FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5624, 2286 aa 1>>>pF1KB5624 2286 - 2286 aa - 2286 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.6944+/-0.0013; mu= 13.4862+/- 0.078 mean_var=113.2097+/-22.567, 0's: 0 Z-trim(103.5): 18 B-trim: 163 in 1/49 Lambda= 0.120540 statistics sampled from 7446 (7452) to 7446 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.229), width: 16 Scan time: 4.120 The best scores are: opt bits E(32554) CCDS9278.1 POLE gene_id:5426|Hs108|chr12 (2286) 15330 2678.5 0 >>CCDS9278.1 POLE gene_id:5426|Hs108|chr12 (2286 aa) initn: 15330 init1: 15330 opt: 15330 Z-score: 14400.8 bits: 2678.5 E(32554): 0 Smith-Waterman score: 15330; 100.0% identity (100.0% similar) in 2286 aa overlap (1-2286:1-2286) 10 20 30 40 50 60 pF1KB5 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 GWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 SKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 AHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 AHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 DGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 SHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 SHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 LCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 DEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 ANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 ANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 RRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 RRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 AAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 AAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 NIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 NIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIM 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB5 VKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 VKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFN 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB5 EDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 EDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSK 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB5 AANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 AANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYII 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB5 SRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 SRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB5 IQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 IQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEA 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB5 SEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 SEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPA 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KB5 LGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 LGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLR 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KB5 RTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 RTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGAS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KB5 YRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 YRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVH 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KB5 LGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 LGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALF 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KB5 GIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 GIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETD 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KB5 LKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 LKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYG 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KB5 VLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 VLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRH 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KB5 NHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 NHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTIL 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KB5 QSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 QSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVV 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KB5 GWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 GWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLG 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 pF1KB5 SSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 SSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPS 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 pF1KB5 NYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 NYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNW 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 pF1KB5 NILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 NILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGA 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 pF1KB5 VGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 VGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNP 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 pF1KB5 ALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 ALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRS 2110 2120 2130 2140 2150 2160 2170 2180 2190 2200 2210 2220 pF1KB5 CNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 CNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLV 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 pF1KB5 CLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS92 CLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQK 2230 2240 2250 2260 2270 2280 pF1KB5 NPQLGH :::::: CCDS92 NPQLGH 2286 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 17:29:21 2016 done: Tue Nov 8 17:29:22 2016 Total Scan time: 4.120 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]