FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2118, 859 aa 1>>>pF1KE2118 859 - 859 aa - 859 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.5463+/-0.000456; mu= -8.0820+/- 0.029 mean_var=739.2528+/-154.009, 0's: 0 Z-trim(124.4): 1427 B-trim: 0 in 0/62 Lambda= 0.047171 statistics sampled from 44031 (46021) to 44031 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.811), E-opt: 0.2 (0.54), width: 16 Scan time: 17.500 The best scores are: opt bits E(85289) XP_016875445 (OMIM: 600447) PREDICTED: mitogen-act ( 859) 5898 417.4 1.4e-115 NP_006292 (OMIM: 600447) mitogen-activated protein ( 859) 5898 417.4 1.4e-115 XP_011537027 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 5582 395.9 4.4e-109 XP_005269195 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 5582 395.9 4.4e-109 XP_006719651 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 5582 395.9 4.4e-109 NP_001180440 (OMIM: 600447) mitogen-activated prot ( 892) 5582 395.9 4.4e-109 XP_011511612 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 2630 195.0 1.4e-48 XP_016862945 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 2630 195.0 1.4e-48 NP_004712 (OMIM: 604915) mitogen-activated protein ( 966) 2630 195.0 1.4e-48 NP_001229243 (OMIM: 604915) mitogen-activated prot ( 966) 2630 195.0 1.4e-48 XP_005269197 (OMIM: 600447) PREDICTED: mitogen-act ( 453) 2558 189.7 2.6e-47 XP_016862946 (OMIM: 604915) PREDICTED: mitogen-act ( 817) 2408 179.8 4.4e-44 NP_001229246 (OMIM: 604915) mitogen-activated prot ( 759) 2070 156.8 3.5e-37 XP_016862948 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 1973 150.2 3.3e-35 XP_016862947 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 1973 150.2 3.3e-35 XP_016859812 (OMIM: 609479,616890) PREDICTED: mito ( 455) 743 66.2 4e-10 XP_016859813 (OMIM: 609479,616890) PREDICTED: mito ( 455) 743 66.2 4e-10 NP_598407 (OMIM: 609479,616890) mitogen-activated ( 455) 743 66.2 4e-10 NP_057737 (OMIM: 609479,616890) mitogen-activated ( 800) 739 66.2 6.7e-10 XP_005246697 (OMIM: 609479,616890) PREDICTED: mito ( 800) 739 66.2 6.7e-10 NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 737 66.2 8.2e-10 NP_001271159 (OMIM: 600136) mitogen-activated prot (1104) 663 61.3 2.9e-08 NP_002410 (OMIM: 600050) mitogen-activated protein ( 847) 648 60.1 5.1e-08 XP_011542607 (OMIM: 614793) PREDICTED: mitogen-act ( 905) 640 59.6 7.7e-08 NP_115811 (OMIM: 614793) mitogen-activated protein (1036) 640 59.7 8.3e-08 XP_005267740 (OMIM: 600136) PREDICTED: mitogen-act (1081) 635 59.3 1.1e-07 NP_149132 (OMIM: 600136) mitogen-activated protein (1118) 635 59.4 1.1e-07 XP_011525284 (OMIM: 600137) PREDICTED: mitogen-act ( 860) 617 58.0 2.2e-07 XP_011525283 (OMIM: 600137) PREDICTED: mitogen-act ( 962) 617 58.1 2.4e-07 XP_011535090 (OMIM: 600136) PREDICTED: mitogen-act (1166) 608 57.6 4e-07 NP_001271160 (OMIM: 600136) mitogen-activated prot ( 880) 562 54.3 3e-06 NP_663306 (OMIM: 157800,602614,617137) mitogen-act ( 491) 535 52.1 7.6e-06 NP_663305 (OMIM: 157800,602614,617137) mitogen-act ( 518) 535 52.1 7.8e-06 NP_003179 (OMIM: 157800,602614,617137) mitogen-act ( 579) 535 52.2 8.3e-06 NP_663304 (OMIM: 157800,602614,617137) mitogen-act ( 606) 535 52.2 8.6e-06 NP_001120662 (OMIM: 124095) tyrosine-protein kinas ( 450) 508 50.2 2.6e-05 NP_004374 (OMIM: 124095) tyrosine-protein kinase C ( 450) 508 50.2 2.6e-05 XP_005254222 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 508 50.2 2.6e-05 XP_016877414 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 508 50.2 2.6e-05 XP_011535094 (OMIM: 600136) PREDICTED: mitogen-act ( 860) 514 51.0 2.8e-05 NP_647611 (OMIM: 600038) megakaryocyte-associated ( 466) 503 49.9 3.3e-05 XP_011526320 (OMIM: 600038) PREDICTED: megakaryocy ( 507) 503 49.9 3.5e-05 NP_647612 (OMIM: 600038) megakaryocyte-associated ( 507) 503 49.9 3.5e-05 NP_002369 (OMIM: 600038) megakaryocyte-associated ( 508) 503 49.9 3.5e-05 NP_001271161 (OMIM: 600136) mitogen-activated prot ( 837) 509 50.6 3.5e-05 NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 490 48.9 5.9e-05 NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 490 49.0 6.4e-05 XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 463 47.0 0.0002 XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 463 47.2 0.00023 XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 463 47.2 0.00023 >>XP_016875445 (OMIM: 600447) PREDICTED: mitogen-activat (859 aa) initn: 5898 init1: 5898 opt: 5898 Z-score: 2195.9 bits: 417.4 E(85289): 1.4e-115 Smith-Waterman score: 5898; 100.0% identity (100.0% similar) in 859 aa overlap (1-859:1-859) 10 20 30 40 50 60 pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST 790 800 810 820 830 840 850 pF1KE2 ELDNSNSVDALRPPASLPP ::::::::::::::::::: XP_016 ELDNSNSVDALRPPASLPP 850 >>NP_006292 (OMIM: 600447) mitogen-activated protein kin (859 aa) initn: 5898 init1: 5898 opt: 5898 Z-score: 2195.9 bits: 417.4 E(85289): 1.4e-115 Smith-Waterman score: 5898; 100.0% identity (100.0% similar) in 859 aa overlap (1-859:1-859) 10 20 30 40 50 60 pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST 790 800 810 820 830 840 850 pF1KE2 ELDNSNSVDALRPPASLPP ::::::::::::::::::: NP_006 ELDNSNSVDALRPPASLPP 850 >>XP_011537027 (OMIM: 600447) PREDICTED: mitogen-activat (892 aa) initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109 Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892) 10 20 30 40 pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH-------------- ::::::::::::::::::::::::::::::::::::::::::::. XP_011 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG 10 20 30 40 50 60 50 60 70 80 pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF ::::::::::::::::::::::::::::::::::::::::: XP_011 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV 790 800 810 820 830 840 810 820 830 840 850 pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP 850 860 870 880 890 >>XP_005269195 (OMIM: 600447) PREDICTED: mitogen-activat (892 aa) initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109 Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892) 10 20 30 40 pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH-------------- ::::::::::::::::::::::::::::::::::::::::::::. XP_005 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG 10 20 30 40 50 60 50 60 70 80 pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF ::::::::::::::::::::::::::::::::::::::::: XP_005 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV 790 800 810 820 830 840 810 820 830 840 850 pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP 850 860 870 880 890 >>XP_006719651 (OMIM: 600447) PREDICTED: mitogen-activat (892 aa) initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109 Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892) 10 20 30 40 pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH-------------- ::::::::::::::::::::::::::::::::::::::::::::. XP_006 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG 10 20 30 40 50 60 50 60 70 80 pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF ::::::::::::::::::::::::::::::::::::::::: XP_006 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV 790 800 810 820 830 840 810 820 830 840 850 pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP 850 860 870 880 890 >>NP_001180440 (OMIM: 600447) mitogen-activated protein (892 aa) initn: 5580 init1: 5580 opt: 5582 Z-score: 2079.5 bits: 395.9 E(85289): 4.4e-109 Smith-Waterman score: 5806; 96.2% identity (96.3% similar) in 891 aa overlap (2-859:2-892) 10 20 30 40 pF1KE2 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTH-------------- ::::::::::::::::::::::::::::::::::::::::::::. NP_001 MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGG 10 20 30 40 50 60 50 60 70 80 pF1KE2 -------------------VLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF ::::::::::::::::::::::::::::::::::::::::: NP_001 GGPSPSPGGEPPPEPFANSVLQLHEQDAGGPGGAAGSPESRASRVRADEVRLQCQSGSGF 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE2 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE2 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE2 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTK 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE2 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE2 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE2 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALM 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE2 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQLELKERELLRREQALERRCPGLLKPHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPD 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE2 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRTAVP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE2 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHEPGGPGSPGGLGGGPSAWEACPPALRGLHHDLLLRKMSSSSPDLLSAALGSRGRGATG 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE2 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTSG 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE2 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGGSRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELTSSQRWPQSLNMRQS 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE2 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTFSSENPSDGEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDPPPSEV 790 800 810 820 830 840 810 820 830 840 850 pF1KE2 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPGPEPSSLPIPHQELLRERGPPNSEDSDCDSTELDNSNSVDALRPPASLPP 850 860 870 880 890 >>XP_011511612 (OMIM: 604915) PREDICTED: mitogen-activat (966 aa) initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48 Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898) 10 20 30 40 50 60 pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA :: .: . ::::.:.: . . . XP_011 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ 40 50 60 70 80 90 70 80 90 100 110 pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED :. .. : ......: .:::: :::::::::::::..:::::::..: ::.: XP_011 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF :::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.: XP_011 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD ::::::::::::.::.::.::::::::::: .:: :::::: :::.:::::::::::::: XP_011 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF :::::.:.:. :.::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS :::::::::::::::::::::::::::::::::::::.::::::::..: :.:::::::: XP_011 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS 340 350 360 370 380 390 360 370 380 390 400 410 pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR ::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. ::: XP_011 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP :::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : :: XP_011 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS : ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: : XP_011 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS 520 530 540 550 560 570 540 550 560 570 580 pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS-------- ..:: :.: :::.....:: .:. .. : .: : . . :: XP_011 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ 580 590 600 610 620 630 590 600 610 pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL .. :::. :: : :.. .::::: XP_011 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL 640 650 660 670 680 690 620 630 640 650 660 pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG .:.:... .:... : . . : : . :: : :. : :: XP_011 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL 700 710 720 730 740 750 670 680 690 700 710 pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI- .:. :. . . : .. :. : :..:: :: :: . :: :: : XP_011 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD 760 770 780 790 800 810 720 730 740 750 760 770 pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV ::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :. XP_011 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE 820 830 840 850 860 870 780 790 800 810 820 830 pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS . . ..: :. ::. :: :::.: XP_011 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY 880 890 900 910 920 930 >>XP_016862945 (OMIM: 604915) PREDICTED: mitogen-activat (966 aa) initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48 Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898) 10 20 30 40 50 60 pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA :: .: . ::::.:.: . . . XP_016 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ 40 50 60 70 80 90 70 80 90 100 110 pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED :. .. : ......: .:::: :::::::::::::..:::::::..: ::.: XP_016 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF :::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.: XP_016 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD ::::::::::::.::.::.::::::::::: .:: :::::: :::.:::::::::::::: XP_016 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF :::::.:.:. :.::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS :::::::::::::::::::::::::::::::::::::.::::::::..: :.:::::::: XP_016 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS 340 350 360 370 380 390 360 370 380 390 400 410 pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR ::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. ::: XP_016 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP :::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : :: XP_016 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS : ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: : XP_016 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS 520 530 540 550 560 570 540 550 560 570 580 pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS-------- ..:: :.: :::.....:: .:. .. : .: : . . :: XP_016 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ 580 590 600 610 620 630 590 600 610 pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL .. :::. :: : :.. .::::: XP_016 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL 640 650 660 670 680 690 620 630 640 650 660 pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG .:.:... .:... : . . : : . :: : :. : :: XP_016 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL 700 710 720 730 740 750 670 680 690 700 710 pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI- .:. :. . . : .. :. : :..:: :: :: . :: :: : XP_016 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD 760 770 780 790 800 810 720 730 740 750 760 770 pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV ::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :. XP_016 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE 820 830 840 850 860 870 780 790 800 810 820 830 pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS . . ..: :. ::. :: :::.: XP_016 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY 880 890 900 910 920 930 >>NP_004712 (OMIM: 604915) mitogen-activated protein kin (966 aa) initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48 Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898) 10 20 30 40 50 60 pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA :: .: . ::::.:.: . . . NP_004 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ 40 50 60 70 80 90 70 80 90 100 110 pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED :. .. : ......: .:::: :::::::::::::..:::::::..: ::.: NP_004 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF :::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.: NP_004 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD ::::::::::::.::.::.::::::::::: .:: :::::: :::.:::::::::::::: NP_004 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF :::::.:.:. :.::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS :::::::::::::::::::::::::::::::::::::.::::::::..: :.:::::::: NP_004 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS 340 350 360 370 380 390 360 370 380 390 400 410 pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR ::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. ::: NP_004 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP :::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : :: NP_004 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS : ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: : NP_004 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS 520 530 540 550 560 570 540 550 560 570 580 pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS-------- ..:: :.: :::.....:: .:. .. : .: : . . :: NP_004 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ 580 590 600 610 620 630 590 600 610 pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL .. :::. :: : :.. .::::: NP_004 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL 640 650 660 670 680 690 620 630 640 650 660 pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG .:.:... .:... : . . : : . :: : :. : :: NP_004 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL 700 710 720 730 740 750 670 680 690 700 710 pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI- .:. :. . . : .. :. : :..:: :: :: . :: :: : NP_004 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD 760 770 780 790 800 810 720 730 740 750 760 770 pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV ::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :. NP_004 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE 820 830 840 850 860 870 780 790 800 810 820 830 pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS . . ..: :. ::. :: :::.: NP_004 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY 880 890 900 910 920 930 >>NP_001229243 (OMIM: 604915) mitogen-activated protein (966 aa) initn: 2872 init1: 2513 opt: 2630 Z-score: 993.4 bits: 195.0 E(85289): 1.4e-48 Smith-Waterman score: 2834; 56.7% identity (73.3% similar) in 836 aa overlap (33-801:70-898) 10 20 30 40 50 60 pF1KE2 CLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGGAA :: .: . ::::.:.: . . . NP_001 PKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQ 40 50 60 70 80 90 70 80 90 100 110 pF1KE2 GSPESR--ASRVRADEVRLQ-CQSGSG---FLEGLFGCLRPVWTMIGKAYSTEHKQQQED :. .. : ......: .:::: :::::::::::::..:::::::..: ::.: NP_001 GNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQD 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE2 LWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITF :::::::: .:::.:::::::::::.:..::::.::::. .::::::::::::::::.: NP_001 TWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAF 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE2 KGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD ::::::::::::.::.::.::::::::::: .:: :::::: :::.:::::::::::::: NP_001 KGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRD 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE2 LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF :::::.:.:. :.::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSF 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE2 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS :::::::::::::::::::::::::::::::::::::.::::::::..: :.:::::::: NP_001 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPS 340 350 360 370 380 390 360 370 380 390 400 410 pF1KE2 FRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRR ::: :.::::::::::.:::::::::::::::::: :::::::::::.:::.:::. ::: NP_001 FRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE2 EELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHP :::::::::::::::::::::::::::.:.:::::..:.::..::::.:.. :: : :: NP_001 EELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHP 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE2 SRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPS : ..: :.::::.:...::.: . ..::::.:..:.. : ..: .. : : :: : NP_001 VRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGI-PTTEVAPTASPLSGSPKMSTS 520 530 540 550 560 570 540 550 560 570 580 pF1KE2 PGRSR-RGKTRHRKASAKGSCGDLPGLRTAVPPHE--PGGPGSPGGLGGGPS-------- ..:: :.: :::.....:: .:. .. : .: : . . :: NP_001 SSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQ 580 590 600 610 620 630 590 600 610 pF1KE2 -AWEACPPALRGLHHDLL-------------------------------LRKMSSSSPDL .. :::. :: : :.. .::::: NP_001 QQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDL 640 650 660 670 680 690 620 630 640 650 660 pF1KE2 LSAALGS---------RGRGATGGAGDPGSPPPARGDTPPSEGS--APGSTSP--DSPGG .:.:... .:... : . . : : . :: : :. : :: NP_001 ISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIP-SAEPVGRSPDL 700 710 720 730 740 750 670 680 690 700 710 pF1KE2 AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHL-TPAALLYRAAVTRS-QKRGI- .:. :. . . : .. :. : :..:: :: :: . :: :: : NP_001 SKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRK---TRPLQKSGDD 760 770 780 790 800 810 720 730 740 750 760 770 pF1KE2 SSEEEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSEN--PSDGEEGTASEPSPSGTPEV ::::::::::::::. :: . .. :: ::::::: ::::::..:. : : :. NP_001 SSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNS--PDE 820 830 840 850 860 870 780 790 800 810 820 830 pF1KE2 GSTNTDERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDS . . ..: :. ::. :: :::.: NP_001 LADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGY 880 890 900 910 920 930 859 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:33:40 2016 done: Sun Nov 6 04:33:42 2016 Total Scan time: 17.500 Total Display time: 0.250 Function used was FASTA [36.3.4 Apr, 2011]