Result of FASTA (omim) for
pFN21AE2077
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2077, 745 aa
1>>>pF1KE2077 745 - 745 aa - 745 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8388+/-0.000585; mu= 17.8957+/- 0.036
mean_var=82.9348+/-17.535, 0's: 0 Z-trim(106.2): 81 B-trim: 844 in 1/51
Lambda= 0.140833
statistics sampled from 14281 (14361) to 14281 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.492), E-opt: 0.2 (0.168), width: 16
Scan time: 9.290
The best scores are: opt bits E(85289)
XP_011518049 (OMIM: 603135) PREDICTED: cullin-2 is ( 745) 4872 1000.9 0
NP_003582 (OMIM: 603135) cullin-2 isoform c [Homo ( 745) 4872 1000.9 0
NP_001185706 (OMIM: 603135) cullin-2 isoform c [Ho ( 745) 4872 1000.9 0
NP_001185708 (OMIM: 603135) cullin-2 isoform b [Ho ( 758) 4872 1000.9 0
NP_001185707 (OMIM: 603135) cullin-2 isoform a [Ho ( 764) 4872 1000.9 0
XP_011518045 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 4872 1000.9 0
XP_011518046 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 4872 1000.9 0
XP_011518047 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 4872 1000.9 0
NP_001311305 (OMIM: 603135) cullin-2 isoform e [Ho ( 614) 3987 821.0 0
NP_001311304 (OMIM: 603135) cullin-2 isoform d [Ho ( 682) 3743 771.5 0
XP_011514933 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 1609 337.9 9.2e-92
XP_005250117 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 1609 337.9 9.2e-92
XP_011514931 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 1609 337.9 9.2e-92
NP_003583 (OMIM: 603134) cullin-1 [Homo sapiens] ( 776) 1609 337.9 9.2e-92
XP_011514934 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 1609 337.9 9.2e-92
XP_011514932 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 1609 337.9 9.2e-92
XP_016868212 (OMIM: 603134) PREDICTED: cullin-1 is ( 455) 1293 273.6 1.3e-72
XP_011529702 (OMIM: 300304,300354) PREDICTED: cull ( 717) 982 210.5 1.9e-53
NP_001073341 (OMIM: 300304,300354) cullin-4B isofo ( 895) 982 210.6 2.3e-53
NP_001317553 (OMIM: 300304,300354) cullin-4B isofo ( 900) 982 210.6 2.3e-53
NP_003579 (OMIM: 300304,300354) cullin-4B isoform ( 913) 982 210.6 2.4e-53
XP_011529703 (OMIM: 300304,300354) PREDICTED: cull ( 701) 969 207.9 1.2e-52
XP_011529701 (OMIM: 300304,300354) PREDICTED: cull ( 719) 969 207.9 1.2e-52
XP_006724847 (OMIM: 300304,300354) PREDICTED: cull ( 902) 969 207.9 1.5e-52
XP_005262538 (OMIM: 300304,300354) PREDICTED: cull ( 915) 969 207.9 1.5e-52
XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A i ( 659) 915 196.9 2.3e-49
NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [H ( 659) 915 196.9 2.3e-49
NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo ( 659) 915 196.9 2.3e-49
NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [H ( 667) 915 196.9 2.3e-49
NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [H ( 759) 915 196.9 2.5e-49
XP_011510297 (OMIM: 603136,614496) PREDICTED: cull ( 754) 666 146.3 4.3e-34
XP_006712863 (OMIM: 603136,614496) PREDICTED: cull ( 757) 666 146.3 4.3e-34
NP_003581 (OMIM: 603136,614496) cullin-3 isoform 1 ( 768) 666 146.3 4.4e-34
NP_001244127 (OMIM: 603136,614496) cullin-3 isofor ( 774) 666 146.3 4.4e-34
NP_001244126 (OMIM: 603136,614496) cullin-3 isofor ( 702) 664 145.9 5.4e-34
XP_011510298 (OMIM: 603136,614496) PREDICTED: cull ( 704) 664 145.9 5.4e-34
XP_011510296 (OMIM: 603136,614496) PREDICTED: cull ( 719) 664 145.9 5.5e-34
XP_016873854 (OMIM: 601741) PREDICTED: cullin-5 is ( 519) 539 120.4 1.8e-26
XP_016873853 (OMIM: 601741) PREDICTED: cullin-5 is ( 519) 539 120.4 1.8e-26
XP_005271739 (OMIM: 601741) PREDICTED: cullin-5 is ( 721) 539 120.5 2.4e-26
NP_003469 (OMIM: 601741) cullin-5 [Homo sapiens] ( 780) 539 120.5 2.6e-26
XP_016873852 (OMIM: 601741) PREDICTED: cullin-5 is ( 742) 537 120.1 3.3e-26
XP_011541315 (OMIM: 601741) PREDICTED: cullin-5 is ( 396) 325 76.9 1.8e-13
NP_037498 (OMIM: 606946) anaphase-promoting comple ( 822) 182 48.0 0.00018
>>XP_011518049 (OMIM: 603135) PREDICTED: cullin-2 isofor (745 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.7 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:1-745)
10 20 30 40 50 60
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
670 680 690 700 710 720
730 740
pF1KE2 CIEVLIDKQYIERSQASADEYSYVA
:::::::::::::::::::::::::
XP_011 CIEVLIDKQYIERSQASADEYSYVA
730 740
>>NP_003582 (OMIM: 603135) cullin-2 isoform c [Homo sapi (745 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.7 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:1-745)
10 20 30 40 50 60
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
670 680 690 700 710 720
730 740
pF1KE2 CIEVLIDKQYIERSQASADEYSYVA
:::::::::::::::::::::::::
NP_003 CIEVLIDKQYIERSQASADEYSYVA
730 740
>>NP_001185706 (OMIM: 603135) cullin-2 isoform c [Homo s (745 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.7 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:1-745)
10 20 30 40 50 60
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
670 680 690 700 710 720
730 740
pF1KE2 CIEVLIDKQYIERSQASADEYSYVA
:::::::::::::::::::::::::
NP_001 CIEVLIDKQYIERSQASADEYSYVA
730 740
>>NP_001185708 (OMIM: 603135) cullin-2 isoform b [Homo s (758 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.5 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:14-758)
10 20 30 40
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCV
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVPGKEFQHYTCTMSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 AYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRY
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 LNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 KNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE2 QESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIR
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 QEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVH
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE2 GKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMT
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE2 ENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGY
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 EFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTF
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE2 AIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE2 FNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSK
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE2 RTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQS
670 680 690 700 710 720
710 720 730 740
pF1KE2 RARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
::::::::::::::::::::::::::::::::::::::
NP_001 RARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
730 740 750
>>NP_001185707 (OMIM: 603135) cullin-2 isoform a [Homo s (764 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.5 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:20-764)
10 20 30 40
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSD
:::::::::::::::::::::::::::::::::::::::::
NP_001 MYRVTWSTFWLRFQHYTCTMSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSD
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 IYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 DCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIR
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 MLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQ
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE2 EASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 CHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE2 SVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKK
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE2 SAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKL
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 KQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQ
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE2 APSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQ
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE2 MAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE2 MNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQ
670 680 690 700 710 720
710 720 730 740
pF1KE2 EVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
730 740 750 760
>>XP_011518045 (OMIM: 603135) PREDICTED: cullin-2 isofor (808 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.1 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:64-808)
10 20 30
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYV
::::::::::::::::::::::::::::::
XP_011 TGQLIGENGTLLYPDCGDGHAWLFQHYTCTMSLKPRVVDFDETWNKLLTTIKAVVMLEYV
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE2 ERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE2 WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKL
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE2 MVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE2 FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE2 VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE2 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPEL
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE2 LAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE2 MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIY
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE2 VLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE2 KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE2 DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKA
700 710 720 730 740 750
700 710 720 730 740
pF1KE2 RKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
760 770 780 790 800
>>XP_011518046 (OMIM: 603135) PREDICTED: cullin-2 isofor (808 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.1 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:64-808)
10 20 30
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYV
::::::::::::::::::::::::::::::
XP_011 TGQLIGENGTLLYPDCGDGHAWLFQHYTCTMSLKPRVVDFDETWNKLLTTIKAVVMLEYV
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE2 ERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE2 WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKL
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE2 MVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE2 FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE2 VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE2 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPEL
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE2 LAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE2 MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIY
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE2 VLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE2 KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE2 DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKA
700 710 720 730 740 750
700 710 720 730 740
pF1KE2 RKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
760 770 780 790 800
>>XP_011518047 (OMIM: 603135) PREDICTED: cullin-2 isofor (808 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5351.1 bits: 1000.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 745 aa overlap (1-745:64-808)
10 20 30
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYV
::::::::::::::::::::::::::::::
XP_011 TGQLIGENGTLLYPDCGDGHAWLFQHYTCTMSLKPRVVDFDETWNKLLTTIKAVVMLEYV
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE2 ERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRY
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE2 WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKL
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE2 MVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESP
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE2 FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRM
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE2 VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNL
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE2 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPEL
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE2 LAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMS
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE2 MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIY
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE2 VLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE2 KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKE
640 650 660 670 680 690
640 650 660 670 680 690
pF1KE2 DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKA
700 710 720 730 740 750
700 710 720 730 740
pF1KE2 RKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
760 770 780 790 800
>>NP_001311305 (OMIM: 603135) cullin-2 isoform e [Homo s (614 aa)
initn: 3987 init1: 3987 opt: 3987 Z-score: 4381.1 bits: 821.0 E(85289): 0
Smith-Waterman score: 3987; 100.0% identity (100.0% similar) in 614 aa overlap (132-745:1-614)
110 120 130 140 150 160
pF1KE2 DCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIR
::::::::::::::::::::::::::::::
NP_001 MNEPLMEIGELALDMWRKLMVEPLQAILIR
10 20 30
170 180 190 200 210 220
pF1KE2 MLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQ
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 EASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAE
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 CHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVE
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 SVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKK
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 SAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKL
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 KQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQ
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE2 APSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQ
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE2 MAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLN
460 470 480 490 500 510
650 660 670 680 690 700
pF1KE2 MNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQ
520 530 540 550 560 570
710 720 730 740
pF1KE2 EVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
580 590 600 610
>>NP_001311304 (OMIM: 603135) cullin-2 isoform d [Homo s (682 aa)
initn: 4443 init1: 3743 opt: 3743 Z-score: 4112.5 bits: 771.5 E(85289): 0
Smith-Waterman score: 4321; 91.4% identity (91.5% similar) in 745 aa overlap (1-745:1-682)
10 20 30 40 50 60
pF1KE2 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLY---------------
70 80 90 100
130 140 150 160 170 180
pF1KE2 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
.:::::::::::
NP_001 ------------------------------------------------SDRGGEDPNQKV
110
190 200 210 220 230 240
pF1KE2 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE2 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE2 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
240 250 260 270 280 290
370 380 390 400 410 420
pF1KE2 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
300 310 320 330 340 350
430 440 450 460 470 480
pF1KE2 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
360 370 380 390 400 410
490 500 510 520 530 540
pF1KE2 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
420 430 440 450 460 470
550 560 570 580 590 600
pF1KE2 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
480 490 500 510 520 530
610 620 630 640 650 660
pF1KE2 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
540 550 560 570 580 590
670 680 690 700 710 720
pF1KE2 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
600 610 620 630 640 650
730 740
pF1KE2 CIEVLIDKQYIERSQASADEYSYVA
:::::::::::::::::::::::::
NP_001 CIEVLIDKQYIERSQASADEYSYVA
660 670 680
745 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 15:32:47 2016 done: Sun Nov 6 15:32:49 2016
Total Scan time: 9.290 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]