Result of FASTA (omim) for
pFN21AE5244
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5244, 236 aa
1>>>pF1KE5244 236 - 236 aa - 236 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3725+/-0.000322; mu= 14.5040+/- 0.020
mean_var=72.0974+/-14.957, 0's: 0 Z-trim(117.9): 21 B-trim: 1114 in 1/48
Lambda= 0.151048
statistics sampled from 30367 (30389) to 30367 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.739), E-opt: 0.2 (0.356), width: 16
Scan time: 6.110
The best scores are: opt bits E(85289)
NP_004660 (OMIM: 606533) chloride intracellular ch ( 236) 1576 352.0 5.3e-97
XP_016870770 (OMIM: 606533) PREDICTED: chloride in ( 236) 1522 340.2 1.8e-93
XP_016870771 (OMIM: 606533) PREDICTED: chloride in ( 207) 1382 309.7 2.5e-84
NP_001280 (OMIM: 300138,300886) chloride intracell ( 247) 790 180.7 2e-45
NP_039234 (OMIM: 606536) chloride intracellular ch ( 253) 775 177.4 2e-44
NP_001279 (OMIM: 602872) chloride intracellular ch ( 241) 773 177.0 2.6e-44
NP_001274523 (OMIM: 602872) chloride intracellular ( 241) 773 177.0 2.6e-44
NP_001274522 (OMIM: 602872) chloride intracellular ( 241) 773 177.0 2.6e-44
NP_058625 (OMIM: 607293,616042) chloride intracell ( 251) 771 176.6 3.6e-44
NP_001107558 (OMIM: 607293,616042) chloride intrac ( 410) 767 175.8 9.8e-44
XP_016866442 (OMIM: 607293,616042) PREDICTED: chlo ( 410) 767 175.8 9.8e-44
NP_444507 (OMIM: 615321) chloride intracellular ch ( 686) 763 175.1 2.7e-43
NP_001303938 (OMIM: 615321) chloride intracellular ( 704) 744 171.0 4.9e-42
NP_001242952 (OMIM: 607293,616042) chloride intrac ( 205) 659 152.1 6.8e-37
XP_011512994 (OMIM: 607293,616042) PREDICTED: chlo ( 371) 659 152.3 1.1e-36
XP_016883895 (OMIM: 615321) PREDICTED: chloride in ( 735) 646 149.6 1.4e-35
XP_011512996 (OMIM: 607293,616042) PREDICTED: chlo ( 331) 458 108.4 1.5e-23
>>NP_004660 (OMIM: 606533) chloride intracellular channe (236 aa)
initn: 1576 init1: 1576 opt: 1576 Z-score: 1862.5 bits: 352.0 E(85289): 5.3e-97
Smith-Waterman score: 1576; 99.6% identity (100.0% similar) in 236 aa overlap (1-236:1-236)
10 20 30 40 50 60
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGS
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 PAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKL
130 140 150 160 170 180
190 200 210 220 230
pF1KE5 HIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
190 200 210 220 230
>>XP_016870770 (OMIM: 606533) PREDICTED: chloride intrac (236 aa)
initn: 1522 init1: 1522 opt: 1522 Z-score: 1798.9 bits: 340.2 E(85289): 1.8e-93
Smith-Waterman score: 1522; 100.0% identity (100.0% similar) in 226 aa overlap (11-236:11-236)
10 20 30 40 50 60
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGS
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRGPYQGPGEKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 PAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKL
130 140 150 160 170 180
190 200 210 220 230
pF1KE5 HIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
190 200 210 220 230
>>XP_016870771 (OMIM: 606533) PREDICTED: chloride intrac (207 aa)
initn: 1382 init1: 1382 opt: 1382 Z-score: 1634.8 bits: 309.7 E(85289): 2.5e-84
Smith-Waterman score: 1382; 100.0% identity (100.0% similar) in 207 aa overlap (30-236:1-207)
10 20 30 40 50 60
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGS
:::::::::::::::::::::::::::::::
XP_016 MVLLLKGVPFTLTTVDTRRSPDVLKDFAPGS
10 20 30
70 80 90 100 110 120
pF1KE5 QLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE5 PAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKL
100 110 120 130 140 150
190 200 210 220 230
pF1KE5 HIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
160 170 180 190 200
>>NP_001280 (OMIM: 300138,300886) chloride intracellular (247 aa)
initn: 779 init1: 530 opt: 790 Z-score: 936.5 bits: 180.7 E(85289): 2e-45
Smith-Waterman score: 790; 51.7% identity (78.0% similar) in 232 aa overlap (2-229:10-239)
10 20 30 40 50
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDV
:. ...:::::. ::::.:.:: ::::::.: :::: :..:::: :.:.
NP_001 MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 LKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKF
:::.:::.. :.:.:... ::: ..::.:::.::.:: .: :.:.:.:: .: ..: ::
NP_001 LKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKF
70 80 90 100 110 120
120 130 140 150 160
pF1KE5 SAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHEL----AGEPQLRESRRRFLDGDR
::.::: .. . ..::. . :::.:: .:: :. : :: . ::: :::::.
NP_001 SAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPV--SRRLFLDGDQ
130 140 150 160 170
170 180 190 200 210 220
pF1KE5 LTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAA
::::::::::::.:. .. ..:. ::::. :: ::: .:. ..:: .:::.. :: .
NP_001 LTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENT
180 190 200 210 220 230
230
pF1KE5 YRPAVHPR
:
NP_001 YANVAKQKS
240
>>NP_039234 (OMIM: 606536) chloride intracellular channe (253 aa)
initn: 773 init1: 529 opt: 775 Z-score: 918.7 bits: 177.4 E(85289): 2e-44
Smith-Waterman score: 775; 50.7% identity (76.9% similar) in 229 aa overlap (3-229:16-244)
10 20 30 40
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTR
: ..:::::. ::::.:.:: :::::.: :::: :..:::: .
NP_039 MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 RSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGND
:.: :...:::.. :.. ..:..:::. .::.::::.: :: . .:.:.. :::::: :
NP_039 RKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 VFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHEL--AGEPQLRESRRRFLD
.: ::::.::: : .::: . ::..: .:: :: .:: :. . ... : :.:::
NP_039 IFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLD
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 GDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEI
:...:::::.:::::::: .: ..:. :: :. :. ::: .:... :: ::: . :.
NP_039 GNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV
190 200 210 220 230 240
230
pF1KE5 LAAYRPAVHPR
::
NP_039 EIAYSDVAKRLTK
250
>>NP_001279 (OMIM: 602872) chloride intracellular channe (241 aa)
initn: 774 init1: 510 opt: 773 Z-score: 916.6 bits: 177.0 E(85289): 2.6e-44
Smith-Waterman score: 773; 52.8% identity (76.4% similar) in 229 aa overlap (3-229:5-233)
10 20 30 40 50
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAP
. ...:::::. :: ..:.:: ::::::: :::: :..:::::.: .... . :
NP_001 MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 GSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKN
:.:::.::: ....::: .::.::: .: :: .:.:: :::::: :.: ::::.:::
NP_001 GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 PVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRE--SRRRFLDGDRLTLADCSL
:: .. : . ::.:: ::.:: .:: .:. : :.:.::::..::::::.:
NP_001 SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 LPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
:::::::..:: ..: :: .:::.:::..:. ..:: ::: . :: ::
NP_001 LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL
190 200 210 220 230 240
NP_001 K
>>NP_001274523 (OMIM: 602872) chloride intracellular cha (241 aa)
initn: 774 init1: 510 opt: 773 Z-score: 916.6 bits: 177.0 E(85289): 2.6e-44
Smith-Waterman score: 773; 52.8% identity (76.4% similar) in 229 aa overlap (3-229:5-233)
10 20 30 40 50
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAP
. ...:::::. :: ..:.:: ::::::: :::: :..:::::.: .... . :
NP_001 MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 GSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKN
:.:::.::: ....::: .::.::: .: :: .:.:: :::::: :.: ::::.:::
NP_001 GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 PVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRE--SRRRFLDGDRLTLADCSL
:: .. : . ::.:: ::.:: .:: .:. : :.:.::::..::::::.:
NP_001 SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 LPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
:::::::..:: ..: :: .:::.:::..:. ..:: ::: . :: ::
NP_001 LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL
190 200 210 220 230 240
NP_001 K
>>NP_001274522 (OMIM: 602872) chloride intracellular cha (241 aa)
initn: 774 init1: 510 opt: 773 Z-score: 916.6 bits: 177.0 E(85289): 2.6e-44
Smith-Waterman score: 773; 52.8% identity (76.4% similar) in 229 aa overlap (3-229:5-233)
10 20 30 40 50
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAP
. ...:::::. :: ..:.:: ::::::: :::: :..:::::.: .... . :
NP_001 MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 GSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKN
:.:::.::: ....::: .::.::: .: :: .:.:: :::::: :.: ::::.:::
NP_001 GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 PVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRE--SRRRFLDGDRLTLADCSL
:: .. : . ::.:: ::.:: .:: .:. : :.:.::::..::::::.:
NP_001 SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 LPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
:::::::..:: ..: :: .:::.:::..:. ..:: ::: . :: ::
NP_001 LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL
190 200 210 220 230 240
NP_001 K
>>NP_058625 (OMIM: 607293,616042) chloride intracellular (251 aa)
initn: 793 init1: 521 opt: 771 Z-score: 914.0 bits: 176.6 E(85289): 3.6e-44
Smith-Waterman score: 771; 52.0% identity (77.3% similar) in 229 aa overlap (3-229:13-241)
10 20 30 40 50
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSP
. ...:::::. ::::.:.:: :::::.: :::: :..:::: .:.:
NP_058 MTDSATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 DVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFH
:...:::.. :.: ...:.:::. .::.:::::: : .:.:: ..::::::: :.:
NP_058 ADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFS
70 80 90 100 110 120
120 130 140 150 160
pF1KE5 KFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEP--QLRESRRRFLDGDR
::::.::: .. :: . : .:: .::.:: .:: .:. .. . . :::.:::::.
NP_058 KFSAYIKNTKQQNNAALERGLTKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 LTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAA
::::::.::::::.: : ..:. ::::. :. ::: .:. . :: :: ..:: :
NP_058 LTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELA
190 200 210 220 230 240
230
pF1KE5 YRPAVHPR
:
NP_058 YADVAKRLSRS
250
>>NP_001107558 (OMIM: 607293,616042) chloride intracellu (410 aa)
initn: 770 init1: 521 opt: 767 Z-score: 906.2 bits: 175.8 E(85289): 9.8e-44
Smith-Waterman score: 767; 52.4% identity (77.1% similar) in 227 aa overlap (5-229:174-400)
10 20 30
pF1KE5 MVETKLQLFVKASEDGESVGHCPSCQRLFMVLLL
.. :::::. ::::.:.:: :::::.: :
NP_001 QHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVKAGIDGESIGNCPFSQRLFMILWL
150 160 170 180 190 200
40 50 60 70 80 90
pF1KE5 KGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSL
::: :..:::: .:.: :...:::.. :.: ...:.:::. .::.:::::: : .:.:
NP_001 KGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKL
210 220 230 240 250 260
100 110 120 130 140 150
pF1KE5 APRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEP
: ..::::::: :.: ::::.::: .. :: . : .:: .::.:: .:: .:. ..
NP_001 AAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALKKLDDYLNTPLPEEIDANT
270 280 290 300 310 320
160 170 180 190 200 210
pF1KE5 --QLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQE
. . :::.:::::.::::::.::::::.: : ..:. ::::. :. ::: .:. .
NP_001 CGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYAR
330 340 350 360 370 380
220 230
pF1KE5 KEFKYTCPHSAEILAAYRPAVHPR
:: :: ..:: ::
NP_001 DEFTNTCAADSEIELAYADVAKRLSRS
390 400 410
236 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:49:25 2016 done: Mon Nov 7 22:49:26 2016
Total Scan time: 6.110 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]