 pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR XP_011 LTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR 450 460 470 480 555 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:12:35 2016 done: Tue Nov 8 16:12:36 2016 Total Scan time: 5.180 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]