FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1868, 389 aa 1>>>pF1KE1868 389 - 389 aa - 389 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6796+/-0.000262; mu= 16.8096+/- 0.017 mean_var=92.7988+/-18.311, 0's: 0 Z-trim(122.1): 60 B-trim: 221 in 2/52 Lambda= 0.133138 statistics sampled from 39607 (39669) to 39607 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.465), width: 16 Scan time: 9.780 The best scores are: opt bits E(85289) NP_003385 (OMIM: 225300,601906,617073) protein Wnt ( 389) 2794 546.1 5.3e-155 XP_016875408 (OMIM: 225300,601906,617073) PREDICTE ( 267) 1958 385.4 8.7e-107 XP_011537024 (OMIM: 225300,601906,617073) PREDICTE ( 267) 1958 385.4 8.7e-107 NP_079492 (OMIM: 150400,224750,257980,606268) prot ( 417) 1282 255.7 1.5e-67 XP_011510231 (OMIM: 150400,224750,257980,606268) P ( 385) 1254 250.3 5.8e-66 XP_011537026 (OMIM: 225300,601906,617073) PREDICTE ( 164) 956 192.7 5.2e-49 NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 740 151.5 2.9e-36 XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt ( 446) 740 151.6 3.4e-36 NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 736 150.7 4.9e-36 NP_006513 (OMIM: 604663) protein Wnt-6 precursor [ ( 365) 723 148.3 2.8e-35 XP_011532393 (OMIM: 228930,276820,601570) PREDICTE ( 282) 713 146.2 8.8e-35 NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 713 146.3 1e-34 NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 708 145.4 2e-34 XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt ( 353) 708 145.4 2e-34 XP_011539900 (OMIM: 158330,603490,611812) PREDICTE ( 296) 685 140.9 3.8e-33 NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 685 140.9 4.3e-33 XP_011539899 (OMIM: 158330,603490,611812) PREDICTE ( 373) 685 141.0 4.5e-33 NP_001278809 (OMIM: 601968) protein Wnt-2b isoform ( 299) 683 140.5 5e-33 NP_004176 (OMIM: 601968) protein Wnt-2b isoform WN ( 372) 683 140.6 5.9e-33 NP_078613 (OMIM: 601968) protein Wnt-2b isoform WN ( 391) 683 140.6 6.1e-33 NP_003382 (OMIM: 147870) protein Wnt-2 precursor [ ( 360) 672 138.5 2.5e-32 NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 669 137.9 3.8e-32 XP_011532389 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32 XP_011532390 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32 XP_006713387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32 XP_016862617 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32 XP_011532388 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32 XP_011532387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32 XP_011532391 (OMIM: 164975,180700) PREDICTED: prot ( 365) 669 137.9 3.8e-32 NP_003383 (OMIM: 164975,180700) protein Wnt-5a iso ( 380) 669 137.9 3.9e-32 XP_016862616 (OMIM: 164975,180700) PREDICTED: prot ( 394) 669 137.9 4e-32 NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 661 136.3 1.1e-31 NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 661 136.3 1.1e-31 XP_011543543 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 643 132.8 9e-31 XP_016873730 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 643 132.8 9e-31 XP_005274288 (OMIM: 603699) PREDICTED: protein Wnt ( 354) 643 132.9 1.2e-30 NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 643 132.9 1.2e-30 XP_011543542 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 643 132.9 1.2e-30 XP_011543540 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 643 132.9 1.2e-30 XP_011543541 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 643 132.9 1.2e-30 NP_057171 (OMIM: 606267) protein Wnt-16 isoform 2 ( 355) 623 129.0 1.7e-29 NP_476509 (OMIM: 606267) protein Wnt-16 isoform 1 ( 365) 623 129.1 1.7e-29 XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt ( 295) 557 116.3 9.6e-26 NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 557 116.4 1.1e-25 NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 520 109.3 1.5e-23 XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt ( 363) 520 109.3 1.5e-23 XP_016873732 (OMIM: 603699) PREDICTED: protein Wnt ( 185) 509 106.9 4e-23 XP_016873731 (OMIM: 603699) PREDICTED: protein Wnt ( 185) 509 106.9 4e-23 NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 455 96.8 8.6e-20 XP_011510232 (OMIM: 150400,224750,257980,606268) P ( 299) 446 95.0 2.5e-19 >>NP_003385 (OMIM: 225300,601906,617073) protein Wnt-10b (389 aa) initn: 2794 init1: 2794 opt: 2794 Z-score: 2903.7 bits: 546.1 E(85289): 5.3e-155 Smith-Waterman score: 2794; 100.0% identity (100.0% similar) in 389 aa overlap (1-389:1-389) 10 20 30 40 50 60 pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 ENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTR 310 320 330 340 350 360 370 380 pF1KE1 VERCHCRFHWCCYVLCDECKVTEWVNVCK ::::::::::::::::::::::::::::: NP_003 VERCHCRFHWCCYVLCDECKVTEWVNVCK 370 380 >>XP_016875408 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa) initn: 1958 init1: 1958 opt: 1958 Z-score: 2038.1 bits: 385.4 E(85289): 8.7e-107 Smith-Waterman score: 1958; 100.0% identity (100.0% similar) in 267 aa overlap (123-389:1-267) 100 110 120 130 140 150 pF1KE1 NCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSG :::::::::::::::::::::::::::::: XP_016 MLAAGVMHAVATACSLGKLVSCGCGWKGSG 10 20 30 160 170 180 190 200 210 pF1KE1 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE1 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE1 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR 160 170 180 190 200 210 340 350 360 370 380 pF1KE1 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK 220 230 240 250 260 >>XP_011537024 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa) initn: 1958 init1: 1958 opt: 1958 Z-score: 2038.1 bits: 385.4 E(85289): 8.7e-107 Smith-Waterman score: 1958; 100.0% identity (100.0% similar) in 267 aa overlap (123-389:1-267) 100 110 120 130 140 150 pF1KE1 NCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSG :::::::::::::::::::::::::::::: XP_011 MLAAGVMHAVATACSLGKLVSCGCGWKGSG 10 20 30 160 170 180 190 200 210 pF1KE1 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE1 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE1 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGR 160 170 180 190 200 210 340 350 360 370 380 pF1KE1 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK 220 230 240 250 260 >>NP_079492 (OMIM: 150400,224750,257980,606268) protein (417 aa) initn: 1791 init1: 664 opt: 1282 Z-score: 1333.8 bits: 255.7 E(85289): 1.5e-67 Smith-Waterman score: 1776; 60.4% identity (80.9% similar) in 404 aa overlap (5-389:14-417) 10 20 30 40 pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALS----NEILGLKLPGEPPLTANTV :.:.: :. . :.:: : . :. :.:: :.:: :: :.:::: NP_079 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 CLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHS :::: :::.::. .:.:.:::.:::.::..::.::::::.::::::::.:: ...:..: NP_079 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 AILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKL--LQLQ :..::::::::.... ::::.:::..::.:::: .::: . :... .: :: :::. NP_079 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 ALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQA ::.:::.. :..: . ::: ::.::::::. :: :::.::.::::::: :::.: NP_079 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 RMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFI :::.::::::::.: ::..:::::::::::::.::::...::::.::: :: :. :: .: NP_079 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI 250 260 270 280 290 300 290 300 310 320 330 pF1KE1 DTHNRNSGAFQPRLR-----------PRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGR ::::.: ..: ::: .. .:::::::::::::.: . : :: :: NP_079 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR 310 320 330 340 350 360 340 350 360 370 380 pF1KE1 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK :::.: :::::.:::::::.::::: :::::::::::.:.:.::..::::.::: NP_079 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK 370 380 390 400 410 >>XP_011510231 (OMIM: 150400,224750,257980,606268) PREDI (385 aa) initn: 1784 init1: 664 opt: 1254 Z-score: 1305.2 bits: 250.3 E(85289): 5.8e-66 Smith-Waterman score: 1748; 62.2% identity (82.4% similar) in 381 aa overlap (24-389:5-385) 10 20 30 40 50 60 pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG ::. :.:: :.:: :: :.:::::::: :::.::. XP_011 MTPPSRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQME 10 20 30 40 70 80 90 100 110 120 pF1KE1 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS .:.:.:::.:::.::..::.::::::.::::::::.:: ...:..: :..::::::::. XP_011 VCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFA 50 60 70 80 90 100 130 140 150 160 170 pF1KE1 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKL--LQLQALSRGKSFPHSLP ... ::::.:::..::.:::: .::: . :... .: :: :::.::.:::.. :..: XP_011 YAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 SPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQV . ::: ::.::::::. :: :::.::.::::::: :::.::::.::::::::. XP_011 EHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 VTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPR : ::..:::::::::::::.::::...::::.::: :: :. :: .: ::::.: ..: XP_011 VMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNGGQLEPG 230 240 250 260 270 280 300 310 320 330 340 pF1KE1 LR-----------PRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCG ::: .. .:::::::::::::.: . : :: :: :::.: :::: XP_011 PAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCG 290 300 310 320 330 340 350 360 370 380 pF1KE1 SLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK :.:::::::.::::: :::::::::::.:.:.::..::::.::: XP_011 SMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK 350 360 370 380 >>XP_011537026 (OMIM: 225300,601906,617073) PREDICTED: p (164 aa) initn: 976 init1: 956 opt: 956 Z-score: 1000.9 bits: 192.7 E(85289): 5.2e-49 Smith-Waterman score: 956; 99.3% identity (99.3% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSP ::::::::::::::::::::: : XP_011 FSMLAAGVMHAVATACSLGKLGSSPGHPGTNANPQQQGGAPGGN 130 140 150 160 >>NP_149122 (OMIM: 606359) protein Wnt-3a precursor [Hom (352 aa) initn: 973 init1: 380 opt: 740 Z-score: 772.1 bits: 151.5 E(85289): 2.9e-36 Smith-Waterman score: 947; 38.4% identity (61.6% similar) in 385 aa overlap (19-389:7-352) 10 20 30 40 50 pF1KE1 MLEEPRPRPPPSGLAGLLFLALCS--RALSNEILGLKLPGEPPLTA----NTVCLTLSGL :: ::: .::.. . .: : .. .: .. :: NP_149 MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGL 10 20 30 40 60 70 80 90 100 110 pF1KE1 SKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGF .:: .: .. :. .:..:...:::::.: .::::.... . : . .: .. NP_149 VPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDS--LAIFGPVLDKAT 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 RESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFP ::::: .. .::: ::. .:. : . :::. . .: NP_149 RESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQG---------------------- 110 120 130 140 180 190 200 210 220 230 pF1KE1 HSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRV ::: : :.::::..:..:: ::.: :.:: : .. : :::.. NP_149 ----SPGKG----------WKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEA 150 160 170 180 190 240 250 260 270 280 290 pF1KE1 GRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRA--IFIDTHNRNS :::... ... :::::: ::::. :::: . :.:::.: :... : . .. : :.: NP_149 GRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKH-RES 200 210 220 230 240 300 310 320 330 340 pF1KE1 GAFQPRLRPR----RLSGE--LVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGS .. :::: .. : :::.: ::.::: .: :: ::: :.:: .:. .::: NP_149 RGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDL 250 260 270 280 290 300 350 360 370 380 pF1KE1 LCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK ::::::::. . : :.:.: ::::::: :.:: . :..:: NP_149 LCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK 310 320 330 340 350 >>XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt-3a (446 aa) initn: 973 init1: 380 opt: 740 Z-score: 770.7 bits: 151.6 E(85289): 3.4e-36 Smith-Waterman score: 947; 38.4% identity (61.6% similar) in 385 aa overlap (19-389:7-352) 10 20 30 40 50 pF1KE1 MLEEPRPRPPPSGLAGLLFLALCS--RALSNEILGLKLPGEPPLTA----NTVCLTLSGL :: ::: .::.. . .: : .. .: .. :: XP_011 MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGL 10 20 30 40 60 70 80 90 100 110 pF1KE1 SKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGF .:: .: .. :. .:..:...:::::.: .::::.... . : . .: .. XP_011 VPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDS--LAIFGPVLDKAT 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 RESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFP ::::: .. .::: ::. .:. : . :::. . .: XP_011 RESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQG---------------------- 110 120 130 140 180 190 200 210 220 230 pF1KE1 HSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRV ::: : :.::::..:..:: ::.: :.:: : .. : :::.. XP_011 ----SPGKG----------WKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEA 150 160 170 180 190 240 250 260 270 280 290 pF1KE1 GRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRA--IFIDTHNRNS :::... ... :::::: ::::. :::: . :.:::.: :... : . .. : :.: XP_011 GRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKH-RES 200 210 220 230 240 300 310 320 330 340 pF1KE1 GAFQPRLRPR----RLSGE--LVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGS .. :::: .. : :::.: ::.::: .: :: ::: :.:: .:. .::: XP_011 RGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDL 250 260 270 280 290 300 350 360 370 380 pF1KE1 LCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK ::::::::. . : :.:.: ::::::: :.:: . :..:: XP_011 LCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCKPCHSWATGREGRRRWST 310 320 330 340 350 360 XP_011 LGCGPRDGCLRTGHSGPCRSLAWIWSPGSQGHDLLEQLPRSGGLGQCSSLQNWTAVSGCL 370 380 390 400 410 420 >>NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt-3 p (355 aa) initn: 953 init1: 391 opt: 736 Z-score: 767.9 bits: 150.7 E(85289): 4.9e-36 Smith-Waterman score: 923; 38.8% identity (60.4% similar) in 374 aa overlap (24-389:28-355) 10 20 30 40 50 pF1KE1 MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSK : ::... .: : :: .: .. :: NP_110 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSL---GSQPL----LCGSIPGLVP 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 RQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRE .:: .: .. :. .:......:::::.: .::::.... . : . .: .. :: NP_110 KQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDS--LAIFGPVLDKATRE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 SAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHS ::: .. .::: ::. .:. : . ::: . .: NP_110 SAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKG------------------------ 120 130 140 180 190 200 210 220 230 pF1KE1 LPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGR : :: : :.::::..: ::: ::.: :.:: : .. : :::..:: NP_110 -P-PGEG----------WKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGR 150 160 170 180 190 240 250 260 270 280 290 pF1KE1 QVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRA--IFIDTHNRNSGA .. .... :::::: ::::. :::: : :.:::.: :... : . .. : :.: . NP_110 TTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKH-RESRG 200 210 220 230 240 250 300 310 320 330 340 pF1KE1 FQPRLRPRR------LSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLC . :: . .:::.:.::.::: .: :: ::: :.:: ::. .::: :: NP_110 WVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLC 260 270 280 290 300 310 350 360 370 380 pF1KE1 CGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK ::::::. . : :.::: ::::::: :.:: :..:: NP_110 CGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 320 330 340 350 >>NP_006513 (OMIM: 604663) protein Wnt-6 precursor [Homo (365 aa) initn: 1014 init1: 326 opt: 723 Z-score: 754.3 bits: 148.3 E(85289): 2.8e-35 Smith-Waterman score: 997; 42.6% identity (63.5% similar) in 392 aa overlap (9-388:3-364) 10 20 30 40 50 pF1KE1 MLEEPRPRPP-PSGLAGLLFLALCSRALSNEILGLKLPGEPPLTAN--TVCLTLSGLSKR :: :: :. ::.: :: .. :: ::. . ..: :. : NP_006 MLPPLPSRLGLLLLLLLCP----AHVGGLWWAVGSPLVMDPTSICRKARRLAGR 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 QLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGG-GRLPHHSAILKRGFRE : :: .:.:.: .: ...:.::: :.: .:::::. . :: ::.. .:: NP_006 QAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGR------ILQQDIRE 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 SAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHS .:: :.. :::. :::. :::.:.:..::: . : :: : ...: . NP_006 TAFVFAITAAGASHAVTQACSMGELLQCGC------QAPRGRAP-------PRPSGLPGT 110 120 130 140 150 180 190 200 210 220 230 pF1KE1 LPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREA-PR-DIQARMRIHNNRV :.: :: . :: . .::::::. :.:::.. :: :.:.:. : ::.: ...:::.. NP_006 -PGP-PGPAGSPEGSAAWEWGGCGDDVDFGDEKSRLFMDARHKRGRGDIRALVQLHNNEA 160 170 180 190 200 240 250 260 270 280 290 pF1KE1 GRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSG- :: .: . . .::::: :::: ..:::. : :: ::: : ::. : . . :.: NP_006 GRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRV--MGTNDGK 210 220 230 240 250 260 300 310 320 330 340 350 pF1KE1 AFQPRLRPRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGR :. : .: . : .:.: ::::: . :::::::::::... :.:: ::::: NP_006 ALLPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGR 270 280 290 300 310 320 360 370 380 pF1KE1 GHNVLRQTRV---ERCHCRFHWCCYVLCDECKVTEWVNVCK :: :: : : : ::::::: : : .:.: . ...: NP_006 GH---RQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLCL 330 340 350 360 389 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:51:51 2016 done: Sun Nov 6 14:51:52 2016 Total Scan time: 9.780 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]