Result of FASTA (omim) for
pFN21AE6611
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6611, 267 aa
1>>>pF1KE6611 267 - 267 aa - 267 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5557+/-0.000346; mu= 15.6338+/- 0.022
mean_var=91.8056+/-18.519, 0's: 0 Z-trim(116.2): 66 B-trim: 0 in 0/56
Lambda= 0.133857
statistics sampled from 27138 (27205) to 27138 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.319), width: 16
Scan time: 5.690
The best scores are: opt bits E(85289)
NP_060186 (OMIM: 606550) membrane-spanning 4-domai ( 267) 1750 347.5 1.5e-95
XP_011543419 (OMIM: 606550) PREDICTED: membrane-sp ( 267) 1750 347.5 1.5e-95
NP_001157942 (OMIM: 606550) membrane-spanning 4-do ( 221) 831 170.0 3.4e-42
NP_113645 (OMIM: 606549) membrane-spanning 4-domai ( 250) 506 107.3 2.9e-23
NP_076926 (OMIM: 606547) membrane-spanning 4-domai ( 220) 289 65.3 1.1e-10
XP_016873398 (OMIM: 606547) PREDICTED: membrane-sp ( 220) 289 65.3 1.1e-10
NP_683876 (OMIM: 606547) membrane-spanning 4-domai ( 239) 289 65.4 1.2e-10
XP_016872851 (OMIM: 147050,147138) PREDICTED: high ( 204) 239 55.6 8.3e-08
NP_000130 (OMIM: 147050,147138) high affinity immu ( 244) 239 55.7 9.4e-08
XP_011543152 (OMIM: 147050,147138) PREDICTED: high ( 244) 239 55.7 9.4e-08
XP_005273903 (OMIM: 147050,147138) PREDICTED: high ( 251) 239 55.7 9.6e-08
NP_690590 (OMIM: 606548) membrane-spanning 4-domai ( 178) 235 54.8 1.3e-07
NP_690605 (OMIM: 112210,613495) B-lymphocyte antig ( 297) 237 55.4 1.4e-07
NP_068769 (OMIM: 112210,613495) B-lymphocyte antig ( 297) 237 55.4 1.4e-07
NP_071744 (OMIM: 606548) membrane-spanning 4-domai ( 225) 230 53.9 3e-07
NP_076434 (OMIM: 606499) membrane-spanning 4-domai ( 200) 229 53.7 3.1e-07
NP_690591 (OMIM: 606548) membrane-spanning 4-domai ( 248) 230 54.0 3.2e-07
NP_001234928 (OMIM: 606548) membrane-spanning 4-do ( 253) 230 54.0 3.2e-07
XP_005274234 (OMIM: 606548) PREDICTED: membrane-sp ( 276) 230 54.0 3.4e-07
NP_001317204 (OMIM: 606548) membrane-spanning 4-do ( 276) 230 54.0 3.4e-07
NP_006129 (OMIM: 606498) membrane-spanning 4-domai ( 214) 225 53.0 5.6e-07
NP_001230195 (OMIM: 606547) membrane-spanning 4-do ( 186) 224 52.7 5.7e-07
XP_016873614 (OMIM: 606548) PREDICTED: membrane-sp ( 145) 179 43.9 0.0002
XP_011543511 (OMIM: 606548) PREDICTED: membrane-sp ( 148) 179 43.9 0.0002
NP_996822 (OMIM: 606502) membrane-spanning 4-domai ( 240) 178 43.9 0.00033
NP_067024 (OMIM: 606502) membrane-spanning 4-domai ( 240) 178 43.9 0.00033
XP_011543665 (OMIM: 606498) PREDICTED: membrane-sp ( 154) 174 43.0 0.0004
NP_996776 (OMIM: 608403) membrane-spanning 4-domai ( 267) 176 43.6 0.00046
XP_011543291 (OMIM: 608403) PREDICTED: membrane-sp ( 290) 176 43.6 0.00049
>>NP_060186 (OMIM: 606550) membrane-spanning 4-domains s (267 aa)
initn: 1750 init1: 1750 opt: 1750 Z-score: 1836.6 bits: 347.5 E(85289): 1.5e-95
Smith-Waterman score: 1750; 100.0% identity (100.0% similar) in 267 aa overlap (1-267:1-267)
10 20 30 40 50 60
pF1KE6 MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN
190 200 210 220 230 240
250 260
pF1KE6 MYESNPVTPASSSAPPRCNNYSANAPK
:::::::::::::::::::::::::::
NP_060 MYESNPVTPASSSAPPRCNNYSANAPK
250 260
>>XP_011543419 (OMIM: 606550) PREDICTED: membrane-spanni (267 aa)
initn: 1750 init1: 1750 opt: 1750 Z-score: 1836.6 bits: 347.5 E(85289): 1.5e-95
Smith-Waterman score: 1750; 100.0% identity (100.0% similar) in 267 aa overlap (1-267:1-267)
10 20 30 40 50 60
pF1KE6 MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN
190 200 210 220 230 240
250 260
pF1KE6 MYESNPVTPASSSAPPRCNNYSANAPK
:::::::::::::::::::::::::::
XP_011 MYESNPVTPASSSAPPRCNNYSANAPK
250 260
>>NP_001157942 (OMIM: 606550) membrane-spanning 4-domain (221 aa)
initn: 831 init1: 831 opt: 831 Z-score: 878.6 bits: 170.0 E(85289): 3.4e-42
Smith-Waterman score: 1339; 82.8% identity (82.8% similar) in 267 aa overlap (1-267:1-221)
10 20 30 40 50 60
pF1KE6 MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMSSKPTSHAEVNETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL
::::::::::::::::::::::::::::::::
NP_001 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALG----------------------------
70 80 90
130 140 150 160 170 180
pF1KE6 GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL
::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------------FIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL
100 110 120 130
190 200 210 220 230 240
pF1KE6 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN
140 150 160 170 180 190
250 260
pF1KE6 MYESNPVTPASSSAPPRCNNYSANAPK
:::::::::::::::::::::::::::
NP_001 MYESNPVTPASSSAPPRCNNYSANAPK
200 210 220
>>NP_113645 (OMIM: 606549) membrane-spanning 4-domains s (250 aa)
initn: 327 init1: 133 opt: 506 Z-score: 538.7 bits: 107.3 E(85289): 2.9e-23
Smith-Waterman score: 506; 42.5% identity (66.4% similar) in 226 aa overlap (52-256:23-240)
30 40 50 60 70
pF1KE6 PSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGI------FASSQPGQGNIQMINP
: .: ::: . .::: . :
NP_113 MNSMTSAVPVANSVLVVAPHNGYPVT-PGIMSHVPLYPNSQPQVHLVPGNPP
10 20 30 40 50
80 90 100 110 120
pF1KE6 SV-----GTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLG-FASTAVIG
:. : :.. .:.:.::.:::..:: :::.: .. . ..: . : . :
NP_113 SLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATV------LVGEYLSISFYG
60 70 80 90 100
130 140 150 160 170 180
pF1KE6 GYPFWGGLSFIISGSLSVSA-SKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCI-NG
:.:::::: :::::::::.: .. : ::..::::.::::.: . .::::...:. : .
NP_113 GFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHP
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 VAGQDY----WAVLSGKGISATLMIFSLLEFFVACATAHFANQ--ANTTTNMSVLVIPNM
: :: :.: : .::..:..: :::: .:::..::. : ..:.:: . ::.
NP_113 YAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSV-IYPNI
170 180 190 200 210 220
250 260
pF1KE6 YESNPV-TPASSSAPPRCNNYSANAPK
: .::: :: ..::
NP_113 YAANPVITPEPVTSPPSYSSEIQANK
230 240 250
>>NP_076926 (OMIM: 606547) membrane-spanning 4-domains s (220 aa)
initn: 246 init1: 173 opt: 289 Z-score: 312.9 bits: 65.3 E(85289): 1.1e-10
Smith-Waterman score: 318; 31.8% identity (63.7% similar) in 223 aa overlap (44-249:5-216)
20 30 40 50 60 70
pF1KE6 ETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIFASSQPGQGNIQMI
:: ..:.: : ..::. : ::. .:
NP_076 MTTMQGMEQAMP-G-AGPGV-----PQLGNMAVI
10 20
80 90 100 110 120 130
pF1KE6 NPSVGTAVMN--FKEEAKALGVIQIMVGLMHIGFGI-VLCLISFSFREVLGFASTAVIGG
. . .... .: : :.:::.::...:: ...:: ..:. : .. : .: :
NP_076 HSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTY----GSNPISVYIG
30 40 50 60 70 80
140 150 160 170 180
pF1KE6 YPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM-------
: .::.. ::::::::..:. . .. ::.:::::::.::.:: :... ..
NP_076 YTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHH
90 100 110 120 130 140
190 200 210 220 230
pF1KE6 --C-INGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQA-NTTTNMSVLVIP
: : ... . .. :... ....:.::: .: . . :. .. : . ::..:
NP_076 PYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILP
150 160 170 180 190 200
240 250 260
pF1KE6 N---MYESNPVTPASSSAPPRCNNYSANAPK
. : :. ::
NP_076 SHSHMAETASPTPLNEV
210 220
>>XP_016873398 (OMIM: 606547) PREDICTED: membrane-spanni (220 aa)
initn: 246 init1: 173 opt: 289 Z-score: 312.9 bits: 65.3 E(85289): 1.1e-10
Smith-Waterman score: 318; 31.8% identity (63.7% similar) in 223 aa overlap (44-249:5-216)
20 30 40 50 60 70
pF1KE6 ETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIFASSQPGQGNIQMI
:: ..:.: : ..::. : ::. .:
XP_016 MTTMQGMEQAMP-G-AGPGV-----PQLGNMAVI
10 20
80 90 100 110 120 130
pF1KE6 NPSVGTAVMN--FKEEAKALGVIQIMVGLMHIGFGI-VLCLISFSFREVLGFASTAVIGG
. . .... .: : :.:::.::...:: ...:: ..:. : .. : .: :
XP_016 HSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTY----GSNPISVYIG
30 40 50 60 70 80
140 150 160 170 180
pF1KE6 YPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM-------
: .::.. ::::::::..:. . .. ::.:::::::.::.:: :... ..
XP_016 YTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHH
90 100 110 120 130 140
190 200 210 220 230
pF1KE6 --C-INGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQA-NTTTNMSVLVIP
: : ... . .. :... ....:.::: .: . . :. .. : . ::..:
XP_016 PYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILP
150 160 170 180 190 200
240 250 260
pF1KE6 N---MYESNPVTPASSSAPPRCNNYSANAPK
. : :. ::
XP_016 SHSHMAETASPTPLNEV
210 220
>>NP_683876 (OMIM: 606547) membrane-spanning 4-domains s (239 aa)
initn: 246 init1: 173 opt: 289 Z-score: 312.5 bits: 65.4 E(85289): 1.2e-10
Smith-Waterman score: 318; 31.8% identity (63.7% similar) in 223 aa overlap (44-249:24-235)
20 30 40 50 60 70
pF1KE6 ETIPNPYPPSSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIFASSQPGQGNIQMI
:: ..:.: : ..::. : ::. .:
NP_683 MHQTYSRHCRPEESTFSAAMTTMQGMEQAMP-G-AGPGV-----PQLGNMAVI
10 20 30 40
80 90 100 110 120 130
pF1KE6 NPSVGTAVMN--FKEEAKALGVIQIMVGLMHIGFGI-VLCLISFSFREVLGFASTAVIGG
. . .... .: : :.:::.::...:: ...:: ..:. : .. : .: :
NP_683 HSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTY----GSNPISVYIG
50 60 70 80 90 100
140 150 160 170 180
pF1KE6 YPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM-------
: .::.. ::::::::..:. . .. ::.:::::::.::.:: :... ..
NP_683 YTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHH
110 120 130 140 150 160
190 200 210 220 230
pF1KE6 --C-INGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQA-NTTTNMSVLVIP
: : ... . .. :... ....:.::: .: . . :. .. : . ::..:
NP_683 PYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILP
170 180 190 200 210 220
240 250 260
pF1KE6 N---MYESNPVTPASSSAPPRCNNYSANAPK
. : :. ::
NP_683 SHSHMAETASPTPLNEV
230
>>XP_016872851 (OMIM: 147050,147138) PREDICTED: high aff (204 aa)
initn: 219 init1: 165 opt: 239 Z-score: 261.2 bits: 55.6 E(85289): 8.3e-08
Smith-Waterman score: 239; 34.5% identity (69.1% similar) in 110 aa overlap (74-183:51-159)
50 60 70 80 90 100
pF1KE6 QGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHI
.: . : . .:.: . ::: ::..... .
XP_016 PQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICL
30 40 50 60 70 80
110 120 130 140 150 160
pF1KE6 GFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLG
:: :.: . ... .. : .. .::::::.. : ::: ::. . .. . ::.::::
XP_016 CFGTVVCSV-LDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLG
90 100 110 120 130
170 180 190 200 210 220
pF1KE6 MNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHF
: .::: . :. .:....
XP_016 ANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTVCIFFCVGRLRFW
140 150 160 170 180 190
>>NP_000130 (OMIM: 147050,147138) high affinity immunogl (244 aa)
initn: 197 init1: 143 opt: 239 Z-score: 260.2 bits: 55.7 E(85289): 9.4e-08
Smith-Waterman score: 239; 34.5% identity (69.1% similar) in 110 aa overlap (74-183:44-152)
50 60 70 80 90 100
pF1KE6 QGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHI
.: . : . .:.: . ::: ::..... .
NP_000 PQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICL
20 30 40 50 60 70
110 120 130 140 150 160
pF1KE6 GFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLG
:: :.: . ... .. : .. .::::::.. : ::: ::. . .. . ::.::::
NP_000 CFGTVVCSV-LDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLG
80 90 100 110 120 130
170 180 190 200 210 220
pF1KE6 MNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHF
: .::: . :. .:....
NP_000 ANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILG
140 150 160 170 180 190
>>XP_011543152 (OMIM: 147050,147138) PREDICTED: high aff (244 aa)
initn: 197 init1: 143 opt: 239 Z-score: 260.2 bits: 55.7 E(85289): 9.4e-08
Smith-Waterman score: 239; 34.5% identity (69.1% similar) in 110 aa overlap (74-183:44-152)
50 60 70 80 90 100
pF1KE6 QGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHI
.: . : . .:.: . ::: ::..... .
XP_011 PQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICL
20 30 40 50 60 70
110 120 130 140 150 160
pF1KE6 GFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLG
:: :.: . ... .. : .. .::::::.. : ::: ::. . .. . ::.::::
XP_011 CFGTVVCSV-LDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLG
80 90 100 110 120 130
170 180 190 200 210 220
pF1KE6 MNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHF
: .::: . :. .:....
XP_011 ANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILG
140 150 160 170 180 190
267 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:45:44 2016 done: Tue Nov 8 14:45:44 2016
Total Scan time: 5.690 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]