FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9625, 779 aa 1>>>pF1KE9625 779 - 779 aa - 779 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5018+/-0.000508; mu= 14.5426+/- 0.031 mean_var=97.8287+/-18.774, 0's: 0 Z-trim(109.9): 52 B-trim: 24 in 2/52 Lambda= 0.129670 statistics sampled from 18067 (18110) to 18067 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.558), E-opt: 0.2 (0.212), width: 16 Scan time: 12.110 The best scores are: opt bits E(85289) NP_004715 (OMIM: 603954) centromere/kinetochore pr ( 779) 5026 951.7 0 XP_016874048 (OMIM: 603954) PREDICTED: centromere/ ( 559) 3633 691.0 3.5e-198 XP_016874047 (OMIM: 603954) PREDICTED: centromere/ ( 715) 3094 590.3 9.9e-168 >>NP_004715 (OMIM: 603954) centromere/kinetochore protei (779 aa) initn: 5026 init1: 5026 opt: 5026 Z-score: 5085.1 bits: 951.7 E(85289): 0 Smith-Waterman score: 5026; 100.0% identity (100.0% similar) in 779 aa overlap (1-779:1-779) 10 20 30 40 50 60 pF1KE9 MASFVTEVLAHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MASFVTEVLAHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQLQEFSTAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQLQEFSTAIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 EYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 WQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 WQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LKSFGQMLLKYILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKSFGQMLLKYILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EVLQKQLLDLPLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EVLQKQLLDLPLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 YEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 NTVKIIPDSKINVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NTVKIIPDSKINVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRIS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 ESVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ESVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 HHNNCMYIAHHLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HHNNCMYIAHHLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGEL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 LERLSSARNFSNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LERLSSARNFSNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 ISEVIGKITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ISEVIGKITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKW 670 680 690 700 710 720 730 740 750 760 770 pF1KE9 MPFKELMMMLQASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MPFKELMMMLQASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK 730 740 750 760 770 >>XP_016874048 (OMIM: 603954) PREDICTED: centromere/kine (559 aa) initn: 3633 init1: 3633 opt: 3633 Z-score: 3678.9 bits: 691.0 E(85289): 3.5e-198 Smith-Waterman score: 3633; 100.0% identity (100.0% similar) in 559 aa overlap (221-779:1-559) 200 210 220 230 240 250 pF1KE9 PSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSKLKSFGQMLLK :::::::::::::::::::::::::::::: XP_016 MPPISSVLLAFSVLGELHSKLKSFGQMLLK 10 20 30 260 270 280 290 300 310 pF1KE9 YILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVLEVLQKQLLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVLEVLQKQLLDL 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE9 PLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQYEEIIQSTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQYEEIIQSTEE 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE9 FENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKIIPDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKIIPDSK 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE9 INVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRISESVKKLMELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRISESVKKLMELA 220 230 240 250 260 270 500 510 520 530 540 550 pF1KE9 YQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAH 280 290 300 310 320 330 560 570 580 590 600 610 pF1KE9 HLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGELLERLSSARNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGELLERLSSARNF 340 350 360 370 380 390 620 630 640 650 660 670 pF1KE9 SNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTAISEVIGKITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTAISEVIGKITA 400 410 420 430 440 450 680 690 700 710 720 730 pF1KE9 LEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKWMPFKELMMML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKWMPFKELMMML 460 470 480 490 500 510 740 750 760 770 pF1KE9 QASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK 520 530 540 550 >>XP_016874047 (OMIM: 603954) PREDICTED: centromere/kine (715 aa) initn: 3082 init1: 3082 opt: 3094 Z-score: 3132.3 bits: 590.3 E(85289): 9.9e-168 Smith-Waterman score: 4485; 91.8% identity (91.8% similar) in 779 aa overlap (1-779:1-715) 10 20 30 40 50 60 pF1KE9 MASFVTEVLAHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASFVTEVLAHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 TQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQLQEFSTAIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQLQEFSTAIE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 EYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 WQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 LKSFGQMLLKYILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVL :::: XP_016 LKSF-------------------------------------------------------- 310 320 330 340 350 360 pF1KE9 EVLQKQLLDLPLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQ :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 --------DLPLDTDLENEKTSTVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQ 250 260 270 280 290 370 380 390 400 410 420 pF1KE9 YEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEEIIQSTEEFENALKEMRFLKGDTTDLLKYARNINSHFANKKCQDVIVAARNLMTSEIH 300 310 320 330 340 350 430 440 450 460 470 480 pF1KE9 NTVKIIPDSKINVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTVKIIPDSKINVPELPTPDEDNKLEVQKVSNTQYHEVMNLEPENTLDQHSFSLPTCRIS 360 370 380 390 400 410 490 500 510 520 530 540 pF1KE9 ESVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESVKKLMELAYQTLLEATTSSDQCAVQLFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAI 420 430 440 450 460 470 550 560 570 580 590 600 pF1KE9 HHNNCMYIAHHLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HHNNCMYIAHHLLTLGHQFRLRLAPILCDGTATFVDLVPGFRRLGTECFLAQMRAQKGEL 480 490 500 510 520 530 610 620 630 640 650 660 pF1KE9 LERLSSARNFSNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LERLSSARNFSNMDDEENYSAASKAVRQVLHQLKRLGIVWQDVLPVNIYCKAMGTLLNTA 540 550 560 570 580 590 670 680 690 700 710 720 pF1KE9 ISEVIGKITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISEVIGKITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNKKYQEEVPVYVPKW 600 610 620 630 640 650 730 740 750 760 770 pF1KE9 MPFKELMMMLQASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPFKELMMMLQASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRAAALAKIK 660 670 680 690 700 710 779 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:35:33 2016 done: Sun Nov 6 06:35:35 2016 Total Scan time: 12.110 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]