FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2289, 508 aa 1>>>pF1KE2289 508 - 508 aa - 508 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4096+/-0.000337; mu= 13.8630+/- 0.021 mean_var=102.6008+/-20.382, 0's: 0 Z-trim(117.8): 76 B-trim: 0 in 0/53 Lambda= 0.126619 statistics sampled from 30148 (30224) to 30148 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.354), width: 16 Scan time: 10.090 The best scores are: opt bits E(85289) NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 3547 658.4 1.4e-188 XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 2455 458.9 1.2e-128 XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 2051 385.1 2e-106 XP_006719464 (OMIM: 601807,611543) PREDICTED: matr ( 279) 1989 373.7 4e-103 XP_011536661 (OMIM: 601807,611543) PREDICTED: matr ( 426) 1802 339.6 1.1e-92 NP_001259030 (OMIM: 601807,611543) matrix metallop ( 305) 1190 227.7 3.7e-59 NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 854 166.5 1.6e-40 NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 848 165.4 3.4e-40 NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 805 157.5 7.9e-38 NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 723 142.5 2.6e-33 XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30 XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30 XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30 XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 658 130.6 8.9e-30 NP_077278 (OMIM: 608417) matrix metalloproteinase- ( 520) 658 130.7 1e-29 NP_002418 (OMIM: 250400,600108,602111) collagenase ( 471) 654 129.9 1.6e-29 NP_004986 (OMIM: 277950,600754) matrix metalloprot ( 582) 633 126.1 2.7e-28 XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 622 124.0 8.2e-28 NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 614 122.6 2.2e-27 XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 613 122.4 2.4e-27 NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 607 121.3 6e-27 NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 589 118.1 5.9e-26 NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 562 113.1 1.6e-24 XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 532 107.6 6.7e-23 XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 532 107.6 6.7e-23 XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 532 107.6 6.7e-23 NP_002414 (OMIM: 178990) matrilysin preproprotein ( 267) 507 102.9 1.2e-21 XP_016874796 (OMIM: 602285) PREDICTED: matrix meta ( 434) 498 101.4 5.6e-21 XP_016883087 (OMIM: 604871) PREDICTED: matrix meta ( 614) 497 101.3 8.4e-21 NP_006681 (OMIM: 604871) matrix metalloproteinase- ( 645) 497 101.3 8.8e-21 XP_016883086 (OMIM: 604871) PREDICTED: matrix meta ( 591) 496 101.1 9.3e-21 XP_016880550 (OMIM: 608417) PREDICTED: matrix meta ( 409) 491 100.1 1.3e-20 XP_011523534 (OMIM: 608417) PREDICTED: matrix meta ( 494) 491 100.2 1.5e-20 NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 475 97.1 6.8e-20 NP_005932 (OMIM: 602262) matrix metalloproteinase- ( 607) 479 98.0 8.1e-20 XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 475 97.2 9.2e-20 XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 475 97.2 1.1e-19 XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 467 95.5 1.5e-19 NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 470 96.3 2e-19 XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 470 96.3 2e-19 NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 470 96.3 2e-19 XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 470 96.3 2e-19 NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 470 96.3 2.1e-19 XP_011523527 (OMIM: 608417) PREDICTED: matrix meta ( 445) 434 89.7 1.9e-17 NP_671724 (OMIM: 608416,616749) matrix metalloprot ( 569) 421 87.4 1.2e-16 XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 381 80.1 1.8e-14 XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 381 80.1 1.8e-14 XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 381 80.1 1.8e-14 NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 381 80.1 2e-14 NP_008914 (OMIM: 603321) matrix metalloproteinase- ( 390) 371 78.2 4.9e-14 >>NP_002420 (OMIM: 601807,611543) matrix metalloproteina (508 aa) initn: 3547 init1: 3547 opt: 3547 Z-score: 3506.7 bits: 658.4 E(85289): 1.4e-188 Smith-Waterman score: 3547; 100.0% identity (100.0% similar) in 508 aa overlap (1-508:1-508) 10 20 30 40 50 60 pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT 430 440 450 460 470 480 490 500 pF1KE2 PSGGNTTPSGTGITLDTTLSATETTFEY :::::::::::::::::::::::::::: NP_002 PSGGNTTPSGTGITLDTTLSATETTFEY 490 500 >>XP_016874798 (OMIM: 601807,611543) PREDICTED: matrix m (366 aa) initn: 2477 init1: 2455 opt: 2455 Z-score: 2430.7 bits: 458.9 E(85289): 1.2e-128 Smith-Waterman score: 2455; 99.4% identity (99.7% similar) in 357 aa overlap (1-357:1-357) 10 20 30 40 50 60 pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY :::::::::::::::::::::::::::::::::::::::::::::::::::::: .: XP_016 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGLRVLAV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG XP_016 GRASPN >>XP_016874797 (OMIM: 601807,611543) PREDICTED: matrix m (387 aa) initn: 2051 init1: 2051 opt: 2051 Z-score: 2031.5 bits: 385.1 E(85289): 2e-106 Smith-Waterman score: 2053; 90.9% identity (92.7% similar) in 342 aa overlap (1-333:1-340) 10 20 30 40 50 60 pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGE 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 R------GKTYAFKGD-YVWTV-SDSG-PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHF :. .. .: .:: :: : .: : :: : XP_016 APPLQAVGRRWGQPADPEAWTNGSDMGLQHEQWR--APWEDLCFQGGLCVDCIRFRTGPL 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 FKGDKVWRYINFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDF XP_016 VPSVCPLGGAPRKPGCCCLLASNTMDSLL 360 370 380 >>XP_006719464 (OMIM: 601807,611543) PREDICTED: matrix m (279 aa) initn: 1989 init1: 1989 opt: 1989 Z-score: 1972.4 bits: 373.7 E(85289): 4e-103 Smith-Waterman score: 1989; 100.0% identity (100.0% similar) in 279 aa overlap (230-508:1-279) 200 210 220 230 240 250 pF1KE2 TYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKS :::::::::::::::::::::::::::::: XP_006 MAPVYEGYRPHFKLHPDDVAGIQALYGKKS 10 20 30 260 270 280 290 300 310 pF1KE2 PVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE2 PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPN 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE2 LDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGR 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE2 VYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTL 220 230 240 250 260 270 500 pF1KE2 SATETTFEY ::::::::: XP_006 SATETTFEY >>XP_011536661 (OMIM: 601807,611543) PREDICTED: matrix m (426 aa) initn: 1802 init1: 1802 opt: 1802 Z-score: 1785.1 bits: 339.6 E(85289): 1.1e-92 Smith-Waterman score: 2807; 83.9% identity (83.9% similar) in 508 aa overlap (1-508:1-426) 10 20 30 40 50 60 pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPG------ 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH XP_011 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP :::::::::::::::::::::::::::::::::::::::::::: XP_011 ----------------KKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP 180 190 200 210 310 320 330 340 350 360 pF1KE2 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE2 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE2 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT 340 350 360 370 380 390 490 500 pF1KE2 PSGGNTTPSGTGITLDTTLSATETTFEY :::::::::::::::::::::::::::: XP_011 PSGGNTTPSGTGITLDTTLSATETTFEY 400 410 420 >>NP_001259030 (OMIM: 601807,611543) matrix metalloprote (305 aa) initn: 1190 init1: 1190 opt: 1190 Z-score: 1183.0 bits: 227.7 E(85289): 3.7e-59 Smith-Waterman score: 1313; 67.0% identity (68.7% similar) in 342 aa overlap (1-333:1-258) 10 20 30 40 50 60 pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPG------ 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH NP_001 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE2 FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP ::::::::::::::::::::::::::::::::::::::::::: NP_001 ----------------KKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGE 180 190 200 210 310 320 330 340 350 pF1KE2 R------GKTYAFKGD-YVWTV-SDSG-PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHF :. .. .: .:: :: : .: : :: : NP_001 APPLQAVGRRWGQPADPEAWTNGSDMGLQHEQWR--APWEDLCFQGGLCVDCIRFRTGPL 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE2 FKGDKVWRYINFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDF NP_001 VPSVCPLGGAPRKPGCCCLLASNTMDSLL 280 290 300 >>NP_005931 (OMIM: 185261) stromelysin-3 preproprotein [ (488 aa) initn: 657 init1: 180 opt: 854 Z-score: 848.3 bits: 166.5 E(85289): 1.6e-40 Smith-Waterman score: 854; 36.0% identity (63.3% similar) in 411 aa overlap (80-472:75-480) 50 60 70 80 90 100 pF1KE2 PEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFN----QKTLKYLLL--GR .: ::::. :: . .. : ..: :: NP_005 RRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 WRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQS :.: ::.::: .: : . .: .. .:.. ::.:.:::: ::. : ::: ..: .: NP_005 WEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDF-ARYW 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 SYCSNTFDGPGRVLAHADIPEL---GSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGL . ::::: .:::: .:. :.:::: :: :: : .:..: .:::: ::.::: NP_005 HGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGL 170 180 190 200 210 220 230 240 250 260 270 pF1KE2 GHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKSPVIRDEEEE---ETELPTVPP :. ..:::. : .: ..: ::: :.: :::. :.. .. .. . : NP_005 QHTTAAKALMSAFYT-FRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEI 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE2 VPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG--PGPLFRVSALWEGLPG .: ::. :: : . .::. ::. . ::. .:: . . :: .: :.:::. NP_005 APLEPDAPPDACEASFDAVST-IRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPS 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE2 NLDAAVYSPRTQWIHFFKGDKVWRYINFK--MSPGFPKKLNRVEPNLDAALYW-PLNQKV .::: . . . : ::.: . : : . : ..:. .:. :. . ::: : : ..:. NP_005 PVDAAFEDAQGH-IWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKI 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE2 FLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLN ..:.: ::.. .: : :. . :::.. .::.. :: .::..:..::... NP_005 YFFRGRDYWRFHPSTRRVDSPVPRRATD-WRGVPSEIDAAFQDADGYAYFLRGRLYWKFD 410 420 430 440 450 460 470 480 490 500 pF1KE2 Q-QLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY .... .:.:: .. ... : NP_005 PVKVKALEGFPRLVGPDFFGCAEPANTFL 460 470 480 >>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa) initn: 645 init1: 178 opt: 848 Z-score: 842.6 bits: 165.4 E(85289): 3.4e-40 Smith-Waterman score: 848; 35.2% identity (62.0% similar) in 460 aa overlap (31-472:37-476) 10 20 30 40 50 pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPED---ITEAL :: .: :.: .. .:. .: :.. . NP_002 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVK---QFRRKDSNLIVKKI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 RAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLP ...:. : :.:.:: : ::.::::. : . ... . .::: :::.::.: NP_002 QGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGM--PKWRKTHLTYRIVNYT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 STLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVL :: .. .:...:.. : .:.::::... : ::: .:: .. . .:::::. : NP_002 PDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFY-SFDGPGHSL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 AHADIPE---LGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVY ::: : :..:::.:: ::: . :.:: ..::::.::.::: :: ..::: :.: NP_002 AHAYPPGPGLYGDIHFDDDEKWTEDA-SGTNLFLVAAHELGHSLGLFHSANTEALMYPLY 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 EGYRP--HFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPP--VPTEPSPMPDPCS ... .:.: ::: :::.::: : :: : :: ::. : :: :. NP_002 NSFTELAQFRLSQDDVNGIQSLYGP--PPASTEE------PLVPTKSVPS-GSEMPAKCD 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 SEL--DAMMLGPRGKTYAFKGDYVWTVSDSGPGPLFR-VSALWEGLPGNLDAAVYSPRTQ : ::. ::. :: : : : .: : :. .::.: .::. :::: . NP_002 PALSFDAISTL-RGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRD 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 WIHFFKGDKVWRYINFKMSPGFPKKLNRV--EPNL---DAALYWPLNQKVFLFKGSGYWQ . .:::.. : . ... :.:. .. . :.. :::. ..:...: .. ::. NP_002 TVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWR 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE2 WDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYP .:: ... ...:. : : :: . .:... : :::.:. .... . :. NP_002 FDENSQSMEQGFPRLIADDFPGVEPKVDAVLQ-AFGFFYFFSGSSQFEFDPNARMVTHIL 410 420 430 440 450 460 470 480 490 500 pF1KE2 RNISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY . :..:.:: NP_002 K--SNSWLHC 470 >>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa) initn: 720 init1: 181 opt: 805 Z-score: 800.1 bits: 157.5 E(85289): 7.9e-38 Smith-Waterman score: 805; 34.5% identity (59.2% similar) in 458 aa overlap (31-472:37-477) 10 20 30 40 50 pF1KE2 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPED-ITEALRA :: .: :.: .. : ... .: NP_002 LLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIRE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 FQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPST .:. : :.:.::. : ::.::::. : . .:. . .::: :::.::.: NP_002 MQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGI--PKWRKTHLTYRIVNYTPD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 LPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAH :: .. .:...:.. : .:.::::... : ::: .:: :. . ::::: :::: NP_002 LPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFY-PFDGPGNVLAH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE2 ADIPELG---SVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEG : : : ..:::.:: ::. : :.:: ..::::.::.::: :: ..::: :.:.. NP_002 AYAPGPGINGDAHFDDDEQWTKDT-TGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE2 YRP--HFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVP--PVPTEPSPMPDPCSSE .:.: ::. :::.::: : . : : :: ::: ::. : :. NP_002 LTDLTRFRLSQDDINGIQSLYGPP-P-------DSPETPLVPTEPVPPEPGT-PANCDPA 250 260 270 280 290 300 310 320 330 340 pF1KE2 L--DAMMLGPRGKTYAFKGDYVWTVSDSGPGP-LFRVSALWEGLPGNLDAAVYSPRTQWI : ::. ::. :: . : : : : .:..: .::...::: . . NP_002 LSFDAVSTL-RGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLV 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE2 HFFKGDKVWRYINFKMSPGFPKKLNRV--EPN---LDAALYWPLNQKVFLFKGSGYWQWD .:::.. : . .. :.:. .. . :. .:::. ..:...: . ::..: NP_002 FIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFD 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE2 ELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRN : . ..:: : : :. .. .:.. . : ::: :. ... . . : NP_002 EKRNSMEPGFPKQIAEDFPGIDSKIDAVFE-EFGFFYFFTGSSQLEFDPNAK--KVTHTL 420 430 440 450 460 470 480 490 500 pF1KE2 ISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY :..:..: NP_002 KSNSWLNC 470 >>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa) initn: 486 init1: 143 opt: 723 Z-score: 719.1 bits: 142.5 E(85289): 2.6e-33 Smith-Waterman score: 723; 34.7% identity (58.2% similar) in 450 aa overlap (44-472:64-483) 20 30 40 50 60 70 pF1KE2 MTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLD :::. . . .. .: : :.:.:: NP_004 WRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNS-----MIRKIKELQAFFGLQVTGKLD 40 50 60 70 80 80 90 100 110 120 130 pF1KE2 DATRARMRQPRCGLEDPFNQKTLKYLLLG--RWRKKHLTFRILNLPSTLPPHTARAALRQ ..: ...::::. : : . :. : .:.:. ::.:: . .. . :... NP_004 QTTMNVIKKPRCGVPDVANYR----LFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEM 90 100 110 120 130 140 140 150 160 170 180 pF1KE2 AFQDWSNVAPLTFQEVQAGAADIRLSF-HGRQSSYCSNTFDGPGRVLAHADIPELG---S :.: ::...::.: ....: ::: .:: .: ... : :::: .:::: : : . NP_004 ALQAWSSAVPLSFVRINSGEADIMISFENGDHGD--SYPFDGPRGTLAHAFAPGEGLGGD 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE2 VHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH-FKLHPD .:::. : :: :: : :: .:::: ::::::.:: .::: :.:. :. :.: : NP_004 THFDNAEKWTMGT-NGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKD 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE2 DVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPC--SSELDAM-MLGPRGK :: ::::::: .. . ::.: .: . .:: : :: .::. ::: . NP_004 DVKGIQALYGPRKVFLGK--------PTLPHAPHHKPSIPDLCDSSSSFDAVTMLGK--E 270 280 290 300 310 310 320 330 340 350 360 pF1KE2 TYAFKGDYVWTVS---DSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY :: : . .: : ... . : .:.::: . .:::: . : NP_004 LLLFKDRIFWRRQVHLRTGIRPS-TITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWIT 320 330 340 350 360 370 370 380 390 400 410 pF1KE2 INFKMS-P-------GFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFS .:.:. : :::...... :::.: ::...: :. :...:: : . NP_004 RGFQMQGPPRTIYDFGFPRHVQQI----DAAVYLREPQKTLFFVGDEYYSYDERKRKMEK 380 390 400 410 420 420 430 440 450 460 470 pF1KE2 SYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHC .::: . :.:: .: .::. .: .:::.: .. . . : : .:. : NP_004 DYPKNTEEEFSGVNGQIDAAVEL-NGYIYFFSGPKTYKYDTE--KEDVVSVVKSSSWIGC 430 440 450 460 470 480 480 490 500 pF1KE2 RPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY 508 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:18:49 2016 done: Tue Nov 8 05:18:50 2016 Total Scan time: 10.090 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]