FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5556, 374 aa 1>>>pF1KE5556 374 - 374 aa - 374 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3319+/-0.000462; mu= 16.7741+/- 0.029 mean_var=70.7373+/-13.905, 0's: 0 Z-trim(109.5): 34 B-trim: 275 in 1/53 Lambda= 0.152493 statistics sampled from 17626 (17653) to 17626 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.551), E-opt: 0.2 (0.207), width: 16 Scan time: 7.100 The best scores are: opt bits E(85289) NP_006351 (OMIM: 609641) eukaryotic translation in ( 374) 2414 540.6 2.1e-153 XP_011518142 (OMIM: 609641) PREDICTED: eukaryotic ( 311) 2013 452.4 6.6e-127 NP_001294858 (OMIM: 609641) eukaryotic translation ( 242) 1498 339.0 6.9e-93 NP_001157565 (OMIM: 616009) COP9 signalosome compl ( 275) 157 44.0 0.00049 XP_005253751 (OMIM: 616009) PREDICTED: COP9 signal ( 275) 157 44.0 0.00049 NP_001157566 (OMIM: 616009) COP9 signalosome compl ( 275) 157 44.0 0.00049 NP_001157567 (OMIM: 616009) COP9 signalosome compl ( 275) 157 44.0 0.00049 NP_057403 (OMIM: 616009) COP9 signalosome complex ( 275) 157 44.0 0.00049 >>NP_006351 (OMIM: 609641) eukaryotic translation initia (374 aa) initn: 2414 init1: 2414 opt: 2414 Z-score: 2875.0 bits: 540.6 E(85289): 2.1e-153 Smith-Waterman score: 2414; 100.0% identity (100.0% similar) in 374 aa overlap (1-374:1-374) 10 20 30 40 50 60 pF1KE5 MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 YTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 LTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 LQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQN 310 320 330 340 350 360 370 pF1KE5 LNKVKNSLLSLSDT :::::::::::::: NP_006 LNKVKNSLLSLSDT 370 >>XP_011518142 (OMIM: 609641) PREDICTED: eukaryotic tran (311 aa) initn: 2013 init1: 2013 opt: 2013 Z-score: 2399.4 bits: 452.4 E(85289): 6.6e-127 Smith-Waterman score: 2013; 100.0% identity (100.0% similar) in 311 aa overlap (64-374:1-311) 40 50 60 70 80 90 pF1KE5 SEGGLHVDLAQIIEACDVCLKEDDKDVESVMNSVVSLLLILEPDKQEALIESLCEKLVKF :::::::::::::::::::::::::::::: XP_011 MNSVVSLLLILEPDKQEALIESLCEKLVKF 10 20 30 100 110 120 130 140 150 pF1KE5 REGERPSLRLQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REGERPSLRLQLLSNLFHGMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISD 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE5 WNLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WNLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALK 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE5 DPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPNAFLFDHLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQN 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE5 MAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVV 220 230 240 250 260 270 340 350 360 370 pF1KE5 VSHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT ::::::::::::::::::::::::::::::::::::::::: XP_011 VSHSTHRTFGKQQWQQLYDTLNAWKQNLNKVKNSLLSLSDT 280 290 300 310 >>NP_001294858 (OMIM: 609641) eukaryotic translation ini (242 aa) initn: 1498 init1: 1498 opt: 1498 Z-score: 1788.6 bits: 339.0 E(85289): 6.9e-93 Smith-Waterman score: 1498; 99.1% identity (99.6% similar) in 233 aa overlap (142-374:10-242) 120 130 140 150 160 170 pF1KE5 GMDKNTPVRYTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEA .: ::::::::::::::::::::::::::: NP_001 MSVPAFIDISEEDQVRKWISDWNLTTEKKHTLLRLLYEA 10 20 30 180 190 200 210 220 230 pF1KE5 LVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKF 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE5 LEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKE 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE5 ISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLY 160 170 180 190 200 210 360 370 pF1KE5 DTLNAWKQNLNKVKNSLLSLSDT ::::::::::::::::::::::: NP_001 DTLNAWKQNLNKVKNSLLSLSDT 220 230 240 >>NP_001157565 (OMIM: 616009) COP9 signalosome complex s (275 aa) initn: 78 init1: 78 opt: 157 Z-score: 193.4 bits: 44.0 E(85289): 0.00049 Smith-Waterman score: 157; 26.0% identity (61.0% similar) in 154 aa overlap (208-357:31-177) 180 190 200 210 220 230 pF1KE5 SDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFL-EGEL : ..:. :....: .:: . :. : :... NP_001 MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDF 10 20 30 40 50 60 240 250 260 270 280 290 pF1KE5 IHD--LLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISF :::.:. . :.:. .: : : : . :.: :. . .:.. : : . NP_001 ASTFRLLTVFAYGTYADYLAEARN-------LPPLTEAQKNKLRHLSVVTLAAKVKCIPY 70 80 90 100 110 300 310 320 330 340 350 pF1KE5 DTMQQELQI-GADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDT .. . : . .. ..: .::.:: . .. ..:: .... :..: : . .:. . . : NP_001 AVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIART 120 130 140 150 160 170 360 370 pF1KE5 LNAWKQNLNKVKNSLLSLSDT :. : NP_001 LQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQ 180 190 200 210 220 230 >>XP_005253751 (OMIM: 616009) PREDICTED: COP9 signalosom (275 aa) initn: 78 init1: 78 opt: 157 Z-score: 193.4 bits: 44.0 E(85289): 0.00049 Smith-Waterman score: 157; 26.0% identity (61.0% similar) in 154 aa overlap (208-357:31-177) 180 190 200 210 220 230 pF1KE5 SDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFL-EGEL : ..:. :....: .:: . :. : :... XP_005 MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDF 10 20 30 40 50 60 240 250 260 270 280 290 pF1KE5 IHD--LLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISF :::.:. . :.:. .: : : : . :.: :. . .:.. : : . XP_005 ASTFRLLTVFAYGTYADYLAEARN-------LPPLTEAQKNKLRHLSVVTLAAKVKCIPY 70 80 90 100 110 300 310 320 330 340 350 pF1KE5 DTMQQELQI-GADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDT .. . : . .. ..: .::.:: . .. ..:: .... :..: : . .:. . . : XP_005 AVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIART 120 130 140 150 160 170 360 370 pF1KE5 LNAWKQNLNKVKNSLLSLSDT :. : XP_005 LQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQ 180 190 200 210 220 230 >>NP_001157566 (OMIM: 616009) COP9 signalosome complex s (275 aa) initn: 78 init1: 78 opt: 157 Z-score: 193.4 bits: 44.0 E(85289): 0.00049 Smith-Waterman score: 157; 26.0% identity (61.0% similar) in 154 aa overlap (208-357:31-177) 180 190 200 210 220 230 pF1KE5 SDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFL-EGEL : ..:. :....: .:: . :. : :... NP_001 MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDF 10 20 30 40 50 60 240 250 260 270 280 290 pF1KE5 IHD--LLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISF :::.:. . :.:. .: : : : . :.: :. . .:.. : : . NP_001 ASTFRLLTVFAYGTYADYLAEARN-------LPPLTEAQKNKLRHLSVVTLAAKVKCIPY 70 80 90 100 110 300 310 320 330 340 350 pF1KE5 DTMQQELQI-GADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDT .. . : . .. ..: .::.:: . .. ..:: .... :..: : . .:. . . : NP_001 AVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIART 120 130 140 150 160 170 360 370 pF1KE5 LNAWKQNLNKVKNSLLSLSDT :. : NP_001 LQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQ 180 190 200 210 220 230 >>NP_001157567 (OMIM: 616009) COP9 signalosome complex s (275 aa) initn: 78 init1: 78 opt: 157 Z-score: 193.4 bits: 44.0 E(85289): 0.00049 Smith-Waterman score: 157; 26.0% identity (61.0% similar) in 154 aa overlap (208-357:31-177) 180 190 200 210 220 230 pF1KE5 SDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFL-EGEL : ..:. :....: .:: . :. : :... NP_001 MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDF 10 20 30 40 50 60 240 250 260 270 280 290 pF1KE5 IHD--LLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISF :::.:. . :.:. .: : : : . :.: :. . .:.. : : . NP_001 ASTFRLLTVFAYGTYADYLAEARN-------LPPLTEAQKNKLRHLSVVTLAAKVKCIPY 70 80 90 100 110 300 310 320 330 340 350 pF1KE5 DTMQQELQI-GADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDT .. . : . .. ..: .::.:: . .. ..:: .... :..: : . .:. . . : NP_001 AVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIART 120 130 140 150 160 170 360 370 pF1KE5 LNAWKQNLNKVKNSLLSLSDT :. : NP_001 LQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQ 180 190 200 210 220 230 >>NP_057403 (OMIM: 616009) COP9 signalosome complex subu (275 aa) initn: 78 init1: 78 opt: 157 Z-score: 193.4 bits: 44.0 E(85289): 0.00049 Smith-Waterman score: 157; 26.0% identity (61.0% similar) in 154 aa overlap (208-357:31-177) 180 190 200 210 220 230 pF1KE5 SDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFL-EGEL : ..:. :....: .:: . :. : :... NP_057 MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDF 10 20 30 40 50 60 240 250 260 270 280 290 pF1KE5 IHD--LLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISF :::.:. . :.:. .: : : : . :.: :. . .:.. : : . NP_057 ASTFRLLTVFAYGTYADYLAEARN-------LPPLTEAQKNKLRHLSVVTLAAKVKCIPY 70 80 90 100 110 300 310 320 330 340 350 pF1KE5 DTMQQELQI-GADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDT .. . : . .. ..: .::.:: . .. ..:: .... :..: : . .:. . . : NP_057 AVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIART 120 130 140 150 160 170 360 370 pF1KE5 LNAWKQNLNKVKNSLLSLSDT :. : NP_057 LQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQ 180 190 200 210 220 230 374 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 01:47:43 2016 done: Tue Nov 8 01:47:44 2016 Total Scan time: 7.100 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]