FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6609, 299 aa 1>>>pF1KE6609 299 - 299 aa - 299 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9167+/-0.000424; mu= 17.3990+/- 0.026 mean_var=60.9217+/-13.084, 0's: 0 Z-trim(111.0): 30 B-trim: 1049 in 1/48 Lambda= 0.164319 statistics sampled from 19508 (19532) to 19508 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.229), width: 16 Scan time: 4.480 The best scores are: opt bits E(85289) NP_008849 (OMIM: 602286,607330) lathosterol oxidas ( 299) 2086 503.2 2.6e-142 NP_001020127 (OMIM: 602286,607330) lathosterol oxi ( 299) 2086 503.2 2.6e-142 NP_006736 (OMIM: 607545,616834) methylsterol monoo ( 293) 279 74.8 2.3e-13 XP_005263233 (OMIM: 607545,616834) PREDICTED: meth ( 293) 279 74.8 2.3e-13 NP_001017369 (OMIM: 607545,616834) methylsterol mo ( 162) 273 73.2 3.8e-13 NP_003947 (OMIM: 604551) cholesterol 25-hydroxylas ( 272) 206 57.4 3.5e-08 XP_006715794 (OMIM: 613738) PREDICTED: alkylglycer ( 423) 150 44.3 0.0005 XP_016867693 (OMIM: 613738) PREDICTED: alkylglycer ( 424) 150 44.3 0.0005 XP_011513704 (OMIM: 613738) PREDICTED: alkylglycer ( 437) 150 44.3 0.00051 NP_001004320 (OMIM: 613738) alkylglycerol monooxyg ( 445) 150 44.3 0.00052 XP_006715793 (OMIM: 613738) PREDICTED: alkylglycer ( 456) 150 44.3 0.00053 >>NP_008849 (OMIM: 602286,607330) lathosterol oxidase [H (299 aa) initn: 2086 init1: 2086 opt: 2086 Z-score: 2675.9 bits: 503.2 E(85289): 2.6e-142 Smith-Waterman score: 2086; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299) 10 20 30 40 50 60 pF1KE6 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE 250 260 270 280 290 >>NP_001020127 (OMIM: 602286,607330) lathosterol oxidase (299 aa) initn: 2086 init1: 2086 opt: 2086 Z-score: 2675.9 bits: 503.2 E(85289): 2.6e-142 Smith-Waterman score: 2086; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299) 10 20 30 40 50 60 pF1KE6 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE 250 260 270 280 290 >>NP_006736 (OMIM: 607545,616834) methylsterol monooxyge (293 aa) initn: 268 init1: 152 opt: 279 Z-score: 360.9 bits: 74.8 E(85289): 2.3e-13 Smith-Waterman score: 279; 29.5% identity (55.1% similar) in 234 aa overlap (45-263:61-284) 20 30 40 50 60 pF1KE6 PYVYPATWPEDDIFRQAISLLIVTNVGAYILYF-FCATLSYYFVFDHALMKH------PQ ::: :: .. : : . :. :. NP_006 EPFKNAWNYMLNNYTKFQIATWGSLIVHEALYFLFCLP-GFLFQFIPYMKKYKIQKDKPE 40 50 60 70 80 70 80 90 100 110 120 pF1KE6 FLKNQ-----VRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVS .:: : .: .: :: .. . .. : : .. : ..: : :.. NP_006 TWENQWKCFKVLLFNHFCIQ-LP---LICGTYYFTE---YFNIPYDWERMPRWYF-LLAR 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE6 IISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHI .. . : . :..:: :::. .:: .:: :: .. : . .. ::.. .. . . : NP_006 CFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGMEAEYAHPLETLILGTGFFI 150 160 170 180 190 200 190 200 210 220 230 pF1KE6 YPFIFPLHKVVYLSLYILVNIW-TISIHDG-DFRV-PQILQPFINGSAHHTDHHMFFDYN .. : :. : .. . . ::..:.: :. . : : :: :: :: ::: : : NP_006 GIVLLCDH-VILLWAWVTIRLLETIDVHSGYDIPLNPLNLIPFYAGSRHHDFHHMNFIGN 210 220 230 240 250 260 240 250 260 270 280 290 pF1KE6 YGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE :.. :: :::: :. .. .... : NP_006 YASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE 270 280 290 >>XP_005263233 (OMIM: 607545,616834) PREDICTED: methylst (293 aa) initn: 268 init1: 152 opt: 279 Z-score: 360.9 bits: 74.8 E(85289): 2.3e-13 Smith-Waterman score: 279; 29.5% identity (55.1% similar) in 234 aa overlap (45-263:61-284) 20 30 40 50 60 pF1KE6 PYVYPATWPEDDIFRQAISLLIVTNVGAYILYF-FCATLSYYFVFDHALMKH------PQ ::: :: .. : : . :. :. XP_005 EPFKNAWNYMLNNYTKFQIATWGSLIVHEALYFLFCLP-GFLFQFIPYMKKYKIQKDKPE 40 50 60 70 80 70 80 90 100 110 120 pF1KE6 FLKNQ-----VRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVS .:: : .: .: :: .. . .. : : .. : ..: : :.. XP_005 TWENQWKCFKVLLFNHFCIQ-LP---LICGTYYFTE---YFNIPYDWERMPRWYF-LLAR 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE6 IISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHI .. . : . :..:: :::. .:: .:: :: .. : . .. ::.. .. . . : XP_005 CFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGMEAEYAHPLETLILGTGFFI 150 160 170 180 190 200 190 200 210 220 230 pF1KE6 YPFIFPLHKVVYLSLYILVNIW-TISIHDG-DFRV-PQILQPFINGSAHHTDHHMFFDYN .. : :. : .. . . ::..:.: :. . : : :: :: :: ::: : : XP_005 GIVLLCDH-VILLWAWVTIRLLETIDVHSGYDIPLNPLNLIPFYAGSRHHDFHHMNFIGN 210 220 230 240 250 260 240 250 260 270 280 290 pF1KE6 YGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE :.. :: :::: :. .. .... : XP_005 YASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE 270 280 290 >>NP_001017369 (OMIM: 607545,616834) methylsterol monoox (162 aa) initn: 268 init1: 152 opt: 273 Z-score: 356.9 bits: 73.2 E(85289): 3.8e-13 Smith-Waterman score: 273; 34.6% identity (62.5% similar) in 136 aa overlap (131-263:19-153) 110 120 130 140 150 160 pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIP : . :..:: :::. .:: .:: :: .. : NP_001 MPRWYFLLARCFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAP 10 20 30 40 170 180 190 200 210 pF1KE6 TPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIW-TISIHDG-DFRV-PQ . .. ::.. .. . . : .. : :. : .. . . ::..:.: :. . : NP_001 FGMEAEYAHPLETLILGTGFFIGIVLLCDH-VILLWAWVTIRLLETIDVHSGYDIPLNPL 50 60 70 80 90 100 220 230 240 250 260 270 pF1KE6 ILQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKR : :: :: :: ::: : ::.. :: :::: :. .. .... : NP_001 NLIPFYAGSRHHDFHHMNFIGNYASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE 110 120 130 140 150 160 280 290 pF1KE6 SSHSGNGCKNEKLFNGEFTKTE >>NP_003947 (OMIM: 604551) cholesterol 25-hydroxylase [H (272 aa) initn: 162 init1: 112 opt: 206 Z-score: 267.8 bits: 57.4 E(85289): 3.5e-08 Smith-Waterman score: 206; 30.3% identity (58.6% similar) in 152 aa overlap (116-258:121-268) 90 100 110 120 130 140 pF1KE6 WISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVSIISFLFFTDM-FIYWIHRGLHHR :. :. :. :.. :: :. : : :::. NP_003 TLYQHVMFVFPVTLLHWARSPALLPHEAPELLLLLHHILFCLLLFDMEFFVW-HL-LHHK 100 110 120 130 140 150 160 170 180 190 200 pF1KE6 L--VYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVN . .:. .:: :: . .:.. . . : .. . .. : .. :.... :: NP_003 VPWLYRTFHKVHHQNSSSFALATQYMSVWELFSLGFFDMMNVTLLGCHPLTTLTFHV-VN 150 160 170 180 190 200 210 220 230 240 250 pF1KE6 IW-TISIHDGDFRVP---QILQPF--INGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKN :: .. :.: . : . : :: .: .:: :: :. :.. ::: ::.: :.... NP_003 IWLSVEDHSG-YNFPWSTHRLVPFGWYGGVVHHDLHHSHFNCNFAPYFTHWDKILGTLRT 210 220 230 240 250 260 260 270 280 290 pF1KE6 PSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE : NP_003 ASVPAR 270 >>XP_006715794 (OMIM: 613738) PREDICTED: alkylglycerol m (423 aa) initn: 182 init1: 81 opt: 150 Z-score: 193.3 bits: 44.3 E(85289): 0.0005 Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251) 110 120 130 140 150 pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W :. ::.:: :. .. :. :: . XP_006 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY 100 110 120 130 140 150 160 170 180 190 200 210 pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ .. : . . ... ... : . :: : .:.:.. .: ..: :: . XP_006 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG 160 170 180 190 200 220 230 240 250 260 270 pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT :. ..: .:: :: . .: ::. . .::.: :.:. XP_006 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE 210 220 230 240 250 260 280 290 pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE XP_006 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS 270 280 290 300 310 320 >>XP_016867693 (OMIM: 613738) PREDICTED: alkylglycerol m (424 aa) initn: 182 init1: 81 opt: 150 Z-score: 193.3 bits: 44.3 E(85289): 0.0005 Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251) 110 120 130 140 150 pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W :. ::.:: :. .. :. :: . XP_016 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY 100 110 120 130 140 150 160 170 180 190 200 210 pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ .. : . . ... ... : . :: : .:.:.. .: ..: :: . XP_016 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG 160 170 180 190 200 220 230 240 250 260 270 pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT :. ..: .:: :: . .: ::. . .::.: :.:. XP_016 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE 210 220 230 240 250 260 280 290 pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE XP_016 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS 270 280 290 300 310 320 >>XP_011513704 (OMIM: 613738) PREDICTED: alkylglycerol m (437 aa) initn: 182 init1: 81 opt: 150 Z-score: 193.1 bits: 44.3 E(85289): 0.00051 Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251) 110 120 130 140 150 pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W :. ::.:: :. .. :. :: . XP_011 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY 100 110 120 130 140 150 160 170 180 190 200 210 pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ .. : . . ... ... : . :: : .:.:.. .: ..: :: . XP_011 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG 160 170 180 190 200 220 230 240 250 260 270 pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT :. ..: .:: :: . .: ::. . .::.: :.:. XP_011 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE 210 220 230 240 250 260 280 290 pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE XP_011 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS 270 280 290 300 310 320 >>NP_001004320 (OMIM: 613738) alkylglycerol monooxygenas (445 aa) initn: 162 init1: 81 opt: 150 Z-score: 193.0 bits: 44.3 E(85289): 0.00052 Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251) 110 120 130 140 150 pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W :. ::.:: :. .. :. :: . NP_001 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY 100 110 120 130 140 150 160 170 180 190 200 210 pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ .. : . . ... ... : . :: : .:.:.. .: ..: :: . NP_001 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG 160 170 180 190 200 220 230 240 250 260 270 pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT :. ..: .:: :: . .: ::. . .::.: :.:. NP_001 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE 210 220 230 240 250 260 280 290 pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE NP_001 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS 270 280 290 300 310 320 299 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 14:44:30 2016 done: Tue Nov 8 14:44:31 2016 Total Scan time: 4.480 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]