FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6742, 1427 aa 1>>>pF1KE6742 1427 - 1427 aa - 1427 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4424+/-0.000363; mu= 20.0642+/- 0.023 mean_var=152.3032+/-30.581, 0's: 0 Z-trim(118.8): 328 B-trim: 0 in 0/52 Lambda= 0.103925 statistics sampled from 31755 (32110) to 31755 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.376), width: 16 Scan time: 15.700 The best scores are: opt bits E(85289) NP_620594 (OMIM: 274150,604134) A disintegrin and (1427) 10218 1545.2 0 XP_016869721 (OMIM: 274150,604134) PREDICTED: A di (1423) 9936 1502.9 0 XP_016869722 (OMIM: 274150,604134) PREDICTED: A di (1297) 9301 1407.6 0 NP_620596 (OMIM: 274150,604134) A disintegrin and (1371) 8210 1244.1 0 XP_011516478 (OMIM: 274150,604134) PREDICTED: A di (1099) 7891 1196.2 0 XP_016869723 (OMIM: 274150,604134) PREDICTED: A di (1097) 7880 1194.5 0 XP_011516480 (OMIM: 274150,604134) PREDICTED: A di ( 982) 7030 1067.0 0 XP_011516481 (OMIM: 274150,604134) PREDICTED: A di ( 982) 6126 931.5 0 NP_620595 (OMIM: 274150,604134) A disintegrin and (1340) 6056 921.1 0 XP_016869724 (OMIM: 274150,604134) PREDICTED: A di ( 744) 5337 813.1 0 NP_008919 (OMIM: 605174) A disintegrin and metallo ( 967) 1087 176.0 1.3e-42 NP_008968 (OMIM: 605175) A disintegrin and metallo ( 889) 1029 167.2 4.9e-40 NP_005090 (OMIM: 603876) A disintegrin and metallo ( 837) 1016 165.3 1.8e-39 XP_011537603 (OMIM: 607506) PREDICTED: A disintegr ( 914) 997 162.4 1.4e-38 XP_011537604 (OMIM: 607506) PREDICTED: A disintegr ( 914) 997 162.4 1.4e-38 NP_631894 (OMIM: 607506) A disintegrin and metallo (1226) 997 162.6 1.7e-38 NP_008969 (OMIM: 605007) A disintegrin and metallo ( 930) 986 160.8 4.4e-38 NP_542453 (OMIM: 607506) A disintegrin and metallo (1223) 979 159.9 1.1e-37 NP_001307265 (OMIM: 603876) A disintegrin and meta ( 846) 971 158.5 2e-37 XP_011519614 (OMIM: 607511,613195) PREDICTED: A di (1145) 968 158.2 3.3e-37 NP_079279 (OMIM: 611681) A disintegrin and metallo (1910) 937 153.8 1.2e-35 NP_620686 (OMIM: 607509) A disintegrin and metallo ( 950) 931 152.6 1.4e-35 XP_011537056 (OMIM: 611681) PREDICTED: A disintegr (1911) 929 152.6 2.7e-35 XP_011541424 (OMIM: 605008) PREDICTED: A disintegr ( 827) 887 145.9 1.2e-33 XP_011541422 (OMIM: 605008) PREDICTED: A disintegr ( 868) 887 145.9 1.2e-33 XP_011541421 (OMIM: 605008) PREDICTED: A disintegr ( 892) 887 145.9 1.3e-33 XP_016865552 (OMIM: 225410,604539) PREDICTED: A di (1046) 875 144.2 4.9e-33 NP_055059 (OMIM: 225410,604539) A disintegrin and (1211) 875 144.3 5.4e-33 XP_011530724 (OMIM: 605011) PREDICTED: A disintegr (1177) 865 142.8 1.5e-32 XP_011530723 (OMIM: 605011) PREDICTED: A disintegr (1186) 865 142.8 1.5e-32 NP_055058 (OMIM: 605011) A disintegrin and metallo (1205) 865 142.8 1.5e-32 NP_620688 (OMIM: 607511,613195) A disintegrin and (1095) 862 142.3 2e-32 XP_005254929 (OMIM: 607511,613195) PREDICTED: A di (1122) 862 142.3 2e-32 XP_016877465 (OMIM: 607511,613195) PREDICTED: A di ( 946) 830 137.4 4.9e-31 XP_016877462 (OMIM: 607511,613195) PREDICTED: A di (1189) 830 137.5 5.7e-31 XP_016877473 (OMIM: 607511,613195) PREDICTED: A di ( 502) 824 136.2 6e-31 XP_016877467 (OMIM: 607511,613195) PREDICTED: A di ( 823) 826 136.8 6.8e-31 NP_620687 (OMIM: 607510) A disintegrin and metallo (1224) 825 136.8 9.8e-31 XP_011521226 (OMIM: 607512,615458) PREDICTED: A di ( 978) 817 135.5 1.9e-30 XP_011521225 (OMIM: 607512,615458) PREDICTED: A di (1049) 817 135.5 2e-30 NP_001313287 (OMIM: 607512,615458) A disintegrin a (1049) 817 135.5 2e-30 NP_955387 (OMIM: 607512,615458) A disintegrin and (1221) 817 135.6 2.3e-30 XP_016878478 (OMIM: 607512,615458) PREDICTED: A di ( 809) 800 132.9 1e-29 XP_016878477 (OMIM: 607512,615458) PREDICTED: A di ( 809) 800 132.9 1e-29 NP_001305710 (OMIM: 605421) A disintegrin and meta (1907) 803 133.7 1.3e-29 NP_891550 (OMIM: 605421) A disintegrin and metallo (1935) 803 133.7 1.3e-29 XP_011537611 (OMIM: 607506) PREDICTED: A disintegr ( 746) 754 125.9 1.1e-27 XP_011537602 (OMIM: 607506) PREDICTED: A disintegr (1056) 756 126.4 1.2e-27 XP_011541429 (OMIM: 605008) PREDICTED: A disintegr ( 612) 734 122.8 7.9e-27 XP_011541428 (OMIM: 605008) PREDICTED: A disintegr ( 613) 734 122.8 7.9e-27 >>NP_620594 (OMIM: 274150,604134) A disintegrin and meta (1427 aa) initn: 10218 init1: 10218 opt: 10218 Z-score: 8283.1 bits: 1545.2 E(85289): 0 Smith-Waterman score: 10218; 100.0% identity (100.0% similar) in 1427 aa overlap (1-1427:1-1427) 10 20 30 40 50 60 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1390 1400 1410 1420 >>XP_016869721 (OMIM: 274150,604134) PREDICTED: A disint (1423 aa) initn: 9936 init1: 9936 opt: 9936 Z-score: 8054.6 bits: 1502.9 E(85289): 0 Smith-Waterman score: 9936; 99.9% identity (100.0% similar) in 1394 aa overlap (34-1427:30-1423) 10 20 30 40 50 60 pF1KE6 RHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSP ..:::::::::::::::::::::::::::: XP_016 MKGIARPFVMMLRSGAVQPASATLLIRRRHRSCLQALEPQAVSSYLSPGAPLKGRPPSP 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 GFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 FRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE6 PSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE6 YYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVE 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE6 KWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRAC 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE6 VGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALC 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE6 RHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWD 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE6 RCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRY 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE6 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE6 EYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQ 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE6 CQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPA 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE6 RCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVT 780 790 800 810 820 830 850 860 870 880 890 900 pF1KE6 EGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGS 840 850 860 870 880 890 910 920 930 940 950 960 pF1KE6 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACS 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE6 VSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE6 CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWME 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KE6 CSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVPHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVPHEE 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE6 AAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPTGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPTGTI 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KE6 DMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDMTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDMTFS 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KE6 SKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATSNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATSNAG 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KE6 GCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWESES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWESES 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 pF1KE6 SQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT :::::::::::::::::::::::::::::::::::::::::::: XP_016 SQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1380 1390 1400 1410 1420 >>XP_016869722 (OMIM: 274150,604134) PREDICTED: A disint (1297 aa) initn: 9301 init1: 9301 opt: 9301 Z-score: 7540.5 bits: 1407.6 E(85289): 0 Smith-Waterman score: 9301; 100.0% identity (100.0% similar) in 1297 aa overlap (131-1427:1-1297) 110 120 130 140 150 160 pF1KE6 ERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQT :::::::::::::::::::::::::::::: XP_016 MVILTEPEGAPNITANLTSSLLSVCGWSQT 10 20 30 170 180 190 200 210 220 pF1KE6 INPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGV 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE6 TIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRAR 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE6 CVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTD 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE6 PLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSC 220 230 240 250 260 270 410 420 430 440 450 460 pF1KE6 GGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRS 280 290 300 310 320 330 470 480 490 500 510 520 pF1KE6 SPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLS 340 350 360 370 380 390 530 540 550 560 570 580 pF1KE6 LCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNL 400 410 420 430 440 450 590 600 610 620 630 640 pF1KE6 TSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRL 460 470 480 490 500 510 650 660 670 680 690 700 pF1KE6 EEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCG 520 530 540 550 560 570 710 720 730 740 750 760 pF1KE6 AGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGG 580 590 600 610 620 630 770 780 790 800 810 820 pF1KE6 GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAG 640 650 660 670 680 690 830 840 850 860 870 880 pF1KE6 GAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKA 700 710 720 730 740 750 890 900 910 920 930 940 pF1KE6 PSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPG 760 770 780 790 800 810 950 960 970 980 990 1000 pF1KE6 SRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPR 820 830 840 850 860 870 1010 1020 1030 1040 1050 1060 pF1KE6 PEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVR 880 890 900 910 920 930 1070 1080 1090 1100 1110 1120 pF1KE6 PEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPV 940 950 960 970 980 990 1130 1140 1150 1160 1170 1180 pF1KE6 TVRGCWAGPCVGQGTPSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVRGCWAGPCVGQGTPSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLP 1000 1010 1020 1030 1040 1050 1190 1200 1210 1220 1230 1240 pF1KE6 GPQENSVQSSACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPQENSVQSSACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGD 1060 1070 1080 1090 1100 1110 1250 1260 1270 1280 1290 1300 pF1KE6 MLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECD 1120 1130 1140 1150 1160 1170 1310 1320 1330 1340 1350 1360 pF1KE6 MQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILI 1180 1190 1200 1210 1220 1230 1370 1380 1390 1400 1410 1420 pF1KE6 RDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQS 1240 1250 1260 1270 1280 1290 pF1KE6 WKGKEGT ::::::: XP_016 WKGKEGT >>NP_620596 (OMIM: 274150,604134) A disintegrin and meta (1371 aa) initn: 8210 init1: 8210 opt: 8210 Z-score: 6656.2 bits: 1244.1 E(85289): 0 Smith-Waterman score: 9719; 96.1% identity (96.1% similar) in 1427 aa overlap (1-1427:1-1371) 10 20 30 40 50 60 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG------ 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT :::::::::: NP_620 --------------------------------------------------ACGRQHLEPT 1140 1210 1220 1230 1240 1250 1260 pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1150 1160 1170 1180 1190 1200 1270 1280 1290 1300 1310 1320 pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1210 1220 1230 1240 1250 1260 1330 1340 1350 1360 1370 1380 pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1270 1280 1290 1300 1310 1320 1390 1400 1410 1420 pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1330 1340 1350 1360 1370 >>XP_011516478 (OMIM: 274150,604134) PREDICTED: A disint (1099 aa) initn: 7891 init1: 7891 opt: 7891 Z-score: 6398.9 bits: 1196.2 E(85289): 0 Smith-Waterman score: 7891; 99.9% identity (100.0% similar) in 1099 aa overlap (329-1427:1-1099) 300 310 320 330 340 350 pF1KE6 AQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGT .::::::::::::::::::::::::::::: XP_011 MDMCQALSCHTDPLDQSSCSRLLVPLLDGT 10 20 30 360 370 380 390 400 410 pF1KE6 ECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAF 40 50 60 70 80 90 420 430 440 450 460 470 pF1KE6 GGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQ 100 110 120 130 140 150 480 490 500 510 520 530 pF1KE6 GDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDS 160 170 180 190 200 210 540 550 560 570 580 590 pF1KE6 QQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR 220 230 240 250 260 270 600 610 620 630 640 650 pF1KE6 IGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVY 280 290 300 310 320 330 660 670 680 690 700 710 pF1KE6 RRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKEL 340 350 360 370 380 390 720 730 740 750 760 770 pF1KE6 VETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLK 400 410 420 430 440 450 780 790 800 810 820 830 pF1KE6 TLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGL 460 470 480 490 500 510 840 850 860 870 880 890 pF1KE6 EAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWT 520 530 540 550 560 570 900 910 920 930 940 950 pF1KE6 PAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYK 580 590 600 610 620 630 960 970 980 990 1000 1010 pF1KE6 LAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKV 640 650 660 670 680 690 1020 1030 1040 1050 1060 1070 pF1KE6 MSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHV 700 710 720 730 740 750 1080 1090 1100 1110 1120 1130 pF1KE6 GTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSL 760 770 780 790 800 810 1140 1150 1160 1170 1180 1190 pF1KE6 VPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLE 820 830 840 850 860 870 1200 1210 1220 1230 1240 1250 pF1KE6 PTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLL 880 890 900 910 920 930 1260 1270 1280 1290 1300 1310 pF1KE6 DMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPA 940 950 960 970 980 990 1320 1330 1340 1350 1360 1370 pF1KE6 TSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLY 1000 1010 1020 1030 1040 1050 1380 1390 1400 1410 1420 pF1KE6 WESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1060 1070 1080 1090 >>XP_016869723 (OMIM: 274150,604134) PREDICTED: A disint (1097 aa) initn: 7880 init1: 7880 opt: 7880 Z-score: 6390.0 bits: 1194.5 E(85289): 0 Smith-Waterman score: 7880; 100.0% identity (100.0% similar) in 1097 aa overlap (331-1427:1-1097) 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC :::::::::::::::::::::::::::::: XP_016 MCQALSCHTDPLDQSSCSRLLVPLLDGTEC 10 20 30 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 40 50 60 70 80 90 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 100 110 120 130 140 150 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 160 170 180 190 200 210 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 220 230 240 250 260 270 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 280 290 300 310 320 330 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 340 350 360 370 380 390 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 400 410 420 430 440 450 790 800 810 820 830 840 pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 460 470 480 490 500 510 850 860 870 880 890 900 pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 520 530 540 550 560 570 910 920 930 940 950 960 pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 580 590 600 610 620 630 970 980 990 1000 1010 1020 pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 640 650 660 670 680 690 1030 1040 1050 1060 1070 1080 pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 700 710 720 730 740 750 1090 1100 1110 1120 1130 1140 pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP 760 770 780 790 800 810 1150 1160 1170 1180 1190 1200 pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT 820 830 840 850 860 870 1210 1220 1230 1240 1250 1260 pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 880 890 900 910 920 930 1270 1280 1290 1300 1310 1320 pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 940 950 960 970 980 990 1330 1340 1350 1360 1370 1380 pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1000 1010 1020 1030 1040 1050 1390 1400 1410 1420 pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1060 1070 1080 1090 >>XP_011516480 (OMIM: 274150,604134) PREDICTED: A disint (982 aa) initn: 7030 init1: 7030 opt: 7030 Z-score: 5701.8 bits: 1067.0 E(85289): 0 Smith-Waterman score: 7030; 100.0% identity (100.0% similar) in 982 aa overlap (446-1427:1-982) 420 430 440 450 460 470 pF1KE6 PAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVP :::::::::::::::::::::::::::::: XP_011 MSQQCARTDGQPLRSSPGGASFYHWGAAVP 10 20 30 480 490 500 510 520 530 pF1KE6 HSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGR 40 50 60 70 80 90 540 550 560 570 580 590 pF1KE6 MDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHL 100 110 120 130 140 150 600 610 620 630 640 650 pF1KE6 AVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADI 160 170 180 190 200 210 660 670 680 690 700 710 pF1KE6 QVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQAR 220 230 240 250 260 270 720 730 740 750 760 770 pF1KE6 KELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGS 280 290 300 310 320 330 780 790 800 810 820 830 pF1KE6 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGA 340 350 360 370 380 390 840 850 860 870 880 890 pF1KE6 DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAH 400 410 420 430 440 450 900 910 920 930 940 950 pF1KE6 VWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW 460 470 480 490 500 510 960 970 980 990 1000 1010 pF1KE6 QYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 520 530 540 550 560 570 1020 1030 1040 1050 1060 1070 pF1KE6 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYR 580 590 600 610 620 630 1080 1090 1100 1110 1120 1130 pF1KE6 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGT 640 650 660 670 680 690 1140 1150 1160 1170 1180 1190 pF1KE6 PSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQ 700 710 720 730 740 750 1200 1210 1220 1230 1240 1250 pF1KE6 HLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCR 760 770 780 790 800 810 1260 1270 1280 1290 1300 1310 pF1KE6 KLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSL 820 830 840 850 860 870 1320 1330 1340 1350 1360 1370 pF1KE6 SPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQ 880 890 900 910 920 930 1380 1390 1400 1410 1420 pF1KE6 VLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 940 950 960 970 980 >>XP_011516481 (OMIM: 274150,604134) PREDICTED: A disint (982 aa) initn: 6126 init1: 6126 opt: 6126 Z-score: 4969.3 bits: 931.5 E(85289): 0 Smith-Waterman score: 6126; 99.7% identity (99.9% similar) in 863 aa overlap (565-1427:120-982) 540 550 560 570 580 590 pF1KE6 RMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTH :. .:::::::::::::::::::::::::: XP_011 HHEAWRQLPRWDPVYAKWPPGGRDPEPVCVGQLQEYVTFLTVTPNLTSVYIANHRPLFTH 90 100 110 120 130 140 600 610 620 630 640 650 pF1KE6 LAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDAD 150 160 170 180 190 200 660 670 680 690 700 710 pF1KE6 IQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQA 210 220 230 240 250 260 720 730 740 750 760 770 pF1KE6 RKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQG 270 280 290 300 310 320 780 790 800 810 820 830 pF1KE6 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 330 340 350 360 370 380 840 850 860 870 880 890 pF1KE6 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 390 400 410 420 430 440 900 910 920 930 940 950 pF1KE6 HVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 450 460 470 480 490 500 960 970 980 990 1000 1010 pF1KE6 WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP 510 520 530 540 550 560 1020 1030 1040 1050 1060 1070 pF1KE6 RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTY 570 580 590 600 610 620 1080 1090 1100 1110 1120 1130 pF1KE6 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG 630 640 650 660 670 680 1140 1150 1160 1170 1180 1190 pF1KE6 TPSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGR 690 700 710 720 730 740 1200 1210 1220 1230 1240 1250 pF1KE6 QHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMC 750 760 770 780 790 800 1260 1270 1280 1290 1300 1310 pF1KE6 RKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPS 810 820 830 840 850 860 1320 1330 1340 1350 1360 1370 pF1KE6 LSPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQ 870 880 890 900 910 920 1380 1390 1400 1410 1420 pF1KE6 QVLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 930 940 950 960 970 980 >>NP_620595 (OMIM: 274150,604134) A disintegrin and meta (1340 aa) initn: 6046 init1: 6046 opt: 6056 Z-score: 4910.9 bits: 921.1 E(85289): 0 Smith-Waterman score: 9400; 93.9% identity (93.9% similar) in 1427 aa overlap (1-1427:1-1340) 10 20 30 40 50 60 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ :::::::::::::::::::::::::::::::::::: NP_620 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA------------------------ 250 260 270 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 -------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 280 290 300 310 320 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 570 580 590 600 610 620 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 630 640 650 660 670 680 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 690 700 710 720 730 740 790 800 810 820 830 840 pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 750 760 770 780 790 800 850 860 870 880 890 900 pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 810 820 830 840 850 860 910 920 930 940 950 960 pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 870 880 890 900 910 920 970 980 990 1000 1010 1020 pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 930 940 950 960 970 980 1030 1040 1050 1060 1070 1080 pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 990 1000 1010 1020 1030 1040 1090 1100 1110 1120 1130 1140 pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG------ 1050 1060 1070 1080 1090 1100 1150 1160 1170 1180 1190 1200 pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT :::::::::: NP_620 --------------------------------------------------ACGRQHLEPT 1110 1210 1220 1230 1240 1250 1260 pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1120 1130 1140 1150 1160 1170 1270 1280 1290 1300 1310 1320 pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1180 1190 1200 1210 1220 1230 1330 1340 1350 1360 1370 1380 pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1240 1250 1260 1270 1280 1290 1390 1400 1410 1420 pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1300 1310 1320 1330 1340 >>XP_016869724 (OMIM: 274150,604134) PREDICTED: A disint (744 aa) initn: 5337 init1: 5337 opt: 5337 Z-score: 4331.4 bits: 813.1 E(85289): 0 Smith-Waterman score: 5337; 100.0% identity (100.0% similar) in 744 aa overlap (1-744:1-744) 10 20 30 40 50 60 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::: XP_016 TVQCQGSQQPPAWPEACVLEPCPP 730 740 1427 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:55:37 2016 done: Tue Nov 8 15:55:39 2016 Total Scan time: 15.700 Total Display time: 0.630 Function used was FASTA [36.3.4 Apr, 2011]