FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5668, 528 aa 1>>>pF1KE5668 528 - 528 aa - 528 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1256+/-0.000401; mu= 19.3479+/- 0.025 mean_var=69.1332+/-13.514, 0's: 0 Z-trim(111.8): 47 B-trim: 22 in 1/50 Lambda= 0.154252 statistics sampled from 20416 (20462) to 20416 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.599), E-opt: 0.2 (0.24), width: 16 Scan time: 8.200 The best scores are: opt bits E(85289) NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 3621 815.3 0 XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 3609 812.7 0 NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 2971 670.7 3.2e-192 NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 2522 570.8 3.8e-162 XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 2385 540.3 5.7e-153 XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 2373 537.6 3.6e-152 NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 2356 533.8 4.7e-151 NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 1975 449.1 1.7e-125 NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 1472 337.2 9.5e-92 XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 1245 286.4 8.6e-77 NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 1006 233.4 1.3e-60 NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 1006 233.4 1.3e-60 NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 1006 233.4 1.3e-60 NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 643 152.6 2.6e-36 NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 583 139.3 3.3e-32 XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 479 116.1 2.4e-25 NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 275 70.8 1.4e-11 NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 248 64.8 9.5e-10 NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 248 64.8 9.7e-10 NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 248 64.8 1e-09 XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 210 56.3 3.1e-07 NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 208 55.9 4.4e-07 XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 208 55.9 4.4e-07 XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 208 55.9 4.4e-07 XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 208 55.9 4.5e-07 XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 174 48.3 8.3e-05 XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 174 48.3 8.3e-05 XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 174 48.3 8.9e-05 XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 174 48.3 8.9e-05 XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 174 48.3 9.2e-05 XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 174 48.3 9.3e-05 XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 174 48.4 9.4e-05 XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 174 48.4 9.5e-05 XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 174 48.4 9.5e-05 XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 174 48.4 9.5e-05 XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 174 48.4 9.8e-05 NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 174 48.4 9.9e-05 XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 174 48.4 0.0001 XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 174 48.4 0.0001 XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 174 48.4 0.0001 XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 174 48.4 0.0001 XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 174 48.4 0.0001 XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 174 48.4 0.0001 XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 174 48.4 0.00011 XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 174 48.4 0.00011 >>NP_001086 (OMIM: 602866) acid-sensing ion channel 1 is (528 aa) initn: 3621 init1: 3621 opt: 3621 Z-score: 4354.2 bits: 815.3 E(85289): 0 Smith-Waterman score: 3621; 100.0% identity (100.0% similar) in 528 aa overlap (1-528:1-528) 10 20 30 40 50 60 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA 430 440 450 460 470 480 490 500 510 520 pF1KE5 DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 490 500 510 520 >>XP_011536654 (OMIM: 602866) PREDICTED: acid-sensing io (529 aa) initn: 1908 init1: 1908 opt: 3609 Z-score: 4339.7 bits: 812.7 E(85289): 0 Smith-Waterman score: 3609; 99.8% identity (99.8% similar) in 529 aa overlap (1-528:1-529) 10 20 30 40 50 60 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQR-LIYLPPPWGTCKAVTMDSDL ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_011 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRQLIYLPPPWGTCKAVTMDSDL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 DFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYET 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 IEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSS 430 440 450 460 470 480 480 490 500 510 520 pF1KE5 ADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 490 500 510 520 >>NP_064423 (OMIM: 602866) acid-sensing ion channel 1 is (574 aa) initn: 2971 init1: 2971 opt: 2971 Z-score: 3571.9 bits: 670.7 E(85289): 3.2e-192 Smith-Waterman score: 3406; 91.8% identity (91.8% similar) in 560 aa overlap (1-514:1-560) 10 20 30 40 50 60 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI 370 380 390 400 410 420 430 pF1KE5 EQKKAYEIAGLLG----------------------------------------------D ::::::::::::: : NP_064 EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE5 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH 490 500 510 520 530 540 500 510 520 pF1KE5 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC :::::::::::::::::::: NP_064 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 550 560 570 >>NP_001243759 (OMIM: 602866) acid-sensing ion channel 1 (562 aa) initn: 2814 init1: 2515 opt: 2522 Z-score: 3032.0 bits: 570.8 E(85289): 3.8e-162 Smith-Waterman score: 2794; 78.9% identity (88.7% similar) in 522 aa overlap (7-528:53-562) 10 20 30 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY .: : .:... :::.: :::: ::: NP_001 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE5 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN . ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: : NP_001 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE5 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE :.::.: :: . . .:.: .. . : . .: ..:. .:::... NP_001 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR 150 160 170 180 190 160 170 180 190 200 210 pF1KE5 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN ::.:. : ..:::: : ..: :. ..:.::::::::::::::::::::::::::::::: NP_001 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE5 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE5 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY 320 330 340 350 360 370 340 350 360 370 380 390 pF1KE5 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 380 390 400 410 420 430 400 410 420 430 440 450 pF1KE5 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY 440 450 460 470 480 490 460 470 480 490 500 510 pF1KE5 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH 500 510 520 530 540 550 520 pF1KE5 HPARGTFEDFTC :::::::::::: NP_001 HPARGTFEDFTC 560 >>XP_011536653 (OMIM: 602866) PREDICTED: acid-sensing io (559 aa) initn: 2380 init1: 2380 opt: 2385 Z-score: 2867.3 bits: 540.3 E(85289): 5.7e-153 Smith-Waterman score: 3549; 94.5% identity (94.5% similar) in 559 aa overlap (1-528:1-559) 10 20 30 40 50 60 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 130 140 150 160 170 180 190 200 pF1KE5 AEDFKV-------------------------------VFTRYGKCYTFNSGRDGRPRLKT :::::: ::::::::::::::::::::::: XP_011 AEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTFNSGRDGRPRLKT 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE5 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE5 QTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVH 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE5 MPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKY 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE5 LAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILT 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE5 VLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTY 490 500 510 520 530 540 510 520 pF1KE5 AANILPHHPARGTFEDFTC ::::::::::::::::::: XP_011 AANILPHHPARGTFEDFTC 550 >>XP_011536652 (OMIM: 602866) PREDICTED: acid-sensing io (560 aa) initn: 2963 init1: 1733 opt: 2373 Z-score: 2852.9 bits: 537.6 E(85289): 3.6e-152 Smith-Waterman score: 3537; 94.3% identity (94.3% similar) in 560 aa overlap (1-528:1-560) 10 20 30 40 50 60 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS 130 140 150 160 170 180 190 200 pF1KE5 AEDFKV-------------------------------VFTRYGKCYTFNSGRDGRPRLKT :::::: ::::::::::::::::::::::: XP_011 AEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTFNSGRDGRPRLKT 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE5 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE5 QTFVACQEQR-LIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMV :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTFVACQEQRQLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMV 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE5 HMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAK 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE5 YLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASIL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE5 TVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMT 490 500 510 520 530 540 510 520 pF1KE5 YAANILPHHPARGTFEDFTC :::::::::::::::::::: XP_011 YAANILPHHPARGTFEDFTC 550 560 >>NP_001085 (OMIM: 601784) acid-sensing ion channel 2 is (512 aa) initn: 1378 init1: 1378 opt: 2356 Z-score: 2833.0 bits: 533.8 E(85289): 4.7e-151 Smith-Waterman score: 2387; 66.1% identity (84.8% similar) in 528 aa overlap (1-528:1-512) 10 20 30 40 50 60 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV :.:: : :..:: ::: ::..:::::. ::: : :...:.:::. :.:::..:: NP_001 MDLKESPSE-GSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVE 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN .:::.::: :.::::.:::.:..:.:::::::::: ::::... :::::::::::::. NP_001 SSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS .::: ..:: . :: :..::::. .::: :.: :: :.:::..::.: :.:.:. :. NP_001 NLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS .:: .:::.::::: ::::.::.: : :.:::::::::::::::::::::.::::.::. NP_001 HQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETT 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD ::::.:::::::.:::::..:::::::::::::: ::::: ::::::: :.. : :: NP_001 FEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM--GLD 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE5 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY :: ::::::::::::::.::::::::::::::::.:::::.::::.::: .:.:::..: NP_001 FFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNY 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE5 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI :.:. :::::::.:::::::::::.::::: :::::::.::.:::::::::::.:::::: NP_001 CLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETI 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE5 EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA :::::::.:.:::::::::::::::::::.:::::: ::.::.:: :: ..: NP_001 EQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLL--DLLGKEEDEGSH 420 430 440 450 460 470 490 500 510 520 pF1KE5 DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC :..:. :... .: .....:. : . . ::.:...: NP_001 DENVS----------TCDTMPNHSETISHTVNV-PLQTTLGTLEEIAC 480 490 500 510 >>NP_899233 (OMIM: 601784) acid-sensing ion channel 2 is (563 aa) initn: 1235 init1: 979 opt: 1975 Z-score: 2374.1 bits: 449.1 E(85289): 1.7e-125 Smith-Waterman score: 2022; 59.8% identity (79.5% similar) in 517 aa overlap (23-528:62-563) 10 20 30 40 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLS----LKRALWAL : . :::: :. . . . .::::.: NP_899 LAAAGQPGGGRGGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE5 CFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDL : :...:: ..:. :.. . :.. . . :: :::::.:: : .:: ..::.:: NP_899 AFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE5 YHAGELLALL-NNRYEIP---DTQMADEKQLEILQDKANFRSF-KPKPFN--MREFYDRA :.::. :.:: :: : . .:: . . .. :.:: : :. :. :.:: NP_899 YYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRL 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE5 GHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIM ::...::::::..:::.:. ..:. :::.::::: ::::.::.: : :.::::::::::: NP_899 GHQLEDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIM 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE5 LDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLI ::::::::::.::::.::.::::.:::::::.:::::..:::::::::::::: ::::: NP_899 LDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLT 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE5 YLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQ ::::::: :.. : :::: ::::::::::::::.::::::::::::::::.::::: NP_899 YLPPPWGECRSSEMG--LDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQ 340 350 360 370 380 350 360 370 380 390 400 pF1KE5 YKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYI .::::.::: .:.:::..::.:. :::::::.:::::::::::.::::: :::::::.:: NP_899 HKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYI 390 400 410 420 430 440 410 420 430 440 450 460 pF1KE5 GENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVI .:::::::::::.:::::::::::::.:.:::::::::::::::::::.:::::: ::.: NP_899 SENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELI 450 460 470 480 490 500 470 480 490 500 510 520 pF1KE5 KHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARG :.:: :: ..: :..:. :... .: .....:. : . . : NP_899 KEKLL--DLLGKEEDEGSHDENVST----------CDTMPNHSETISHTVNV-PLQTTLG 510 520 530 540 550 pF1KE5 TFEDFTC :.:...: NP_899 TLEEIAC 560 >>NP_061144 (OMIM: 606715) acid-sensing ion channel 4 is (666 aa) initn: 1129 init1: 865 opt: 1472 Z-score: 1768.2 bits: 337.2 E(85289): 9.5e-92 Smith-Waterman score: 1675; 49.7% identity (73.7% similar) in 525 aa overlap (12-528:163-666) 10 20 30 40 pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSL :. : .. .:::.::::::.. . .: NP_061 VCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGL 140 150 160 170 180 190 50 60 70 80 90 100 pF1KE5 KRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRF .:.:::: .: :::..: . .. :. :.. .: .: . .. ::::::::.:.:: NP_061 RRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRH 200 210 220 230 240 250 110 120 130 140 150 160 pF1KE5 SQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDR : .: :..: ..: .: : . .. :..: :.: .: .. .: NP_061 SALSDADIFHLANLTGL-------PPKDRDGHR-------AAGLRY--PEP-DMVDILNR 260 270 280 290 170 180 190 200 210 220 pF1KE5 AGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEI .::.. ::: ::.: :. ::: .:.::.::::::::::. : : : . :: :.:::: NP_061 TGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEI 300 310 320 330 340 350 230 240 250 260 270 280 pF1KE5 MLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRL ::::::.::::.: ::.::::::::.::::::.:::.: ::::::.:::::::.:::::: NP_061 MLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRL 360 370 380 390 400 410 290 300 310 320 330 pF1KE5 IYLPPPWGTCKAVTM--DSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCT ::: :::.:.: . . .:. ...::..:::. :: . ... :.::::::::. : NP_061 TYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICP 420 430 440 450 460 470 340 350 360 370 380 390 pF1KE5 PEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE :. : :::: .:: : . : : ::::::::::.:::.::...::.:::.:.:..: NP_061 PNIYIECADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNE 480 490 500 510 520 530 400 410 420 430 440 450 pF1KE5 QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAY :: ::.::::.:::.:. :..::. :: ...::::.::::::::::::::.::..:: : NP_061 TYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIY 540 550 560 570 580 590 460 470 480 490 500 510 pF1KE5 EVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHH- :: .: : . : :.:. .:.:...:...:: : ::. : ....::.: NP_061 EVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPS-RGRVEG-GGVSSLLPNHH 600 610 620 630 640 650 520 pF1KE5 ----PARGTFEDFTC : : ::::.: NP_061 HPHGPPGGLFEDFAC 660 >>XP_016859928 (OMIM: 606715) PREDICTED: acid-sensing io (320 aa) initn: 1257 init1: 739 opt: 1245 Z-score: 1499.7 bits: 286.4 E(85289): 8.6e-77 Smith-Waterman score: 1245; 56.4% identity (79.1% similar) in 321 aa overlap (215-528:2-320) 190 200 210 220 230 240 pF1KE5 KVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAG :.::::::::::.::::.: ::.::::::: XP_016 MGSGLEIMLDIQQEEYLPIWRETNETSFEAG 10 20 30 250 260 270 280 290 300 pF1KE5 IKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTM--DSDLDFF :.::::::.:::.: ::::::.:::::::.:::::: ::: :::.:.: . . .:. . XP_016 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 40 50 60 70 80 90 310 320 330 340 350 360 pF1KE5 DSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCV ..::..:::. :: . ... :.::::::::. : :. : :::: .:: : . : XP_016 SAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCF 100 110 120 130 140 150 370 380 390 400 410 420 pF1KE5 CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ : ::::::::::.:::.::...::.:::.:.:..: :: ::.::::.:::.:. :..:: XP_016 CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQ 160 170 180 190 200 210 430 440 450 460 470 480 pF1KE5 KKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADK . :: ...::::.::::::::::::::.::..:: ::: .: : . : :.:. XP_016 RAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGG 220 230 240 250 260 270 490 500 510 520 pF1KE5 GVALSLDDVKRHNPCESLRGHPAGMTYAANILPHH-----PARGTFEDFTC .:.:...:...:: : ::. : ....::.: : : ::::.: XP_016 ISTLGLQELKEQSPCPS-RGRVEGGG-VSSLLPNHHHPHGPPGGLFEDFAC 280 290 300 310 320 528 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:42:19 2016 done: Tue Nov 8 05:42:20 2016 Total Scan time: 8.200 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]