FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2734, 313 aa 1>>>pF1KE2734 313 - 313 aa - 313 aa Library: /omim/omim.rfq.tfa 64942286 residues in 91783 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1477+/-0.000367; mu= 16.4618+/- 0.023 mean_var=64.5755+/-13.138, 0's: 0 Z-trim(112.5): 123 B-trim: 969 in 1/53 Lambda= 0.159603 statistics sampled from 22105 (22235) to 22105 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.242), width: 16 Scan time: 3.270 The best scores are: opt bits E(91783) NP_683695 (OMIM: 609769,617574) short-chain dehydr ( 313) 2071 485.7 5.5e-137 XP_006719735 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70 XP_005269266 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70 XP_011537227 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70 XP_005269265 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70 XP_011537228 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70 XP_005269264 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70 XP_011537229 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70 NP_003716 (OMIM: 606623) 17-beta-hydroxysteroid de ( 317) 1103 262.8 6.9e-70 NP_002896 (OMIM: 136880,601617) 11-cis retinol deh ( 318) 1004 240.0 5e-63 NP_001186700 (OMIM: 136880,601617) 11-cis retinol ( 318) 1004 240.0 5e-63 NP_001135743 (OMIM: 612131) dehydrogenase/reductas ( 319) 940 225.3 1.4e-58 NP_954674 (OMIM: 612131) dehydrogenase/reductase S ( 319) 940 225.3 1.4e-58 NP_001135742 (OMIM: 612131) dehydrogenase/reductas ( 319) 940 225.3 1.4e-58 XP_011508777 (OMIM: 612131) dehydrogenase/reductas ( 319) 940 225.3 1.4e-58 NP_001276692 (OMIM: 612131) dehydrogenase/reductas ( 379) 940 225.3 1.6e-58 XP_024305019 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 917 220.0 4.6e-57 XP_024305018 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 917 220.0 4.6e-57 XP_024305017 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 917 220.0 4.6e-57 XP_016862498 (OMIM: 603063) D-beta-hydroxybutyrate ( 324) 661 161.1 3e-39 XP_016862499 (OMIM: 603063) D-beta-hydroxybutyrate ( 324) 661 161.1 3e-39 XP_016862501 (OMIM: 603063) D-beta-hydroxybutyrate ( 330) 661 161.1 3.1e-39 XP_016862497 (OMIM: 603063) D-beta-hydroxybutyrate ( 330) 661 161.1 3.1e-39 XP_016862500 (OMIM: 603063) D-beta-hydroxybutyrate ( 330) 661 161.1 3.1e-39 NP_976059 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 661 161.1 3.2e-39 NP_976060 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 661 161.1 3.2e-39 NP_004042 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 661 161.1 3.2e-39 XP_005269409 (OMIM: 603063) D-beta-hydroxybutyrate ( 343) 661 161.1 3.2e-39 XP_016862496 (OMIM: 603063) D-beta-hydroxybutyrate ( 343) 661 161.1 3.2e-39 XP_011511369 (OMIM: 603063) D-beta-hydroxybutyrate ( 347) 661 161.1 3.2e-39 NP_002144 (OMIM: 109685) estradiol 17-beta-dehydro ( 387) 560 137.9 3.5e-32 XP_005269412 (OMIM: 603063) D-beta-hydroxybutyrate ( 206) 490 121.6 1.5e-27 XP_016862504 (OMIM: 603063) D-beta-hydroxybutyrate ( 206) 490 121.6 1.5e-27 NP_000187 (OMIM: 218030,614232) corticosteroid 11- ( 405) 481 119.7 1.1e-26 NP_000404 (OMIM: 109684) estradiol 17-beta-dehydro ( 328) 304 78.9 1.7e-14 NP_001317148 (OMIM: 109684) estradiol 17-beta-dehy ( 329) 292 76.1 1.2e-13 NP_056540 (OMIM: 608575) retinol dehydrogenase 8 [ ( 331) 291 75.9 1.4e-13 NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 251 66.7 8.3e-11 XP_016876857 (OMIM: 612833) dehydrogenase/reductas ( 404) 251 66.7 9.6e-11 NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 239 63.9 4.9e-10 NP_620419 (OMIM: 608989) epidermal retinol dehydro ( 309) 238 63.7 6.1e-10 NP_001304978 (OMIM: 608989) epidermal retinol dehy ( 318) 238 63.7 6.3e-10 XP_024306453 (OMIM: 616160) dehydrogenase/reductas ( 287) 232 62.3 1.5e-09 NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 232 62.3 1.6e-09 XP_016879915 (OMIM: 616160) dehydrogenase/reductas ( 325) 232 62.3 1.7e-09 NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325) 232 62.3 1.7e-09 XP_011522088 (OMIM: 616160) dehydrogenase/reductas ( 334) 232 62.3 1.7e-09 XP_005256652 (OMIM: 616160) dehydrogenase/reductas ( 372) 232 62.3 1.9e-09 NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 228 61.3 2.7e-09 NP_000851 (OMIM: 119900,259100,601688) 15-hydroxyp ( 266) 212 57.6 3.4e-08 >>NP_683695 (OMIM: 609769,617574) short-chain dehydrogen (313 aa) initn: 2071 init1: 2071 opt: 2071 Z-score: 2580.9 bits: 485.7 E(91783): 5.5e-137 Smith-Waterman score: 2071; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313) 10 20 30 40 50 60 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF 250 260 270 280 290 300 310 pF1KE2 ILSRYLPRPADSV ::::::::::::: NP_683 ILSRYLPRPADSV 310 >>XP_006719735 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: XP_006 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : XP_006 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: XP_006 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. XP_006 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: XP_006 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: XP_006 LADYILTRSWPKPAQAV 310 >>XP_005269266 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: XP_005 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : XP_005 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: XP_005 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. XP_005 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: XP_005 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: XP_005 LADYILTRSWPKPAQAV 310 >>XP_011537227 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: XP_011 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : XP_011 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: XP_011 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. XP_011 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: XP_011 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: XP_011 LADYILTRSWPKPAQAV 310 >>XP_005269265 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: XP_005 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : XP_005 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: XP_005 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. XP_005 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: XP_005 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: XP_005 LADYILTRSWPKPAQAV 310 >>XP_011537228 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: XP_011 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : XP_011 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: XP_011 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. XP_011 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: XP_011 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: XP_011 LADYILTRSWPKPAQAV 310 >>XP_005269264 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: XP_005 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : XP_005 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: XP_005 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. XP_005 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: XP_005 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: XP_005 LADYILTRSWPKPAQAV 310 >>XP_011537229 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: XP_011 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : XP_011 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: XP_011 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. XP_011 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: XP_011 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: XP_011 LADYILTRSWPKPAQAV 310 >>NP_003716 (OMIM: 606623) 17-beta-hydroxysteroid dehydr (317 aa) initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70 Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC .::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..::::: NP_003 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG .::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. : NP_003 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK :::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . ::::::: NP_003 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE .::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::. NP_003 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .:: . .:. . . : . ::::..: :: ::. : :::...:::. ::: NP_003 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..:.::.: :.::..: NP_003 LADYILTRSWPKPAQAV 310 >>NP_002896 (OMIM: 136880,601617) 11-cis retinol dehydro (318 aa) initn: 980 init1: 810 opt: 1004 Z-score: 1253.1 bits: 240.0 E(91783): 5e-63 Smith-Waterman score: 1004; 51.2% identity (77.0% similar) in 291 aa overlap (24-313:27-317) 10 20 30 40 50 pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACF :. .::::::::::: ::: :: .::..:::.:. NP_002 MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 TEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGP : :.. ::: .: ::.:::::.: .:.. ::.::. .: : ::..:::::::. :: NP_002 TPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 NEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKF . :::.::: .:.::: .: : ::: .::....:::::.:..: ::.:. ::::::::: NP_002 TPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 GVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGED :.::::::.::.. .::..: :.::: .:: . . :.::. .. : ::: :. :: NP_002 GLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 YFRIYTDKLKNIMQ-VAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP .. : . ::. . .: . : .:::...: :: ::.:: :::::..: . ::. NP_002 FLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAS 250 260 270 280 290 300 300 310 pF1KE2 VTDFILSRYLPRPADSV ..: .:. ::.::..: NP_002 LVDAVLTWVLPKPAQAVY 310 313 residues in 1 query sequences 64942286 residues in 91783 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Sep 25 16:01:40 2018 done: Tue Sep 25 16:01:40 2018 Total Scan time: 3.270 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]