FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5437, 351 aa 1>>>pF1KE5437 351 - 351 aa - 351 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1899+/-0.000333; mu= 13.2560+/- 0.021 mean_var=94.2396+/-18.562, 0's: 0 Z-trim(116.7): 5 B-trim: 0 in 0/55 Lambda= 0.132117 statistics sampled from 27998 (28002) to 27998 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.328), width: 16 Scan time: 7.480 The best scores are: opt bits E(85289) NP_612366 (OMIM: 614197) calcium uniporter protein ( 351) 2329 453.8 2.5e-127 NP_001257609 (OMIM: 614197) calcium uniporter prot ( 302) 1983 387.8 1.6e-107 XP_016872371 (OMIM: 614197) PREDICTED: calcium uni ( 358) 1984 388.1 1.6e-107 NP_001257608 (OMIM: 614197) calcium uniporter prot ( 330) 1107 220.9 3.2e-57 >>NP_612366 (OMIM: 614197) calcium uniporter protein, mi (351 aa) initn: 2329 init1: 2329 opt: 2329 Z-score: 2406.8 bits: 453.8 E(85289): 2.5e-127 Smith-Waterman score: 2329; 100.0% identity (100.0% similar) in 351 aa overlap (1-351:1-351) 10 20 30 40 50 60 pF1KE5 MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 LGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 GIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 GIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 TLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 TLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYL 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 LFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 LFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD 310 320 330 340 350 >>NP_001257609 (OMIM: 614197) calcium uniporter protein, (302 aa) initn: 1983 init1: 1983 opt: 1983 Z-score: 2051.3 bits: 387.8 E(85289): 1.6e-107 Smith-Waterman score: 1983; 100.0% identity (100.0% similar) in 301 aa overlap (51-351:2-302) 30 40 50 60 70 80 pF1KE5 GGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVVPSDDVTVVYQ :::::::::::::::::::::::::::::: NP_001 MVHQRIASWQNLGAVYCSTVVPSDDVTVVYQ 10 20 30 90 100 110 120 130 140 pF1KE5 NGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTG 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE5 IDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE5 RELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSW 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE5 DIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQL 220 230 240 250 260 270 330 340 350 pF1KE5 KDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD ::::::::::::::::::::::::::::::: NP_001 KDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD 280 290 300 >>XP_016872371 (OMIM: 614197) PREDICTED: calcium uniport (358 aa) initn: 1983 init1: 1983 opt: 1984 Z-score: 2051.3 bits: 388.1 E(85289): 1.6e-107 Smith-Waterman score: 1984; 97.1% identity (98.7% similar) in 311 aa overlap (41-351:48-358) 20 30 40 50 60 70 pF1KE5 LLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQNLGAVYCSTVV : ..... :::::::::::::::::::: XP_016 SSFTFVFFSLIQIAEGSGGRGEDVESPESWRVERRKKAVKVHQRIASWQNLGAVYCSTVV 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE5 PSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSP 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE5 DGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTL 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE5 CIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGIL 200 210 220 230 240 250 260 270 280 290 300 310 pF1KE5 ARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKS 260 270 280 290 300 310 320 330 340 350 pF1KE5 RFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD ::::::::::::::::::::::::::::::::::::::::: XP_016 RFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD 320 330 340 350 >>NP_001257608 (OMIM: 614197) calcium uniporter protein, (330 aa) initn: 1978 init1: 1107 opt: 1107 Z-score: 1148.4 bits: 220.9 E(85289): 3.2e-57 Smith-Waterman score: 1933; 86.0% identity (88.9% similar) in 351 aa overlap (1-351:1-330) 10 20 30 40 50 60 pF1KE5 MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 GIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVK ::::::::::::::::::::::::::::::::::::::::::::: .. ... : . NP_001 GIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRVEMGFCHVGQ-NGFE 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 TLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGL :... : : : . ::::::::::::::::::::: NP_001 LLTSSY--------------------LPASASQSAEIIAVRIEISRKAEKRTTLVLWGGL 180 190 200 210 250 260 270 280 290 300 pF1KE5 AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYL 220 230 240 250 260 270 310 320 330 340 350 pF1KE5 LFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD 280 290 300 310 320 330 351 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 00:45:14 2016 done: Tue Nov 8 00:45:16 2016 Total Scan time: 7.480 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]