FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6483, 553 aa 1>>>pF1KE6483 553 - 553 aa - 553 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5971+/-0.000374; mu= 17.2675+/- 0.023 mean_var=72.2311+/-15.206, 0's: 0 Z-trim(113.8): 194 B-trim: 1361 in 1/48 Lambda= 0.150908 statistics sampled from 23161 (23360) to 23161 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.274), width: 16 Scan time: 9.090 The best scores are: opt bits E(85289) NP_653186 (OMIM: 220150,607096) solute carrier fam ( 553) 3692 813.3 0 NP_001263255 (OMIM: 220150,607096) solute carrier ( 519) 2204 489.3 1.2e-137 NP_700357 (OMIM: 220150,607096) solute carrier fam ( 332) 2185 485.1 1.5e-136 XP_006718494 (OMIM: 220150,607096) PREDICTED: solu ( 543) 2186 485.4 2e-136 XP_006718493 (OMIM: 220150,607096) PREDICTED: solu ( 578) 2186 485.4 2.1e-136 NP_060954 (OMIM: 607097) solute carrier family 22 ( 550) 1920 427.5 5.4e-119 NP_001263256 (OMIM: 220150,607096) solute carrier ( 445) 1801 401.5 2.8e-111 NP_001034841 (OMIM: 607580) solute carrier family ( 541) 1744 389.2 1.8e-107 XP_011543318 (OMIM: 607580) PREDICTED: solute carr ( 541) 1744 389.2 1.8e-107 NP_001129978 (OMIM: 611698) solute carrier family ( 552) 1641 366.7 1e-100 NP_955384 (OMIM: 610792) solute carrier family 22 ( 547) 1591 355.8 2e-97 XP_016873176 (OMIM: 610792) PREDICTED: solute carr ( 547) 1591 355.8 2e-97 NP_543142 (OMIM: 607579) solute carrier family 22 ( 553) 1541 345.0 3.7e-94 XP_016873188 (OMIM: 607580) PREDICTED: solute carr ( 489) 1540 344.7 3.9e-94 NP_695008 (OMIM: 607582) solute carrier family 22 ( 550) 1476 330.8 6.8e-90 NP_004781 (OMIM: 607582) solute carrier family 22 ( 563) 1473 330.2 1.1e-89 XP_016874051 (OMIM: 607582) PREDICTED: solute carr ( 551) 1464 328.2 4.1e-89 NP_001294914 (OMIM: 607097) solute carrier family ( 442) 1372 308.1 3.7e-83 NP_004245 (OMIM: 607581) solute carrier family 22 ( 542) 1356 304.7 4.9e-82 NP_001171661 (OMIM: 607581) solute carrier family ( 542) 1356 304.7 4.9e-82 XP_016873190 (OMIM: 607580) PREDICTED: solute carr ( 424) 1292 290.7 6.2e-78 NP_001171662 (OMIM: 607581) solute carrier family ( 451) 1283 288.7 2.5e-77 NP_695009 (OMIM: 607582) solute carrier family 22 ( 506) 1268 285.5 2.7e-76 NP_695010 (OMIM: 607582) solute carrier family 22 ( 519) 1268 285.5 2.8e-76 XP_016872648 (OMIM: 607579) PREDICTED: solute carr ( 445) 1254 282.4 2e-75 XP_016873191 (OMIM: 607580) PREDICTED: solute carr ( 365) 1211 273.0 1.1e-72 XP_011543666 (OMIM: 607581) PREDICTED: solute carr ( 419) 1151 260.0 1.1e-68 NP_001171665 (OMIM: 607581) solute carrier family ( 419) 1151 260.0 1.1e-68 XP_011543469 (OMIM: 607097) PREDICTED: solute carr ( 417) 1150 259.8 1.2e-68 NP_006663 (OMIM: 604995) solute carrier family 22 ( 546) 1090 246.8 1.3e-64 XP_006715034 (OMIM: 604995) PREDICTED: solute carr ( 549) 1086 245.9 2.4e-64 NP_696961 (OMIM: 604995) solute carrier family 22 ( 548) 1078 244.2 8.2e-64 XP_006715033 (OMIM: 604995) PREDICTED: solute carr ( 551) 1070 242.4 2.7e-63 NP_004247 (OMIM: 604047) solute carrier family 22 ( 551) 1052 238.5 4.2e-62 XP_016873180 (OMIM: 610792) PREDICTED: solute carr ( 452) 994 225.8 2.2e-58 XP_016873179 (OMIM: 610792) PREDICTED: solute carr ( 452) 994 225.8 2.2e-58 XP_016873178 (OMIM: 610792) PREDICTED: solute carr ( 466) 994 225.8 2.3e-58 XP_016873177 (OMIM: 610792) PREDICTED: solute carr ( 477) 994 225.8 2.3e-58 XP_016873174 (OMIM: 610792) PREDICTED: solute carr ( 577) 985 223.9 1.1e-57 XP_016873173 (OMIM: 610792) PREDICTED: solute carr ( 577) 985 223.9 1.1e-57 XP_016873175 (OMIM: 610792) PREDICTED: solute carr ( 577) 985 223.9 1.1e-57 XP_016873183 (OMIM: 610792) PREDICTED: solute carr ( 379) 980 222.7 1.6e-57 XP_016873182 (OMIM: 610792) PREDICTED: solute carr ( 381) 980 222.7 1.6e-57 XP_016873181 (OMIM: 610792) PREDICTED: solute carr ( 405) 980 222.8 1.7e-57 NP_775857 (OMIM: 611698) solute carrier family 22 ( 322) 932 212.3 1.9e-54 XP_016873192 (OMIM: 607580) PREDICTED: solute carr ( 331) 907 206.8 8.6e-53 XP_016865689 (OMIM: 604995) PREDICTED: solute carr ( 543) 906 206.7 1.5e-52 XP_011512558 (OMIM: 604995) PREDICTED: solute carr ( 610) 900 205.4 4.1e-52 XP_016865687 (OMIM: 604995) PREDICTED: solute carr ( 602) 899 205.2 4.8e-52 NP_003051 (OMIM: 212140,603377) solute carrier fam ( 557) 898 205.0 5.2e-52 >>NP_653186 (OMIM: 220150,607096) solute carrier family (553 aa) initn: 3692 init1: 3692 opt: 3692 Z-score: 4342.3 bits: 813.3 E(85289): 0 Smith-Waterman score: 3692; 100.0% identity (100.0% similar) in 553 aa overlap (1-553:1-553) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH 490 500 510 520 530 540 550 pF1KE6 GTLGNSVLKSTQF ::::::::::::: NP_653 GTLGNSVLKSTQF 550 >>NP_001263255 (OMIM: 220150,607096) solute carrier fami (519 aa) initn: 2194 init1: 2194 opt: 2204 Z-score: 2591.9 bits: 489.3 E(85289): 1.2e-137 Smith-Waterman score: 3387; 93.7% identity (93.9% similar) in 553 aa overlap (1-553:1-519) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG :::::: .::::::::::::::::::: NP_001 LQMAVM----------------------------------VMEWTAARARPLVMTLNSLG 190 200 250 260 270 280 290 300 pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH 450 460 470 480 490 500 550 pF1KE6 GTLGNSVLKSTQF ::::::::::::: NP_001 GTLGNSVLKSTQF 510 >>NP_700357 (OMIM: 220150,607096) solute carrier family (332 aa) initn: 2185 init1: 2185 opt: 2185 Z-score: 2572.5 bits: 485.1 E(85289): 1.5e-136 Smith-Waterman score: 2185; 100.0% identity (100.0% similar) in 332 aa overlap (222-553:1-332) 200 210 220 230 240 250 pF1KE6 FAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAV :::::::::::::::::::::::::::::: NP_700 MEWTAARARPLVMTLNSLGFSFGHGLTAAV 10 20 30 260 270 280 290 300 310 pF1KE6 AYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_700 AYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAV 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE6 QDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_700 QDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDL 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE6 QALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_700 QALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMG 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE6 ALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_700 ALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGV 220 230 240 250 260 270 500 510 520 530 540 550 pF1KE6 HGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_700 HGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKST 280 290 300 310 320 330 pF1KE6 QF :: NP_700 QF >>XP_006718494 (OMIM: 220150,607096) PREDICTED: solute c (543 aa) initn: 3446 init1: 2186 opt: 2186 Z-score: 2570.4 bits: 485.4 E(85289): 2e-136 Smith-Waterman score: 3400; 95.2% identity (95.4% similar) in 543 aa overlap (36-553:1-543) 10 20 30 40 50 60 pF1KE6 LLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILG :::::::::::::::::::::::::::::: XP_006 MLENFSAAVPSHRCWAPLLDNSTAQASILG 10 20 30 70 80 90 100 110 120 pF1KE6 SLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 IFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAV 100 110 120 130 140 150 190 200 210 220 pF1KE6 MGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTL------------------------- ::::::::::::::::::::::::::::::::::: XP_006 MGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLA 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE6 LMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLA .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLA 220 230 240 250 260 270 290 300 310 320 330 340 pF1KE6 ESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTL 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE6 LRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLL 340 350 360 370 380 390 410 420 430 440 450 460 pF1KE6 SHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELF 400 410 420 430 440 450 470 480 490 500 510 520 pF1KE6 PTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQS 460 470 480 490 500 510 530 540 550 pF1KE6 LPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF ::::::::::::::::::::::::::::::::: XP_006 LPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF 520 530 540 >>XP_006718493 (OMIM: 220150,607096) PREDICTED: solute c (578 aa) initn: 3674 init1: 2186 opt: 2186 Z-score: 2570.0 bits: 485.4 E(85289): 2.1e-136 Smith-Waterman score: 3628; 95.5% identity (95.7% similar) in 578 aa overlap (1-553:1-578) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 130 140 150 160 170 180 190 200 210 220 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTL-------------------- :::::::::::::::::::::::::::::::::::::::: XP_006 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEP 190 200 210 220 230 240 230 240 250 260 270 pF1KE6 -----LMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLY .:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LGLLAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLY 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE6 SWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE6 SLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMG 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE6 ALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIY 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE6 SSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLL 490 500 510 520 530 540 520 530 540 550 pF1KE6 PETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF :::::::::::::::::::::::::::::::::::::: XP_006 PETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF 550 560 570 >>NP_060954 (OMIM: 607097) solute carrier family 22 memb (550 aa) initn: 1837 init1: 1084 opt: 1920 Z-score: 2257.3 bits: 427.5 E(85289): 5.4e-119 Smith-Waterman score: 1920; 52.1% identity (80.5% similar) in 555 aa overlap (1-553:1-550) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ ::::.::. .::.: ::.::...... . . .: .:::::::.:.::::. .:::..: NP_060 MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW .. ...:.:::.::::::::: :::::::::::::::::::::::::::::::::::: NP_060 ST---NMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY :::::.:::::::::.:::.:..:::..:::...:::::. : : ::::. .:.: NP_060 VYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCC 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG ::.:: ::.. :::.: .:: .::. ::..::..... ::..:::.. : ..::. . . NP_060 LQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW :: :.. ...:...::: :::..::::: : :::: ::::::. :. : .:::: NP_060 FSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELR 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF .:: :::. ... :: :::.:...::.. .. : :. :. .: ::.:.: . :.. NP_060 KVARINGHKEAKN-LTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI ....::..:::.:: .::::: ..:.::. .. . :::: :::: :.: .::: : NP_060 LISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAI 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA ::: :::... .:: ..:::: : : ..::.:::..::::: .:::: :. . ..: :: NP_060 LANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGA 420 430 440 450 460 470 490 500 510 520 530 pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALL-LPETQSLPLPDTIQDVQNQAVKKAT ..:::. . : :: :.::.. . :.:..:. :::::.:::::::::...: . :. NP_060 MMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQK-STAA 480 490 500 510 520 530 540 550 pF1KE6 HGTLGNSV-LKSTQF .:. ..: ..::.. NP_060 QGNRQEAVTVESTSL 540 550 >>NP_001263256 (OMIM: 220150,607096) solute carrier fami (445 aa) initn: 1801 init1: 1801 opt: 1801 Z-score: 2118.7 bits: 401.5 E(85289): 2.8e-111 Smith-Waterman score: 2740; 80.5% identity (80.5% similar) in 553 aa overlap (1-553:1-445) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDR----------- 130 140 150 160 190 200 210 220 230 240 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG NP_001 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW ::::::::::::::::::::::: NP_001 -------------------------------------WLAESARWLLTTGRLDWGLQELW 170 180 190 310 320 330 340 350 360 pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 200 210 220 230 240 250 370 380 390 400 410 420 pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 260 270 280 290 300 310 430 440 450 460 470 480 pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 320 330 340 350 360 370 490 500 510 520 530 540 pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH 380 390 400 410 420 430 550 pF1KE6 GTLGNSVLKSTQF ::::::::::::: NP_001 GTLGNSVLKSTQF 440 >>NP_001034841 (OMIM: 607580) solute carrier family 22 m (541 aa) initn: 1744 init1: 1744 opt: 1744 Z-score: 2050.4 bits: 389.2 E(85289): 1.8e-107 Smith-Waterman score: 1744; 50.3% identity (75.2% similar) in 533 aa overlap (1-533:1-533) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ ::: :::. ::::::::.:. . .. :.: : . .::::.::.:.::::. .:::.:.. NP_001 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW .. : :: .::: :::: : ::..:::: .:::::: :.: : :::::::::::: NP_001 GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY :::.: : ::::.::.:::: ..:: ..: . :.:.:::. : .:::::::..: : NP_001 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG ::.:. : :::::.:::::..::: .:. .. :.. . :: .. ::. :.: . NP_001 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW .:.:. . ...:: ::: :..:.:::::. :: : ::.::::::. :..:: ::. : NP_001 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF .:: :: ...::. ::. :.:.:::. .: ... :.: :..: : :: .. :: NP_001 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI . :.: ..:: .::::::::.. :.: . .. ::: :.:.::: . ..:.:: : NP_001 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA ::::.::.:: .:: ::: ::.: .:.:. .... ::.::::: : :. :.: :: NP_001 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH :.::. : : :: ..:: :...:: ..:::::..:::::::.::.:: NP_001 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK 490 500 510 520 530 540 550 pF1KE6 GTLGNSVLKSTQF NP_001 A >>XP_011543318 (OMIM: 607580) PREDICTED: solute carrier (541 aa) initn: 1744 init1: 1744 opt: 1744 Z-score: 2050.4 bits: 389.2 E(85289): 1.8e-107 Smith-Waterman score: 1744; 50.3% identity (75.2% similar) in 533 aa overlap (1-533:1-533) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ ::: :::. ::::::::.:. . .. :.: : . .::::.::.:.::::. .:::.:.. XP_011 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW .. : :: .::: :::: : ::..:::: .:::::: :.: : :::::::::::: XP_011 GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY :::.: : ::::.::.:::: ..:: ..: . :.:.:::. : .:::::::..: : XP_011 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG ::.:. : :::::.:::::..::: .:. .. :.. . :: .. ::. :.: . XP_011 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW .:.:. . ...:: ::: :..:.:::::. :: : ::.::::::. :..:: ::. : XP_011 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF .:: :: ...::. ::. :.:.:::. .: ... :.: :..: : :: .. :: XP_011 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI . :.: ..:: .::::::::.. :.: . .. ::: :.:.::: . ..:.:: : XP_011 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA ::::.::.:: .:: ::: ::.: .:.:. .... ::.::::: : :. :.: :: XP_011 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH :.::. : : :: ..:: :...:: ..:::::..:::::::.::.:: XP_011 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK 490 500 510 520 530 540 550 pF1KE6 GTLGNSVLKSTQF XP_011 A >>NP_001129978 (OMIM: 611698) solute carrier family 22 m (552 aa) initn: 1613 init1: 1613 opt: 1641 Z-score: 1929.0 bits: 366.7 E(85289): 1e-100 Smith-Waterman score: 1641; 46.1% identity (74.6% similar) in 555 aa overlap (1-553:1-552) 10 20 30 40 50 60 pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ :.:. ::: :::.::::. . .. . : . .::::.: .::::::.:::::.:.. NP_001 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW . :.:: . :: :::: : ::..:.:: .:::::: :.: . .: ::::::::: NP_001 DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY ::::: : ::::..:.:::.:..:: :.::...:: :.:. : ::: ::... . NP_001 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG ::.:. .: :::::.: :::..::: .:.. .. :: : .::: :.: ... . . NP_001 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW .: :. : ...:....:: .:::.::.:... :: :: ..::::::. ...:: ::.:: NP_001 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF ::: :::: ...::: :.. :.:..::. . .:. .:.: : ::.: . ::. : NP_001 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMR--VFGLCFVRF 310 320 330 340 350 370 380 390 400 410 pF1KE6 GFT--FFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGL ..: :.:: :.:: ::::. :.:.. :.: . :. .:: :.:.::: . . .:: NP_001 AITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGL 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 CILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG ::.::..:.:: :: .::.::.:.:.:: . ... .:: ::.:: :..:.. ...: NP_001 FILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRT 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKA :: :.::. : ...: :: . ::. :.:. . ::::::..::::.:::::.:. : . NP_001 GAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENDR-KDS 480 490 500 510 520 530 540 550 pF1KE6 THGTLGNSVLKSTQF . .. .: ::: NP_001 RNIKQEDTCMKVTQF 540 550 553 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:44:22 2016 done: Tue Nov 8 13:44:23 2016 Total Scan time: 9.090 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]