FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4049, 278 aa 1>>>pF1KE4049 278 - 278 aa - 278 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5579+/-0.000531; mu= 8.0614+/- 0.032 mean_var=167.4026+/-36.741, 0's: 0 Z-trim(113.3): 676 B-trim: 1230 in 2/48 Lambda= 0.099127 statistics sampled from 21758 (22609) to 21758 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.265), width: 16 Scan time: 7.230 The best scores are: opt bits E(85289) NP_078977 (OMIM: 615055) ankyrin repeat and SOCS b ( 278) 1871 280.1 3.1e-75 XP_011529918 (OMIM: 615050) PREDICTED: ankyrin rep ( 284) 713 114.5 2.2e-25 XP_011529919 (OMIM: 615050) PREDICTED: ankyrin rep ( 276) 700 112.7 8e-25 NP_543150 (OMIM: 615050) ankyrin repeat and SOCS b ( 329) 696 112.2 1.3e-24 XP_005262816 (OMIM: 615050) PREDICTED: ankyrin rep ( 329) 696 112.2 1.3e-24 XP_005274503 (OMIM: 300890) PREDICTED: ankyrin rep ( 294) 694 111.8 1.5e-24 NP_001026909 (OMIM: 300890) ankyrin repeat and SOC ( 294) 694 111.8 1.5e-24 XP_016884772 (OMIM: 300890) PREDICTED: ankyrin rep ( 377) 688 111.1 3.2e-24 NP_001012428 (OMIM: 300626) ankyrin repeat and SOC ( 302) 674 109.0 1.1e-23 NP_543149 (OMIM: 300626) ankyrin repeat and SOCS b ( 323) 674 109.0 1.2e-23 NP_076992 (OMIM: 300890) ankyrin repeat and SOCS b ( 262) 605 99.0 9.5e-21 NP_001162003 (OMIM: 300890) ankyrin repeat and SOC ( 262) 605 99.0 9.5e-21 XP_016884775 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 599 98.3 2.1e-20 XP_016884774 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 599 98.3 2.1e-20 NP_001188512 (OMIM: 300626) ankyrin repeat and SOC ( 306) 530 88.4 1.8e-17 XP_011543760 (OMIM: 300890) PREDICTED: ankyrin rep ( 265) 520 86.9 4.4e-17 XP_016884773 (OMIM: 300890) PREDICTED: ankyrin rep ( 348) 520 87.0 5.2e-17 XP_011543762 (OMIM: 300890) PREDICTED: ankyrin rep ( 233) 431 74.1 2.7e-13 NP_001162002 (OMIM: 300890) ankyrin repeat and SOC ( 252) 352 62.8 7.2e-10 XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 354 64.1 2.1e-09 XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 354 64.1 2.1e-09 XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 354 64.1 2.1e-09 XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 354 64.1 2.1e-09 XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 354 64.1 2.1e-09 XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 354 64.1 2.1e-09 XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 354 64.1 2.1e-09 XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 354 64.1 2.1e-09 XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 354 64.1 2.2e-09 XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 354 64.1 2.2e-09 XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 354 64.1 2.2e-09 XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850) 354 64.1 2.2e-09 XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851) 354 64.1 2.2e-09 XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 354 64.1 2.2e-09 XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862) 354 64.1 2.2e-09 NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863) 354 64.1 2.2e-09 XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 354 64.1 2.2e-09 XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871) 354 64.1 2.2e-09 NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 354 64.1 2.2e-09 XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 354 64.1 2.2e-09 XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881) 354 64.1 2.2e-09 XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882) 354 64.1 2.2e-09 XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 354 64.1 2.2e-09 XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 354 64.1 2.2e-09 XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893) 354 64.1 2.2e-09 XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 354 64.2 2.2e-09 XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 354 64.2 2.2e-09 XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 354 64.2 2.2e-09 XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 354 64.2 2.2e-09 XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 354 64.2 2.2e-09 XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 354 64.2 2.2e-09 >>NP_078977 (OMIM: 615055) ankyrin repeat and SOCS box p (278 aa) initn: 1871 init1: 1871 opt: 1871 Z-score: 1471.7 bits: 280.1 E(85289): 3.1e-75 Smith-Waterman score: 1871; 100.0% identity (100.0% similar) in 278 aa overlap (1-278:1-278) 10 20 30 40 50 60 pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL 190 200 210 220 230 240 250 260 270 pF1KE4 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN :::::::::::::::::::::::::::::::::::::: NP_078 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN 250 260 270 >>XP_011529918 (OMIM: 615050) PREDICTED: ankyrin repeat (284 aa) initn: 1006 init1: 680 opt: 713 Z-score: 576.6 bits: 114.5 E(85289): 2.2e-25 Smith-Waterman score: 713; 42.1% identity (71.1% similar) in 266 aa overlap (12-277:18-283) 10 20 30 40 50 pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSIT ::.: :..:.:.::::..:. : :. :. .: :: ::.: .: XP_011 MSRIYLDSGWCEVPWGDGDLGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP ::: : : .. :.. :: :::.:.: .::: ::: .::..:: :..::: ::::.. XP_011 PLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 LYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGA :: ::: .: ::. .::. : ... . :.::::.::: ... :. :: ::: XP_011 SCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEY .:. .: .: :: ::. ........:.:::..: :.... .: : . ::: . . XP_011 DVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQ 190 200 210 220 230 240 240 250 260 270 pF1KE4 YEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN .: :: .: ::::. .:. : :. : .:..: : ..:.: XP_011 HEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 250 260 270 280 >>XP_011529919 (OMIM: 615050) PREDICTED: ankyrin repeat (276 aa) initn: 1006 init1: 621 opt: 700 Z-score: 566.7 bits: 112.7 E(85289): 8e-25 Smith-Waterman score: 700; 41.3% identity (70.5% similar) in 271 aa overlap (7-277:5-275) 10 20 30 40 50 60 pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS .: :. .: :..:.:.::::..:. : :. :. .: :: ::.: .:::: : XP_011 MPLCNGGNLAVTGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEAC 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP : .. :.. :: :::.:.: .::: ::: .::..:: :..::: ::::.. :: XP_011 LGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK ::: .: ::. .::. : ... . :.::::.::: ... :. :: :::.:. .: XP_011 THEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL .: :: ::. ........:.:::..: :.... .: : . ::: . . .: :: XP_011 YWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPS 180 190 200 210 220 230 250 260 270 pF1KE4 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN .: ::::. .:. : :. : .:..: : ..:.: XP_011 SLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 240 250 260 270 >>NP_543150 (OMIM: 615050) ankyrin repeat and SOCS box p (329 aa) initn: 947 init1: 621 opt: 696 Z-score: 562.7 bits: 112.2 E(85289): 1.3e-24 Smith-Waterman score: 696; 41.8% identity (70.7% similar) in 263 aa overlap (15-277:66-328) 10 20 30 40 pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGAC : :..:.:.::::..:. : :. :. .: NP_543 AILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYN 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE4 VNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLL :: ::.: .:::: : : .. :.. :: :::.:.: .::: ::: .::..:: :..:: NP_543 VNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE4 LSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLD : ::::.. :: ::: .: ::. .::. : ... . :.::::.::: ... NP_543 LEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFH 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE4 CVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWS :. :: :::.:. .: .: :: ::. ........:.:::..: :.... .: : . : NP_543 CIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATS 220 230 240 250 260 270 230 240 250 260 270 pF1KE4 SSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN :: . . .: :: .: ::::. .:. : :. : .:..: : ..:.: NP_543 SSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 280 290 300 310 320 >>XP_005262816 (OMIM: 615050) PREDICTED: ankyrin repeat (329 aa) initn: 947 init1: 621 opt: 696 Z-score: 562.7 bits: 112.2 E(85289): 1.3e-24 Smith-Waterman score: 696; 41.8% identity (70.7% similar) in 263 aa overlap (15-277:66-328) 10 20 30 40 pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGAC : :..:.:.::::..:. : :. :. .: XP_005 AILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYN 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE4 VNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLL :: ::.: .:::: : : .. :.. :: :::.:.: .::: ::: .::..:: :..:: XP_005 VNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE4 LSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLD : ::::.. :: ::: .: ::. .::. : ... . :.::::.::: ... XP_005 LEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFH 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE4 CVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWS :. :: :::.:. .: .: :: ::. ........:.:::..: :.... .: : . : XP_005 CIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATS 220 230 240 250 260 270 230 240 250 260 270 pF1KE4 SSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN :: . . .: :: .: ::::. .:. : :. : .:..: : ..:.: XP_005 SSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 280 290 300 310 320 >>XP_005274503 (OMIM: 300890) PREDICTED: ankyrin repeat (294 aa) initn: 971 init1: 577 opt: 694 Z-score: 561.7 bits: 111.8 E(85289): 1.5e-24 Smith-Waterman score: 694; 42.3% identity (70.0% similar) in 267 aa overlap (10-275:29-291) 10 20 30 40 pF1KE4 MEPRAADGCFLGD-VGFWVERTPVHEAAQRGESLQLQQLIE ..:: :. : .:.:::: .:..:.:..:: XP_005 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDW---SPMHEAAIHGHQLSLRNLIS 10 20 30 40 50 50 60 70 80 90 100 pF1KE4 SGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIEC .: :: .:.: ..::: : : :. ::..:: ::::.. . : ::: .::.::: .: XP_005 QGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDC 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAR :.:::..::.:.: :::.::: : ::: :: :.:.. . :.::::..:: XP_005 VNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACEN 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 EHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSD .. ::: ::..::.:: .: ... :: .:.. . .: .:..::.. :.. .::.: . XP_005 QQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVE 180 190 200 210 220 230 230 240 250 260 270 pF1KE4 YTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN . : :. : : : .: ::::. .:: :.. .::.:: .: : ..: XP_005 LVPPESPLAQLFLEREGPP-SLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 240 250 260 270 280 290 >>NP_001026909 (OMIM: 300890) ankyrin repeat and SOCS bo (294 aa) initn: 971 init1: 577 opt: 694 Z-score: 561.7 bits: 111.8 E(85289): 1.5e-24 Smith-Waterman score: 694; 42.3% identity (70.0% similar) in 267 aa overlap (10-275:29-291) 10 20 30 40 pF1KE4 MEPRAADGCFLGD-VGFWVERTPVHEAAQRGESLQLQQLIE ..:: :. : .:.:::: .:..:.:..:: NP_001 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDW---SPMHEAAIHGHQLSLRNLIS 10 20 30 40 50 50 60 70 80 90 100 pF1KE4 SGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIEC .: :: .:.: ..::: : : :. ::..:: ::::.. . : ::: .::.::: .: NP_001 QGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDC 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 VKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAR :.:::..::.:.: :::.::: : ::: :: :.:.. . :.::::..:: NP_001 VNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACEN 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 EHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSD .. ::: ::..::.:: .: ... :: .:.. . .: .:..::.. :.. .::.: . NP_001 QQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVE 180 190 200 210 220 230 230 240 250 260 270 pF1KE4 YTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN . : :. : : : .: ::::. .:: :.. .::.:: .: : ..: NP_001 LVPPESPLAQLFLEREGPP-SLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL 240 250 260 270 280 290 >>XP_016884772 (OMIM: 300890) PREDICTED: ankyrin repeat (377 aa) initn: 971 init1: 577 opt: 688 Z-score: 555.8 bits: 111.1 E(85289): 3.2e-24 Smith-Waterman score: 691; 40.9% identity (67.7% similar) in 279 aa overlap (6-275:97-374) 10 20 pF1KE4 MEPRAADGCFLGDVGFW---------VERTPVHEA :: . :. :.: . .:.::: XP_016 SYKLSFLPDKLQGFLTDWSQFGKGRDISNFADLGLEGSCGLWRASSQLDAVSDWSPMHEA 70 80 90 100 110 120 30 40 50 60 70 80 pF1KE4 AQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGS : .:..:.:..:: .: :: .:.: ..::: : : :. ::..:: ::::.. . : XP_016 AIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWH 130 140 150 160 170 180 90 100 110 120 130 140 pF1KE4 TPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAH ::: .::.::: .::.:::..::.:.: :::.::: : ::: :: :.:.. . XP_016 TPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHK 190 200 210 220 230 240 150 160 170 180 190 200 pF1KE4 DCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGG :.::::..:: .. ::: ::..::.:: .: ... :: .:.. . .: .:..::. XP_016 ISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGA 250 260 270 280 290 300 210 220 230 240 250 260 pF1KE4 NIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLN . :.. .::.: . . : :. : : : .: ::::. .:: :.. .::.:: XP_016 DTQAKNAEGKRPVELVPPESPLAQLFLEREGPP-SLMQLCRLRIRKCFGIQQHHKITKLV 310 320 330 340 350 360 270 pF1KE4 IPPRLIDYLSYN .: : ..: XP_016 LPEDLKQFLLHL 370 >>NP_001012428 (OMIM: 300626) ankyrin repeat and SOCS bo (302 aa) initn: 785 init1: 548 opt: 674 Z-score: 546.1 bits: 109.0 E(85289): 1.1e-23 Smith-Waterman score: 674; 40.3% identity (69.8% similar) in 268 aa overlap (10-277:37-301) 10 20 30 pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLI : :: :..:.:.:::: .:. : :. :: NP_001 ENEKNCEVSERIRRSGPWKEISFGDYICHTFQGDC--WADRSPLHEAAAQGRLLALKTLI 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE4 ESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIE .:. :: ::.. .. :: : : :.. :.. :: ::.:.. .. :.::: .:: ::: NP_001 AQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE4 CVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACA ::..:: .:::.. .. :::.::: : ::...:. ..:.. . ..::::.:::. NP_001 CVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE4 REHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPS ...:::: ::. ::.:. .. .: :: ::. .::..:..: ..:.:. :. .::. NP_001 YQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE4 DYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN : . .:. . . : : .::::::. .:: : . : ::..: : .: : NP_001 DLAAPKSSVEQALLLREGPP-ALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 250 260 270 280 290 300 >>NP_543149 (OMIM: 300626) ankyrin repeat and SOCS box p (323 aa) initn: 785 init1: 548 opt: 674 Z-score: 545.8 bits: 109.0 E(85289): 1.2e-23 Smith-Waterman score: 674; 39.4% identity (69.0% similar) in 274 aa overlap (4-277:50-322) 10 20 30 pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESL : :. . : :..:.:.:::: .:. : NP_543 TFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLL 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE4 QLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDAC :. :: .:. :: ::.. .. :: : : :.. :.. :: ::.:.. .. :.::: .:: NP_543 ALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE4 ASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTP ::: ::..:: .:::.. .. :::.::: : ::...:. ..:.. . ..::: NP_543 CSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTP 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE4 LHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDN :.:::. ...:::: ::. ::.:. .. .: :: ::. .::..:..: ..:.:. :. NP_543 LYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNA 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE4 RGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLID .::. : . .:. . . : : .::::::. .:: : . : ::..: : NP_543 QGKSALDLAAPKSSVEQALLLREGPP-ALSQLCRLCVRKCLGRACHQAIHKLHLPEPLER 260 270 280 290 300 310 pF1KE4 YLSYN .: : NP_543 FLLYQ 320 278 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:16:05 2016 done: Sun Nov 6 04:16:06 2016 Total Scan time: 7.230 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]