FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5802, 471 aa 1>>>pF1KB5802 471 - 471 aa - 471 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7894+/-0.000534; mu= 21.4684+/- 0.033 mean_var=109.6630+/-28.684, 0's: 0 Z-trim(107.6): 666 B-trim: 732 in 1/54 Lambda= 0.122474 statistics sampled from 14867 (15666) to 14867 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.527), E-opt: 0.2 (0.184), width: 16 Scan time: 8.200 The best scores are: opt bits E(85289) NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 3069 554.3 2.6e-157 NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 2195 399.8 7.1e-111 NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 939 177.9 5e-44 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 939 177.9 5e-44 NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 782 150.2 1.1e-35 XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 782 150.2 1.1e-35 NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 782 150.2 1.2e-35 NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 626 122.6 2.2e-27 NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 626 122.6 2.2e-27 NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 626 122.7 2.3e-27 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 620 121.6 5e-27 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 562 111.3 5.3e-24 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 541 107.6 7.5e-23 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 540 107.4 8.1e-23 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 540 107.4 8.1e-23 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 540 107.4 8.4e-23 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 540 107.5 8.6e-23 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 540 107.5 8.6e-23 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 540 107.5 8.6e-23 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 540 107.5 8.6e-23 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 537 107.0 1.4e-22 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 525 104.7 4.8e-22 NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 523 104.3 5.8e-22 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 521 103.9 7.1e-22 NP_001243690 (OMIM: 312861) 5-hydroxytryptamine re ( 248) 519 103.4 7.7e-22 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 520 103.7 8e-22 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 520 103.8 8.5e-22 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 520 103.8 9e-22 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 520 104.0 1.1e-21 XP_005246577 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 362) 510 102.0 2.9e-21 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 507 101.6 4.7e-21 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 489 98.4 4.2e-20 NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 463 93.8 1e-18 XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 463 93.8 1e-18 NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 462 93.6 1.1e-18 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 456 92.5 2.2e-18 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 455 92.3 2.4e-18 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 455 92.3 2.4e-18 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 454 92.0 2.5e-18 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 454 92.0 2.5e-18 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 454 92.0 2.6e-18 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 454 92.1 2.7e-18 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 454 92.1 2.8e-18 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 454 92.3 3.2e-18 NP_000788 (OMIM: 126452,143465,601696) D(4) dopami ( 419) 439 89.5 1.9e-17 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 412 84.7 4.7e-16 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 412 84.7 4.7e-16 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 412 84.7 5e-16 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 412 84.8 5.2e-16 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 412 84.8 5.2e-16 >>NP_000612 (OMIM: 103780,164230,181500,182135,606788,60 (471 aa) initn: 3069 init1: 3069 opt: 3069 Z-score: 2945.2 bits: 554.3 E(85289): 2.6e-157 Smith-Waterman score: 3069; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471) 10 20 30 40 50 60 pF1KB5 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV 430 440 450 460 470 >>NP_001159419 (OMIM: 103780,164230,181500,182135,606788 (387 aa) initn: 2195 init1: 2195 opt: 2195 Z-score: 2111.5 bits: 399.8 E(85289): 7.1e-111 Smith-Waterman score: 2195; 100.0% identity (100.0% similar) in 333 aa overlap (139-471:55-387) 110 120 130 140 150 160 pF1KB5 TNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCA :::::::::::::::::::::::::::::: NP_001 GTLHQFNYCERCSESQNNKCISCVDPEDKWYRWPLPSKLCAVWIYLDVLFSTASIMHLCA 30 40 50 60 70 80 170 180 190 200 210 220 pF1KB5 ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCL 90 100 110 120 130 140 230 240 250 260 270 280 pF1KB5 LADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSS 150 160 170 180 190 200 290 300 310 320 330 340 pF1KB5 LSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVI 210 220 230 240 250 260 350 360 370 380 390 400 pF1KB5 CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQL 270 280 290 300 310 320 410 420 430 440 450 460 pF1KB5 ILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKV 330 340 350 360 370 380 470 pF1KB5 SCV ::: NP_001 SCV >>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor (458 aa) initn: 1240 init1: 769 opt: 939 Z-score: 911.4 bits: 177.9 E(85289): 5e-44 Smith-Waterman score: 1413; 55.0% identity (78.0% similar) in 409 aa overlap (74-471:53-458) 50 60 70 80 90 100 pF1KB5 NWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEK .:: :: ...::.::.::::::::::.:: NP_000 CDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEK 30 40 50 60 70 80 110 120 130 140 150 160 pF1KB5 KLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASI ::.::::::::::::::::.:.::::.:.:.::: : :::: :: ::: :::::::::: NP_000 KLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASI 90 100 110 120 130 140 170 180 190 200 210 220 pF1KB5 MHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF- ::::::::::::::.:::.::::::::::..:: ::.::.:.:.::::.::.:. ::: NP_000 MHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFV 150 160 170 180 190 200 230 240 250 260 270 280 pF1KB5 KEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFS .. .:.: : :::::::::.:::::::::::: ::: :...: . . . :.. NP_000 NNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLD 210 220 230 240 250 260 290 300 310 320 330 pF1KB5 FLP--------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVV :: . . .. . : . .:. : :::.:.::.:: ::::::::.:.. NP_000 FLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLI 270 280 290 300 310 320 340 350 360 370 380 390 pF1KB5 MWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY ::::::::::..:.:..:::. .. ::::::::::. :..:::::::::: :: ::: : NP_000 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY 330 340 350 360 370 380 400 410 420 430 440 450 pF1KB5 IQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQH ..:.:: .::: . . . : : .. .:... ..... . :..::. .. . . NP_000 LRCNYKVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVE 390 400 410 420 430 460 470 pF1KB5 SEEASKDNSDGVNEKVSCV . : . :. :.:..: : NP_000 NLELPVNPSSVVSERISSV 440 450 >>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept (458 aa) initn: 1240 init1: 769 opt: 939 Z-score: 911.4 bits: 177.9 E(85289): 5e-44 Smith-Waterman score: 1413; 55.0% identity (78.0% similar) in 409 aa overlap (74-471:53-458) 50 60 70 80 90 100 pF1KB5 NWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEK .:: :: ...::.::.::::::::::.:: NP_001 CDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEK 30 40 50 60 70 80 110 120 130 140 150 160 pF1KB5 KLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASI ::.::::::::::::::::.:.::::.:.:.::: : :::: :: ::: :::::::::: NP_001 KLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASI 90 100 110 120 130 140 170 180 190 200 210 220 pF1KB5 MHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF- ::::::::::::::.:::.::::::::::..:: ::.::.:.:.::::.::.:. ::: NP_001 MHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFV 150 160 170 180 190 200 230 240 250 260 270 280 pF1KB5 KEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFS .. .:.: : :::::::::.:::::::::::: ::: :...: . . . :.. NP_001 NNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLD 210 220 230 240 250 260 290 300 310 320 330 pF1KB5 FLP--------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVV :: . . .. . : . .:. : :::.:.::.:: ::::::::.:.. NP_001 FLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLI 270 280 290 300 310 320 340 350 360 370 380 390 pF1KB5 MWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY ::::::::::..:.:..:::. .. ::::::::::. :..:::::::::: :: ::: : NP_001 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY 330 340 350 360 370 380 400 410 420 430 440 450 pF1KB5 IQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQH ..:.:: .::: . . . : : .. .:... ..... . :..::. .. . . NP_001 LRCNYKVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVE 390 400 410 420 430 460 470 pF1KB5 SEEASKDNSDGVNEKVSCV . : . :. :.:..: : NP_001 NLELPVNPSSVVSERISSV 440 450 >>NP_001307687 (OMIM: 601122) 5-hydroxytryptamine recept (439 aa) initn: 1182 init1: 628 opt: 782 Z-score: 761.6 bits: 150.2 E(85289): 1.1e-35 Smith-Waterman score: 1200; 53.4% identity (78.0% similar) in 350 aa overlap (75-403:13-361) 50 60 70 80 90 100 pF1KB5 WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKK .:.::: .::: ::.:: :::.::::::: NP_001 MKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK 10 20 30 40 110 120 130 140 150 160 pF1KB5 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM :: ::::::::::.::.:.:..:::...:::.. :::: :: .:..::::::::::: NP_001 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB5 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKE ::::::.:::.::..::. ...:::. ::.:: .:: ::.::..:.:. :.. : .. NP_001 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB5 GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASF .:.:. . .:.:.::...:: ::.::..::::::..:::.: : . : . NP_001 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTV 170 180 190 200 210 220 290 300 310 320 pF1KB5 SFLPQSSL----SSEKLFQRSIHRE----PGS----------YTGRRTMQSISNEQKACK : . : . : ::. . . :. :.: :....:.:::::.: : NP_001 STVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASK 230 240 250 260 270 280 330 340 350 360 370 380 pF1KB5 VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLF :::::::::..:::::::::: :.: .:::. .. ::..::::::.::.::::::::: NP_001 VLGIVFFLFLLMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF 290 300 310 320 330 340 390 400 410 420 430 440 pF1KB5 NKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDC :::.:.::.::: :.:. .: NP_001 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ 350 360 370 380 390 400 >>XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytrypta (456 aa) initn: 1182 init1: 628 opt: 782 Z-score: 761.5 bits: 150.2 E(85289): 1.1e-35 Smith-Waterman score: 1200; 53.4% identity (78.0% similar) in 350 aa overlap (75-403:30-378) 50 60 70 80 90 100 pF1KB5 WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKK .:.::: .::: ::.:: :::.::::::: XP_006 MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK 10 20 30 40 50 110 120 130 140 150 160 pF1KB5 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM :: ::::::::::.::.:.:..:::...:::.. :::: :: .:..::::::::::: XP_006 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM 60 70 80 90 100 110 170 180 190 200 210 220 pF1KB5 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKE ::::::.:::.::..::. ...:::. ::.:: .:: ::.::..:.:. :.. : .. XP_006 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN 120 130 140 150 160 170 230 240 250 260 270 280 pF1KB5 GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASF .:.:. . .:.:.::...:: ::.::..::::::..:::.: : . : . XP_006 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTV 180 190 200 210 220 230 290 300 310 320 pF1KB5 SFLPQSSL----SSEKLFQRSIHRE----PGS----------YTGRRTMQSISNEQKACK : . : . : ::. . . :. :.: :....:.:::::.: : XP_006 STVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASK 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB5 VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLF :::::::::..:::::::::: :.: .:::. .. ::..::::::.::.::::::::: XP_006 VLGIVFFLFLLMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB5 NKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDC :::.:.::.::: :.:. .: XP_006 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ 360 370 380 390 400 410 >>NP_000858 (OMIM: 601122) 5-hydroxytryptamine receptor (481 aa) initn: 1182 init1: 628 opt: 782 Z-score: 761.2 bits: 150.2 E(85289): 1.2e-35 Smith-Waterman score: 1200; 53.4% identity (78.0% similar) in 350 aa overlap (75-403:55-403) 50 60 70 80 90 100 pF1KB5 WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKK .:.::: .::: ::.:: :::.::::::: NP_000 HVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK 30 40 50 60 70 80 110 120 130 140 150 160 pF1KB5 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM :: ::::::::::.::.:.:..:::...:::.. :::: :: .:..::::::::::: NP_000 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM 90 100 110 120 130 140 170 180 190 200 210 220 pF1KB5 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKE ::::::.:::.::..::. ...:::. ::.:: .:: ::.::..:.:. :.. : .. NP_000 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN 150 160 170 180 190 200 230 240 250 260 270 280 pF1KB5 GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASF .:.:. . .:.:.::...:: ::.::..::::::..:::.: : . : . NP_000 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTV 210 220 230 240 250 260 290 300 310 320 pF1KB5 SFLPQSSL----SSEKLFQRSIHRE----PGS----------YTGRRTMQSISNEQKACK : . : . : ::. . . :. :.: :....:.:::::.: : NP_000 STVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASK 270 280 290 300 310 320 330 340 350 360 370 380 pF1KB5 VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLF :::::::::..:::::::::: :.: .:::. .. ::..::::::.::.::::::::: NP_000 VLGIVFFLFLLMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF 330 340 350 360 370 380 390 400 410 420 430 440 pF1KB5 NKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDC :::.:.::.::: :.:. .: NP_000 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ 390 400 410 420 430 440 >>NP_062874 (OMIM: 182137) 5-hydroxytryptamine receptor (432 aa) initn: 528 init1: 326 opt: 626 Z-score: 612.7 bits: 122.6 E(85289): 2.2e-27 Smith-Waterman score: 634; 31.8% identity (64.7% similar) in 380 aa overlap (36-404:51-409) 10 20 30 40 50 60 pF1KB5 EENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC :...: : .: . .: . :: NP_062 LPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNAS-----GCGEQ-- 30 40 50 60 70 70 80 90 100 110 120 pF1KB5 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGF .. .... ...:: .. .:::::: ::...: . :::.. .::...:::.::. .. NP_062 INYGRVEKVVIGSILT-LITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV 80 90 100 110 120 130 130 140 150 160 170 180 pF1KB5 LVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS- ::: .: : : .: . .: :.: .::. ::::: ::.::.:::..: :. . NP_062 AVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPV 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB5 RFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSF : :.. : . :..:: .:..:..: :.:: .. : . ::...: .... .. :.: NP_062 RQNGKCMAKM-ILSVWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAF 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 FIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFL-PQSSLSSEKL--FQRSIH .::...:.. :. :. .: :. . :. .: . :.: .. . . .:. .. NP_062 YIPMSVMLFMYYQIYKAARKSAA--------KHKFPGFPRVEPDSVIALNGIVKLQKEVE 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 REPG-SYTGRRTMQSIS---NEQKACKVLGIVFFLFVVMWCPFFI-TNIMAVICKESCNE . . : .. ..:: :::: .:::. :.: : :::. .. :: ::. NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKE-NKKPLQLILVNTI . . .:.:.:: .: .::..:..::. :... .::::.. :.: NP_062 -IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEAL 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 PALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV NP_062 KLAERPERPEFVL 420 430 >>NP_000863 (OMIM: 182137) 5-hydroxytryptamine receptor (445 aa) initn: 528 init1: 326 opt: 626 Z-score: 612.6 bits: 122.6 E(85289): 2.2e-27 Smith-Waterman score: 634; 31.8% identity (64.7% similar) in 380 aa overlap (36-404:51-409) 10 20 30 40 50 60 pF1KB5 EENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC :...: : .: . .: . :: NP_000 LPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNAS-----GCGEQ-- 30 40 50 60 70 70 80 90 100 110 120 pF1KB5 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGF .. .... ...:: .. .:::::: ::...: . :::.. .::...:::.::. .. NP_000 INYGRVEKVVIGSILT-LITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV 80 90 100 110 120 130 130 140 150 160 170 180 pF1KB5 LVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS- ::: .: : : .: . .: :.: .::. ::::: ::.::.:::..: :. . NP_000 AVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPV 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB5 RFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSF : :.. : . :..:: .:..:..: :.:: .. : . ::...: .... .. :.: NP_000 RQNGKCMAKM-ILSVWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAF 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 FIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFL-PQSSLSSEKL--FQRSIH .::...:.. :. :. .: :. . :. .: . :.: .. . . .:. .. NP_000 YIPMSVMLFMYYQIYKAARKSAA--------KHKFPGFPRVEPDSVIALNGIVKLQKEVE 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 REPG-SYTGRRTMQSIS---NEQKACKVLGIVFFLFVVMWCPFFI-TNIMAVICKESCNE . . : .. ..:: :::: .:::. :.: : :::. .. :: ::. NP_000 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKE-NKKPLQLILVNTI . . .:.:.:: .: .::..:..::. :... .::::.. :.: NP_000 -IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEAL 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 PALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV NP_000 KLAERPERPEFVLQNADYCRKKGHDS 420 430 440 >>NP_062873 (OMIM: 182137) 5-hydroxytryptamine receptor (479 aa) initn: 528 init1: 326 opt: 626 Z-score: 612.3 bits: 122.7 E(85289): 2.3e-27 Smith-Waterman score: 634; 31.8% identity (64.7% similar) in 380 aa overlap (36-404:51-409) 10 20 30 40 50 60 pF1KB5 EENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSC :...: : .: . .: . :: NP_062 LPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNAS-----GCGEQ-- 30 40 50 60 70 70 80 90 100 110 120 pF1KB5 LSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGF .. .... ...:: .. .:::::: ::...: . :::.. .::...:::.::. .. NP_062 INYGRVEKVVIGSILT-LITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV 80 90 100 110 120 130 130 140 150 160 170 180 pF1KB5 LVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS- ::: .: : : .: . .: :.: .::. ::::: ::.::.:::..: :. . NP_062 AVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPV 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB5 RFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSF : :.. : . :..:: .:..:..: :.:: .. : . ::...: .... .. :.: NP_062 RQNGKCMAKM-ILSVWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAF 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 FIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFL-PQSSLSSEKL--FQRSIH .::...:.. :. :. .: :. . :. .: . :.: .. . . .:. .. NP_062 YIPMSVMLFMYYQIYKAARKSAA--------KHKFPGFPRVEPDSVIALNGIVKLQKEVE 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 REPG-SYTGRRTMQSIS---NEQKACKVLGIVFFLFVVMWCPFFI-TNIMAVICKESCNE . . : .. ..:: :::: .:::. :.: : :::. .. :: ::. NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKE-NKKPLQLILVNTI . . .:.:.:: .: .::..:..::. :... .::::.. :.: NP_062 -IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEAL 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 PALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV NP_062 KLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD 420 430 440 450 460 470 471 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:36:11 2016 done: Sun Nov 6 14:36:13 2016 Total Scan time: 8.200 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]