FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1592, 404 aa 1>>>pF1KE1592 404 - 404 aa - 404 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1986+/-0.000399; mu= 18.1313+/- 0.025 mean_var=68.7640+/-13.430, 0's: 0 Z-trim(111.7): 121 B-trim: 0 in 0/53 Lambda= 0.154666 statistics sampled from 20227 (20352) to 20227 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.239), width: 16 Scan time: 7.390 The best scores are: opt bits E(85289) NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404) 2686 608.6 8.9e-174 NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404) 2686 608.6 8.9e-174 XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374) 2494 565.7 6.6e-161 XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 2494 565.7 7e-161 XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401) 2494 565.7 7e-161 XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380) 1992 453.7 3.5e-127 NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383) 1992 453.7 3.5e-127 NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383) 1992 453.7 3.5e-127 NP_150635 (OMIM: 147678) caspase-1 isoform gamma [ ( 311) 1972 449.2 6.6e-126 NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263) 1177 271.7 1.5e-72 NP_001216 (OMIM: 602664) caspase-4 isoform alpha p ( 377) 1134 262.2 1.5e-69 NP_150649 (OMIM: 602664) caspase-4 isoform gamma p ( 321) 1132 261.7 1.8e-69 XP_016873886 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1123 259.7 6.6e-69 XP_011541321 (OMIM: 602664) PREDICTED: caspase-4 i ( 286) 1123 259.7 6.6e-69 NP_001129581 (OMIM: 602665) caspase-5 isoform b pr ( 376) 1089 252.2 1.6e-66 NP_004338 (OMIM: 602665) caspase-5 isoform a precu ( 434) 1089 252.2 1.8e-66 NP_001129584 (OMIM: 602665) caspase-5 isoform f pr ( 447) 1089 252.2 1.8e-66 NP_001129582 (OMIM: 602665) caspase-5 isoform c [H ( 292) 1078 249.7 7.1e-66 NP_001177945 (OMIM: 608633) inactive caspase-12 [H ( 341) 895 208.9 1.6e-53 XP_011541323 (OMIM: 602665) PREDICTED: caspase-5 i ( 319) 656 155.5 1.7e-37 NP_443121 (OMIM: 615680) caspase recruitment domai ( 97) 563 134.4 1.1e-31 NP_001017534 (OMIM: 615680) caspase recruitment do ( 197) 552 132.2 1.1e-30 NP_001007233 (OMIM: 609490) caspase recruitment do ( 110) 543 130.0 2.8e-30 XP_011541140 (OMIM: 609490) PREDICTED: caspase rec ( 125) 543 130.0 3.1e-30 XP_011540885 (OMIM: 615680) PREDICTED: caspase rec ( 265) 540 129.6 9e-30 NP_150637 (OMIM: 147678) caspase-1 isoform epsilon ( 88) 495 119.2 3.9e-27 NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452) 368 91.4 4.9e-18 NP_067546 (OMIM: 605354) caspase recruitment domai ( 90) 315 79.1 4.9e-15 NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312) 318 80.1 8.3e-15 NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478) 283 72.4 2.6e-12 NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479) 283 72.4 2.6e-12 XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521) 283 72.4 2.8e-12 NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521) 283 72.4 2.8e-12 NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522) 283 72.4 2.8e-12 XP_006712859 (OMIM: 601762,603909,605027,613659) P ( 272) 278 71.1 3.6e-12 NP_036246 (OMIM: 605848) caspase-14 precursor [Hom ( 242) 266 68.4 2.1e-11 XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 i ( 421) 265 68.4 3.9e-11 XP_011526163 (OMIM: 605848) PREDICTED: caspase-14 ( 230) 254 65.7 1.3e-10 XP_011510271 (OMIM: 114480,114550,211980,601763,60 ( 334) 253 65.6 2e-10 XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464) 254 65.9 2.3e-10 NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464) 254 65.9 2.3e-10 NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464) 254 65.9 2.3e-10 NP_001219 (OMIM: 114480,114550,211980,601763,60727 ( 496) 254 65.9 2.4e-10 XP_005246942 (OMIM: 114480,114550,211980,601763,60 ( 523) 254 66.0 2.5e-10 XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10 XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10 XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10 XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10 XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479) 253 65.7 2.7e-10 NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479) 253 65.7 2.7e-10 >>NP_150634 (OMIM: 147678) caspase-1 isoform alpha precu (404 aa) initn: 2686 init1: 2686 opt: 2686 Z-score: 3240.8 bits: 608.6 E(85289): 8.9e-174 Smith-Waterman score: 2686; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 310 320 330 340 350 360 370 380 390 400 pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH :::::::::::::::::::::::::::::::::::::::::::: NP_150 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 370 380 390 400 >>NP_001244047 (OMIM: 147678) caspase-1 isoform alpha pr (404 aa) initn: 2686 init1: 2686 opt: 2686 Z-score: 3240.8 bits: 608.6 E(85289): 8.9e-174 Smith-Waterman score: 2686; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 310 320 330 340 350 360 370 380 390 400 pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH :::::::::::::::::::::::::::::::::::::::::::: NP_001 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 370 380 390 400 >>XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 isofo (374 aa) initn: 2494 init1: 2494 opt: 2494 Z-score: 3009.7 bits: 565.7 E(85289): 6.6e-161 Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 373 aa overlap (32-404:2-374) 10 20 30 40 50 60 pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV :::::::::::::::::::::::::::::: XP_016 MTRVLNKEEMEKVKRENATVMDKTRALIDSV 10 20 30 70 80 90 100 110 120 pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA 280 290 300 310 320 330 370 380 390 400 pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH ::::::::::::::::::::::::::::::::::::::::::: XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 340 350 360 370 >>XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 isofo (401 aa) initn: 2494 init1: 2494 opt: 2494 Z-score: 3009.3 bits: 565.7 E(85289): 7e-161 Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 373 aa overlap (32-404:29-401) 10 20 30 40 50 60 pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV :::::::::::::::::::::::::::::: XP_016 MYRPCQKGRRSILSVSVTQEGRREKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSV 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA 300 310 320 330 340 350 370 380 390 400 pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH ::::::::::::::::::::::::::::::::::::::::::: XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 360 370 380 390 400 >>XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 isofo (401 aa) initn: 2494 init1: 2494 opt: 2494 Z-score: 3009.3 bits: 565.7 E(85289): 7e-161 Smith-Waterman score: 2494; 100.0% identity (100.0% similar) in 373 aa overlap (32-404:29-401) 10 20 30 40 50 60 pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV :::::::::::::::::::::::::::::: XP_016 MYRPCQKGRRSILSVSVTQEGRREKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSV 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA 300 310 320 330 340 350 370 380 390 400 pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH ::::::::::::::::::::::::::::::::::::::::::: XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 360 370 380 390 400 >>XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 isofo (380 aa) initn: 2340 init1: 1972 opt: 1992 Z-score: 2404.3 bits: 453.7 E(85289): 3.5e-127 Smith-Waterman score: 2302; 94.4% identity (94.4% similar) in 373 aa overlap (32-404:29-380) 10 20 30 40 50 60 pF1KE1 ADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSV :::::::::::::::::::::::::::::: XP_016 MYRPCQKGRRSILSVSVTQEGRREKPWPTRVLNKEEMEKVKRENATVMDKTRALIDSV 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP :::::::::::::::::::::::::::::: ::::::::: XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDNP 60 70 80 90 130 140 150 160 170 180 pF1KE1 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIRE 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA 280 290 300 310 320 330 370 380 390 400 pF1KE1 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH ::::::::::::::::::::::::::::::::::::::::::: XP_016 CSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 340 350 360 370 380 >>NP_001214 (OMIM: 147678) caspase-1 isoform beta precur (383 aa) initn: 2532 init1: 1972 opt: 1992 Z-score: 2404.2 bits: 453.7 E(85289): 3.5e-127 Smith-Waterman score: 2494; 94.8% identity (94.8% similar) in 404 aa overlap (1-404:1-383) 10 20 30 40 50 60 pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN ::::::::::::::::::::::::::::::: :::::::: NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDN 70 80 90 130 140 150 160 170 180 pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 280 290 300 310 320 330 370 380 390 400 pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH :::::::::::::::::::::::::::::::::::::::::::: NP_001 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 340 350 360 370 380 >>NP_001244048 (OMIM: 147678) caspase-1 isoform beta pre (383 aa) initn: 2532 init1: 1972 opt: 1992 Z-score: 2404.2 bits: 453.7 E(85289): 3.5e-127 Smith-Waterman score: 2494; 94.8% identity (94.8% similar) in 404 aa overlap (1-404:1-383) 10 20 30 40 50 60 pF1KE1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN ::::::::::::::::::::::::::::::: :::::::: NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDN 70 80 90 130 140 150 160 170 180 pF1KE1 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 280 290 300 310 320 330 370 380 390 400 pF1KE1 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH :::::::::::::::::::::::::::::::::::::::::::: NP_001 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 340 350 360 370 380 >>NP_150635 (OMIM: 147678) caspase-1 isoform gamma [Homo (311 aa) initn: 2076 init1: 1972 opt: 1972 Z-score: 2381.4 bits: 449.2 E(85289): 6.6e-126 Smith-Waterman score: 1972; 100.0% identity (100.0% similar) in 292 aa overlap (113-404:20-311) 90 100 110 120 130 140 pF1KE1 LAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ :::::::::::::::::::::::::::::: NP_150 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ 10 20 30 40 150 160 170 180 190 200 pF1KE1 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV 50 60 70 80 90 100 210 220 230 240 250 260 pF1KE1 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF 110 120 130 140 150 160 270 280 290 300 310 320 pF1KE1 NMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 NMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 170 180 190 200 210 220 330 340 350 360 370 380 pF1KE1 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG 230 240 250 260 270 280 390 400 pF1KE1 RAQMPTTERVTLTRCFYLFPGH :::::::::::::::::::::: NP_150 RAQMPTTERVTLTRCFYLFPGH 290 300 310 >>NP_150636 (OMIM: 147678) caspase-1 isoform delta [Homo (263 aa) initn: 1287 init1: 1163 opt: 1177 Z-score: 1423.7 bits: 271.7 E(85289): 1.5e-72 Smith-Waterman score: 1542; 83.6% identity (83.6% similar) in 292 aa overlap (113-404:20-263) 90 100 110 120 130 140 pF1KE1 LAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ :::::::::::::::::::::::::::::: NP_150 MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQ 10 20 30 40 150 160 170 180 190 200 pF1KE1 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 RIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDV 50 60 70 80 90 100 210 220 230 240 250 260 pF1KE1 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 KKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIF 110 120 130 140 150 160 270 280 290 300 310 320 pF1KE1 NMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH :::::::::::::::::::::::::: NP_150 NMLNTKNCPSLKDKPKVIIIQACRGD---------------------------------- 170 180 190 330 340 350 360 370 380 pF1KE1 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG :::::::::::::::::::::::::::::::::::::::::::::: NP_150 --------------NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDG 200 210 220 230 240 390 400 pF1KE1 RAQMPTTERVTLTRCFYLFPGH :::::::::::::::::::::: NP_150 RAQMPTTERVTLTRCFYLFPGH 250 260 404 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:00:42 2016 done: Sun Nov 6 15:00:44 2016 Total Scan time: 7.390 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]