FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0233, 407 aa 1>>>pF1KE0233 407 - 407 aa - 407 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1299+/-0.000281; mu= 15.0090+/- 0.018 mean_var=108.3493+/-21.752, 0's: 0 Z-trim(120.9): 67 B-trim: 0 in 0/56 Lambda= 0.123214 statistics sampled from 36669 (36737) to 36669 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.431), width: 16 Scan time: 8.920 The best scores are: opt bits E(85289) NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 2825 512.3 8.3e-145 XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 2825 512.3 8.3e-145 NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 1383 256.0 1.1e-67 NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 314 66.0 2e-10 NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 310 65.3 3.4e-10 NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 308 65.0 4.8e-10 NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 302 63.9 8.6e-10 NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 302 63.9 9e-10 NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 299 63.4 1.3e-09 NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 298 63.1 1.4e-09 NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 298 63.1 1.4e-09 XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 293 62.1 1.7e-09 NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 293 62.2 2.5e-09 XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 293 62.2 2.5e-09 NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 293 62.2 2.5e-09 XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 294 62.5 2.7e-09 NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 294 62.5 2.7e-09 NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 294 62.5 2.7e-09 XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 287 61.0 3.6e-09 NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 287 61.2 5.6e-09 NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 287 61.2 5.8e-09 NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 275 59.1 2.6e-08 XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 270 58.1 3.9e-08 XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 270 58.1 3.9e-08 NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 270 58.1 4e-08 XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 270 58.2 4.4e-08 NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 270 58.2 4.4e-08 NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 270 58.2 4.4e-08 XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 270 58.2 4.4e-08 NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 263 57.0 1.2e-07 NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 259 56.2 1.7e-07 XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 259 56.2 1.8e-07 NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 250 54.6 5.3e-07 NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 247 54.1 7.2e-07 NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 238 52.3 1.4e-06 NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 238 52.4 2e-06 NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 232 51.4 4.2e-06 NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 217 48.7 3e-05 NP_001316683 (OMIM: 112265) bone morphogenetic pro ( 417) 210 47.5 7.2e-05 XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 206 46.7 8.7e-05 NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 205 46.5 0.00011 XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011 NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011 XP_006714648 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011 NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011 XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011 NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011 NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011 XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011 NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011 >>NP_005802 (OMIM: 603936) growth/differentiation factor (407 aa) initn: 2825 init1: 2825 opt: 2825 Z-score: 2720.7 bits: 512.3 E(85289): 8.3e-145 Smith-Waterman score: 2825; 100.0% identity (100.0% similar) in 407 aa overlap (1-407:1-407) 10 20 30 40 50 60 pF1KE0 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ 310 320 330 340 350 360 370 380 390 400 pF1KE0 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS ::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 370 380 390 400 >>XP_006719257 (OMIM: 603936) PREDICTED: growth/differen (407 aa) initn: 2825 init1: 2825 opt: 2825 Z-score: 2720.7 bits: 512.3 E(85289): 8.3e-145 Smith-Waterman score: 2825; 100.0% identity (100.0% similar) in 407 aa overlap (1-407:1-407) 10 20 30 40 50 60 pF1KE0 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ 310 320 330 340 350 360 370 380 390 400 pF1KE0 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 370 380 390 400 >>NP_005250 (OMIM: 601788,614160) growth/differentiation (375 aa) initn: 1349 init1: 1088 opt: 1383 Z-score: 1335.9 bits: 256.0 E(85289): 1.1e-67 Smith-Waterman score: 1645; 65.1% identity (84.9% similar) in 352 aa overlap (58-407:34-375) 30 40 50 60 70 80 pF1KE0 PAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDG-CPVCVWRQHSRELRLESIKSQILSK : .: : .:.:::... :.:.:: ::::: NP_005 LQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSK 10 20 30 40 50 60 90 100 110 120 130 140 pF1KE0 LRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMA :::. :::::..:..:::::::::....: .: : : . . ::.:.:::::::.:.: NP_005 LRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDD-SSDGSLEDDDYHATTETIITMP 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE0 QETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRL-KPLTG :.: .:.::.: :: :.:: :....::.:::::.::::: :.::..::::: ::. NP_005 TESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKD 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE0 EGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPS : :. :::::.... .: ::::: : ::..:..::.:: ::::.:.: . NP_005 ---------GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDEN 190 200 210 220 230 270 280 290 300 310 320 pF1KE0 GTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAF : ::::: ::: .::.::.:..: .. :::::..::::::::.:::::::::::::::: NP_005 GHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAF 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE0 GWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYF ::::::::::::::::::.::..:.:::::::::.::::::::::::::::::::::::: NP_005 GWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYF 300 310 320 330 340 350 390 400 pF1KE0 NDKQQIIYGKIPGMVVDRCGCS : :.::::::::.::::::::: NP_005 NGKEQIIYGKIPAMVVDRCGCS 360 370 >>NP_055297 (OMIM: 608748) bone morphogenetic protein 10 (424 aa) initn: 315 init1: 136 opt: 314 Z-score: 308.2 bits: 66.0 E(85289): 2e-10 Smith-Waterman score: 314; 36.9% identity (57.3% similar) in 157 aa overlap (258-406:278-423) 230 240 250 260 270 280 pF1KE0 LHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMEL .. .: : : : ::: :.: . NP_055 KHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLD--SFSSGPGEEALLQMRSN 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 RVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCE . ..: : ::: .. . : : :: .::. .::: ::::: :.: : : :. NP_055 IIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCN 310 320 330 340 350 350 360 370 380 390 pF1KE0 YMFMQKY-PHTHLVQQA-----NPRGSAGPCCTPTKMSPINMLYFNDKQQIIYG-KIPGM : . .. : : . :: : . .. ::.:::. ::..::. :: . : : :: NP_055 YPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYL-DKGVVTYKFKYEGM 360 370 380 390 400 410 400 pF1KE0 VVDRCGCS .:..::: NP_055 AVSECGCR 420 >>NP_878248 (OMIM: 604651) growth/differentiation factor (450 aa) initn: 320 init1: 152 opt: 310 Z-score: 304.0 bits: 65.3 E(85289): 3.4e-10 Smith-Waterman score: 320; 30.4% identity (57.0% similar) in 230 aa overlap (186-406:240-449) 160 170 180 190 200 210 pF1KE0 DGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGG ::: : : . :: : : ::::.. NP_878 AFDVADAMRRHRREPRPPRAFCLLLRAVAGPVPSP----LALRRL----GFGWPGGGGSA 210 220 230 240 250 260 220 230 240 250 260 270 pF1KE0 RRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG .. :.. . . ::. . .:. :... : : . : .: : .. . . NP_878 AEE---RAVLV-VSSRTQRKESL-FREI-----RAQARALGAAL-ASEPL-PDPGTGTAS 270 280 290 300 280 290 300 310 320 330 pF1KE0 PGAEGLHPFMELRVLENTKRSRRNLGLDCDEHS--SESRCCRYPLTVDFEAFGWD-WIIA : : . .: .:. .. . : :. ..::: : :: :::. .::: :::: NP_878 PRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIA 310 320 330 340 350 360 340 350 360 370 380 pF1KE0 PKRYKANYCSGQCEYMFMQKY-PHTHLVQQA-----NPRGSAGPCCTPTKMSPINMLYFN : :.: .: : :.. . .. : .: . :. : .. . ::.:...:::..::.. NP_878 PLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYID 370 380 390 400 410 420 390 400 pF1KE0 DKQQIIYGKIPGMVVDRCGCS ....: . :::. ::: NP_878 AANNVVYKQYEDMVVEACGCR 430 440 450 >>NP_001709 (OMIM: 112266) bone morphogenetic protein 6 (513 aa) initn: 314 init1: 170 opt: 308 Z-score: 301.3 bits: 65.0 E(85289): 4.8e-10 Smith-Waterman score: 335; 31.7% identity (56.2% similar) in 208 aa overlap (235-406:305-512) 210 220 230 240 250 260 pF1KE0 GEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDP : .:. . . : :: : :..... NP_001 SIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTR 280 290 300 310 320 330 270 280 290 300 pF1KE0 SGTDLAVTSLG-PGAEGLH---PFM---------ELRVLENTKRSRRNLGLD-------- .:. . . : : .: . ::: ..:. .... ::. . . NP_001 DGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDV 340 350 360 370 380 390 310 320 330 340 350 pF1KE0 ------CDEHSSESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMF---MQ : .::: . : .. : :.:. .:: ::::::: : ::::.:.: . . :. NP_001 ARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMN 400 410 420 430 440 450 360 370 380 390 400 pF1KE0 KYPHT---HLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS :. ::. ::. :::.:::.. :..:::.:....: : .::: ::: NP_001 ATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 460 470 480 490 500 510 >>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa) initn: 325 init1: 119 opt: 302 Z-score: 296.8 bits: 63.9 E(85289): 8.6e-10 Smith-Waterman score: 353; 25.5% identity (49.2% similar) in 419 aa overlap (54-407:16-414) 30 40 50 60 70 80 pF1KE0 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI .:: . : . : :. :.:.:..:: NP_003 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI 10 20 30 40 90 100 110 120 130 pF1KE0 LSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP---------EDFLEEDE ::::.: :. : ..:: ....... : :: : ..: NP_003 LSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDEE 50 60 70 80 90 140 150 160 170 180 pF1KE0 YHATTETVISMAQ--ETDPAVQ-TDGSPLCCHFHFSPKVMF---TKVLKAQLWVY--LRP :.: :.: .. :. : : .:. ..: ....::.. :. : NP_003 YYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNP 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE0 ---VPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQV ::. :::. : ::. .:.: . .: . . :.: :.: .. NP_003 KARVPEQRIELYQILKSKDLTSPT--------QRYIDSKVVKTRAE---GEWLSFDVTDA 160 170 180 190 200 250 260 270 pF1KE0 LHSWFRQPQSNWGIEIN------AFDPS---------------------------GTDLA .: :... . : :..:. .: :: : . . NP_003 VHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKT 210 220 230 240 250 260 280 290 300 310 320 pF1KE0 VTSLGPGAEGLHPFMELRVL--------ENTKRSRRNLGLDCDEHSSESRCCRYPLTVDF . : : : . : .: ....:..: : .. .. :: :: .:: NP_003 IKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDF 270 280 290 300 310 320 330 340 350 360 370 pF1KE0 EA-FGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMS . .:: :: :: :.::.:.: : :.. . :.. : . ::..::.:::. . NP_003 KRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLE 330 340 350 360 370 380 380 390 400 pF1KE0 PINMLYFNDKQQIIYGKIPGMVVDRCGCS :...::. : : .. .:.: : :: NP_003 PLTILYYIGKTPKIE-QLSNMIVKSCKCS 390 400 410 >>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa) initn: 325 init1: 119 opt: 302 Z-score: 296.4 bits: 63.9 E(85289): 9e-10 Smith-Waterman score: 330; 25.3% identity (47.4% similar) in 447 aa overlap (54-407:16-442) 30 40 50 60 70 80 pF1KE0 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI .:: . : . : :. :.:.:..:: NP_001 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI 10 20 30 40 90 100 110 120 130 pF1KE0 LSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP---------EDFLEEDE ::::.: :. : ..:: ....... : :: : ..: NP_001 LSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDEE 50 60 70 80 90 140 150 160 pF1KE0 YHATTETVISM-----AQETDPAVQT-DGS--PLC-------CHF-------HFSPK--- :.: :.: .. . :.: : .:: :: : . . : NP_001 YYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRI 100 110 120 130 140 150 170 180 190 200 210 pF1KE0 VMF---------TKVLKAQLWVY--LRP---VPRPATVYLQILRLKPLTGEGTAGGGGGG : : ....::.. :. : ::. :::. : ::. NP_001 VRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPT-------- 160 170 180 190 200 220 230 240 250 260 pF1KE0 RRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN------AFDPS---- .:.: . .: . . :.: :.: ...: :... . : :..:. .: :: NP_001 QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYI 210 220 230 240 250 260 270 280 290 pF1KE0 -----------------------GTDLAVTSLGPGAEGLHPFMELRVL--------ENTK : . .. : : : . : .: .... NP_001 IPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNR 270 280 290 300 310 320 300 310 320 330 340 350 pF1KE0 RSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQKY :..: : .. .. :: :: .::. .:: :: :: :.::.:.: : :.. . NP_001 RKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDT 330 340 350 360 370 380 360 370 380 390 400 pF1KE0 PHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS :.. : . ::..::.:::. . :...::. : : .. .:.: : :: NP_001 QHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS 390 400 410 420 430 440 >>NP_001001557 (OMIM: 118100,601147,613094,613703,615360 (455 aa) initn: 250 init1: 146 opt: 299 Z-score: 293.4 bits: 63.4 E(85289): 1.3e-09 Smith-Waterman score: 306; 36.7% identity (62.0% similar) in 150 aa overlap (275-406:306-454) 250 260 270 280 290 pF1KE0 HSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHP----FMELRV-LENTKRSRRN : :::: : . : : . : :: NP_001 ALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRR 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE0 LGLDC---DEHSSESR--CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKY .. .:...:: : . :: :.:. .::: ::::: .:.: .: : :.. . .. NP_001 TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHL 340 350 360 370 380 390 360 370 380 390 400 pF1KE0 -PHTHLVQQA-----NPRGSAGP-CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC : .: . :. .: ::. : ::.:::..::..::.. ....: . :::. ::: NP_001 EPTNHAIIQTLMNSMDP-GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 400 410 420 430 440 450 pF1KE0 S NP_001 R >>NP_003230 (OMIM: 107970,190230,615582) transforming gr (412 aa) initn: 325 init1: 119 opt: 298 Z-score: 293.0 bits: 63.1 E(85289): 1.4e-09 Smith-Waterman score: 377; 27.8% identity (51.8% similar) in 396 aa overlap (70-407:34-412) 40 50 60 70 80 90 pF1KE0 AAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPN--ISR : .. :.:.:..:::::::: :. . NP_003 HLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMT 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE0 EVVKQLLPKAPPLQQILD-LHDFQGDALQPEDFLEEDEYHATT----ETVISMAQETDPA .: :.: ...:. .: . .. :. :.::.: . . ..:.... : NP_003 HVPYQVLALYNSTRELLEEMHGEREEGCTQEN--TESEYYAKEIHKFDMIQGLAEHNELA 70 80 90 100 110 120 160 170 180 190 200 pF1KE0 VQTDG-SPLCCHFHFSP-KVMFTKVLKAQLWVYLRPVPRPAT------VYL-QILRLKPL : : . .:. : . :....:.. : :: :: :.. . : :::: : NP_003 VCPKGITSKVFRFNVSSVEKNRTNLFRAEFRV-LR-VPNPSSKRNEQRIELFQILR--P- 130 140 150 160 170 210 220 230 240 250 260 pF1KE0 TGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN--- : : .:.: ..: . ...: :.: .... :. . .:: :.::. NP_003 -DEHIAK-----QRYIGGKNLPTR---GTAEWLSFDVTDTVREWLLRRESNLGLEISIHC 180 190 200 210 220 270 280 pF1KE0 ---AFDPSGTDLA-------VTSLGPGAEGLH----------------PFMELRV----- .:.:.: : . : : : : . : . NP_003 PCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHR 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE0 LENT----KRSRRNLGLDCDEHSSESRCCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQ :.: .:..: : . .. : :: :: .:: . .:: :. :: : ::.::: NP_003 LDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE0 CEYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVV : :. :. : . ::..::.:::.: . :...::. . . .. .::: NP_003 CPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVV 350 360 370 380 390 400 pF1KE0 DRCGCS : :: NP_003 KSCKCS 410 407 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 01:30:01 2016 done: Tue Nov 8 01:30:02 2016 Total Scan time: 8.920 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]