FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4460, 477 aa 1>>>pF1KE4460 477 - 477 aa - 477 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.6319+/-0.000323; mu= 7.8444+/- 0.020 mean_var=134.1893+/-26.583, 0's: 0 Z-trim(119.4): 75 B-trim: 0 in 0/58 Lambda= 0.110717 statistics sampled from 33280 (33355) to 33280 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.391), width: 16 Scan time: 9.230 The best scores are: opt bits E(85289) NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 3274 534.2 3.1e-151 NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 2656 435.5 1.6e-121 NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 1695 282.0 2.5e-75 NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 1464 245.1 3.3e-64 NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 1029 175.6 2.7e-43 NP_002418 (OMIM: 250400,600108,602111) collagenase ( 471) 1023 174.6 5.2e-43 NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 973 166.6 1.3e-40 NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 916 157.5 7.5e-38 NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 909 156.4 1.5e-37 XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 909 156.4 1.5e-37 XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 909 156.4 1.5e-37 NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 909 156.4 1.5e-37 XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 906 155.9 1.8e-37 XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 906 155.9 2.2e-37 NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 860 148.5 3.2e-35 NP_002414 (OMIM: 178990) matrilysin preproprotein ( 267) 847 146.4 9.4e-35 NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 805 139.8 1.7e-32 XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 676 119.1 2e-26 NP_004521 (OMIM: 120360,259600) 72 kDa type IV col ( 660) 658 116.4 2.5e-25 NP_001121363 (OMIM: 120360,259600) 72 kDa type IV ( 610) 653 115.6 4e-25 NP_001289439 (OMIM: 120360,259600) 72 kDa type IV ( 584) 633 112.4 3.5e-24 NP_001289437 (OMIM: 120360,259600) 72 kDa type IV ( 584) 633 112.4 3.5e-24 NP_001289438 (OMIM: 120360,259600) 72 kDa type IV ( 584) 633 112.4 3.5e-24 NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 626 111.1 3.9e-24 XP_016874796 (OMIM: 602285) PREDICTED: matrix meta ( 434) 615 109.4 2e-23 NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 615 109.5 2.7e-23 XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 604 107.5 3.4e-23 XP_011526802 (OMIM: 604871) PREDICTED: matrix meta ( 556) 611 108.8 3.9e-23 XP_016883087 (OMIM: 604871) PREDICTED: matrix meta ( 614) 611 108.9 4.2e-23 NP_006681 (OMIM: 604871) matrix metalloproteinase- ( 645) 611 108.9 4.4e-23 NP_004985 (OMIM: 120361,613073) matrix metalloprot ( 707) 611 108.9 4.8e-23 XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 592 105.7 2.3e-22 XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 578 103.6 1.4e-21 XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 578 103.6 1.4e-21 XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 578 103.6 1.4e-21 NP_004986 (OMIM: 277950,600754) matrix metalloprot ( 582) 549 98.9 3.9e-20 XP_011520906 (OMIM: 608482) PREDICTED: matrix meta ( 478) 481 88.0 6.1e-17 XP_011520904 (OMIM: 608482) PREDICTED: matrix meta ( 528) 481 88.1 6.6e-17 NP_071913 (OMIM: 608482) matrix metalloproteinase- ( 562) 481 88.1 7e-17 NP_005932 (OMIM: 602262) matrix metalloproteinase- ( 607) 463 85.2 5.5e-16 XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 452 83.4 1.2e-15 XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 452 83.4 1.2e-15 XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 452 83.4 1.2e-15 XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 452 83.4 1.3e-15 NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 452 83.4 1.3e-15 XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 452 83.4 1.4e-15 XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15 XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15 XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15 XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15 >>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa) initn: 3274 init1: 3274 opt: 3274 Z-score: 2836.2 bits: 534.2 E(85289): 3.1e-151 Smith-Waterman score: 3274; 99.8% identity (100.0% similar) in 477 aa overlap (1-477:1-477) 10 20 30 40 50 60 pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_002 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 430 440 450 460 470 >>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa) initn: 2731 init1: 2443 opt: 2656 Z-score: 2302.7 bits: 435.5 E(85289): 1.6e-121 Smith-Waterman score: 2656; 78.4% identity (92.0% similar) in 477 aa overlap (1-477:1-476) 10 20 30 40 50 60 pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV : : .:.:::. :::::::.:::. ::.. .:.:.:::.::.:::::::: :::::. . NP_002 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN ::::. ::::::::::::::.::::::::::::::::::: .:::.:::::::::::::: NP_002 VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV ::::::.::::::.:::::::::::::::::::::::::::::::.:::::: :::::. NP_002 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY ::::: ::::. :: ::::::.::.:..:::::::::::.:::::::::::::::::::: NP_002 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS .:.:.:..:::::::.::::::::::: : : :::::. :: ::.:::::::::.: NP_002 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF ::::: :.::::.:::.: . :::.::::.::::::: .::::::.:.: :::::::.: NP_002 TLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP ::::::::.:::::::::::::::.::::::.:::::.:::::. ::::::::. .::: NP_002 WAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQ 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC :::. ::.::::.. :.:::.. :::::::.::::.::::::. ::: :::::::.: NP_002 GFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 420 430 440 450 460 470 >>NP_002417 (OMIM: 601046) macrophage metalloelastase pr (470 aa) initn: 1514 init1: 807 opt: 1695 Z-score: 1473.2 bits: 282.0 E(85289): 2.5e-75 Smith-Waterman score: 1695; 51.6% identity (77.7% similar) in 479 aa overlap (1-477:1-470) 10 20 30 40 50 60 pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV :: : :::: .: .: ::.... : ... . ..:::..: :: . .. : :: . NP_002 MKFLLILLLQATA-SGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNL 10 20 30 40 50 70 80 90 100 110 pF1KE4 VK-KIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIV .: ::.:::.::::.:::.::..:::.:. :::::::: ::: .:: : ::: ..:::: NP_002 MKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRIN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 NYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGN :::::. .. :: :..::..:: .:::: ::.. : :::.. :: ::::. ::: :. NP_002 NYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 VLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPL .::::..:: ::.::::::.:: :: . ::::::.:.::::::::: ::.. .:.:.: NP_002 ILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 YHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAV :. . :.. :::: ::: ::::::: : .. . : :. . :: ::: :::::: NP_002 YKYV-DINTFRLSADDIRGIQSLYGDPKENQRLP-------NPDNSEPALCDPNLSFDAV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 STLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQ .:. ..:..:::: :: : .. . ..::::.::.::::..::::. ... ::.:: .. NP_002 TTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 FWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME .: : . . . .::..::..::: :.:::::. . . .:::::...:::.::.:. :. NP_002 YWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMD 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 PGFPKQIAEDFPGIDSKIDAVF-EEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC ::.:: :...: :: :::::: . ..::: ::.:.:.: ...:.:::::::..: NP_002 PGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 420 430 440 450 460 470 >>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa) initn: 1316 init1: 797 opt: 1464 Z-score: 1273.6 bits: 245.1 E(85289): 3.3e-64 Smith-Waterman score: 1464; 46.4% identity (72.6% similar) in 489 aa overlap (1-477:1-483) 10 20 30 40 50 pF1KE4 MKSLP-----ILLLLCVAVCSAYPLDGAA--RGEDTSMNLVQKYLENYYDLEK--DVKQF :: :: ..:.. . .: : :: : ... :.: ::..:: .. .. .. NP_004 MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 VRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRK : : :. ...::.:.: :.::.::::::. :..:..:::::::::...: ::: :::.: NP_004 VAR-GSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKK 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 THLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDF . ::::: .:::.. . ::.::: ::..: ..::.: :. ::::::::: .::: NP_004 NTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 YPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSAN :::::: ..::::.::: :..::.:::. :.:: :.: ::: :::::.::.::: ::.. NP_004 YPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 TEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCD ::::: :. . :.: .::..:::.:::: : .: : .:. : :: NP_004 PSALMYPTYK-YKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAP-HHKPSIPDLCD 240 250 260 270 280 290 300 310 320 330 340 pF1KE4 PALSFDAVSTLRGEILIFKDRHFWRKS--LRK-LEPELHLISSFWPSLPSGVDAAYEVTS . :::::. : :.:.:::: :::.. :: ..: :.: .:.: :.:::::::. NP_004 SSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPS--TITSSFPQLMSNVDAAYEVAE 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 KDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKY . ...::: ..: :: ... : :: :. .::: :..::::. .: .:: ::: :.: NP_004 RGTAYFFKGPHYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEY 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 WRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHT . .::.. .:: .::. :.: :....:::. : :..:::.: . ..: . . :. . NP_004 YSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSV 420 430 440 450 460 470 470 pF1KE4 LKSNSWLNC .::.::..: NP_004 VKSSSWIGC 480 >>NP_002412 (OMIM: 120353,226600,606963) interstitial co (469 aa) initn: 1387 init1: 956 opt: 1029 Z-score: 898.3 bits: 175.6 E(85289): 2.7e-43 Smith-Waterman score: 1786; 53.1% identity (79.1% similar) in 478 aa overlap (1-477:1-466) 10 20 30 40 50 60 pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV :.:.: :::: .. . .. . .. ...:::::::.::.:..: .: .:..:::: NP_002 MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN :.:...::.:.::.:::: :..::.::..::::::::..: : :.:..::::::: : NP_002 VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV ::::::. :: :.:::...: .::::::... ::.:::::::. .: : ::::::. NP_002 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY ::::. :::::.::::::.::.::.. :: :::::.:::::: ::.. ::::: : NP_002 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS :. .:.::::.:::..:: . :..:. :. :: :: :.:::.. NP_002 TFSGDV---QLAQDDIDGIQAIYGRSQN-------PVQPIGPQ--TPKACDSKLTFDAIT 250 260 270 280 310 320 330 340 350 360 pF1KE4 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF :.:::...:::: . : . : ::..:: :::.::.:..:::: ...: : .::::.. NP_002 TIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKY 290 300 310 320 330 340 370 380 390 400 410 pF1KE4 WAIRGNEVRAGYPRGIHT-LGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME ::..:..: :::. :.. .::: ::..::::.:... .:::::: .::::.:: . ::. NP_002 WAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMD 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE4 PGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC ::.::.::.::::: :.:::: . :::::: :. : .:::..:.. :.:::.:: NP_002 PGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRK 410 420 430 440 450 460 NP_002 N >>NP_002418 (OMIM: 250400,600108,602111) collagenase 3 p (471 aa) initn: 1663 init1: 867 opt: 1023 Z-score: 893.1 bits: 174.6 E(85289): 5.2e-43 Smith-Waterman score: 1669; 49.5% identity (77.6% similar) in 477 aa overlap (4-477:6-471) 10 20 30 40 50 pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTS---MNLVQKYLENYYDLEKDVKQFVRRK : .:.: . : : :: ... .: : ......::..:: .. ..... NP_002 MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYH-PTNLAGILKEN 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 DSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLT .. .....::::.:.:::::::::..::.::.::::::::::.. .:: :: : .:: NP_002 AASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 YRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFD :::::::::. .. :..: .::.::: .::::.:.::..: :::::::...::::::::: NP_002 YRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFD 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 GPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEAL ::...::::. :::. .::::::::: ::... : :::::::::.:::::: :: . :: NP_002 GPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGAL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 MYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALS :.:.: . : ..: : .::..:::::::: ..:. : .: :: .:::.:: NP_002 MFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPN---------PKHPKTPDKCDPSLS 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 FDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIF .::...:::: .::::: ::: .... :: : .:::: ::. .::::: :.::.::: NP_002 LDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIF 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 KGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKR .: .:::. : .. :::. : ::.: :.::.::. .. .:: .: .. ::.:. NP_002 RGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTN 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE4 NSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWL . :. .:. : :::::: .:.:::.:. :..:::.: :.:.. ........ .:: : NP_002 HIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSIL 410 420 430 440 450 460 pF1KE4 NC : NP_002 WC 470 >>NP_002415 (OMIM: 120355) neutrophil collagenase isofor (467 aa) initn: 1607 init1: 816 opt: 973 Z-score: 850.0 bits: 166.6 E(85289): 1.3e-40 Smith-Waterman score: 1708; 50.5% identity (77.4% similar) in 477 aa overlap (1-477:4-464) 10 20 30 40 50 pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDS .:.::.:::: : . .:.:... .. : :: :::..:.: .. : .:.. . NP_002 MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKT----VQDYLEKFYQLPSNQYQSTRKNGT 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 GPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYR . .:.:..:::.:.::.:::: . .::..:.:::::::: : : :: :::..:.:::: NP_002 NVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 IVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGP : ::::.: . :. :.. :...: ..:: :.:. .::::: :.: :.::: ::::: NP_002 IRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 GNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMY ...::::. :: ::.:::::: .: ::. ... :::::::::.:::::: ::.. :::: NP_002 NGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMY 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 PLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFD : : .. . . . : ::::.:::..:: . :. :: : :.: :::.:.:: NP_002 PNY-AFRETSNYSLPQDDIDGIQAIYGLSSN----PIQPTGPSTPKP-----CDPSLTFD 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 AVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKG :..:::::::.::::.:::. . . :...:: ::::::.:..:::: ..::.:.::: NP_002 AITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKG 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 NQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNS ::.::. : .. :::. : . ::: .:. ::::. ..::::::.:..::.:..:. NP_002 NQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQF 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE4 MEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC ::::.::.:. ::::.::.::::.. ::. :.: :: :..::.. ..:.:::: NP_002 MEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 410 420 430 440 450 460 NP_002 RYG >>NP_005931 (OMIM: 185261) stromelysin-3 preproprotein [ (488 aa) initn: 797 init1: 371 opt: 916 Z-score: 800.5 bits: 157.5 E(85289): 7.5e-38 Smith-Waterman score: 916; 42.8% identity (63.0% similar) in 397 aa overlap (87-460:75-460) 60 70 80 90 100 pF1KE4 SGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVG--------HFRTFPGIPK .: ::::::: . . : . . NP_005 RRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE4 WRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREH :.:: :::::. . .: .. : ... .::::: .::::::....::.:::::.:: : NP_005 WEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWH 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE4 GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT-KDTTGTNLFLVAAHEIGHSLGLF :: ::::::..::::. : .::.::: :: :: : ::.:. :::::.:: ::: NP_005 GDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQ 170 180 190 200 210 220 230 240 250 260 270 pF1KE4 HSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPP-PD-SPETP-LVP------TE :.. ..::: .: :. :: :: :.: ::: : : . .:: : : .: NP_005 HTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNE 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 PVPPEPGTPAN-CDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELH-LISSFWPSL .: :: .: . :. :::::::.:::...:: :: .:.: : : : .: NP_005 IAPLEPDAPPDACEA--SFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGL 290 300 310 320 330 340 350 360 370 380 390 pF1KE4 PSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVR-KIDAAIS-D :: ::::.: .. ...:.: :.:. :.. : : . ::. :: . ::. NP_005 PSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL---VRFPVHAALVWG 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE4 KEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEF-GFFYFFTGS :::: ::: :::: . .. :.. : :. :. :.:::.:.. :. ::. : NP_005 PEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATDWRGVPSEIDAAFQDADGYAYFLRGR 400 410 420 430 440 450 460 470 pF1KE4 SQLEFDPNAKKVTHTLKSNSWLNC .::: NP_005 LYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL 460 470 480 >>NP_001291371 (OMIM: 120355) neutrophil collagenase iso (444 aa) initn: 1663 init1: 805 opt: 909 Z-score: 795.1 bits: 156.4 E(85289): 1.5e-37 Smith-Waterman score: 1644; 51.4% identity (78.2% similar) in 444 aa overlap (34-477:10-441) 10 20 30 40 50 60 pF1KE4 LPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPVVKK .. :::..:.: .. : .:.. .. .:.: NP_001 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEK 10 20 30 70 80 90 100 110 120 pF1KE4 IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTP ..:::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: :::: NP_001 LKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 DLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAH .: . :. :.. :...: ..:: :.:. .::::: :.: :.::: :::::...::: NP_001 QLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 AYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSL :. :: ::.:::::: .: ::. ... :::::::::.:::::: ::.. ::::: : .. NP_001 AFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 TDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLR . . . : ::::.:::..:: . :. :: : :.: :::.:.:::..::: NP_001 RETSNYSLPQDDIDGIQAIYGLSSN----PIQPTGPSTPKP-----CDPSLTFDAITTLR 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 GEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAI ::::.::::.:::. . . :...:: ::::::.:..:::: ..::.:.:::::.::. NP_001 GEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 RGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFP : .. :::. : . ::: .:. ::::. ..::::::.:..::.:..:. ::::.: NP_001 SGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYP 330 340 350 360 370 380 430 440 450 460 470 pF1KE4 KQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC :.:. ::::.::.::::.. ::. :.: :: :..::.. ..:.:::: NP_001 KSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG 390 400 410 420 430 440 >>XP_011541137 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa) initn: 1663 init1: 805 opt: 909 Z-score: 795.1 bits: 156.4 E(85289): 1.5e-37 Smith-Waterman score: 1644; 51.4% identity (78.2% similar) in 444 aa overlap (34-477:10-441) 10 20 30 40 50 60 pF1KE4 LPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPVVKK .. :::..:.: .. : .:.. .. .:.: XP_011 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEK 10 20 30 70 80 90 100 110 120 pF1KE4 IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTP ..:::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: :::: XP_011 LKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 DLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAH .: . :. :.. :...: ..:: :.:. .::::: :.: :.::: :::::...::: XP_011 QLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 AYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSL :. :: ::.:::::: .: ::. ... :::::::::.:::::: ::.. ::::: : .. XP_011 AFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 TDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLR . . . : ::::.:::..:: . :. :: : :.: :::.:.:::..::: XP_011 RETSNYSLPQDDIDGIQAIYGLSSN----PIQPTGPSTPKP-----CDPSLTFDAITTLR 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 GEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAI ::::.::::.:::. . . :...:: ::::::.:..:::: ..::.:.:::::.::. XP_011 GEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 RGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFP : .. :::. : . ::: .:. ::::. ..::::::.:..::.:..:. ::::.: XP_011 SGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYP 330 340 350 360 370 380 430 440 450 460 470 pF1KE4 KQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC :.:. ::::.::.::::.. ::. :.: :: :..::.. ..:.:::: XP_011 KSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG 390 400 410 420 430 440 477 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:58:31 2016 done: Sun Nov 6 00:58:33 2016 Total Scan time: 9.230 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]