Result of FASTA (omim) for
pFN21AE5314
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5314, 288 aa
1>>>pF1KE5314 288 - 288 aa - 288 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3628+/-0.000335; mu= 16.3789+/- 0.021
mean_var=81.7346+/-16.996, 0's: 0 Z-trim(116.2): 16 B-trim: 1407 in 1/56
Lambda= 0.141864
statistics sampled from 27260 (27276) to 27260 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.32), width: 16
Scan time: 6.480
The best scores are: opt bits E(85289)
NP_055056 (OMIM: 610467) very-long-chain (3R)-3-hy ( 288) 1887 395.5 6.4e-110
NP_940684 (OMIM: 615939) very-long-chain (3R)-3-hy ( 254) 1070 228.2 1.3e-59
XP_005252698 (OMIM: 610467) PREDICTED: very-long-c ( 252) 847 182.6 6.9e-46
NP_001316712 (OMIM: 615939) very-long-chain (3R)-3 ( 277) 806 174.2 2.5e-43
NP_001316713 (OMIM: 615939) very-long-chain (3R)-3 ( 161) 763 165.2 7.3e-41
NP_001316716 (OMIM: 615939) very-long-chain (3R)-3 ( 143) 704 153.1 2.9e-37
NP_001316715 (OMIM: 615939) very-long-chain (3R)-3 ( 143) 704 153.1 2.9e-37
XP_016861345 (OMIM: 615939) PREDICTED: very-long-c ( 130) 447 100.5 1.8e-21
XP_011519966 (OMIM: 615940) PREDICTED: very-long-c ( 245) 357 82.3 1e-15
NP_057479 (OMIM: 615940) very-long-chain (3R)-3-hy ( 362) 357 82.4 1.4e-15
NP_001010915 (OMIM: 615941) very-long-chain (3R)-3 ( 232) 292 68.9 1e-11
NP_001308812 (OMIM: 615941) very-long-chain (3R)-3 ( 195) 280 66.4 4.8e-11
XP_016870203 (OMIM: 615941) PREDICTED: very-long-c ( 227) 196 49.3 8.1e-06
NP_001308832 (OMIM: 615941) very-long-chain (3R)-3 ( 283) 196 49.4 9.6e-06
XP_016870202 (OMIM: 615941) PREDICTED: very-long-c ( 246) 184 46.9 4.8e-05
>>NP_055056 (OMIM: 610467) very-long-chain (3R)-3-hydrox (288 aa)
initn: 1887 init1: 1887 opt: 1887 Z-score: 2094.4 bits: 395.5 E(85289): 6.4e-110
Smith-Waterman score: 1887; 99.3% identity (99.7% similar) in 288 aa overlap (1-288:1-288)
10 20 30 40 50 60
pF1KE5 MGRLTEAAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MGRLTEAAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 APGKRRRLGFLATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQT
:::.::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 APGERRRLGVLATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 FALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 TRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPN
190 200 210 220 230 240
250 260 270 280
pF1KE5 KYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHGEVIVEKDD
::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHGEVIVEKDD
250 260 270 280
>>NP_940684 (OMIM: 615939) very-long-chain (3R)-3-hydrox (254 aa)
initn: 1095 init1: 1040 opt: 1070 Z-score: 1191.5 bits: 228.2 E(85289): 1.3e-59
Smith-Waterman score: 1070; 62.1% identity (87.1% similar) in 248 aa overlap (37-281:2-248)
10 20 30 40 50 60
pF1KE5 AAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDREAPGKRR
::. :.. :..::...:: .: : :.
NP_940 MAAVAATAAAKGNGGGGGRAGAG-DASGTRK
10 20 30
70 80 90 100 110 120
pF1KE5 RLGF--LATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALL
. : ::::.:..:...:::::::.:...:: :. ::....:: ::.: :::::: :::
NP_940 KKGPGPLATAYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIEKPLKFFQTGALL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE5 EIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEITRYS
::.:: :::::.::..:. :: ::.:..: .:::.: .:.:.::.::..:::.::: :::
NP_940 EILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE5 FYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKYNV
:::::::.::::.::::::..::.:::.::.::::::::::: :...:..:: ::::::
NP_940 FYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTIYAALPFVRQAGLYSISLPNKYNF
160 170 180 190 200 210
250 260 270 280
pF1KE5 SFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVL-HGEVIVEKDD
::::: ::.. : ::::.::::::::..::::.: : :
NP_940 SFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHTEEHKKFE
220 230 240 250
>>XP_005252698 (OMIM: 610467) PREDICTED: very-long-chain (252 aa)
initn: 845 init1: 845 opt: 847 Z-score: 944.8 bits: 182.6 E(85289): 6.9e-46
Smith-Waterman score: 1571; 86.8% identity (87.2% similar) in 288 aa overlap (1-288:1-252)
10 20 30 40 50 60
pF1KE5 MGRLTEAAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGRLTEAAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 APGKRRRLGFLATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQT
:::.::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGERRRLGVLATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 FALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEI
:::::: ::::::::::::::::::
XP_005 FALLEI------------------------------------QNEESVVLFLVAWTVTEI
130 140
190 200 210 220 230 240
pF1KE5 TRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPN
150 160 170 180 190 200
250 260 270 280
pF1KE5 KYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHGEVIVEKDD
::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHGEVIVEKDD
210 220 230 240 250
>>NP_001316712 (OMIM: 615939) very-long-chain (3R)-3-hyd (277 aa)
initn: 1056 init1: 797 opt: 806 Z-score: 898.9 bits: 174.2 E(85289): 2.5e-43
Smith-Waterman score: 1014; 56.8% identity (79.7% similar) in 271 aa overlap (37-281:2-271)
10 20 30 40 50 60
pF1KE5 AAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDREAPGKRR
::. :.. :..::...:: .: : :.
NP_001 MAAVAATAAAKGNGGGGGRAGAG-DASGTRK
10 20 30
70 80 90 100 110 120
pF1KE5 RLGF--LATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALL
. : ::::.:..:...:::::::.:...:: :. ::....:: ::.: :::::: :::
NP_001 KKGPGPLATAYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIEKPLKFFQTGALL
40 50 60 70 80 90
130 140 150 160
pF1KE5 E-----------------------IVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKP
: :.:: :::::.::..:. :: ::.:..: .:::.:
NP_001 ENLGQYSSHKLQRSKFGVKTIRLPILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKE
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE5 IQNEESVVLFLVAWTVTEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTI
.:.:.::.::..:::.::: ::::::::::.::::.::::::..::.:::.::.::::::
NP_001 VQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE5 YAALPHVKKTGMFSIRLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVL-HG
::::: :...:..:: :::::: ::::: ::.. : ::::.::::::::..::::.: :
NP_001 YAALPFVRQAGLYSISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHT
220 230 240 250 260 270
pF1KE5 EVIVEKDD
:
NP_001 EEHKKFE
>>NP_001316713 (OMIM: 615939) very-long-chain (3R)-3-hyd (161 aa)
initn: 780 init1: 761 opt: 763 Z-score: 854.6 bits: 165.2 E(85289): 7.3e-41
Smith-Waterman score: 763; 68.9% identity (91.4% similar) in 151 aa overlap (132-281:5-155)
110 120 130 140 150 160
pF1KE5 GTHRGLYKSIQKTLKFFQTFALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKP
::::.::..:. :: ::.:..: .:::.:
NP_001 MGEWGIVPSSVVLTSFQVMSRVFLIWAVTHSVKE
10 20 30
170 180 190 200 210 220
pF1KE5 IQNEESVVLFLVAWTVTEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTI
.:.:.::.::..:::.::: ::::::::::.::::.::::::..::.:::.::.::::::
NP_001 VQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTI
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE5 YAALPHVKKTGMFSIRLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVL-HG
::::: :...:..:: :::::: ::::: ::.. : ::::.::::::::..::::.: :
NP_001 YAALPFVRQAGLYSISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHT
100 110 120 130 140 150
pF1KE5 EVIVEKDD
:
NP_001 EEHKKFE
160
>>NP_001316716 (OMIM: 615939) very-long-chain (3R)-3-hyd (143 aa)
initn: 721 init1: 702 opt: 704 Z-score: 790.0 bits: 153.1 E(85289): 2.9e-37
Smith-Waterman score: 704; 69.9% identity (91.9% similar) in 136 aa overlap (147-281:2-137)
120 130 140 150 160 170
pF1KE5 FFQTFALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWT
::.:..: .:::.: .:.:.::.::..:::
NP_001 MSRVFLIWAVTHSVKEVQSEDSVLLFVIAWT
10 20 30
180 190 200 210 220 230
pF1KE5 VTEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSI
.::: ::::::::::.::::.::::::..::.:::.::.::::::::::: :...:..::
NP_001 ITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTIYAALPFVRQAGLYSI
40 50 60 70 80 90
240 250 260 270 280
pF1KE5 RLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVL-HGEVIVEKDD
:::::: ::::: ::.. : ::::.::::::::..::::.: : :
NP_001 SLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHTEEHKKFE
100 110 120 130 140
>>NP_001316715 (OMIM: 615939) very-long-chain (3R)-3-hyd (143 aa)
initn: 721 init1: 702 opt: 704 Z-score: 790.0 bits: 153.1 E(85289): 2.9e-37
Smith-Waterman score: 704; 69.9% identity (91.9% similar) in 136 aa overlap (147-281:2-137)
120 130 140 150 160 170
pF1KE5 FFQTFALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWT
::.:..: .:::.: .:.:.::.::..:::
NP_001 MSRVFLIWAVTHSVKEVQSEDSVLLFVIAWT
10 20 30
180 190 200 210 220 230
pF1KE5 VTEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSI
.::: ::::::::::.::::.::::::..::.:::.::.::::::::::: :...:..::
NP_001 ITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTIYAALPFVRQAGLYSI
40 50 60 70 80 90
240 250 260 270 280
pF1KE5 RLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVL-HGEVIVEKDD
:::::: ::::: ::.. : ::::.::::::::..::::.: : :
NP_001 SLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHTEEHKKFE
100 110 120 130 140
>>XP_016861345 (OMIM: 615939) PREDICTED: very-long-chain (130 aa)
initn: 455 init1: 419 opt: 447 Z-score: 506.3 bits: 100.5 E(85289): 1.8e-21
Smith-Waterman score: 447; 52.3% identity (82.0% similar) in 128 aa overlap (37-162:2-128)
10 20 30 40 50 60
pF1KE5 AAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDREAPGKRR
::. :.. :..::...:: .: : :.
XP_016 MAAVAATAAAKGNGGGGGRAGAG-DASGTRK
10 20 30
70 80 90 100 110 120
pF1KE5 RLGF--LATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALL
. : ::::.:..:...:::::::.:...:: :. ::....:: ::.: :::::: :::
XP_016 KKGPGPLATAYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIEKPLKFFQTGALL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE5 EIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEITRYS
::.:: :::::.::..:. :: ::.:..: .:::.: .
XP_016 EILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKEVLC
100 110 120 130
190 200 210 220 230 240
pF1KE5 FYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKYNV
>>XP_011519966 (OMIM: 615940) PREDICTED: very-long-chain (245 aa)
initn: 285 init1: 230 opt: 357 Z-score: 403.0 bits: 82.3 E(85289): 1e-15
Smith-Waterman score: 357; 27.8% identity (61.4% similar) in 223 aa overlap (60-276:17-235)
30 40 50 60 70 80
pF1KE5 SPTSPRCAATMASSDEDGTNGGASEAGEDREAPGKRRRLGFLATAWLTFYDIAMTAG--W
:. :. . : : ..: .:.... : :
XP_011 MELRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSW
10 20 30 40
90 100 110 120 130 140
pF1KE5 LVLAIAMVRF-YMEKGTHRGLYKSIQKTLKFFQTFALLEIVHCLIGIVPTSVIVTGVQVS
. . .. ::: . : . .... . : : .:..: .. ::.. . :. . .:.
XP_011 IFVNLT-VRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSLIQLL
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE5 SRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEITRYSFYTFSLLDHLPYFIKWARYNFF
.: :....: ... .::. : . . :.. :: ::::: .. .: . : ::...
XP_011 GRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLW
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE5 IILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKYNVSFDYYYFLLITMASYIPLFPQL
: :::.: .: ... ..: ..:: ::. :: ... . .:: : . : .: :
XP_011 IPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYL---IMIFLGL
170 180 190 200 210 220
270 280
pF1KE5 YF---HMLRQRRKVLHGEVIVEKDD
:. :. .:::.
XP_011 YINFRHLYKQRRRRYGQKKKKIH
230 240
>>NP_057479 (OMIM: 615940) very-long-chain (3R)-3-hydrox (362 aa)
initn: 285 init1: 230 opt: 357 Z-score: 400.7 bits: 82.4 E(85289): 1.4e-15
Smith-Waterman score: 357; 27.8% identity (61.4% similar) in 223 aa overlap (60-276:134-352)
30 40 50 60 70 80
pF1KE5 SPTSPRCAATMASSDEDGTNGGASEAGEDREAPGKRRRLGFLATAWLTFYDIAMTAG--W
:. :. . : : ..: .:.... : :
NP_057 APDFDRWLDESDAEMELRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSW
110 120 130 140 150 160
90 100 110 120 130 140
pF1KE5 LVLAIAMVRF-YMEKGTHRGLYKSIQKTLKFFQTFALLEIVHCLIGIVPTSVIVTGVQVS
. . .. ::: . : . .... . : : .:..: .. ::.. . :. . .:.
NP_057 IFVNLT-VRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSLIQLL
170 180 190 200 210 220
150 160 170 180 190 200
pF1KE5 SRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEITRYSFYTFSLLDHLPYFIKWARYNFF
.: :....: ... .::. : . . :.. :: ::::: .. .: . : ::...
NP_057 GRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLW
230 240 250 260 270 280
210 220 230 240 250 260
pF1KE5 IILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKYNVSFDYYYFLLITMASYIPLFPQL
: :::.: .: ... ..: ..:: ::. :: ... . .:: : . : .: :
NP_057 IPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYL---IMIFLGL
290 300 310 320 330
270 280
pF1KE5 YF---HMLRQRRKVLHGEVIVEKDD
:. :. .:::.
NP_057 YINFRHLYKQRRRRYGQKKKKIH
340 350 360
288 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 07:30:45 2016 done: Tue Nov 8 07:30:46 2016
Total Scan time: 6.480 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]