FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3980, 529 aa 1>>>pF1KE3980 529 - 529 aa - 529 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1646+/-0.000696; mu= 19.9050+/- 0.042 mean_var=83.8180+/-16.757, 0's: 0 Z-trim(110.7): 97 B-trim: 66 in 1/48 Lambda= 0.140090 statistics sampled from 11642 (11790) to 11642 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.362), width: 16 Scan time: 3.290 The best scores are: opt bits E(32554) CCDS8534.1 KCNA6 gene_id:3742|Hs108|chr12 ( 529) 3570 731.3 6.4e-211 CCDS8536.1 KCNA5 gene_id:3741|Hs108|chr12 ( 613) 1247 261.9 1.5e-69 CCDS827.1 KCNA2 gene_id:3737|Hs108|chr1 ( 499) 1236 259.6 6.1e-69 CCDS8535.1 KCNA1 gene_id:3736|Hs108|chr12 ( 495) 1200 252.3 9.4e-67 CCDS41629.1 KCNA4 gene_id:3739|Hs108|chr11 ( 653) 1199 252.2 1.3e-66 CCDS55625.1 KCNA2 gene_id:3737|Hs108|chr1 ( 356) 907 193.0 5e-49 CCDS828.2 KCNA3 gene_id:3738|Hs108|chr1 ( 575) 904 192.6 1.1e-48 CCDS12755.1 KCNA7 gene_id:3743|Hs108|chr19 ( 456) 864 184.4 2.5e-46 CCDS826.1 KCNA10 gene_id:3744|Hs108|chr1 ( 511) 824 176.3 7.2e-44 CCDS10945.1 KCNG4 gene_id:93107|Hs108|chr16 ( 519) 576 126.2 9e-29 CCDS13418.1 KCNB1 gene_id:3745|Hs108|chr20 ( 858) 576 126.4 1.3e-28 CCDS13436.1 KCNG1 gene_id:3755|Hs108|chr20 ( 513) 573 125.6 1.4e-28 CCDS6209.1 KCNB2 gene_id:9312|Hs108|chr8 ( 911) 566 124.4 5.5e-28 CCDS1809.1 KCNG3 gene_id:170850|Hs108|chr2 ( 436) 537 118.3 1.9e-26 CCDS12019.1 KCNG2 gene_id:26251|Hs108|chr18 ( 466) 536 118.1 2.2e-26 CCDS6447.1 KCNV2 gene_id:169522|Hs108|chr9 ( 545) 535 118.0 2.9e-26 CCDS42674.1 KCNG3 gene_id:170850|Hs108|chr2 ( 425) 532 117.3 3.7e-26 CCDS12793.1 KCNC3 gene_id:3748|Hs108|chr19 ( 757) 531 117.3 6.4e-26 CCDS7827.1 KCNC1 gene_id:3746|Hs108|chr11 ( 511) 521 115.1 2e-25 CCDS44547.1 KCNC1 gene_id:3746|Hs108|chr11 ( 585) 521 115.2 2.2e-25 CCDS9006.1 KCNC2 gene_id:3747|Hs108|chr12 ( 558) 512 113.3 7.4e-25 CCDS58255.1 KCNC2 gene_id:3747|Hs108|chr12 ( 583) 512 113.3 7.6e-25 CCDS9005.1 KCNC2 gene_id:3747|Hs108|chr12 ( 613) 512 113.4 7.9e-25 CCDS58257.1 KCNC2 gene_id:3747|Hs108|chr12 ( 618) 512 113.4 8e-25 CCDS58256.1 KCNC2 gene_id:3747|Hs108|chr12 ( 629) 512 113.4 8.1e-25 CCDS9007.1 KCNC2 gene_id:3747|Hs108|chr12 ( 638) 512 113.4 8.1e-25 CCDS5776.1 KCND2 gene_id:3751|Hs108|chr7 ( 630) 508 112.6 1.4e-24 CCDS14314.1 KCND1 gene_id:3750|Hs108|chrX ( 647) 506 112.2 1.9e-24 CCDS844.1 KCND3 gene_id:3752|Hs108|chr1 ( 636) 504 111.8 2.5e-24 CCDS843.1 KCND3 gene_id:3752|Hs108|chr1 ( 655) 504 111.8 2.5e-24 CCDS44193.1 KCNC4 gene_id:3749|Hs108|chr1 ( 626) 502 111.3 3.3e-24 CCDS821.1 KCNC4 gene_id:3749|Hs108|chr1 ( 635) 502 111.4 3.3e-24 CCDS13342.1 KCNS1 gene_id:3787|Hs108|chr20 ( 526) 480 106.8 6.3e-23 CCDS1692.1 KCNS3 gene_id:3790|Hs108|chr2 ( 491) 469 104.6 2.8e-22 CCDS6279.1 KCNS2 gene_id:3788|Hs108|chr8 ( 477) 446 99.9 6.8e-21 CCDS1676.1 KCNF1 gene_id:3754|Hs108|chr2 ( 494) 443 99.3 1.1e-20 CCDS6314.1 KCNV1 gene_id:27012|Hs108|chr8 ( 500) 435 97.7 3.3e-20 CCDS13521.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 393) 294 69.1 1.1e-11 CCDS46629.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 841) 294 69.4 1.8e-11 CCDS13518.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 844) 294 69.4 1.8e-11 CCDS13519.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 854) 294 69.4 1.8e-11 CCDS13520.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 872) 294 69.4 1.9e-11 CCDS7736.1 KCNQ1 gene_id:3784|Hs108|chr11 ( 676) 284 67.3 6.3e-11 >>CCDS8534.1 KCNA6 gene_id:3742|Hs108|chr12 (529 aa) initn: 3570 init1: 3570 opt: 3570 Z-score: 3900.2 bits: 731.3 E(32554): 6.4e-211 Smith-Waterman score: 3570; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529) 10 20 30 40 50 60 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV 430 440 450 460 470 480 490 500 510 520 pF1KE3 TCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 TCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV 490 500 510 520 >>CCDS8536.1 KCNA5 gene_id:3741|Hs108|chr12 (613 aa) initn: 1514 init1: 945 opt: 1247 Z-score: 1362.0 bits: 261.9 E(32554): 1.5e-69 Smith-Waterman score: 2056; 70.3% identity (81.0% similar) in 468 aa overlap (12-473:86-531) 10 20 30 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG------GG : : : .... :: : : : CCDS85 AQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGD-PGLGTVEDQALGT 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE3 GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA . .:. :::::::::::: ::. ::.::::::..:.:.::::::::::::::::::. CCDS85 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDG 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE3 ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQP ::::::::::::::::: ::.: .:::::::::::. :::::: . : .::::: . CCDS85 ILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKE---EEKPLPRNE 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE3 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVS :::::::.:::::::: ::.:::::::::::::. :::::::.:: : : . : CCDS85 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFR-DERE-----LLRHP 240 250 260 270 280 220 230 240 250 260 270 pF1KE3 PVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT :. . . : : :. .. ... : ..::::.::: :..::: CCDS85 PAPHQPPAPAPGANGS---------GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT 290 300 310 320 330 280 290 300 310 320 330 pF1KE3 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQA ::::::: ::::: .: ::::::::.::::::::::::::. ::::..:::::::::: CCDS85 FELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA---EQQPGGGGGGQNGQQA 340 350 360 370 380 390 340 350 360 370 380 390 pF1KE3 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY 400 410 420 430 440 450 400 410 420 430 440 450 pF1KE3 FAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVP :::::.. . : ::::::::::::::::::::: :.:::::::::::::::::::::::: CCDS85 FAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE3 VIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPT ::::::::::::::..:: CCDS85 VIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENA 520 530 540 550 560 570 >>CCDS827.1 KCNA2 gene_id:3737|Hs108|chr1 (499 aa) initn: 1794 init1: 891 opt: 1236 Z-score: 1351.2 bits: 259.6 E(32554): 6.1e-69 Smith-Waterman score: 2087; 69.5% identity (80.6% similar) in 489 aa overlap (20-503:17-460) 10 20 30 40 50 60 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS :. ::. : ::: :: ::.:::::::::::::.::. CCDS82 MTVATGDPADEAAALPGHPQDTYD-PEADHE--CC--ERVVINISGLRFETQLKTLA 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE ::.:::::: .:.:.::::::::::::::::::::::::::::::::::::::::: :: CCDS82 QFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS ::::.::.::. :::::: . : .:.::: . ::::::::::::::::::: ::::: CCDS82 IRFYELGEEAMEMFREDEGYIKE---EERPLPENEFQRQVWLLFEYPESSGPARIIAIVS 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP :.::::::: ::::::: :: .:.:: : . : . CCDS82 VMVILISIVSFCLETLPIFR----------------------DENEDMHGSGVTFHTYSN 170 180 190 200 250 260 270 280 290 300 pF1KE3 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID . .: :.: ::::::.::::::.::.::.:::: ::::: .:: ::::::: CCDS82 STIGYQQSTS--------FTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 210 220 230 240 250 310 320 330 340 350 360 pF1KE3 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK .:::.::::::::::... :. .:.::::::::::::::::::::::::::::: CCDS82 IVAIIPYFITLGTELAEKPED-------AQQGQQAMSLAILRVIRLVRVFRIFKLSRHSK 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE3 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM ::::::.::.::::::::::::::::::::::::::::::. .: :::::::::::::.: CCDS82 GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSM 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE3 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV :::::::: : :.::::::::::::::::::::::::::::::::::::: :::.:: .: CCDS82 TTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQV 380 390 400 410 420 430 490 500 510 520 pF1KE3 T-CGQ-PA-PDLRATDNG--LGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV : : . :. :::. . .. ..: :. : CCDS82 TSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNI 440 450 460 470 480 490 >>CCDS8535.1 KCNA1 gene_id:3736|Hs108|chr12 (495 aa) initn: 2044 init1: 851 opt: 1200 Z-score: 1311.9 bits: 252.3 E(32554): 9.4e-67 Smith-Waterman score: 2015; 66.3% identity (80.9% similar) in 487 aa overlap (14-498:11-443) 10 20 30 40 50 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGG--CCSSERLVINISGLRFETQLRT :. . :. :: :..:. . :: ::.:::::::::::::.: CCDS85 MTVMSGENVDEASAAPGHPQD-GSYPRQADHDDHECC--ERVVINISGLRFETQLKT 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 LSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFL :. ::.::::.: .:.:.:::::::::::::::::::::::::::::::::::::::.: CCDS85 LAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAI :::.::.::.::. :::::: . :.:.::: . .:::::::::::::::::: ::: CCDS85 EEIKFYELGEEAMEKFREDEGFIK---EEERPLPEKEYQRQVWLLFEYPESSGPARVIAI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 VSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGI :::.:::::::::::::::... : .: : :. :.. .... CCDS85 VSVMVILISIVIFCLETLPELKDD--KDFTGTVHRI--------------DNTTVIYN-- 180 190 200 210 240 250 260 270 280 290 pF1KE3 TPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNI ...::::::.::::::.::.:::.::: ::::: ::.::::. CCDS85 -----------------SNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNF 220 230 240 250 300 310 320 330 340 350 pF1KE3 IDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRH ::.:::.:::::::::...:. :.:.:.:: :::::::::::::::::::::: CCDS85 IDIVAIIPYFITLGTEIAEQE--------GNQKGEQATSLAILRVIRLVRVFRIFKLSRH 260 270 280 290 300 360 370 380 390 400 410 pF1KE3 SKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVV ::::::::.::.:::::::::::::::::::::::::::::.. .: : ::::::::::: CCDS85 SKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVV 310 320 330 340 350 360 420 430 440 450 460 470 pF1KE3 TMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYT .:::::::::::.:.::::::::::::::::::::::::::::::::::::: :::.: CCDS85 SMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLL 370 380 390 400 410 420 480 490 500 510 520 pF1KE3 HVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV ::. .:.: :.:. :.. CCDS85 HVS----SPNL-ASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQ 430 440 450 460 470 480 >>CCDS41629.1 KCNA4 gene_id:3739|Hs108|chr11 (653 aa) initn: 2031 init1: 864 opt: 1199 Z-score: 1309.2 bits: 252.2 E(32554): 1.3e-66 Smith-Waterman score: 2019; 65.9% identity (80.6% similar) in 501 aa overlap (20-503:148-613) 10 20 30 40 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDF-PEAGGGGG--------CCSS :.. . :. :. :::: :: CCDS41 LRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC-- 120 130 140 150 160 170 50 60 70 80 90 100 pF1KE3 ERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYY ::.:::.::::::::..::. ::.:::::: .:...:::::::::::::::::::::::: CCDS41 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY 180 190 200 210 220 230 110 120 130 140 150 160 pF1KE3 QSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQV ::::::.::::::.::: ::..:::::.::: :::::: . : :... :: . :..:. CCDS41 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVRE--EEDRALPENEFKKQI 240 250 260 270 280 290 170 180 190 200 210 220 pF1KE3 WLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRG ::::::::::.::::::::::::::::::::::::::.:: : : . : .: : CCDS41 WLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFR-DDR-------DLVMALSAG 300 310 320 330 340 230 240 250 260 270 280 pF1KE3 SQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLV . :: : .. .. : . : ..:.::::.:::.:::::.::..: CCDS41 G--------------HG---GLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVV 350 360 370 380 290 300 310 320 330 340 pF1KE3 RFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAI : ::::. ::.:::::::.:.:.::::::::.:.::: .::.::. :::::.:: CCDS41 RCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQ-----GGGNGQQ-QQAMSFAI 390 400 410 420 430 440 350 360 370 380 390 400 pF1KE3 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEAD ::.:::::::::::::::::::::::.::.:::::::::::::::::::::::::::::: CCDS41 LRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEAD 450 460 470 480 490 500 410 420 430 440 450 460 pF1KE3 DDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSN . . : ::::::::::::::::::::: :.::::::::::::::::::::::::::::: CCDS41 EPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSN 510 520 530 540 550 560 470 480 490 500 510 pF1KE3 FNYFYHRETEQEEQGQYTH--VTCGQ-PAPDLR----ATDNGLG-KPDFPEANRERRPSY ::::::::::.::: : :. :.: :. :. .:...:: : .. : CCDS41 FNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESL 570 580 590 600 610 620 520 pF1KE3 LPTPHRAYAEKRMLTEV CCDS41 CAKEEKCQGKGDDSETDKNNCSNAKAVETDV 630 640 650 >>CCDS55625.1 KCNA2 gene_id:3737|Hs108|chr1 (356 aa) initn: 995 init1: 589 opt: 907 Z-score: 993.7 bits: 193.0 E(32554): 5e-49 Smith-Waterman score: 1283; 61.0% identity (74.6% similar) in 354 aa overlap (20-373:17-323) 10 20 30 40 50 60 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS :. ::. : ::: :: ::.:::::::::::::.::. CCDS55 MTVATGDPADEAAALPGHPQDTYD-PEADH--ECC--ERVVINISGLRFETQLKTLA 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE ::.:::::: .:.:.::::::::::::::::::::::::::::::::::::::::: :: CCDS55 QFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS ::::.::.::. :::::: . :.:.::: . ::::::::::::::::::: ::::: CCDS55 IRFYELGEEAMEMFREDEGYIK---EEERPLPENEFQRQVWLLFEYPESSGPARIIAIVS 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP :.::::::: ::::::: :: .:.:: : . : . CCDS55 VMVILISIVSFCLETLPIFR----------------------DENEDMHGSGVTFHTYSN 170 180 190 200 250 260 270 280 290 300 pF1KE3 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID . .: :.: ::::::.::::::.::.::.:::: ::::: .:: ::::::: CCDS55 STIGYQQSTS--------FTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 210 220 230 240 250 310 320 330 340 350 360 pF1KE3 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK .:::.::::::::::... :. .:.::::::::::::::: : : .. .. .. CCDS55 IVAIIPYFITLGTELAEKPED-------AQQGQQAMSLAILRVIRLER--RPLQSQKSKR 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE3 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM : : :. . . .. CCDS55 GRQHLNTSHDCTLGINLVAGMTVQWTRASGPDDRQTPAVTTLHRMY 320 330 340 350 >>CCDS828.2 KCNA3 gene_id:3738|Hs108|chr1 (575 aa) initn: 1828 init1: 894 opt: 904 Z-score: 987.7 bits: 192.6 E(32554): 1.1e-48 Smith-Waterman score: 2109; 68.9% identity (78.9% similar) in 508 aa overlap (19-501:63-529) 10 20 30 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG--GGGC--------- : : :.: : :: :::: CCDS82 HTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPS 40 50 60 70 80 90 40 50 60 70 80 pF1KE3 --------CSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRN : .::.:::::::::::::.:: ::.:::::: ::.:.::::::::::::: CCDS82 LPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRN 100 110 120 130 140 150 90 100 110 120 130 140 pF1KE3 RPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEK ::::::::::::::::.:::::::.::: :::::::::.::. :::::: : :.:. CCDS82 RPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLR---EEER 160 170 180 190 200 150 160 170 180 190 200 pF1KE3 PLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNG ::: . ::::::::::::::::::::::::::::::::::::::::::.:: . CCDS82 PLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDE------- 210 220 230 240 250 260 210 220 230 240 250 260 pF1KE3 GVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETL . :.: :: ::. ..:.:.: : :.: :.::::.:::: CCDS82 ---KDYPAST-SQ-------DSFE----------AAGNSTSGSRAGASSFSDPFFVVETL 270 280 290 300 270 280 290 300 310 320 pF1KE3 CIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGG ::.::.::::::: ::::: .: :::::.::.:::.::::::::::...: : CCDS82 CIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQ------G--- 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVIL ::::::::::::::::::::::::::::::::::::.::.::::::::::::::::::: CCDS82 -NGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVIL 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE3 FSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLT :::::::::::: : : :::::::::::::::::::::.:.:.:::::::::::::::: CCDS82 FSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLT 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE3 IALPVPVIVSNFNYFYHRETEQEEQGQYTHV-TC---GQPAPDLRA--TDNGLGKPDFPE ::::::::::::::::::::: :::.:: :: .: .. : .:: ... :.: .. CCDS82 IALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMV 480 490 500 510 520 530 510 520 pF1KE3 ANRERRPSYLPTPHRAYAEKRMLTEV CCDS82 IEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV 540 550 560 570 >>CCDS12755.1 KCNA7 gene_id:3743|Hs108|chr19 (456 aa) initn: 1931 init1: 860 opt: 864 Z-score: 945.4 bits: 184.4 E(32554): 2.5e-46 Smith-Waterman score: 1906; 63.4% identity (77.3% similar) in 497 aa overlap (36-529:10-456) 10 20 30 40 50 60 pF1KE3 SLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDT ::: ::::.:..::::::. :::. :::: CCDS12 MEPRCPPPCGCC--ERLVLNVAGLRFETRARTLGRFPDT 10 20 30 70 80 90 100 110 120 pF1KE3 LLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQ :::::.:: ::.: : ::::::.::::::.:::::::::::::..::::.::::. :: CCDS12 LLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE3 LGDEALAAFREDEGC-LPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVI :: ::: .:::::: .: :.::: . : ::.:::::.:::: :: .:.:::::: CCDS12 LGAAALARLREDEGCPVP----PERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVI 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE3 LISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMG :.:::.:::::::.:: : : :. :.. .. . : :. . CCDS12 LVSIVVFCLETLPDFR-DDRDGT--GLAAAAAA-------------------GPFPAPL- 160 170 180 190 250 260 270 280 290 300 pF1KE3 TGGSSSLSTLGGSF-FTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVA .:::.. . :.::::.:::::: ::.::::::. .:::: ::.:.::.::.:: CCDS12 -NGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVA 200 210 220 230 240 310 320 330 340 350 360 pF1KE3 IFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQ :.:::..:::::..:. : :::::::::::::::::::::::::::::::: CCDS12 ILPYFVALGTELARQR-------G---VGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQ 250 260 270 280 290 370 380 390 400 410 420 pF1KE3 ILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTV :::.::.:::::::::::::::::.::::::::::.: :: : :::..::::::::::: CCDS12 ILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFWWAVVTMTTV 300 310 320 330 340 350 430 440 450 460 470 480 pF1KE3 GYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCG ::::: :.:::::::::::::::::::.::::::::::.:::::::: :: :...:: CCDS12 GYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDM- 360 370 380 390 400 410 490 500 510 520 pF1KE3 QPAPDLRATDNG-LGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV :: :.. :: : . :: :: : : :...::: CCDS12 QPCGPLEGKANGGLVDGEVPE---------LPPPLWAPPGKHLVTEV 420 430 440 450 >>CCDS826.1 KCNA10 gene_id:3744|Hs108|chr1 (511 aa) initn: 1906 init1: 811 opt: 824 Z-score: 901.0 bits: 176.3 E(32554): 7.2e-44 Smith-Waterman score: 1796; 64.4% identity (78.5% similar) in 452 aa overlap (26-474:68-473) 10 20 30 40 50 pF1KE3 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSE---RLVINISGLRF ::. . : .: :..:::.:::: CCDS82 KGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRF 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE3 ETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNV :::::::: ::.::::: .:..::: .::::::::::::::.:::::::::..:::.:: CCDS82 ETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANV 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE3 PLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGP :.::: .:: ::.::.::. :::::: . . : ::.. ..:: ::::::::::. CCDS82 PIDIFADEISFYELGSEAMDQFREDEGFIKD---PETLLPTNDIHRQFWLLFEYPESSSA 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE3 ARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSY ::..:.:::::..:::.::::::::.:: : : : : : . CCDS82 ARAVAVVSVLVVVISITIFCLETLPEFRED----------RELKVVR---------DPNL 220 230 240 250 240 250 260 270 280 290 pF1KE3 TFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFF .. : ..:. ..::::::.::. :::::::::..:: .:::: :: CCDS82 NM---------------SKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 RNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRI ::::::::...:.::: :: ::::: : .:.. :: :::::::.::::::::: CCDS82 RNIMNIIDIISIIPYFATLITELVQ--ETEPSA-------QQNMSLAILRIIRLVRVFRI 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 FKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDA ::::::::::::::.::.::::::::::::::::::::::::::::.:. .: : ::::. CCDS82 FKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDG 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE3 FWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQE :::::::::::::::: : : ::::::.::::::::::::::::::::::::::::::.: CCDS82 FWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENE 420 430 440 450 460 470 480 490 500 510 520 pF1KE3 EQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV :. CCDS82 EKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK 480 490 500 510 >>CCDS10945.1 KCNG4 gene_id:93107|Hs108|chr16 (519 aa) initn: 633 init1: 217 opt: 576 Z-score: 630.1 bits: 126.2 E(32554): 9e-29 Smith-Waterman score: 596; 28.3% identity (55.0% similar) in 491 aa overlap (41-493:59-491) 20 30 40 50 60 70 pF1KE3 APGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDP ....::..: :. ::. :: . :. CCDS10 SPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLSRLSKL 30 40 50 60 70 80 80 90 100 110 120 pF1KE3 GRRVRFFDPL----------RNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE : : .. . .:.::::. .: .:. . .: . :. : :: CCDS10 -RLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALS-FQEE 90 100 110 120 130 140 130 140 150 pF1KE3 IRFYQLGD------------------EALAAF-REDEGCLPEGGEDEKPLPSQP----FQ . .. . . : :: . ::: : . : ..: . . CCDS10 LAYWGIEEAHLERCCLRKLLRKLEELEELAKLHRED--VLRQQRETRRPASHSSRWGLCM 150 160 170 180 190 200 160 170 180 190 200 210 pF1KE3 RQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPV .. . : :.:. :.. .: .:.: . . : .:. :.:..:. CCDS10 NRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRA---------------- 210 220 230 240 220 230 240 250 260 270 pF1KE3 SRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFE ::.. : . .. .:.:::.:..::..: CCDS10 -----EEDQGECSRKCYY---------------------------IFIVETICVAWFSLE 250 260 270 280 290 300 310 320 330 pF1KE3 LLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASG--GGGQNGQQA . .:: .: ::.. .::::..:: ::...:.. .:. : .: .:.. . CCDS10 FCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAV-----SEEPPEDGERPSGSSYLEK 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE3 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY ..: .:::.: .:.. ...:.::: ::: :: :.. ::.:::..:: ... ::: :: CCDS10 VGL-VLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVY 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE3 FAEADDDDSL-FPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPV :: .. : : ::: ..:::...::::::::: : .: :..:. ..:.: .:.:. CCDS10 VAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPA 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE3 PVIVSNFNYFYHR-ETEQEE-QGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSY : .:.. : . . :::. :.. :. :: . . : CCDS10 TSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEHELMNDVNDLILE 460 470 480 490 500 510 520 pF1KE3 LPTPHRAYAEKRMLTEV CCDS10 GPALPIMHM 529 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:44:35 2016 done: Sat Nov 5 22:44:35 2016 Total Scan time: 3.290 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]