FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6774, 592 aa 1>>>pF1KE6774 592 - 592 aa - 592 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0943+/-0.000357; mu= 19.7464+/- 0.022 mean_var=64.3686+/-12.956, 0's: 0 Z-trim(113.0): 29 B-trim: 519 in 1/52 Lambda= 0.159859 statistics sampled from 22131 (22153) to 22131 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.26), width: 16 Scan time: 7.770 The best scores are: opt bits E(85289) NP_068600 (OMIM: 236730,613469) inactive heparanas ( 592) 3935 916.7 0 NP_001159718 (OMIM: 236730,613469) inactive hepara ( 548) 3579 834.5 0 XP_016871984 (OMIM: 236730,613469) PREDICTED: inac ( 545) 3576 833.8 0 XP_011538331 (OMIM: 236730,613469) PREDICTED: inac ( 543) 3262 761.4 0 XP_016871986 (OMIM: 236730,613469) PREDICTED: inac ( 420) 2781 650.4 3.4e-186 XP_006718000 (OMIM: 236730,613469) PREDICTED: inac ( 420) 2781 650.4 3.4e-186 XP_011538333 (OMIM: 236730,613469) PREDICTED: inac ( 420) 2781 650.4 3.4e-186 XP_011538332 (OMIM: 236730,613469) PREDICTED: inac ( 538) 2594 607.4 4e-173 XP_016871985 (OMIM: 236730,613469) PREDICTED: inac ( 441) 2417 566.5 6.6e-161 NP_001159716 (OMIM: 236730,613469) inactive hepara ( 534) 2220 521.1 3.6e-147 NP_001159717 (OMIM: 236730,613469) inactive hepara ( 480) 2214 519.7 8.7e-147 XP_016871987 (OMIM: 236730,613469) PREDICTED: inac ( 324) 2162 507.6 2.6e-143 XP_011538335 (OMIM: 236730,613469) PREDICTED: inac ( 324) 2162 507.6 2.6e-143 NP_006656 (OMIM: 604724) heparanase isoform 1 prep ( 543) 978 234.7 6.2e-61 NP_001092010 (OMIM: 604724) heparanase isoform 1 p ( 543) 978 234.7 6.2e-61 NP_001186759 (OMIM: 604724) heparanase isoform 3 p ( 485) 693 168.9 3.5e-41 NP_001159970 (OMIM: 604724) heparanase isoform 2 p ( 469) 387 98.3 5.9e-20 >>NP_068600 (OMIM: 236730,613469) inactive heparanase-2 (592 aa) initn: 3935 init1: 3935 opt: 3935 Z-score: 4900.0 bits: 916.7 E(85289): 0 Smith-Waterman score: 3935; 99.7% identity (100.0% similar) in 592 aa overlap (1-592:1-592) 10 20 30 40 50 60 pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_068 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSV 490 500 510 520 530 540 550 560 570 580 590 pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR ::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_068 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR 550 560 570 580 590 >>NP_001159718 (OMIM: 236730,613469) inactive heparanase (548 aa) initn: 3579 init1: 3579 opt: 3579 Z-score: 4456.8 bits: 834.5 E(85289): 0 Smith-Waterman score: 3579; 99.6% identity (100.0% similar) in 539 aa overlap (1-539:1-539) 10 20 30 40 50 60 pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::. NP_001 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKTQ 490 500 510 520 530 540 550 560 570 580 590 pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR NP_001 RCQYCGII >>XP_016871984 (OMIM: 236730,613469) PREDICTED: inactive (545 aa) initn: 3576 init1: 3576 opt: 3576 Z-score: 4453.1 bits: 833.8 E(85289): 0 Smith-Waterman score: 3576; 99.6% identity (100.0% similar) in 539 aa overlap (1-539:1-539) 10 20 30 40 50 60 pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::.: XP_016 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSNSS 490 500 510 520 530 540 550 560 570 580 590 pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR XP_016 CLKRI >>XP_011538331 (OMIM: 236730,613469) PREDICTED: inactive (543 aa) initn: 3608 init1: 3258 opt: 3262 Z-score: 4061.7 bits: 761.4 E(85289): 0 Smith-Waterman score: 3514; 91.6% identity (91.7% similar) in 592 aa overlap (1-592:1-543) 10 20 30 40 50 60 pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV :::::::: ::: XP_011 YAHCTNHH-------------------------------------------------KSV 490 550 560 570 580 590 pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR ::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_011 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR 500 510 520 530 540 >>XP_016871986 (OMIM: 236730,613469) PREDICTED: inactive (420 aa) initn: 2781 init1: 2781 opt: 2781 Z-score: 3463.8 bits: 650.4 E(85289): 3.4e-186 Smith-Waterman score: 2781; 99.5% identity (100.0% similar) in 420 aa overlap (173-592:1-420) 150 160 170 180 190 200 pF1KE6 YLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLIL :::::::::::::::::::::::::::::: XP_016 MLELQREKAAQMHLVLLKEQFSNTYSNLIL 10 20 30 210 220 230 240 250 260 pF1KE6 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE6 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE6 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE6 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY 220 230 240 250 260 270 450 460 470 480 490 500 pF1KE6 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII 280 290 300 310 320 330 510 520 530 540 550 560 pF1KE6 NLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP 340 350 360 370 380 390 570 580 590 pF1KE6 LRAGRTLVIPPVTMGFFVVKNVNALACRYR ::::::::::::::::.::::::::::::: XP_016 LRAGRTLVIPPVTMGFYVVKNVNALACRYR 400 410 420 >>XP_006718000 (OMIM: 236730,613469) PREDICTED: inactive (420 aa) initn: 2781 init1: 2781 opt: 2781 Z-score: 3463.8 bits: 650.4 E(85289): 3.4e-186 Smith-Waterman score: 2781; 99.5% identity (100.0% similar) in 420 aa overlap (173-592:1-420) 150 160 170 180 190 200 pF1KE6 YLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLIL :::::::::::::::::::::::::::::: XP_006 MLELQREKAAQMHLVLLKEQFSNTYSNLIL 10 20 30 210 220 230 240 250 260 pF1KE6 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE6 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE6 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE6 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY 220 230 240 250 260 270 450 460 470 480 490 500 pF1KE6 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII 280 290 300 310 320 330 510 520 530 540 550 560 pF1KE6 NLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP 340 350 360 370 380 390 570 580 590 pF1KE6 LRAGRTLVIPPVTMGFFVVKNVNALACRYR ::::::::::::::::.::::::::::::: XP_006 LRAGRTLVIPPVTMGFYVVKNVNALACRYR 400 410 420 >>XP_011538333 (OMIM: 236730,613469) PREDICTED: inactive (420 aa) initn: 2781 init1: 2781 opt: 2781 Z-score: 3463.8 bits: 650.4 E(85289): 3.4e-186 Smith-Waterman score: 2781; 99.5% identity (100.0% similar) in 420 aa overlap (173-592:1-420) 150 160 170 180 190 200 pF1KE6 YLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLIL :::::::::::::::::::::::::::::: XP_011 MLELQREKAAQMHLVLLKEQFSNTYSNLIL 10 20 30 210 220 230 240 250 260 pF1KE6 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE6 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE6 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE6 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY 220 230 240 250 260 270 450 460 470 480 490 500 pF1KE6 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII 280 290 300 310 320 330 510 520 530 540 550 560 pF1KE6 NLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP 340 350 360 370 380 390 570 580 590 pF1KE6 LRAGRTLVIPPVTMGFFVVKNVNALACRYR ::::::::::::::::.::::::::::::: XP_011 LRAGRTLVIPPVTMGFYVVKNVNALACRYR 400 410 420 >>XP_011538332 (OMIM: 236730,613469) PREDICTED: inactive (538 aa) initn: 3577 init1: 2594 opt: 2594 Z-score: 3229.2 bits: 607.4 E(85289): 4e-173 Smith-Waterman score: 3473; 90.5% identity (90.9% similar) in 592 aa overlap (1-592:1-538) 10 20 30 40 50 60 pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK ::::::::::::::::::::::::::::: XP_011 DFLQFQNLRNPAKSRGGPGPDYYLKNYED------------------------------- 130 140 190 200 210 220 230 240 pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS ::::::::::::::::::::::::::::::::::::: XP_011 -----------------------ARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS 150 160 170 180 250 260 270 280 290 300 pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: XP_011 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSV 430 440 450 460 470 480 550 560 570 580 590 pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR ::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_011 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR 490 500 510 520 530 >>XP_016871985 (OMIM: 236730,613469) PREDICTED: inactive (441 aa) initn: 2417 init1: 2417 opt: 2417 Z-score: 3009.8 bits: 566.5 E(85289): 6.6e-161 Smith-Waterman score: 2417; 100.0% identity (100.0% similar) in 366 aa overlap (1-366:1-366) 10 20 30 40 50 60 pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR :::::: XP_016 IRKIQKHPASVSVPPLHVTIMLFSAHGRYRVHKPPTVPQTHASGLLPITTSPTSEGKTTN 370 380 390 400 410 420 >>NP_001159716 (OMIM: 236730,613469) inactive heparanase (534 aa) initn: 3539 init1: 2212 opt: 2220 Z-score: 2763.1 bits: 521.1 E(85289): 3.6e-147 Smith-Waterman score: 3427; 89.9% identity (90.2% similar) in 592 aa overlap (1-592:1-534) 10 20 30 40 50 60 pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS ::::::::::::::::::::::: NP_001 AAQMHLVLLKEQFSNTYSNLILT------------------------------------- 190 200 250 260 270 280 290 300 pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS ::::::::::::::::::::::::::::::::::::::: NP_001 ---------------------EPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS 210 220 230 240 310 320 330 340 350 360 pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSV 430 440 450 460 470 480 550 560 570 580 590 pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR ::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_001 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR 490 500 510 520 530 592 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:15:20 2016 done: Tue Nov 8 16:15:21 2016 Total Scan time: 7.770 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]