FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3937, 199 aa 1>>>pF1KE3937 199 - 199 aa - 199 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7411+/-0.000427; mu= 16.6166+/- 0.027 mean_var=73.5166+/-14.641, 0's: 0 Z-trim(112.2): 417 B-trim: 465 in 1/52 Lambda= 0.149583 statistics sampled from 20587 (21079) to 20587 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.619), E-opt: 0.2 (0.247), width: 16 Scan time: 5.020 The best scores are: opt bits E(85289) NP_116307 (OMIM: 612664) ras-related and estrogen- ( 199) 1285 286.4 2e-77 XP_016875610 (OMIM: 612664) PREDICTED: ras-related ( 196) 1160 259.4 2.6e-69 NP_001177655 (OMIM: 612664) ras-related and estrog ( 180) 1037 232.9 2.4e-61 NP_036382 (OMIM: 600098) ras-related protein R-Ras ( 204) 506 118.3 8.3e-27 NP_008843 (OMIM: 609591,615355) GTP-binding protei ( 219) 496 116.2 3.9e-26 NP_001243750 (OMIM: 609591,615355) GTP-binding pro ( 236) 496 116.2 4.1e-26 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 490 114.8 8.5e-26 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 490 114.8 8.5e-26 NP_002921 (OMIM: 609592) GTP-binding protein Rit2 ( 217) 490 114.9 9.5e-26 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 467 109.9 2.6e-24 XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 467 109.9 2.6e-24 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 467 109.9 2.6e-24 NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 467 109.9 2.6e-24 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 467 109.9 2.6e-24 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 467 109.9 2.6e-24 NP_004976 (OMIM: 109800,114480,137215,163200,19007 ( 188) 454 107.1 1.9e-23 XP_011518955 (OMIM: 109800,114480,137215,163200,19 ( 188) 454 107.1 1.9e-23 XP_016872852 (OMIM: 600098) PREDICTED: ras-related ( 182) 445 105.1 7e-23 NP_203524 (OMIM: 109800,114480,137215,163200,19007 ( 189) 445 105.1 7.2e-23 XP_006719132 (OMIM: 109800,114480,137215,163200,19 ( 189) 445 105.1 7.2e-23 XP_016874782 (OMIM: 109800,114480,137215,163200,19 ( 227) 445 105.2 8.2e-23 XP_011513768 (OMIM: 179550) PREDICTED: ras-related ( 206) 443 104.7 1e-22 XP_006715825 (OMIM: 179550) PREDICTED: ras-related ( 206) 443 104.7 1e-22 NP_005393 (OMIM: 179550) ras-related protein Ral-A ( 206) 443 104.7 1e-22 NP_002877 (OMIM: 179541) ras-related protein Rap-2 ( 183) 440 104.0 1.5e-22 NP_066361 (OMIM: 179540) ras-related protein Rap-2 ( 183) 439 103.8 1.7e-22 XP_016861376 (OMIM: 608435) PREDICTED: ras-related ( 208) 439 103.9 1.9e-22 NP_036351 (OMIM: 608435) ras-related protein M-Ras ( 208) 439 103.9 1.9e-22 XP_005247285 (OMIM: 608435) PREDICTED: ras-related ( 208) 439 103.9 1.9e-22 NP_001078518 (OMIM: 608435) ras-related protein M- ( 208) 439 103.9 1.9e-22 NP_001239019 (OMIM: 608435) ras-related protein M- ( 208) 439 103.9 1.9e-22 NP_001170785 (OMIM: 600098) ras-related protein R- ( 169) 435 102.9 3e-22 NP_002515 (OMIM: 114500,137550,162900,163200,16479 ( 189) 435 103.0 3.2e-22 NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 431 102.1 5.7e-22 XP_016860111 (OMIM: 179551) PREDICTED: ras-related ( 206) 429 101.7 8.4e-22 XP_005263785 (OMIM: 179551) PREDICTED: ras-related ( 206) 429 101.7 8.4e-22 NP_002872 (OMIM: 179551) ras-related protein Ral-B ( 206) 429 101.7 8.4e-22 XP_005263784 (OMIM: 179551) PREDICTED: ras-related ( 206) 429 101.7 8.4e-22 XP_005263786 (OMIM: 179551) PREDICTED: ras-related ( 206) 429 101.7 8.4e-22 XP_005263781 (OMIM: 179551) PREDICTED: ras-related ( 228) 429 101.8 9e-22 XP_016860110 (OMIM: 179551) PREDICTED: ras-related ( 228) 429 101.8 9e-22 XP_011509875 (OMIM: 179551) PREDICTED: ras-related ( 229) 429 101.8 9.1e-22 NP_005334 (OMIM: 109800,137550,162900,163200,18847 ( 189) 428 101.5 9.2e-22 NP_001123914 (OMIM: 109800,137550,162900,163200,18 ( 189) 428 101.5 9.2e-22 NP_996563 (OMIM: 612403) ras-like protein family m ( 242) 426 101.1 1.5e-21 XP_016857450 (OMIM: 179520) PREDICTED: ras-related ( 195) 415 98.7 6.6e-21 XP_016857449 (OMIM: 179520) PREDICTED: ras-related ( 195) 415 98.7 6.6e-21 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 398 95.0 9e-20 XP_005247286 (OMIM: 608435) PREDICTED: ras-related ( 170) 396 94.5 1e-19 NP_076429 (OMIM: 612404) ras-like protein family m ( 248) 395 94.5 1.6e-19 >>NP_116307 (OMIM: 612664) ras-related and estrogen-regu (199 aa) initn: 1285 init1: 1285 opt: 1285 Z-score: 1510.9 bits: 286.4 E(85289): 2e-77 Smith-Waterman score: 1285; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR 130 140 150 160 170 180 190 pF1KE3 SSTTHVKQAINKMLTKISS ::::::::::::::::::: NP_116 SSTTHVKQAINKMLTKISS 190 >>XP_016875610 (OMIM: 612664) PREDICTED: ras-related and (196 aa) initn: 1160 init1: 1160 opt: 1160 Z-score: 1365.2 bits: 259.4 E(85289): 2.6e-69 Smith-Waterman score: 1160; 100.0% identity (100.0% similar) in 178 aa overlap (22-199:19-196) 10 20 30 40 50 60 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD ::::::::::::::::::::::::::::::::::::::: XP_016 MNSGPVVTQQPAHCHAHTLVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR 120 130 140 150 160 170 190 pF1KE3 SSTTHVKQAINKMLTKISS ::::::::::::::::::: XP_016 SSTTHVKQAINKMLTKISS 180 190 >>NP_001177655 (OMIM: 612664) ras-related and estrogen-r (180 aa) initn: 1037 init1: 1037 opt: 1037 Z-score: 1222.2 bits: 232.9 E(85289): 2.4e-61 Smith-Waterman score: 1109; 90.5% identity (90.5% similar) in 199 aa overlap (1-199:1-180) 10 20 30 40 50 60 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD :::::::::::::::::::: ::::::::::::::::::::: NP_001 MAKSAEVKLAIFGRAGVGKS-------------------ESTYRHQATIDDEVVSMEILD 10 20 30 40 70 80 90 100 110 120 pF1KE3 TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR 110 120 130 140 150 160 190 pF1KE3 SSTTHVKQAINKMLTKISS ::::::::::::::::::: NP_001 SSTTHVKQAINKMLTKISS 170 180 >>NP_036382 (OMIM: 600098) ras-related protein R-Ras2 is (204 aa) initn: 477 init1: 279 opt: 506 Z-score: 602.3 bits: 118.3 E(85289): 8.3e-27 Smith-Waterman score: 506; 46.6% identity (77.9% similar) in 163 aa overlap (8-169:16-177) 10 20 30 40 50 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDE .:.. : .:::::::...:. . :. .::::.:..: .: .:::. NP_036 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 VVSMEILDTAGQEDT-IQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNV .. ..::::::::. .:: .:: ::::.::...::::::::. .. . ..: . NP_036 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 TLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRR .::.::::::::.:::. :::..:: .: ...: :: . :. . :.:: : .:. NP_036 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKI-RMNVDQAFHELVRVIRKFQ 130 140 150 160 170 180 190 pF1KE3 MVQGKTRRRSSTTHVKQAINKMLTKISS NP_036 EQECPPSPEPTRKEKDKKGCHCVIF 180 190 200 >>NP_008843 (OMIM: 609591,615355) GTP-binding protein Ri (219 aa) initn: 457 init1: 265 opt: 496 Z-score: 590.2 bits: 116.2 E(85289): 3.9e-26 Smith-Waterman score: 496; 45.2% identity (77.4% similar) in 168 aa overlap (4-170:19-185) 10 20 30 40 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRH : : ::...: .::::::....:...:: ..:::.:..:. NP_008 MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 QATIDDEVVSMEILDTAGQED-TIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDE . :::: ....::::::: . : .:. .:: ::::.. :.:::: ::.:: .:... . NP_008 RIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYR 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 IKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELC ... .. ..:::::.:: . :::. ::: :: :..: :.: :: . : ..:. : NP_008 VRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAY-RYYIDDVFHALV 130 140 150 160 170 170 180 190 pF1KE3 REVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS ::.::. NP_008 REIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT 180 190 200 210 >>NP_001243750 (OMIM: 609591,615355) GTP-binding protein (236 aa) initn: 457 init1: 265 opt: 496 Z-score: 589.8 bits: 116.2 E(85289): 4.1e-26 Smith-Waterman score: 496; 45.2% identity (77.4% similar) in 168 aa overlap (4-170:36-202) 10 20 30 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIW : : ::...: .::::::....:...:: NP_001 FLGATEEGPKRTMDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 EYDPTLESTYRHQATIDDEVVSMEILDTAGQED-TIQREGHMRWGEGFVLVYDITDRGSF ..:::.:..:. . :::: ....::::::: . : .:. .:: ::::.. :.:::: :: NP_001 DHDPTIEDAYKIRIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSF 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 EEVLPLKNILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTG .:: .:... .... .. ..:::::.:: . :::. ::: :: :..: :.: :: NP_001 HEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAY- 130 140 150 160 170 180 160 170 180 190 pF1KE3 EGNITEIFYELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS . : ..:. : ::.::. NP_001 RYYIDDVFHALVREIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT 190 200 210 220 230 >>NP_056461 (OMIM: 179530) ras-related protein Rap-1b is (184 aa) initn: 464 init1: 277 opt: 490 Z-score: 584.2 bits: 114.8 E(85289): 8.5e-26 Smith-Waterman score: 490; 44.7% identity (75.4% similar) in 179 aa overlap (6-182:3-180) 10 20 30 40 50 60 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD : ::...: .:::::::.:.:. :. .::::.:..::.:. .: . .:::: NP_056 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILD 10 20 30 40 50 70 80 90 100 110 pF1KE3 TAGQED-TIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNK ::: :. : .:. .:. :.::.:::.:: ...:... :.. . ..: .: .:::::: NP_056 TAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 ADLDHSRQVSTEEGEKLATELA-CAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTR ::. : :. :.:..:: . ::: : :: .. :..::::.: :.. :. : ::.: NP_056 CDLEDERVVGKEQGQNLARQWNNCAFLESSA-KSKINVNEIFYDLVRQINRKTPVPGKAR 120 130 140 150 160 170 180 190 pF1KE3 RRSSTTHVKQAINKMLTKISS ..:: NP_056 KKSSCQLL 180 >>NP_001010942 (OMIM: 179530) ras-related protein Rap-1b (184 aa) initn: 464 init1: 277 opt: 490 Z-score: 584.2 bits: 114.8 E(85289): 8.5e-26 Smith-Waterman score: 490; 44.7% identity (75.4% similar) in 179 aa overlap (6-182:3-180) 10 20 30 40 50 60 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD : ::...: .:::::::.:.:. :. .::::.:..::.:. .: . .:::: NP_001 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILD 10 20 30 40 50 70 80 90 100 110 pF1KE3 TAGQED-TIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNK ::: :. : .:. .:. :.::.:::.:: ...:... :.. . ..: .: .:::::: NP_001 TAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 ADLDHSRQVSTEEGEKLATELA-CAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTR ::. : :. :.:..:: . ::: : :: .. :..::::.: :.. :. : ::.: NP_001 CDLEDERVVGKEQGQNLARQWNNCAFLESSA-KSKINVNEIFYDLVRQINRKTPVPGKAR 120 130 140 150 160 170 180 190 pF1KE3 RRSSTTHVKQAINKMLTKISS ..:: NP_001 KKSSCQLL 180 >>NP_002921 (OMIM: 609592) GTP-binding protein Rit2 isof (217 aa) initn: 453 init1: 277 opt: 490 Z-score: 583.3 bits: 114.9 E(85289): 9.5e-26 Smith-Waterman score: 490; 42.4% identity (75.5% similar) in 184 aa overlap (4-182:18-200) 10 20 30 40 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQ : : :....: .::::::....:....: .:::.:..:. : NP_002 MEVENEASCSPGSASGGSREYKVVMLGAGGVGKSAMTMQFISHQFPDYHDPTIEDAYKTQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 ATIDDEVVSMEILDTAGQED-TIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEI . ::.: . ..::::::: . : .:: .:: ::::.. :..::: ::.:. .:... .. NP_002 VRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVTDRQSFQEAAKFKELIFQV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 KKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCR .. .. :.::::: ::.. :::::::: .:: : :.:.: :: . : . :. : : NP_002 RHTYEIPLVLVGNKIDLEQFRQVSTEEGLSLAQEYNCGFFETSAAL-RFCIDDAFHGLVR 130 140 150 160 170 170 180 190 pF1KE3 EVRRRR----MVQGKTRRRSSTTHVKQAINKMLTKISS :.:... ... : .:..: NP_002 EIRKKESMPSLMEKKLKRKDSLWKKLKGSLKKKRENMT 180 190 200 210 >>XP_016857451 (OMIM: 179520) PREDICTED: ras-related pro (184 aa) initn: 440 init1: 229 opt: 467 Z-score: 557.3 bits: 109.9 E(85289): 2.6e-24 Smith-Waterman score: 467; 43.0% identity (74.9% similar) in 179 aa overlap (6-182:3-180) 10 20 30 40 50 60 pF1KE3 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD : ::...: .:::::::.:.:. :. .::::.:..::.:. .: . .:::: XP_016 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILD 10 20 30 40 50 70 80 90 100 110 pF1KE3 TAGQED-TIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNK ::: :. : .:. .:. :.::.:::.:: ...:... :.. . ..: ..: .:::::: XP_016 TAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 ADLDHSRQVSTEEGEKLATELA-CAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTR ::. : :. :.:..:: . ::: : :: .. :..::::.: :.. :. :. : XP_016 CDLEDERVVGKEQGQNLARQWCNCAFLESSA-KSKINVNEIFYDLVRQINRKTPVEKKKP 120 130 140 150 160 170 180 190 pF1KE3 RRSSTTHVKQAINKMLTKISS ...: XP_016 KKKSCLLL 180 199 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:46:54 2016 done: Sun Nov 6 08:46:54 2016 Total Scan time: 5.020 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]