FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6514, 147 aa 1>>>pF1KE6514 147 - 147 aa - 147 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2201+/-0.000313; mu= 11.6598+/- 0.020 mean_var=57.6141+/-11.345, 0's: 0 Z-trim(114.9): 32 B-trim: 37 in 1/51 Lambda= 0.168970 statistics sampled from 25006 (25038) to 25006 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.693), E-opt: 0.2 (0.294), width: 16 Scan time: 3.250 The best scores are: opt bits E(85289) NP_640342 (OMIM: 608402) membrane-spanning 4-domai ( 147) 928 234.0 6.5e-62 XP_016873614 (OMIM: 606548) PREDICTED: membrane-sp ( 145) 293 79.2 2.6e-15 XP_011543511 (OMIM: 606548) PREDICTED: membrane-sp ( 148) 293 79.2 2.6e-15 NP_690590 (OMIM: 606548) membrane-spanning 4-domai ( 178) 293 79.3 3.1e-15 NP_071744 (OMIM: 606548) membrane-spanning 4-domai ( 225) 293 79.3 3.8e-15 NP_690591 (OMIM: 606548) membrane-spanning 4-domai ( 248) 293 79.3 4.1e-15 NP_001234928 (OMIM: 606548) membrane-spanning 4-do ( 253) 293 79.3 4.2e-15 NP_001317204 (OMIM: 606548) membrane-spanning 4-do ( 276) 293 79.3 4.5e-15 XP_005274234 (OMIM: 606548) PREDICTED: membrane-sp ( 276) 293 79.3 4.5e-15 XP_016873613 (OMIM: 606548) PREDICTED: membrane-sp ( 180) 283 76.8 1.7e-14 XP_016873612 (OMIM: 606548) PREDICTED: membrane-sp ( 203) 283 76.9 1.9e-14 XP_006718724 (OMIM: 606548) PREDICTED: membrane-sp ( 208) 283 76.9 1.9e-14 XP_006718723 (OMIM: 606548) PREDICTED: membrane-sp ( 231) 283 76.9 2.1e-14 NP_996823 (OMIM: 606502) membrane-spanning 4-domai ( 195) 182 52.2 4.7e-07 NP_996821 (OMIM: 606502) membrane-spanning 4-domai ( 195) 182 52.2 4.7e-07 NP_996822 (OMIM: 606502) membrane-spanning 4-domai ( 240) 182 52.3 5.6e-07 NP_067024 (OMIM: 606502) membrane-spanning 4-domai ( 240) 182 52.3 5.6e-07 >>NP_640342 (OMIM: 608402) membrane-spanning 4-domains s (147 aa) initn: 928 init1: 928 opt: 928 Z-score: 1232.5 bits: 234.0 E(85289): 6.5e-62 Smith-Waterman score: 928; 100.0% identity (100.0% similar) in 147 aa overlap (1-147:1-147) 10 20 30 40 50 60 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_640 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_640 ALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGT 70 80 90 100 110 120 130 140 pF1KE6 LSLMLVSTVLEFCLAVLTAVLQWKQTV ::::::::::::::::::::::::::: NP_640 LSLMLVSTVLEFCLAVLTAVLQWKQTV 130 140 >>XP_016873614 (OMIM: 606548) PREDICTED: membrane-spanni (145 aa) initn: 295 init1: 277 opt: 293 Z-score: 396.0 bits: 79.2 E(85289): 2.6e-15 Smith-Waterman score: 293; 61.9% identity (79.8% similar) in 84 aa overlap (1-84:29-105) 10 20 30 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ :::::. :::::.::::::::::::::::::: XP_016 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 GQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDI :::::::.:.:..::::. . : : .. .: :.:: : :...: : XP_016 GQDSLKKHLHAEIKVIGTIQILCGMMVLSL----GIILAS---ASFSPNFTQVTSTLLNS 70 80 90 100 110 100 110 120 130 140 pF1KE6 PTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV XP_016 AYPFIGPFFFIISGSLSIATEKRLTKLLGFLS 120 130 140 >>XP_011543511 (OMIM: 606548) PREDICTED: membrane-spanni (148 aa) initn: 277 init1: 277 opt: 293 Z-score: 395.8 bits: 79.2 E(85289): 2.6e-15 Smith-Waterman score: 293; 61.9% identity (79.8% similar) in 84 aa overlap (1-84:29-105) 10 20 30 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ :::::. :::::.::::::::::::::::::: XP_011 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 GQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDI :::::::.:.:..::::. . : : .. .: :.:: : :...: : XP_011 GQDSLKKHLHAEIKVIGTIQILCGMMVLSL----GIILAS---ASFSPNFTQVTSTLLNS 70 80 90 100 110 100 110 120 130 140 pF1KE6 PTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV XP_011 AYPFIGPFFFIISGSLSIATEKRLTKLLGLMLEIM 120 130 140 >>NP_690590 (OMIM: 606548) membrane-spanning 4-domains s (178 aa) initn: 316 init1: 277 opt: 293 Z-score: 394.6 bits: 79.3 E(85289): 3.1e-15 Smith-Waterman score: 317; 45.2% identity (54.8% similar) in 168 aa overlap (1-103:1-168) 10 20 30 40 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG----------- :::::. :::::.::::::::::::::::::::::::::.:.:..:::: NP_690 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL 10 20 30 40 50 60 50 pF1KE6 -----------------------------------------------------VHSSLAG :::::.: NP_690 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG 70 80 90 100 110 120 60 70 80 90 100 110 pF1KE6 SILSALSALVGFILLSVNPAALNPASLQ-CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKA :::::::::::::.:::. :.::::::: .:.. :. . .: : NP_690 SILSALSALVGFIILSVKQATLNPASLQWNSLSDADLHSAGILPSCAHCCAAVETGLL 130 140 150 160 170 120 130 140 pF1KE6 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV >>NP_071744 (OMIM: 606548) membrane-spanning 4-domains s (225 aa) initn: 512 init1: 277 opt: 293 Z-score: 393.0 bits: 79.3 E(85289): 3.8e-15 Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:1-179) 10 20 30 40 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG----------- :::::. :::::.::::::::::::::::::::::::::.:.:..:::: NP_071 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL 10 20 30 40 50 60 50 pF1KE6 -----------------------------------------------------VHSSLAG :::::.: NP_071 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG 70 80 90 100 110 120 60 70 80 90 100 110 pF1KE6 SILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYH-SPYTMDCHRAKA :::::::::::::.:::. :.::::::::.::...:::: .:: :: : :: ::. :: NP_071 SILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKA 130 140 150 160 170 180 120 130 140 pF1KE6 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV NP_071 SLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGVSVLAGFT 190 200 210 220 >-- initn: 170 init1: 170 opt: 170 Z-score: 230.9 bits: 49.3 E(85289): 4e-06 Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:180-210) 90 100 110 120 130 140 pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK :::::::::::. :.::::::::::::.:: NP_071 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK 150 160 170 180 190 200 pF1KE6 QTV : NP_071 QAYSDFPGVSVLAGFT 210 220 >>NP_690591 (OMIM: 606548) membrane-spanning 4-domains s (248 aa) initn: 512 init1: 277 opt: 293 Z-score: 392.3 bits: 79.3 E(85289): 4.1e-15 Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:1-179) 10 20 30 40 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG----------- :::::. :::::.::::::::::::::::::::::::::.:.:..:::: NP_690 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL 10 20 30 40 50 60 50 pF1KE6 -----------------------------------------------------VHSSLAG :::::.: NP_690 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG 70 80 90 100 110 120 60 70 80 90 100 110 pF1KE6 SILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYH-SPYTMDCHRAKA :::::::::::::.:::. :.::::::::.::...:::: .:: :: : :: ::. :: NP_690 SILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKA 130 140 150 160 170 180 120 130 140 pF1KE6 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV NP_690 SLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGSVLFLPHSYIGNSGMSSKMTHDC 190 200 210 220 230 240 >-- initn: 170 init1: 170 opt: 170 Z-score: 230.2 bits: 49.3 E(85289): 4.4e-06 Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:180-210) 90 100 110 120 130 140 pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK :::::::::::. :.::::::::::::.:: NP_690 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK 150 160 170 180 190 200 pF1KE6 QTV : NP_690 QAYSDFPGSVLFLPHSYIGNSGMSSKMTHDCGYEELLTS 210 220 230 240 >>NP_001234928 (OMIM: 606548) membrane-spanning 4-domain (253 aa) initn: 512 init1: 277 opt: 293 Z-score: 392.2 bits: 79.3 E(85289): 4.2e-15 Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:29-207) 10 20 30 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ :::::. :::::.::::::::::::::::::: NP_001 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ 10 20 30 40 50 60 40 pF1KE6 GQDSLKKRLQAKVKVIG------------------------------------------- :::::::.:.:..:::: NP_001 GQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGP 70 80 90 100 110 120 50 60 70 80 pF1KE6 ---------------------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLD :::::.::::::::::::::.:::. :.::::::::.:: NP_001 FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE6 EKDIPTRLLLSYDYH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV ...:::: .:: :: : :: ::. :: NP_001 KNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAY 190 200 210 220 230 240 >-- initn: 170 init1: 170 opt: 170 Z-score: 230.1 bits: 49.3 E(85289): 4.4e-06 Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:208-238) 90 100 110 120 130 140 pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK :::::::::::. :.::::::::::::.:: NP_001 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK 180 190 200 210 220 230 pF1KE6 QTV : NP_001 QAYSDFPGVSVLAGFT 240 250 >>NP_001317204 (OMIM: 606548) membrane-spanning 4-domain (276 aa) initn: 498 init1: 277 opt: 293 Z-score: 391.6 bits: 79.3 E(85289): 4.5e-15 Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:29-207) 10 20 30 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ :::::. :::::.::::::::::::::::::: NP_001 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ 10 20 30 40 50 60 40 pF1KE6 GQDSLKKRLQAKVKVIG------------------------------------------- :::::::.:.:..:::: NP_001 GQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGP 70 80 90 100 110 120 50 60 70 80 pF1KE6 ---------------------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLD :::::.::::::::::::::.:::. :.::::::::.:: NP_001 FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE6 EKDIPTRLLLSYDYH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV ...:::: .:: :: : :: ::. :: NP_001 KNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAY 190 200 210 220 230 240 >-- initn: 170 init1: 170 opt: 170 Z-score: 229.5 bits: 49.4 E(85289): 4.8e-06 Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:208-238) 90 100 110 120 130 140 pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK :::::::::::. :.::::::::::::.:: NP_001 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK 180 190 200 210 220 230 pF1KE6 QTV : NP_001 QAYSDFPGSVLFLPHSYIGNSGMSSKMTHDCGYEELLTS 240 250 260 270 >>XP_005274234 (OMIM: 606548) PREDICTED: membrane-spanni (276 aa) initn: 498 init1: 277 opt: 293 Z-score: 391.6 bits: 79.3 E(85289): 4.5e-15 Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:29-207) 10 20 30 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ :::::. :::::.::::::::::::::::::: XP_005 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ 10 20 30 40 50 60 40 pF1KE6 GQDSLKKRLQAKVKVIG------------------------------------------- :::::::.:.:..:::: XP_005 GQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGP 70 80 90 100 110 120 50 60 70 80 pF1KE6 ---------------------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLD :::::.::::::::::::::.:::. :.::::::::.:: XP_005 FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE6 EKDIPTRLLLSYDYH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV ...:::: .:: :: : :: ::. :: XP_005 KNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAY 190 200 210 220 230 240 >-- initn: 170 init1: 170 opt: 170 Z-score: 229.5 bits: 49.4 E(85289): 4.8e-06 Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:208-238) 90 100 110 120 130 140 pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK :::::::::::. :.::::::::::::.:: XP_005 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK 180 190 200 210 220 230 pF1KE6 QTV : XP_005 QAYSDFPGSVLFLPHSYIGNSGMSSKMTHDCGYEELLTS 240 250 260 270 >>XP_016873613 (OMIM: 606548) PREDICTED: membrane-spanni (180 aa) initn: 512 init1: 277 opt: 283 Z-score: 381.3 bits: 76.8 E(85289): 1.7e-14 Smith-Waterman score: 687; 70.9% identity (82.4% similar) in 165 aa overlap (1-145:1-165) 10 20 30 40 pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG----------- :::::. :::::.::::::::::::::::::::::::::.:.:..:::: XP_016 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGFIISGSLSIAT 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 --------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYD :::::.::::::::::::::.:::. :.::::::::.::...:::: .:: XP_016 EKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYF 70 80 90 100 110 120 110 120 130 140 pF1KE6 YH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV :: : :: ::. :::::::::::::. :.::::::::::::.::: XP_016 YHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGVSVLAGFT 130 140 150 160 170 180 147 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:59:53 2016 done: Tue Nov 8 13:59:54 2016 Total Scan time: 3.250 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]