FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6256, 209 aa 1>>>pF1KE6256 209 - 209 aa - 209 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2473+/-0.000392; mu= 13.3873+/- 0.024 mean_var=56.2458+/-11.450, 0's: 0 Z-trim(112.2): 25 B-trim: 570 in 2/47 Lambda= 0.171013 statistics sampled from 20986 (21011) to 20986 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.246), width: 16 Scan time: 4.990 The best scores are: opt bits E(85289) NP_057517 (OMIM: 608949) glycolipid transfer prote ( 209) 1379 348.3 5.4e-96 XP_011536736 (OMIM: 608949) PREDICTED: glycolipid ( 168) 1021 259.9 1.7e-69 XP_016868235 (OMIM: 608639) PREDICTED: pleckstrin ( 320) 364 97.9 1.9e-20 XP_016868236 (OMIM: 608639) PREDICTED: pleckstrin ( 320) 364 97.9 1.9e-20 XP_011513898 (OMIM: 608639) PREDICTED: pleckstrin ( 350) 364 97.9 2.1e-20 NP_001183955 (OMIM: 608639) pleckstrin homology do ( 519) 364 98.0 2.9e-20 XP_016868233 (OMIM: 608639) PREDICTED: pleckstrin ( 491) 311 84.9 2.4e-16 XP_011513893 (OMIM: 608639) PREDICTED: pleckstrin ( 491) 311 84.9 2.4e-16 XP_011513896 (OMIM: 608639) PREDICTED: pleckstrin ( 455) 309 84.4 3.2e-16 NP_001183956 (OMIM: 608639) pleckstrin homology do ( 459) 309 84.4 3.2e-16 XP_011513894 (OMIM: 608639) PREDICTED: pleckstrin ( 475) 309 84.4 3.3e-16 XP_016868238 (OMIM: 608639) PREDICTED: pleckstrin ( 260) 255 71.0 2e-12 XP_016868237 (OMIM: 608639) PREDICTED: pleckstrin ( 290) 255 71.0 2.2e-12 XP_011513897 (OMIM: 608639) PREDICTED: pleckstrin ( 439) 255 71.1 3.2e-12 NP_116028 (OMIM: 608639) pleckstrin homology domai ( 440) 255 71.1 3.2e-12 XP_016868234 (OMIM: 608639) PREDICTED: pleckstrin ( 441) 255 71.1 3.2e-12 XP_005249954 (OMIM: 608639) PREDICTED: pleckstrin ( 459) 255 71.1 3.3e-12 XP_011540502 (OMIM: 615467) PREDICTED: ceramide-1- ( 214) 156 46.5 3.7e-05 NP_001025056 (OMIM: 615467) ceramide-1-phosphate t ( 214) 156 46.5 3.7e-05 XP_005244858 (OMIM: 615467) PREDICTED: ceramide-1- ( 214) 156 46.5 3.7e-05 XP_005244859 (OMIM: 615467) PREDICTED: ceramide-1- ( 151) 122 38.1 0.0091 >>NP_057517 (OMIM: 608949) glycolipid transfer protein [ (209 aa) initn: 1379 init1: 1379 opt: 1379 Z-score: 1844.4 bits: 348.3 E(85289): 5.4e-96 Smith-Waterman score: 1379; 100.0% identity (100.0% similar) in 209 aa overlap (1-209:1-209) 10 20 30 40 50 60 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 PNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKI 130 140 150 160 170 180 190 200 pF1KE6 RLFLVNYTATIDVIYEMYTQMNAELNYKV ::::::::::::::::::::::::::::: NP_057 RLFLVNYTATIDVIYEMYTQMNAELNYKV 190 200 >>XP_011536736 (OMIM: 608949) PREDICTED: glycolipid tran (168 aa) initn: 1042 init1: 1021 opt: 1021 Z-score: 1368.6 bits: 259.9 E(85289): 1.7e-69 Smith-Waterman score: 1021; 98.1% identity (98.7% similar) in 159 aa overlap (51-209:10-168) 30 40 50 60 70 80 pF1KE6 GPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEM :. :::::::::::::::::::::::::: XP_011 MTATSGLPPGSYKKIKAVYDTNPAKFRTLQNILEVEKEM 10 20 30 90 100 110 120 130 140 pF1KE6 YGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYH 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 GWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQ 100 110 120 130 140 150 pF1KE6 MNAELNYKV ::::::::: XP_011 MNAELNYKV 160 >>XP_016868235 (OMIM: 608639) PREDICTED: pleckstrin homo (320 aa) initn: 352 init1: 142 opt: 364 Z-score: 488.1 bits: 97.9 E(85289): 1.9e-20 Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:128-312) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: XP_016 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 100 110 120 130 140 150 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. XP_016 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 160 170 180 190 200 210 110 120 130 140 150 160 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA . :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. : XP_016 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA 220 230 240 250 260 270 170 180 190 200 pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV :. .. ..: . . . :.: . : .:..::.. XP_016 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV 280 290 300 310 320 >>XP_016868236 (OMIM: 608639) PREDICTED: pleckstrin homo (320 aa) initn: 352 init1: 142 opt: 364 Z-score: 488.1 bits: 97.9 E(85289): 1.9e-20 Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:128-312) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: XP_016 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 100 110 120 130 140 150 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. XP_016 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 160 170 180 190 200 210 110 120 130 140 150 160 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA . :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. : XP_016 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA 220 230 240 250 260 270 170 180 190 200 pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV :. .. ..: . . . :.: . : .:..::.. XP_016 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV 280 290 300 310 320 >>XP_011513898 (OMIM: 608639) PREDICTED: pleckstrin homo (350 aa) initn: 352 init1: 142 opt: 364 Z-score: 487.4 bits: 97.9 E(85289): 2.1e-20 Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:158-342) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: XP_011 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 130 140 150 160 170 180 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. XP_011 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 190 200 210 220 230 240 110 120 130 140 150 160 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA . :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. : XP_011 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA 250 260 270 280 290 300 170 180 190 200 pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV :. .. ..: . . . :.: . : .:..::.. XP_011 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV 310 320 330 340 350 >>NP_001183955 (OMIM: 608639) pleckstrin homology domain (519 aa) initn: 352 init1: 142 opt: 364 Z-score: 484.7 bits: 98.0 E(85289): 2.9e-20 Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:327-511) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: NP_001 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 300 310 320 330 340 350 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. NP_001 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 360 370 380 390 400 410 110 120 130 140 150 160 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA . :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. : NP_001 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA 420 430 440 450 460 170 180 190 200 pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV :. .. ..: . . . :.: . : .:..::.. NP_001 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV 470 480 490 500 510 >>XP_016868233 (OMIM: 608639) PREDICTED: pleckstrin homo (491 aa) initn: 303 init1: 142 opt: 311 Z-score: 414.4 bits: 84.9 E(85289): 2.4e-16 Smith-Waterman score: 311; 39.9% identity (62.8% similar) in 148 aa overlap (15-157:327-467) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: XP_016 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 300 310 320 330 340 350 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. XP_016 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 360 370 380 390 400 410 110 120 130 140 150 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIF----QAALYAA-PYKS . :: . .::.: :.. ..:: .:...:::.:. .: : : .: :: XP_016 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAVLDQMKLQTAHPYLQ 420 430 440 450 460 160 170 180 190 200 pF1KE6 DFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV XP_016 YTLNNHNGYHVAIGHLLCTRHS 470 480 490 >>XP_011513893 (OMIM: 608639) PREDICTED: pleckstrin homo (491 aa) initn: 303 init1: 142 opt: 311 Z-score: 414.4 bits: 84.9 E(85289): 2.4e-16 Smith-Waterman score: 311; 39.9% identity (62.8% similar) in 148 aa overlap (15-157:327-467) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: XP_011 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 300 310 320 330 340 350 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. XP_011 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 360 370 380 390 400 410 110 120 130 140 150 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIF----QAALYAA-PYKS . :: . .::.: :.. ..:: .:...:::.:. .: : : .: :: XP_011 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAVLDQMKLQTAHPYLQ 420 430 440 450 460 160 170 180 190 200 pF1KE6 DFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV XP_011 YTLNNHNGYHVAIGHLLCTRHS 470 480 490 >>XP_011513896 (OMIM: 608639) PREDICTED: pleckstrin homo (455 aa) initn: 303 init1: 142 opt: 309 Z-score: 412.3 bits: 84.4 E(85289): 3.2e-16 Smith-Waterman score: 309; 40.3% identity (64.9% similar) in 134 aa overlap (15-148:327-453) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: XP_011 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 300 310 320 330 340 350 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. XP_011 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 360 370 380 390 400 410 110 120 130 140 150 160 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA . :: . .::.: :.. ..:: .:...:::.:. .: XP_011 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAV 420 430 440 450 170 180 190 200 pF1KE6 LSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV >>NP_001183956 (OMIM: 608639) pleckstrin homology domain (459 aa) initn: 303 init1: 142 opt: 309 Z-score: 412.2 bits: 84.4 E(85289): 3.2e-16 Smith-Waterman score: 309; 40.3% identity (64.9% similar) in 134 aa overlap (15-148:327-453) 10 20 30 40 pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP :. : : :: . . : .: :: ::.: NP_001 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 300 310 320 330 340 350 50 60 70 80 90 100 pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI .: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:. NP_001 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL 360 370 380 390 400 410 110 120 130 140 150 160 pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA . :: . .::.: :.. ..:: .:...:::.:. .: NP_001 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAGHTNV 420 430 440 450 170 180 190 200 pF1KE6 LSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV 209 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:31:52 2016 done: Tue Nov 8 11:31:53 2016 Total Scan time: 4.990 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]