FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5871, 464 aa 1>>>pF1KB5871 464 - 464 aa - 464 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.2393+/-0.000548; mu= -26.1197+/- 0.033 mean_var=762.0794+/-175.600, 0's: 0 Z-trim(118.6): 429 B-trim: 1897 in 1/54 Lambda= 0.046459 statistics sampled from 31172 (31710) to 31172 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.372), width: 16 Scan time: 8.340 The best scores are: opt bits E(85289) NP_001251 (OMIM: 603184) cyclin-dependent kinase 8 ( 464) 3211 231.1 5e-60 NP_001305297 (OMIM: 603184) cyclin-dependent kinas ( 463) 3193 229.9 1.2e-59 XP_005266273 (OMIM: 603184) PREDICTED: cyclin-depe ( 404) 2808 204.0 6.2e-52 NP_055891 (OMIM: 614720) cyclin-dependent kinase 1 ( 502) 2453 180.3 1e-44 XP_016875806 (OMIM: 603184) PREDICTED: cyclin-depe ( 338) 2356 173.6 7.2e-43 NP_001287893 (OMIM: 614720) cyclin-dependent kinas ( 442) 2078 155.1 3.5e-37 NP_001287892 (OMIM: 614720) cyclin-dependent kinas ( 442) 2078 155.1 3.5e-37 NP_001333430 (OMIM: 603184) cyclin-dependent kinas ( 291) 2038 152.2 1.7e-36 XP_011533166 (OMIM: 603184) PREDICTED: cyclin-depe ( 291) 2038 152.2 1.7e-36 XP_011533167 (OMIM: 603184) PREDICTED: cyclin-depe ( 291) 2038 152.2 1.7e-36 XP_016875807 (OMIM: 603184) PREDICTED: cyclin-depe ( 290) 2020 151.0 3.9e-36 XP_016866076 (OMIM: 614720) PREDICTED: cyclin-depe ( 442) 2025 151.6 4.1e-36 XP_011533934 (OMIM: 614720) PREDICTED: cyclin-depe ( 256) 1517 117.3 5.1e-26 XP_005266928 (OMIM: 614720) PREDICTED: cyclin-depe ( 378) 1472 114.4 5.3e-25 XP_011533933 (OMIM: 614720) PREDICTED: cyclin-depe ( 515) 1467 114.2 8.3e-25 XP_016866077 (OMIM: 614720) PREDICTED: cyclin-depe ( 329) 1328 104.7 3.9e-22 NP_001287889 (OMIM: 614720) cyclin-dependent kinas ( 458) 1323 104.5 6.2e-22 XP_011533932 (OMIM: 614720) PREDICTED: cyclin-depe ( 555) 1059 86.9 1.5e-16 XP_011521707 (OMIM: 603464) PREDICTED: cyclin-depe ( 392) 504 49.6 1.9e-05 XP_011521709 (OMIM: 603464) PREDICTED: cyclin-depe ( 375) 494 48.9 2.9e-05 XP_011521719 (OMIM: 603464) PREDICTED: cyclin-depe ( 261) 484 48.0 3.6e-05 XP_011521710 (OMIM: 603464) PREDICTED: cyclin-depe ( 369) 486 48.3 4.1e-05 XP_011521708 (OMIM: 603464) PREDICTED: cyclin-depe ( 386) 486 48.4 4.3e-05 NP_112557 (OMIM: 603309) cyclin-dependent kinase 1 (1452) 479 48.5 0.00014 NP_003709 (OMIM: 603309) cyclin-dependent kinase 1 (1512) 479 48.5 0.00015 XP_016879295 (OMIM: 603464) PREDICTED: cyclin-depe ( 355) 455 46.2 0.00017 XP_005257515 (OMIM: 615514) PREDICTED: cyclin-depe (1256) 468 47.7 0.00021 XP_016880242 (OMIM: 615514) PREDICTED: cyclin-depe (1261) 468 47.7 0.00021 XP_016880240 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 468 47.7 0.00021 XP_016880241 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 468 47.7 0.00021 XP_016880239 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 468 47.7 0.00021 XP_011523209 (OMIM: 615514) PREDICTED: cyclin-depe (1262) 468 47.7 0.00021 XP_011523203 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523196 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523205 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523197 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523207 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523202 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523204 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523198 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523201 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_016880233 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_016880238 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523199 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_016880234 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523208 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523195 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_016880235 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_016880236 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 XP_011523200 (OMIM: 615514) PREDICTED: cyclin-depe (1393) 468 47.8 0.00023 >>NP_001251 (OMIM: 603184) cyclin-dependent kinase 8 iso (464 aa) initn: 3211 init1: 3211 opt: 3211 Z-score: 1198.7 bits: 231.1 E(85289): 5e-60 Smith-Waterman score: 3211; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464) 10 20 30 40 50 60 pF1KB5 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS 370 380 390 400 410 420 430 440 450 460 pF1KB5 DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY :::::::::::::::::::::::::::::::::::::::::::: NP_001 DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY 430 440 450 460 >>NP_001305297 (OMIM: 603184) cyclin-dependent kinase 8 (463 aa) initn: 2651 init1: 2599 opt: 3193 Z-score: 1192.2 bits: 229.9 E(85289): 1.2e-59 Smith-Waterman score: 3193; 99.8% identity (99.8% similar) in 464 aa overlap (1-464:1-463) 10 20 30 40 50 60 pF1KB5 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEPDDKGDK-NQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS 370 380 390 400 410 430 440 450 460 pF1KB5 DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY :::::::::::::::::::::::::::::::::::::::::::: NP_001 DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY 420 430 440 450 460 >>XP_005266273 (OMIM: 603184) PREDICTED: cyclin-dependen (404 aa) initn: 2808 init1: 2808 opt: 2808 Z-score: 1053.4 bits: 204.0 E(85289): 6.2e-52 Smith-Waterman score: 2808; 100.0% identity (100.0% similar) in 404 aa overlap (61-464:1-404) 40 50 60 70 80 90 pF1KB5 TYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHAD :::::::::::::::::::::::::::::: XP_005 MSACREIALLRELKHPNVISLQKVFLSHAD 10 20 30 100 110 120 130 140 150 pF1KB5 RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 DLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB5 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB5 KKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAM 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB5 QDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGN 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB5 QDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSAT 340 350 360 370 380 390 460 pF1KB5 SQQPPQYSHQTHRY :::::::::::::: XP_005 SQQPPQYSHQTHRY 400 >>NP_055891 (OMIM: 614720) cyclin-dependent kinase 19 is (502 aa) initn: 2629 init1: 2400 opt: 2453 Z-score: 923.7 bits: 180.3 E(85289): 1e-44 Smith-Waterman score: 2552; 77.9% identity (87.2% similar) in 493 aa overlap (1-457:1-493) 10 20 30 40 50 60 pF1KB5 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS ::::::.::..:::::::::::::::::::::::::::.::::::.:.:::::::::::: NP_055 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP :::::::::::::::::::.::::::::.::::::::::::::::::::::::::::::: NP_055 MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF .::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH ::::::.:::::::::.:::::::::::::.::::. ::.:::::.::.: ::::::::: NP_055 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT :::::::.: :::::::::: ::::::::.::::: :::::: ::::::::::::::::. NP_055 KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN 310 320 330 340 350 360 370 380 pF1KB5 EEEPDDKGDKKNQQQQ-----------------------QGNNHTNGT-GHPG------- :..:..::::..:::: :....:::: : : NP_055 EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB5 -----NQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSS .:::: .: :: :: :. : ..::: .: ::::.:. . : . ..:: ::. NP_055 AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST 430 440 450 460 470 480 450 460 pF1KB5 MGYSATSQQPPQYSHQTHRY .:::..::: :: NP_055 LGYSSSSQQSSQYHPSHQAHRY 490 500 >>XP_016875806 (OMIM: 603184) PREDICTED: cyclin-dependen (338 aa) initn: 2356 init1: 2356 opt: 2356 Z-score: 890.6 bits: 173.6 E(85289): 7.2e-43 Smith-Waterman score: 2356; 100.0% identity (100.0% similar) in 338 aa overlap (127-464:1-338) 100 110 120 130 140 150 pF1KB5 FDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPAN :::::::::::::::::::::::::::::: XP_016 MVKSLLYQILDGIHYLHANWVLHRDLKPAN 10 20 30 160 170 180 190 200 210 pF1KB5 ILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAID 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB5 IWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH 100 110 120 130 140 150 280 290 300 310 320 330 pF1KB5 STLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFL 160 170 180 190 200 210 340 350 360 370 380 390 pF1KB5 EDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHT 220 230 240 250 260 270 400 410 420 430 440 450 pF1KB5 QGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQ 280 290 300 310 320 330 460 pF1KB5 YSHQTHRY :::::::: XP_016 YSHQTHRY >>NP_001287893 (OMIM: 614720) cyclin-dependent kinase 19 (442 aa) initn: 2254 init1: 2025 opt: 2078 Z-score: 788.5 bits: 155.1 E(85289): 3.5e-37 Smith-Waterman score: 2177; 76.2% identity (85.5% similar) in 433 aa overlap (61-457:1-433) 40 50 60 70 80 90 pF1KB5 TYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHAD :::::::::::::::::::.::::::::.: NP_001 MSACREIALLRELKHPNVIALQKVFLSHSD 10 20 30 100 110 120 130 140 150 pF1KB5 RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHR ::::::::::::::::::::::::::::::.::::.:::::::::::::::::::::::: NP_001 RKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 DLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB5 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDI ::::::::::::::::::::::::::::::::::::.:::::::::.::::::::::::: NP_001 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB5 KKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAM .::::. ::.:::::.::.: ::::::::::::::::.: :::::::::: ::::::::. NP_001 RKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQAL 220 230 240 250 260 270 340 350 360 370 pF1KB5 QDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQ-------------- ::::: :::::: ::::::::::::::::.:..:..::::..:::: NP_001 QDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAA 280 290 300 310 320 330 380 390 400 410 pF1KB5 ---------QGNNHTNGT-GHPG------------NQDSSHTQGPPLKKVRVVPPTTTSG :....:::: : : .:::: .: :: :: :. : ..:: NP_001 APPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSG 340 350 360 370 380 390 420 430 440 450 460 pF1KB5 GLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY : .: ::::.:. . : . ..:: ::..:::..::: :: NP_001 GPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY 400 410 420 430 440 >>NP_001287892 (OMIM: 614720) cyclin-dependent kinase 19 (442 aa) initn: 2254 init1: 2025 opt: 2078 Z-score: 788.5 bits: 155.1 E(85289): 3.5e-37 Smith-Waterman score: 2177; 76.2% identity (85.5% similar) in 433 aa overlap (61-457:1-433) 40 50 60 70 80 90 pF1KB5 TYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHAD :::::::::::::::::::.::::::::.: NP_001 MSACREIALLRELKHPNVIALQKVFLSHSD 10 20 30 100 110 120 130 140 150 pF1KB5 RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHR ::::::::::::::::::::::::::::::.::::.:::::::::::::::::::::::: NP_001 RKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 DLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB5 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDI ::::::::::::::::::::::::::::::::::::.:::::::::.::::::::::::: NP_001 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB5 KKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAM .::::. ::.:::::.::.: ::::::::::::::::.: :::::::::: ::::::::. NP_001 RKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQAL 220 230 240 250 260 270 340 350 360 370 pF1KB5 QDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQ-------------- ::::: :::::: ::::::::::::::::.:..:..::::..:::: NP_001 QDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAA 280 290 300 310 320 330 380 390 400 410 pF1KB5 ---------QGNNHTNGT-GHPG------------NQDSSHTQGPPLKKVRVVPPTTTSG :....:::: : : .:::: .: :: :: :. : ..:: NP_001 APPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSG 340 350 360 370 380 390 420 430 440 450 460 pF1KB5 GLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY : .: ::::.:. . : . ..:: ::..:::..::: :: NP_001 GPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY 400 410 420 430 440 >>NP_001333430 (OMIM: 603184) cyclin-dependent kinase 8 (291 aa) initn: 2038 init1: 2038 opt: 2038 Z-score: 776.2 bits: 152.2 E(85289): 1.7e-36 Smith-Waterman score: 2038; 100.0% identity (100.0% similar) in 291 aa overlap (174-464:1-291) 150 160 170 180 190 200 pF1KB5 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE :::::::::::::::::::::::::::::: NP_001 MGFARLFNSPLKPLADLDPVVVTFWYRAPE 10 20 30 210 220 230 240 250 260 pF1KB5 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA 40 50 60 70 80 90 270 280 290 300 310 320 pF1KB5 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR 100 110 120 130 140 150 330 340 350 360 370 380 pF1KB5 ITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTN 160 170 180 190 200 210 390 400 410 420 430 440 pF1KB5 GTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQS 220 230 240 250 260 270 450 460 pF1KB5 SMGYSATSQQPPQYSHQTHRY ::::::::::::::::::::: NP_001 SMGYSATSQQPPQYSHQTHRY 280 290 >>XP_011533166 (OMIM: 603184) PREDICTED: cyclin-dependen (291 aa) initn: 2038 init1: 2038 opt: 2038 Z-score: 776.2 bits: 152.2 E(85289): 1.7e-36 Smith-Waterman score: 2038; 100.0% identity (100.0% similar) in 291 aa overlap (174-464:1-291) 150 160 170 180 190 200 pF1KB5 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE :::::::::::::::::::::::::::::: XP_011 MGFARLFNSPLKPLADLDPVVVTFWYRAPE 10 20 30 210 220 230 240 250 260 pF1KB5 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA 40 50 60 70 80 90 270 280 290 300 310 320 pF1KB5 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR 100 110 120 130 140 150 330 340 350 360 370 380 pF1KB5 ITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTN 160 170 180 190 200 210 390 400 410 420 430 440 pF1KB5 GTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQS 220 230 240 250 260 270 450 460 pF1KB5 SMGYSATSQQPPQYSHQTHRY ::::::::::::::::::::: XP_011 SMGYSATSQQPPQYSHQTHRY 280 290 >>XP_011533167 (OMIM: 603184) PREDICTED: cyclin-dependen (291 aa) initn: 2038 init1: 2038 opt: 2038 Z-score: 776.2 bits: 152.2 E(85289): 1.7e-36 Smith-Waterman score: 2038; 100.0% identity (100.0% similar) in 291 aa overlap (174-464:1-291) 150 160 170 180 190 200 pF1KB5 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE :::::::::::::::::::::::::::::: XP_011 MGFARLFNSPLKPLADLDPVVVTFWYRAPE 10 20 30 210 220 230 240 250 260 pF1KB5 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA 40 50 60 70 80 90 270 280 290 300 310 320 pF1KB5 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR 100 110 120 130 140 150 330 340 350 360 370 380 pF1KB5 ITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTN 160 170 180 190 200 210 390 400 410 420 430 440 pF1KB5 GTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQS 220 230 240 250 260 270 450 460 pF1KB5 SMGYSATSQQPPQYSHQTHRY ::::::::::::::::::::: XP_011 SMGYSATSQQPPQYSHQTHRY 280 290 464 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:29:54 2016 done: Sun Nov 6 05:29:55 2016 Total Scan time: 8.340 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]