FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2299, 429 aa 1>>>pF1KE2299 429 - 429 aa - 429 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8754+/-0.000359; mu= 14.3871+/- 0.022 mean_var=72.3714+/-14.435, 0's: 0 Z-trim(114.9): 82 B-trim: 548 in 2/48 Lambda= 0.150762 statistics sampled from 24900 (24982) to 24900 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.293), width: 16 Scan time: 8.450 The best scores are: opt bits E(85289) NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 2890 637.8 1.6e-182 NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 1052 238.0 3.4e-62 NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 418 100.1 1.2e-20 XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 398 95.7 1.4e-19 NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 400 96.2 2e-19 NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 400 96.2 2e-19 XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 400 96.2 2e-19 NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 398 95.8 2.4e-19 XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 394 94.8 2.5e-19 NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 394 94.9 3.9e-19 NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 393 94.7 5.7e-19 NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 392 94.5 5.9e-19 XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 389 93.8 7.4e-19 XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 389 93.8 7.4e-19 NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 389 93.8 8.5e-19 XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 389 93.8 8.5e-19 XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 389 93.8 8.5e-19 NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 389 93.8 8.5e-19 NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 378 91.4 4.7e-18 NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 371 89.9 1.3e-17 XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 371 89.9 1.3e-17 NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 343 83.7 5e-16 NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 343 83.8 7.6e-16 NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 332 81.4 4.2e-15 NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 329 80.8 8.2e-15 NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 323 79.5 2.1e-14 NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 317 78.1 4.1e-14 NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 296 73.6 1e-12 NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 277 69.5 1.9e-11 XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 277 69.5 1.9e-11 XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 277 69.5 2.1e-11 XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 277 69.5 2.4e-11 XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 259 65.5 2e-10 NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10 XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10 XP_006714648 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10 XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10 NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10 NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10 NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10 NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 259 65.5 2.5e-10 XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 259 65.5 2.5e-10 XP_011541610 (OMIM: 601918) PREDICTED: growth/diff ( 454) 259 65.6 3.1e-10 NP_005251 (OMIM: 601918) growth/differentiation fa ( 454) 259 65.6 3.1e-10 NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 250 63.6 1e-09 NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 250 63.6 1.1e-09 XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 250 63.6 1.1e-09 NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 246 62.7 2e-09 NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 244 62.2 2.1e-09 NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 238 61.0 5.7e-09 >>NP_057288 (OMIM: 605120,615506) growth/differentiation (429 aa) initn: 2890 init1: 2890 opt: 2890 Z-score: 3397.9 bits: 637.8 E(85289): 1.6e-182 Smith-Waterman score: 2890; 100.0% identity (100.0% similar) in 429 aa overlap (1-429:1-429) 10 20 30 40 50 60 pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 NVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 AWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 DISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 EEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 FFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEG 370 380 390 400 410 420 pF1KE2 MSVAECGCR ::::::::: NP_057 MSVAECGCR >>NP_055297 (OMIM: 608748) bone morphogenetic protein 10 (424 aa) initn: 821 init1: 540 opt: 1052 Z-score: 1237.5 bits: 238.0 E(85289): 3.4e-62 Smith-Waterman score: 1052; 42.1% identity (71.6% similar) in 437 aa overlap (4-429:2-424) 10 20 30 40 50 pF1KE2 MCPGALWVALPLLSLLAGSL-QGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHT-FNLKMF :.: ..: : ::. : .:.:... .. . ... : . :. ... . NP_055 MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPL----EEDMSLFGDVFSEQDGVDFNTL 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAI :...: .::..:::: .:.::...:.::.::..:::....:... :..::.:::. :: . NP_055 LQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDG : .. . ..:. ::::.:::.::.. ::::::. : . ...:..::.. NP_055 SQPVSFN-GLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLES 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 TDAWDSATETKTF-LVSQDIQDEG--WETLEVSSAVKRWVRSDSTKSKNKLEVTVES-HR :. : . . ::: .: . :::..:..:..:: .: : : ..::: .:: : NP_055 KG--DNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGS--STHQLEVHIESKHD 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 KGCDT----LDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKD .. :. :.:.. ... :...:::.:.:: :: . :: ::::::: : .:. : NP_055 EAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD-KERKEELNEMISHEQLPELDNLGLD 230 240 250 260 270 280 300 310 320 330 340 pF1KE2 G-STEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPK . :. :: . . ... :: :: .:.: :..:..: : ..:..:::::::::: NP_055 SFSSGPGEEALLQ-MRSNIIYDST-ARIRRNA-KGNYCKRTPLYIDFKEIGWDSWIIAPP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE2 EYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDM ::::::.: : .:::. .:::::::.:.::::: :..::::::::: :::.:: : NP_055 GYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK- 350 360 370 380 390 400 410 420 pF1KE2 GVPTLKYHYEGMSVAECGCR :: : :..::::.:.::::: NP_055 GVVTYKFKYEGMAVSECGCR 410 420 >>NP_001001557 (OMIM: 118100,601147,613094,613703,615360 (455 aa) initn: 427 init1: 327 opt: 418 Z-score: 491.7 bits: 100.1 E(85289): 1.2e-20 Smith-Waterman score: 479; 31.3% identity (55.3% similar) in 387 aa overlap (76-429:85-455) 50 60 70 80 90 100 pF1KE2 GGLPEHTFNLKMFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYT-SDKSTTP : :: : .::...: :. ..: NP_001 PRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGIN 60 70 80 90 100 110 110 120 130 140 150 pF1KE2 ASNIVRSFSMEDAISIT--ATEDF---PFQKHILLFNISI-PRHEQITRAELRLYVSCQN :: . : : . :.. . .:. :.... ::..:. .:... :::::. . . NP_001 ASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQAPS 120 130 140 150 160 170 160 170 180 190 200 pF1KE2 ----------HVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETL--E ::. :. .. .:: : .. :. : : : .. . :. : : NP_001 APWGPPAGPLHVQLFPCLSPLLLDARTLDPQGAPPAGWEV--FDVWQGLRHQPWKQLCLE 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE2 VSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISV---PPGSRNLPFFVVFSNDHSS . .: : . :. ... . . . .: .. :: : : .:::. : NP_001 LRAA---WGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERAL--LVVFT---RS 240 250 260 270 280 270 280 290 300 310 320 pF1KE2 GTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGA :. :.::... :.. . .:: .. :.. : ::.:.: : NP_001 QRKNLFAEMREQLGSA-EAAGPGAGAEGSWPPPSGA----PDARPWLPSPGRRRRRTAFA 290 300 310 320 330 330 340 350 360 370 pF1KE2 GSH-----------CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTK . : :.: :.:::...:::.::::: :::::.:.: : ::: . . ::. NP_001 SRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTN 340 350 360 370 380 390 380 390 400 410 420 pF1KE2 HAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR :::.:::.. : .. .:::::::.:::.:: : : .. .:: : : :::: NP_001 HAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYID-AGNNVVYKQYEDMVVESCGCR 400 410 420 430 440 450 >>XP_016866687 (OMIM: 112265) PREDICTED: bone morphogene (239 aa) initn: 422 init1: 351 opt: 398 Z-score: 472.7 bits: 95.7 E(85289): 1.4e-19 Smith-Waterman score: 409; 33.3% identity (60.3% similar) in 237 aa overlap (199-428:29-238) 170 180 190 200 210 220 pF1KE2 SVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEV : :: ..... . ..:: . .:.: . XP_016 MEAERAQVLPTVRDADLFLLDTRKAQALDVGWLVFDITVTSNHWV----INPQNNLGL 10 20 30 40 50 230 240 250 260 270 280 pF1KE2 TVESHRKGCDTLDISVP-------PGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQE . .. ..... : :.. ::.:.: : ... :: . XP_016 QLCAETGDGRSINVKSAGLVGRQGPQSKQ-PFMVAF-------FKASEVLLRSV------ 60 70 80 90 100 290 300 310 320 330 340 pF1KE2 SVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGW . .: . . ..:: ..:.. ..:. . ....: :.: : :.:.:.:: XP_016 ---RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQA-----CKKHELYVSFRDLGW 110 120 130 140 150 350 360 370 380 390 400 pF1KE2 DSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPI ..:::::. : :. : : : ::: .. :.:::::::::: :: .: : ::.::::. : XP_016 QDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAI 160 170 180 190 200 210 410 420 pF1KE2 SVLYKDDMGVPTLKYHYEGMSVAECGCR :::: :: . :: .:..: : ::: XP_016 SVLYFDDSSNVILK-KYRNMVVRSCGCH 220 230 >>NP_000548 (OMIM: 112600,113100,200700,201250,228900,60 (501 aa) initn: 375 init1: 326 opt: 400 Z-score: 469.9 bits: 96.2 E(85289): 2e-19 Smith-Waterman score: 444; 27.1% identity (55.7% similar) in 431 aa overlap (18-429:102-501) 10 20 30 40 pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLG-VPGG :. . :: . .: . . .: : .::: NP_000 ANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG 80 90 100 110 120 130 50 60 70 80 90 100 pF1KE2 GLPEHTFNL-KMFLENVKVDFLRSLNLSGVPSQDKTRVEPP-----QYMIDLYNRYTSDK : .. .. . :: :.. : : . : .:: .::..:: : :: NP_000 KAPPKAGSVPSSFL-------LKKAREPGPPREPKEPFRPPPITPHEYMLSLY-RTLSDA 140 150 160 170 180 110 120 130 140 150 pF1KE2 STTPASNIVR-SFSMEDAIS--ITATED--FPF-QKHILLFNISIPRHEQITRAELR-LY . ... :. .. ..:. : .: : .:. .:.:: ... . :::: : NP_000 DRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILR 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE2 VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKR . .. . :. : .. . . .. . :. . : .. :::.... NP_000 KKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVP-GLDGSGWEVFDI------ 250 260 270 280 290 220 230 240 250 260 pF1KE2 WVRSDSTKSKNKLEVTVESHRKG--CDTLDISVPPGSRNL---PFFVVFSNDHSSGTKET : . :.. .: . .:. ..: : .. ..:.. .:.::. NP_000 WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFG---------- 300 310 320 330 340 270 280 290 300 310 320 pF1KE2 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ : . :... .: .: : . . . : . .. .. ..: : . ..:. NP_000 RTKKRDLFFNE----IKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRP-SKNLKARCS 350 360 370 380 390 400 330 340 350 360 370 380 pF1KE2 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV . .:.:::.:.:::.::::: ::::..:.: : ::: . . ::.::..:::.. : .. NP_000 RKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPEST 410 420 430 440 450 460 390 400 410 420 pF1KE2 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR .:::::.:::::.:. :. . . : .:: : : :::: NP_000 PPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR 470 480 490 500 >>NP_001306067 (OMIM: 112600,113100,200700,201250,228900 (501 aa) initn: 375 init1: 326 opt: 400 Z-score: 469.9 bits: 96.2 E(85289): 2e-19 Smith-Waterman score: 444; 27.1% identity (55.7% similar) in 431 aa overlap (18-429:102-501) 10 20 30 40 pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLG-VPGG :. . :: . .: . . .: : .::: NP_001 ANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG 80 90 100 110 120 130 50 60 70 80 90 100 pF1KE2 GLPEHTFNL-KMFLENVKVDFLRSLNLSGVPSQDKTRVEPP-----QYMIDLYNRYTSDK : .. .. . :: :.. : : . : .:: .::..:: : :: NP_001 KAPPKAGSVPSSFL-------LKKAREPGPPREPKEPFRPPPITPHEYMLSLY-RTLSDA 140 150 160 170 180 110 120 130 140 150 pF1KE2 STTPASNIVR-SFSMEDAIS--ITATED--FPF-QKHILLFNISIPRHEQITRAELR-LY . ... :. .. ..:. : .: : .:. .:.:: ... . :::: : NP_001 DRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILR 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE2 VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKR . .. . :. : .. . . .. . :. . : .. :::.... NP_001 KKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVP-GLDGSGWEVFDI------ 250 260 270 280 290 220 230 240 250 260 pF1KE2 WVRSDSTKSKNKLEVTVESHRKG--CDTLDISVPPGSRNL---PFFVVFSNDHSSGTKET : . :.. .: . .:. ..: : .. ..:.. .:.::. NP_001 WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFG---------- 300 310 320 330 340 270 280 290 300 310 320 pF1KE2 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ : . :... .: .: : . . . : . .. .. ..: : . ..:. NP_001 RTKKRDLFFNE----IKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRP-SKNLKARCS 350 360 370 380 390 400 330 340 350 360 370 380 pF1KE2 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV . .:.:::.:.:::.::::: ::::..:.: : ::: . . ::.::..:::.. : .. NP_001 RKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPEST 410 420 430 440 450 460 390 400 410 420 pF1KE2 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR .:::::.:::::.:. :. . . : .:: : : :::: NP_001 PPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR 470 480 490 500 >>XP_011527377 (OMIM: 112600,113100,200700,201250,228900 (501 aa) initn: 375 init1: 326 opt: 400 Z-score: 469.9 bits: 96.2 E(85289): 2e-19 Smith-Waterman score: 444; 27.1% identity (55.7% similar) in 431 aa overlap (18-429:102-501) 10 20 30 40 pF1KE2 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLG-VPGG :. . :: . .: . . .: : .::: XP_011 ANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGG 80 90 100 110 120 130 50 60 70 80 90 100 pF1KE2 GLPEHTFNL-KMFLENVKVDFLRSLNLSGVPSQDKTRVEPP-----QYMIDLYNRYTSDK : .. .. . :: :.. : : . : .:: .::..:: : :: XP_011 KAPPKAGSVPSSFL-------LKKAREPGPPREPKEPFRPPPITPHEYMLSLY-RTLSDA 140 150 160 170 180 110 120 130 140 150 pF1KE2 STTPASNIVR-SFSMEDAIS--ITATED--FPF-QKHILLFNISIPRHEQITRAELR-LY . ... :. .. ..:. : .: : .:. .:.:: ... . :::: : XP_011 DRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILR 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE2 VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKR . .. . :. : .. . . .. . :. . : .. :::.... XP_011 KKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPAALLDVRSVP-GLDGSGWEVFDI------ 250 260 270 280 290 220 230 240 250 260 pF1KE2 WVRSDSTKSKNKLEVTVESHRKG--CDTLDISVPPGSRNL---PFFVVFSNDHSSGTKET : . :.. .: . .:. ..: : .. ..:.. .:.::. XP_011 WKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFG---------- 300 310 320 330 340 270 280 290 300 310 320 pF1KE2 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ : . :... .: .: : . . . : . .. .. ..: : . ..:. XP_011 RTKKRDLFFNE----IKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRP-SKNLKARCS 350 360 370 380 390 400 330 340 350 360 370 380 pF1KE2 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV . .:.:::.:.:::.::::: ::::..:.: : ::: . . ::.::..:::.. : .. XP_011 RKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPEST 410 420 430 440 450 460 390 400 410 420 pF1KE2 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR .:::::.:::::.:. :. . . : .:: : : :::: XP_011 PPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR 470 480 490 500 >>NP_066551 (OMIM: 112265) bone morphogenetic protein 5 (454 aa) initn: 451 init1: 351 opt: 398 Z-score: 468.3 bits: 95.8 E(85289): 2.4e-19 Smith-Waterman score: 453; 31.0% identity (58.5% similar) in 316 aa overlap (124-428:168-453) 100 110 120 130 140 pF1KE2 NRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQK-HI--LLFNIS-IPRHEQITRAE .:: :. : . :... ::. : .: :: NP_066 QSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAE 140 150 160 170 180 190 150 160 170 180 190 200 pF1KE2 LRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSS .:.: . .:. .. .: . ::... :. .: . : :: ..... NP_066 FRIYKDRSNNRFENETIK--ISIYQIIKEYTNRDADLFLLDTRKAQAL-DVGWLVFDITV 200 210 220 230 240 250 210 220 230 240 250 260 pF1KE2 AVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVP-------PGSRNLPFFVVFSNDHS . ..:: . .:.: . . .. ..... : :.. ::.:.: NP_066 TSNHWV----INPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQ-PFMVAF----- 260 270 280 290 300 270 280 290 300 310 320 pF1KE2 SGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAG : ... :: . . .: . . ..:: ..:.. ..:. . ....: NP_066 --FKASEVLLRSV---------RAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQA- 310 320 330 340 350 330 340 350 360 370 380 pF1KE2 AGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHL :.: : :.:.:.::..:::::. : :. : : : ::: .. :.:::::::::: NP_066 ----CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHL 360 370 380 390 400 390 400 410 420 pF1KE2 KFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR :: .: : ::.::::. ::::: :: . :: .:..: : ::: NP_066 MFPDHVPKPCCAPTKLNAISVLYFDDSSNVILK-KYRNMVVRSCGCH 410 420 430 440 450 >>XP_011527625 (OMIM: 112261,112600,235200) PREDICTED: b (240 aa) initn: 375 init1: 190 opt: 394 Z-score: 468.0 bits: 94.8 E(85289): 2.5e-19 Smith-Waterman score: 412; 31.5% identity (59.1% similar) in 276 aa overlap (157-429:2-240) 130 140 150 160 170 180 pF1KE2 PFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSAT :. . . ... . ::... . : .. XP_011 MQDALGNNSSFHHRINIYEIIKPATANSKFP 10 20 30 190 200 210 220 230 240 pF1KE2 ETK---TFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDIS :. : ::.:. . ::...:. :: ::. . .. .::. ...: . . XP_011 VTRLLDTRLVNQNASR--WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVR 40 50 60 70 80 250 260 270 280 290 300 pF1KE2 VPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEED . ::.: ...:: . ..: . : ...::. :. :... XP_011 I---SRSL-----HQDEHSWS------QIRPL--------LVTFGHDGK---GHPLHKRE 90 100 110 120 310 320 330 340 350 360 pF1KE2 TDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFP . :..:. : :.. : :.: :.::..::.:: :.:. :.: : :: XP_011 --------KRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFP 130 140 150 160 170 370 380 390 400 410 420 pF1KE2 LADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSV ::: .. :.::::::::. . .:. :::::::.:: ::.:: :. .:: .:. : : XP_011 LADHLNSTNHAIVQTLVN-SVNSKIPKACCVPTELSAISMLYLDENEKVVLK-NYQDMVV 180 190 200 210 220 230 pF1KE2 AECGCR :::: XP_011 EGCGCR 240 >>NP_001191 (OMIM: 112261,112600,235200) bone morphogene (396 aa) initn: 459 init1: 190 opt: 394 Z-score: 464.5 bits: 94.9 E(85289): 3.9e-19 Smith-Waterman score: 520; 31.7% identity (58.1% similar) in 382 aa overlap (67-429:55-396) 40 50 60 70 80 90 pF1KE2 AHSPLGVPGGGLPEHTFNLKMFLENVKVDFLRSLNLSGV---PSQDKTRVEPPQYMIDLY :: :.. :. :. .. : :: ::.::: NP_001 VPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPP-YMLDLY 30 40 50 60 70 80 100 110 120 130 140 pF1KE2 NRYTSDKSTTPA-----------SNIVRSFSMEDAISITATEDFPFQKHILLFNIS-IPR :. : . .:: .: :::: :... . .. ..::.: :: NP_001 RRH-SGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRR-FFFNLSSIPT 90 100 110 120 130 140 150 160 170 180 190 pF1KE2 HEQITRAELRLYV-SCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETK---TFLVSQDI .: :: :::... . :. . . ... . ::... . : .. :. : ::.:. NP_001 EEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNA 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE2 QDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVF . ::...:. :: ::. . .. .::. ...: . . . ::.: NP_001 SR--WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRI---SRSL-----H 210 220 230 240 250 260 270 280 290 300 310 pF1KE2 SNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARR ...:: . ..: . : ...::. :. :... . :.. NP_001 QDEHSWS------QIRPL--------LVTFGHDGK---GHPLHKRE--------KRQAKH 260 270 280 320 330 340 350 360 370 pF1KE2 KRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQ :. : :.. : :.: :.::..::.:: :.:. :.: : ::::: .. :.::::: NP_001 KQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQ 290 300 310 320 330 340 380 390 400 410 420 pF1KE2 TLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR :::. . .:. :::::::.:: ::.:: :. .:: .:. : : :::: NP_001 TLVN-SVNSKIPKACCVPTELSAISMLYLDENEKVVLK-NYQDMVVEGCGCR 350 360 370 380 390 429 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:32:11 2016 done: Sun Nov 6 15:32:13 2016 Total Scan time: 8.450 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]