FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6455, 569 aa 1>>>pF1KE6455 569 - 569 aa - 569 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6297+/-0.000388; mu= -3.7926+/- 0.024 mean_var=306.0957+/-62.679, 0's: 0 Z-trim(122.7): 54 B-trim: 0 in 0/56 Lambda= 0.073307 statistics sampled from 41117 (41173) to 41117 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.483), width: 16 Scan time: 8.670 The best scores are: opt bits E(85289) NP_671724 (OMIM: 608416,616749) matrix metalloprot ( 569) 4040 440.7 5.9e-123 NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 455 61.5 7e-09 NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 438 59.7 2.4e-08 NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 421 57.9 8.9e-08 XP_016880550 (OMIM: 608417) PREDICTED: matrix meta ( 409) 394 55.0 5.4e-07 NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 393 55.0 6.5e-07 NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 389 54.5 8.9e-07 NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 383 53.9 1.3e-06 XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 383 53.9 1.3e-06 XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 383 53.9 1.3e-06 NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 383 53.9 1.3e-06 NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 383 53.9 1.3e-06 XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 383 53.9 1.4e-06 NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 379 53.5 1.9e-06 XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 358 51.3 9.1e-06 XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 358 51.3 9.1e-06 XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 358 51.3 9.1e-06 NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 358 51.3 1e-05 NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 349 50.3 1.5e-05 NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 349 50.3 1.6e-05 XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 343 49.6 2.1e-05 XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 343 49.6 2.2e-05 NP_001289438 (OMIM: 120360,259600) 72 kDa type IV ( 584) 326 47.9 0.0001 NP_001289437 (OMIM: 120360,259600) 72 kDa type IV ( 584) 326 47.9 0.0001 NP_001289439 (OMIM: 120360,259600) 72 kDa type IV ( 584) 326 47.9 0.0001 NP_001121363 (OMIM: 120360,259600) 72 kDa type IV ( 610) 326 48.0 0.00011 XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 313 46.2 0.00011 NP_004521 (OMIM: 120360,259600) 72 kDa type IV col ( 660) 326 48.0 0.00012 NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 313 46.3 0.00015 XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 312 46.3 0.00021 NP_071913 (OMIM: 608482) matrix metalloproteinase- ( 562) 316 46.9 0.00021 XP_011520904 (OMIM: 608482) PREDICTED: matrix meta ( 528) 310 46.2 0.00031 XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 301 45.2 0.00047 XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 301 45.2 0.00047 XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 301 45.2 0.00047 XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 301 45.2 0.00048 NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 301 45.2 0.00048 XP_011520906 (OMIM: 608482) PREDICTED: matrix meta ( 478) 303 45.4 0.00048 XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 301 45.2 0.0005 XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052 XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052 XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052 XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052 NP_077278 (OMIM: 608417) matrix metalloproteinase- ( 520) 301 45.3 0.0006 >>NP_671724 (OMIM: 608416,616749) matrix metalloproteina (569 aa) initn: 4040 init1: 4040 opt: 4040 Z-score: 2328.5 bits: 440.7 E(85289): 5.9e-123 Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 569 aa overlap (1-569:1-569) 10 20 30 40 50 60 pF1KE6 MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 GWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 DMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 LGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 LGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 AFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 MQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 MQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 NSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 NSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 SDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 SDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 VLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 VLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSW 490 500 510 520 530 540 550 560 pF1KE6 LPANGLFPKKFISEKWFDVCDVHISTLNM ::::::::::::::::::::::::::::: NP_671 LPANGLFPKKFISEKWFDVCDVHISTLNM 550 560 >>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa) initn: 339 init1: 144 opt: 455 Z-score: 280.5 bits: 61.5 E(85289): 7e-09 Smith-Waterman score: 536; 29.6% identity (53.4% similar) in 487 aa overlap (85-541:59-474) 60 70 80 90 100 110 pF1KE6 RFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNR ... .. .:. .: ..:.::. :: .: . NP_002 SNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRK 30 40 50 60 70 80 120 130 140 150 160 170 pF1KE6 PRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKR :::::::. . : :: : :. : NP_002 PRCGVPDV-----GHFSSFPGMPK------------------WR--------------KT 90 100 110 180 190 200 210 220 230 pF1KE6 TLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGR :..:... . . ...:. . :...: ::::: : . : : :: ..:. . NP_002 HLTYRIVNYTPDLPRDAVDS--AIEKALKVWEEVTPLTFSR--LYEGEA-DIMISFAVKE 120 130 140 150 160 240 250 260 270 280 pF1KE6 HLGCPRAFDGSGQEFAHAWR-----LGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVL : : .::: :. .:::. :::::::::..: .: : .:. ::.::.:: : NP_002 H-GDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDAS--GTNLFLVAAHELGHSL 170 180 190 200 210 220 290 300 310 320 330 pF1KE6 GLPHTYRTGSIMQP--NYIPQEPAFELDWSDRKAIQKLYG----SCE-----------GS :: :. : ..: : : . . :.:. .: ..::.::: : : :: NP_002 GLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGS 230 240 250 260 270 280 340 350 360 370 380 pF1KE6 -----FDTA--FDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTG : : :: : :..: ::.. ..: . : . .. : . NP_002 EMPAKCDPALSFDAISTLRGEY---------LFFKDRYFWRRSHWNPEPEFH---LISAF 290 300 310 320 330 390 400 410 420 430 440 pF1KE6 WPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLI-SEGF ::..:.. .:: .. . :: ..:.::..: ... :: .::. : . :: NP_002 WPSLPSY-LDAAYEVNS--RDTVFIFKGNEFWAIRGNEVQA--------GYPRGIHTLGF 340 350 360 370 380 450 460 470 480 490 500 pF1KE6 PGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFR : .:.: :...: ::: . . :: : . . ...:. :.. ::.: :. NP_002 PPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVL 390 400 410 420 430 440 510 520 530 540 550 560 pF1KE6 NIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHI . . .: .. .: : : :: ..:. :. :::: NP_002 QAFGFFYFFSGSSQFEFDPNA--RMVTHILKS-NSWLHC 450 460 470 pF1KE6 STLNM >>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa) initn: 334 init1: 138 opt: 438 Z-score: 270.7 bits: 59.7 E(85289): 2.4e-08 Smith-Waterman score: 525; 28.2% identity (53.3% similar) in 493 aa overlap (85-541:60-475) 60 70 80 90 100 110 pF1KE6 RFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNR ... .:..:. .: ..:.::. :: .: . NP_002 SMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRK 30 40 50 60 70 80 120 130 140 150 160 170 pF1KE6 PRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKR :::::::. .. : : : :. : NP_002 PRCGVPDV-----------------GHFRTFPGIP------KWR--------------KT 90 100 110 180 190 200 210 220 230 pF1KE6 TLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGR :..:... . . ...:. : :...: ::::: : . : : :: ..:. . NP_002 HLTYRIVNYTPDLPKDAVDS--AVEKALKVWEEVTPLTFSR--LYEGEA-DIMISFAVRE 120 130 140 150 160 240 250 260 270 280 pF1KE6 HLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVL : : ::: :. .:::. : : ::::::..: : :: .:. ::.::::: : NP_002 H-GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDT--TGTNLFLVAAHEIGHSL 170 180 190 200 210 220 290 300 310 320 330 pF1KE6 GLPHTYRTGSIMQPNY--IPQEPAFELDWSDRKAIQKLYGSCEGSFDT------------ :: :. : ..: : : . . :.:. .: ..::.::: : .: NP_002 GLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEP 230 240 250 260 270 280 340 350 360 370 380 pF1KE6 ----------AFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTG .:: . : ::... :.. .: :.. . ...... NP_002 GTPANCDPALSFDAVSTLR---GEILI------FKDRHFW----RKSLRKLEPELHLISS 290 300 310 320 330 390 400 410 420 430 440 pF1KE6 -WPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLI-SEG ::..:. ..:: .. . .: ..:.:::.: :. .: .::. : . : NP_002 FWPSLPS-GVDAAYEVTS--KDLVFIFKGNQFW--------AIRGNEVRAGYPRGIHTLG 340 350 360 370 380 450 460 470 480 490 500 pF1KE6 FPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPF :: .:.:. :.... ::: :. . :: .:: . ..::.:.: ::.. . NP_002 FPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSK---- 390 400 410 420 430 510 520 530 540 550 pF1KE6 RNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDK-----QQNSWLPANGLFPKKFISEKWFD ::... ... ..:: :.. . . : ..:::: NP_002 --IDAVFEEFGF--FYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 440 450 460 470 560 pF1KE6 VCDVHISTLNM >>NP_002420 (OMIM: 601807,611543) matrix metalloproteina (508 aa) initn: 552 init1: 166 opt: 421 Z-score: 260.6 bits: 57.9 E(85289): 8.9e-08 Smith-Waterman score: 570; 30.2% identity (54.3% similar) in 523 aa overlap (56-556:31-469) 30 40 50 60 70 80 pF1KE6 SLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAAL .::.::. .: .. : . NP_002 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYL-------QKPLEGSNNFKPEDI 10 20 30 40 50 90 100 110 120 130 140 pF1KE6 AEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRS .::.: ::.:. ::.::.:: :: : : .::::. : : .. . NP_002 TEALRAFQEASELPVSGQLDDATRARMRQPRCGLED---------------PFNQKTLKY 60 70 80 90 150 160 170 180 190 200 pF1KE6 PRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMW : :.: :. :. :..:.:. : : : : . ::. : NP_002 ----LLLGR--WR--------------KKHLTFRILN--LPSTLPPHTARAALRQAFQDW 100 110 120 130 210 220 230 240 250 260 pF1KE6 SEVTPLDFREDLAAPGAAVDIKLGFGRGRHLG-CPRAFDGSGQEFAHA--WRLGDIHFDD :.:.:: :.: : ::: ::.:.: .::. . : .::: :. .::: .::..:::. NP_002 SNVAPLTFQEVQA--GAA-DIRLSF-HGRQSSYCSNTFDGPGRVLAHADIPELGSVHFDE 140 150 160 170 180 190 270 280 290 300 310 320 pF1KE6 DEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAI :: .: : :..: .:.::.::.::: :. . ..: : : .: :.: .: .: NP_002 DEFWTEGTY-RGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGI 200 210 220 230 240 250 330 340 350 360 pF1KE6 QKLYGSC------EGSFDTAFDWI-----------RKERNQYGEVMV--RFSTYFFRNSW : :::. : .: . . .. .:. : .:: :.... NP_002 QALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDY 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE6 YWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDK : . . : ... . : :.: :.:: :. . . . .::.:.. ::: . : NP_002 VWTVSDSGP----GPLFRVSALWEGLPG-NLDAAVY--SPRTQWIHFFKGDKVWRYINFK 320 330 340 350 360 430 440 450 460 470 480 pF1KE6 DQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLN .. ..:: ... :. ::.:.: .. ...:: : . .: .. NP_002 --------MSPGFPKKLNRVEPN----LDAALYWPLNQKVFLFKGSGYWQWDELARTDFS 370 380 390 400 410 490 500 510 520 530 540 pF1KE6 SYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPA :::: : .: .: : :.: :: .:. . ..::::..::.. :. : . NP_002 SYPKPIKGLFTGV-P-NQP-----SAAMSWQDGRVYFFKGKVYWRL--------NQQLRV 420 430 440 450 550 560 pF1KE6 NGLFPKKFISEKWFDVCDVHISTLNM . .:.. ::..: NP_002 EKGYPRN-ISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY 460 470 480 490 500 >>XP_016880550 (OMIM: 608417) PREDICTED: matrix metallop (409 aa) initn: 349 init1: 116 opt: 394 Z-score: 246.5 bits: 55.0 E(85289): 5.4e-07 Smith-Waterman score: 459; 30.1% identity (51.3% similar) in 435 aa overlap (112-539:1-385) 90 100 110 120 130 140 pF1KE6 GAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRAR :.:::::: : : . :: XP_016 MTRPRCGVTDTNS---YAAWAERISDLFAR 10 20 150 160 170 180 190 pF1KE6 SRRSPRAPLSLSRRG--WQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVA : . : ....: : : .: : ..: .: : : XP_016 HRTKMRRKKRFAKQGNKWYK---------QHLSYRLVNW-------PEHLPEPAVRGAVR 30 40 50 60 70 200 210 220 230 240 250 pF1KE6 LAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHL-GCPRAFDGSGQEFAHAW--RLG ::..::.:. :.: : : : : ::.: : .: : : :::: : .:::. : : XP_016 AAFQLWSNVSALEFWEA-PATGPA-DIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRG 80 90 100 110 120 260 270 280 290 300 310 pF1KE6 DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDW . :::.::... . : .:. : .:::::.::: :. ..: : : :.: XP_016 EAHFDQDERWSL-SRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSW 130 140 150 160 170 180 320 330 340 350 360 370 pF1KE6 SDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFST-YFFRNSWYWLYENRNNRTR .: :.:.:: : : .. . : : :: .. : . :.:..: .: .: . XP_016 DDVLAVQSLYVSPELQYKLG-GWTVKARNPKPQARCRQQQLYIFKGSHFWEVAADGNVS- 190 200 210 220 230 240 380 390 400 410 420 430 pF1KE6 YGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKS .: . : :.: ::.: . . . . :::.:.. ::. . : : XP_016 --EPRPLQERWVGLPP-NIEAAA--VSLNDGDFYFFKGGRCWRFRGPKPV------WG-- 250 260 270 280 290 440 450 460 470 480 490 pF1KE6 YPKLISEGFPGIPSPLDTA-FYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP :.: : :.: :.: :. ..:: .:: . ... . .: ::. . . XP_016 LPQLCRAG--GLPRHPDAALFFPPLRRLI-LFKGARYYVLARGGLQVEPYYPRSLQDW-- 300 310 320 330 340 500 510 520 530 540 550 pF1KE6 AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISE . ::.. ...: .::.::. . ::.. :. : : . XP_016 GGIPEE-----VSGAL-PRPDGSIIFFRDDRYWRL--DQAKLQATTSGRWATELPWMGCW 350 360 370 380 390 400 560 pF1KE6 KWFDVCDVHISTLNM XP_016 HANSGSALF >>NP_002417 (OMIM: 601046) macrophage metalloelastase pr (470 aa) initn: 528 init1: 116 opt: 393 Z-score: 245.1 bits: 55.0 E(85289): 6.5e-07 Smith-Waterman score: 526; 28.5% identity (54.8% similar) in 478 aa overlap (82-541:57-468) 60 70 80 90 100 110 pF1KE6 AAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAA : . : ....:. .: ..:.::..:: NP_002 KNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEM 30 40 50 60 70 80 120 130 140 150 160 170 pF1KE6 MNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAF :. :::::::.. . :. : .:. :. NP_002 MHAPRCGVPDVH-----------------HFREMPGGPV------WR------------- 90 100 110 180 190 200 210 220 230 pF1KE6 SKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFG :. ...:. . . ... : . ::..::.:::: : . : : :: . :. NP_002 -KHYITYRI--NNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSK--INTGMA-DILVVFA 120 130 140 150 160 240 250 260 270 280 pF1KE6 RGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAVHEIG :: : : .::::.: .:::. : : :::.:: .: : . : .:. .:::::: NP_002 RGAH-GDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWT--THSGGTNLFLTAVHEIG 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE6 HVLGLPHTYRTGSIMQPNYIPQE-PAFELDWSDRKAIQKLYGSCE-----GSFDTAFDWI : ::: :. ..: :.: . .:.:. .: ..::.:::. . . :.. . NP_002 HSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPAL 230 240 250 260 270 280 350 360 370 380 390 pF1KE6 RKERNQYGEVM-VRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVH .. : : . .::.. ..:: .. .: . : . :: .:. .:.: . NP_002 CDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVN---LISSLWPTLPS-GIEAAYE 290 300 310 320 330 400 410 420 430 440 450 pF1KE6 IWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLI-SEGFPGIPSPLDTAFYDR : . :.. ..:. ..:: .. . . .::: : : :::.. . .:.: .. NP_002 IEA--RNQVFLFKDDKYWLISNLRPEP--------NYPKSIHSFGFPNFVKKIDAAVFNP 340 350 360 370 380 460 470 480 490 500 510 pF1KE6 RQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSI : ::: .. . .: :. . .::: ::. : .. :. ::...:: . NP_002 RFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPK------IDAVFYS-KNKYY 390 400 410 420 430 440 520 530 540 550 560 pF1KE6 FFFKGNAYWKV-----VNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM .::.:. .. : ..:::. NP_002 YFFQGSNQFEYDFLLQRITKTLKSNSWFGC 450 460 470 >>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa) initn: 335 init1: 94 opt: 389 Z-score: 242.6 bits: 54.5 E(85289): 8.9e-07 Smith-Waterman score: 462; 27.1% identity (51.8% similar) in 483 aa overlap (84-541:67-481) 60 70 80 90 100 110 pF1KE6 QRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMN .. . ....: .: ..:.:: .:. ... NP_004 NYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIK 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE6 RPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSK .:::::::. : : : : :. : NP_004 KPRCGVPDV-----------------ANYRLFPGEP------KWK--------------K 100 110 180 190 200 210 220 230 pF1KE6 RTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRG ::..:. . ..: .. . : .:.. :: ..::.: . : : :: ..: : NP_004 NTLTYRI--SKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVR--INSGEA-DIMISFENG 120 130 140 150 160 170 240 250 260 270 280 pF1KE6 RHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHV : : ::: .:::. : : :::. :..: :. :..:. ::.::.::. NP_004 DH-GDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTN--GFNLFTVAAHEFGHA 180 190 200 210 220 230 290 300 310 320 330 pF1KE6 LGLPHTYRTGSIMQPNYIPQEP-AFELDWSDRKAIQKLYGSCE---GS--------FDTA ::: :. ...: :.: ..: .:.: .: :.:: ::: . :. . NP_004 LGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPS 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE6 FDWIRKERNQYGEV-MVRFSTYFFRNSWYWLYENRNNRTRYG-DPIQILTGWPGIPTHNI . . ... : :. .:.. .: :. . : : : : ...: . . :. NP_004 IPDLCDSSSSFDAVTMLGKELLLFKDRIFW---RRQVHLRTGIRPSTITSSFPQLMS-NV 300 310 320 330 340 400 410 420 430 440 450 pF1KE6 DAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISE-GFPGIPSPLDT :: .. .: :::.: .:: .:. : .. :. : . ::: . .:. NP_004 DAAYEV--AERGTAYFFKGPHYW---------ITRGFQMQGPPRTIYDFGFPRHVQQIDA 350 360 370 380 390 460 470 480 490 500 510 pF1KE6 AFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSY : : :. . :: . ...: . .. ..::: : : .: : ::.: NP_004 AVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQ------IDAAVELN 400 410 420 430 440 450 520 530 540 550 560 pF1KE6 AYNSIFFFKGNAYWKVVNDKDK-----QQNSWLPANGLFPKKFISEKWFDVCDVHISTLN .: :.::.: .: ..:. ...::. NP_004 GY--IYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 460 470 480 pF1KE6 M >>NP_001291371 (OMIM: 120355) neutrophil collagenase iso (444 aa) initn: 478 init1: 113 opt: 383 Z-score: 239.7 bits: 53.9 E(85289): 1.3e-06 Smith-Waterman score: 495; 29.1% identity (54.4% similar) in 478 aa overlap (71-518:21-425) 50 60 70 80 90 pF1KE6 LRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGA-ALAEAVRRFQRANALP :: . .:. ...: ....:: .: NP_001 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLN 10 20 30 40 50 100 110 120 130 140 150 pF1KE6 ASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQP ..:. . :: :..::::::: .. :: : :. NP_001 VTGKPNEETLDMMKKPRCGVPD-----SGGFMLTPGNPK------------------WE- 60 70 80 160 170 180 190 200 210 pF1KE6 RGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAA . .:..:. . . ::: :. .: . ::..:: ..:: : . . NP_001 -------------RTNLTYRI--RNYTPQLSEAEVERAIKDAFELWSVASPLIFTR--IS 90 100 110 120 220 230 240 250 260 270 pF1KE6 PGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTG : : ::...: . : : ::: . .:::.. : : ::: .: .: ..... NP_001 QGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT--NTSAN 130 140 150 160 170 180 280 290 300 310 320 pF1KE6 ISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSDRKAIQKLYG------ .:. ::.::.:: ::: :. :..: ::: .: . . : .: .:: .:: NP_001 YNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPI 190 200 210 220 230 240 330 340 350 360 370 pF1KE6 ---------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGD :. :. .:: : : ::.. ::.. ..: . . .:... . NP_001 QPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRYFWRRHPQLQRVEM-N 250 260 270 280 290 380 390 400 410 420 430 pF1KE6 PIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPK :... ::..:: .:.: . . :: ..:.::::: ::. . ..::: NP_001 FISLF--WPSLPT-GIQAAYE--DFDRDLIFLFKGNQYW--------ALSGYDILQGYPK 300 310 320 330 340 440 450 460 470 480 490 pF1KE6 LISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP--- ::. :::. . .:.: . : . ::: .. . .: .:. . .::: :. .:: NP_001 DISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIE 350 360 370 380 390 500 510 520 530 540 550 pF1KE6 ----AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKK ::. :.: :. ... : ::.. : NP_001 SKVDAVFQQEHFFHVFSGPRY-YAFDLIAQRVTRVARGNKWLNCRYG 400 410 420 430 440 >>XP_016873260 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa) initn: 478 init1: 113 opt: 383 Z-score: 239.7 bits: 53.9 E(85289): 1.3e-06 Smith-Waterman score: 495; 29.1% identity (54.4% similar) in 478 aa overlap (71-518:21-425) 50 60 70 80 90 pF1KE6 LRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGA-ALAEAVRRFQRANALP :: . .:. ...: ....:: .: XP_016 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLN 10 20 30 40 50 100 110 120 130 140 150 pF1KE6 ASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQP ..:. . :: :..::::::: .. :: : :. XP_016 VTGKPNEETLDMMKKPRCGVPD-----SGGFMLTPGNPK------------------WE- 60 70 80 160 170 180 190 200 210 pF1KE6 RGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAA . .:..:. . . ::: :. .: . ::..:: ..:: : . . XP_016 -------------RTNLTYRI--RNYTPQLSEAEVERAIKDAFELWSVASPLIFTR--IS 90 100 110 120 220 230 240 250 260 270 pF1KE6 PGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTG : : ::...: . : : ::: . .:::.. : : ::: .: .: ..... XP_016 QGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT--NTSAN 130 140 150 160 170 180 280 290 300 310 320 pF1KE6 ISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSDRKAIQKLYG------ .:. ::.::.:: ::: :. :..: ::: .: . . : .: .:: .:: XP_016 YNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPI 190 200 210 220 230 240 330 340 350 360 370 pF1KE6 ---------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGD :. :. .:: : : ::.. ::.. ..: . . .:... . XP_016 QPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRYFWRRHPQLQRVEM-N 250 260 270 280 290 380 390 400 410 420 430 pF1KE6 PIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPK :... ::..:: .:.: . . :: ..:.::::: ::. . ..::: XP_016 FISLF--WPSLPT-GIQAAYE--DFDRDLIFLFKGNQYW--------ALSGYDILQGYPK 300 310 320 330 340 440 450 460 470 480 490 pF1KE6 LISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP--- ::. :::. . .:.: . : . ::: .. . .: .:. . .::: :. .:: XP_016 DISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIE 350 360 370 380 390 500 510 520 530 540 550 pF1KE6 ----AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKK ::. :.: :. ... : ::.. : XP_016 SKVDAVFQQEHFFHVFSGPRY-YAFDLIAQRVTRVARGNKWLNCRYG 400 410 420 430 440 >>XP_011541137 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa) initn: 478 init1: 113 opt: 383 Z-score: 239.7 bits: 53.9 E(85289): 1.3e-06 Smith-Waterman score: 495; 29.1% identity (54.4% similar) in 478 aa overlap (71-518:21-425) 50 60 70 80 90 pF1KE6 LRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGA-ALAEAVRRFQRANALP :: . .:. ...: ....:: .: XP_011 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLN 10 20 30 40 50 100 110 120 130 140 150 pF1KE6 ASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQP ..:. . :: :..::::::: .. :: : :. XP_011 VTGKPNEETLDMMKKPRCGVPD-----SGGFMLTPGNPK------------------WE- 60 70 80 160 170 180 190 200 210 pF1KE6 RGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAA . .:..:. . . ::: :. .: . ::..:: ..:: : . . XP_011 -------------RTNLTYRI--RNYTPQLSEAEVERAIKDAFELWSVASPLIFTR--IS 90 100 110 120 220 230 240 250 260 270 pF1KE6 PGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTG : : ::...: . : : ::: . .:::.. : : ::: .: .: ..... XP_011 QGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT--NTSAN 130 140 150 160 170 180 280 290 300 310 320 pF1KE6 ISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSDRKAIQKLYG------ .:. ::.::.:: ::: :. :..: ::: .: . . : .: .:: .:: XP_011 YNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPI 190 200 210 220 230 240 330 340 350 360 370 pF1KE6 ---------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGD :. :. .:: : : ::.. ::.. ..: . . .:... . XP_011 QPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRYFWRRHPQLQRVEM-N 250 260 270 280 290 380 390 400 410 420 430 pF1KE6 PIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPK :... ::..:: .:.: . . :: ..:.::::: ::. . ..::: XP_011 FISLF--WPSLPT-GIQAAYE--DFDRDLIFLFKGNQYW--------ALSGYDILQGYPK 300 310 320 330 340 440 450 460 470 480 490 pF1KE6 LISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP--- ::. :::. . .:.: . : . ::: .. . .: .:. . .::: :. .:: XP_011 DISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIE 350 360 370 380 390 500 510 520 530 540 550 pF1KE6 ----AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKK ::. :.: :. ... : ::.. : XP_011 SKVDAVFQQEHFFHVFSGPRY-YAFDLIAQRVTRVARGNKWLNCRYG 400 410 420 430 440 569 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:27:36 2016 done: Tue Nov 8 13:27:37 2016 Total Scan time: 8.670 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]