FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6742, 1427 aa 1>>>pF1KE6742 1427 - 1427 aa - 1427 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1189+/-0.000911; mu= 22.1371+/- 0.055 mean_var=143.3145+/-28.302, 0's: 0 Z-trim(111.5): 92 B-trim: 0 in 0/51 Lambda= 0.107134 statistics sampled from 12309 (12403) to 12309 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.381), width: 16 Scan time: 4.420 The best scores are: opt bits E(32554) CCDS6970.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1427) 10218 1592.2 0 CCDS6972.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1371) 8210 1281.8 0 CCDS6971.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1340) 6056 948.9 0 CCDS33524.1 ADAMTS1 gene_id:9510|Hs108|chr21 ( 967) 1087 180.7 1.8e-44 CCDS41732.1 ADAMTS8 gene_id:11095|Hs108|chr11 ( 889) 1029 171.7 8.5e-42 CCDS1223.1 ADAMTS4 gene_id:9507|Hs108|chr1 ( 837) 1016 169.7 3.3e-41 CCDS7307.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1226) 997 166.9 3.2e-40 CCDS13579.1 ADAMTS5 gene_id:11096|Hs108|chr21 ( 930) 986 165.1 8.8e-40 CCDS7306.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1223) 979 164.1 2.2e-39 CCDS31778.2 ADAMTS20 gene_id:80070|Hs108|chr12 (1910) 937 157.9 2.7e-37 CCDS8488.1 ADAMTS15 gene_id:170689|Hs108|chr11 ( 950) 931 156.6 3.2e-37 CCDS4444.1 ADAMTS2 gene_id:9509|Hs108|chr5 (1211) 875 148.1 1.5e-34 CCDS3553.1 ADAMTS3 gene_id:9508|Hs108|chr4 (1205) 865 146.5 4.4e-34 CCDS10383.1 ADAMTS17 gene_id:170691|Hs108|chr15 (1095) 862 146.0 5.7e-34 CCDS43299.1 ADAMTS16 gene_id:170690|Hs108|chr5 (1224) 825 140.3 3.2e-32 CCDS10926.1 ADAMTS18 gene_id:170692|Hs108|chr16 (1221) 817 139.1 7.6e-32 CCDS82801.1 ADAMTS9 gene_id:56999|Hs108|chr3 (1907) 803 137.1 4.6e-31 CCDS2903.1 ADAMTS9 gene_id:56999|Hs108|chr3 (1935) 803 137.2 4.6e-31 CCDS47954.1 ADAMTSL1 gene_id:92949|Hs108|chr9 (1762) 612 107.6 3.4e-22 CCDS34311.1 ADAMTS2 gene_id:9509|Hs108|chr5 ( 566) 527 93.9 1.4e-18 CCDS4146.1 ADAMTS19 gene_id:171019|Hs108|chr5 (1207) 513 92.1 1.1e-17 CCDS34140.1 ADAMTS12 gene_id:81792|Hs108|chr5 (1594) 450 82.5 1.1e-14 CCDS6485.1 ADAMTSL1 gene_id:92949|Hs108|chr9 ( 525) 415 76.5 2.2e-13 CCDS32303.1 ADAMTS7 gene_id:11173|Hs108|chr15 (1686) 414 77.0 5.3e-13 CCDS30852.1 ADAMTSL4 gene_id:54507|Hs108|chr1 ( 877) 398 74.2 1.9e-12 CCDS955.1 ADAMTSL4 gene_id:54507|Hs108|chr1 (1074) 398 74.3 2.2e-12 CCDS72908.1 ADAMTSL4 gene_id:54507|Hs108|chr1 (1097) 398 74.3 2.2e-12 CCDS73773.1 ADAMTSL3 gene_id:57188|Hs108|chr15 (1682) 393 73.7 5e-12 CCDS10326.1 ADAMTSL3 gene_id:57188|Hs108|chr15 (1691) 393 73.7 5.1e-12 >>CCDS6970.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1427 aa) initn: 10218 init1: 10218 opt: 10218 Z-score: 8537.2 bits: 1592.2 E(32554): 0 Smith-Waterman score: 10218; 100.0% identity (100.0% similar) in 1427 aa overlap (1-1427:1-1427) 10 20 30 40 50 60 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1390 1400 1410 1420 >>CCDS6972.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1371 aa) initn: 8210 init1: 8210 opt: 8210 Z-score: 6860.1 bits: 1281.8 E(32554): 0 Smith-Waterman score: 9719; 96.1% identity (96.1% similar) in 1427 aa overlap (1-1427:1-1371) 10 20 30 40 50 60 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG------ 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT :::::::::: CCDS69 --------------------------------------------------ACGRQHLEPT 1140 1210 1220 1230 1240 1250 1260 pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1150 1160 1170 1180 1190 1200 1270 1280 1290 1300 1310 1320 pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1210 1220 1230 1240 1250 1260 1330 1340 1350 1360 1370 1380 pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1270 1280 1290 1300 1310 1320 1390 1400 1410 1420 pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1330 1340 1350 1360 1370 >>CCDS6971.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1340 aa) initn: 6046 init1: 6046 opt: 6056 Z-score: 5061.0 bits: 948.9 E(32554): 0 Smith-Waterman score: 9400; 93.9% identity (93.9% similar) in 1427 aa overlap (1-1427:1-1340) 10 20 30 40 50 60 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ :::::::::::::::::::::::::::::::::::: CCDS69 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA------------------------ 250 260 270 310 320 330 340 350 360 pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 -------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 280 290 300 310 320 370 380 390 400 410 420 pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 570 580 590 600 610 620 670 680 690 700 710 720 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 630 640 650 660 670 680 730 740 750 760 770 780 pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 690 700 710 720 730 740 790 800 810 820 830 840 pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 750 760 770 780 790 800 850 860 870 880 890 900 pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 810 820 830 840 850 860 910 920 930 940 950 960 pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 870 880 890 900 910 920 970 980 990 1000 1010 1020 pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 930 940 950 960 970 980 1030 1040 1050 1060 1070 1080 pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 990 1000 1010 1020 1030 1040 1090 1100 1110 1120 1130 1140 pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG------ 1050 1060 1070 1080 1090 1100 1150 1160 1170 1180 1190 1200 pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT :::::::::: CCDS69 --------------------------------------------------ACGRQHLEPT 1110 1210 1220 1230 1240 1250 1260 pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1120 1130 1140 1150 1160 1170 1270 1280 1290 1300 1310 1320 pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1180 1190 1200 1210 1220 1230 1330 1340 1350 1360 1370 1380 pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1240 1250 1260 1270 1280 1290 1390 1400 1410 1420 pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT ::::::::::::::::::::::::::::::::::::::::::::::: CCDS69 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1300 1310 1320 1330 1340 >>CCDS33524.1 ADAMTS1 gene_id:9510|Hs108|chr21 (967 aa) initn: 804 init1: 283 opt: 1087 Z-score: 911.9 bits: 180.7 E(32554): 1.8e-44 Smith-Waterman score: 1235; 30.2% identity (56.7% similar) in 786 aa overlap (51-804:230-966) 30 40 50 60 70 pF1KE6 CGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAP-LKG--RPPSPGFQRQRQRQRRAAG :: : :.: .: . : :..: .. CCDS33 VVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTG----SIRKKRFVS 200 210 220 230 240 250 80 90 100 110 120 130 pF1KE6 GILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEP . ..: .... .. . : ..:.:: ....:.: . ::. . . .::.... . CCDS33 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDE 260 270 280 290 300 310 140 150 160 170 180 190 pF1KE6 EGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQ . .:..:.: . .: . :.:.. :: .: : : : .. .:: :: . . .. :... CCDS33 QKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDL-CGSQTCDTLGMAD 320 330 340 350 360 370 200 210 220 230 240 250 pF1KE6 LGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG----SGCGPSGHVMASDG .: .:.:. :: . :: :.. . : :::.:: :.. :: : .: . ..:.::: CCDS33 VGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASML 380 390 400 410 420 430 260 270 280 290 300 310 pF1KE6 AAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRV . . ::::: .. :.:. :...:. : :. .: . : :: :.::.::. CCDS33 SNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ-NPIQL---PGDLPGTSYDANRQCQF 440 450 460 470 480 490 320 330 340 350 360 370 pF1KE6 AFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRS .:: . : : . :..: : :. : ::: :: ::: .:.: . CCDS33 TFGEDSKHCPDAA---STCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVN 500 510 520 530 540 380 390 400 410 420 430 pF1KE6 LVELTPI-AAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEM .. . . :: :. ::: . :::.::::: :.:.:: : ::. : : .. . CCDS33 KTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRS 550 560 570 580 590 600 440 450 460 470 480 pF1KE6 CNTQAC-EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA---LCRHMCR :: . : ... : .:: .. .. ..: :.. .: .:. : . :. .:. CCDS33 CNLEDCPDNNGKTFREEQC-EAHNEFSKASFGSGPAVEW---IPKYAGVSPKDRCKLICQ 610 620 630 640 650 660 490 500 510 520 530 540 pF1KE6 A--IGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQ : :: :... . .::: : : :.: :.::.:.: ::: .::.. .:.: CCDS33 AKGIGYFFVLQ--PKVVDGTPCSP-----DST-SVCVQGQCVKAGCDRIIDSKKKFDKCG 670 680 690 700 710 550 560 570 580 590 600 pF1KE6 VCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIA--NHRPLFTH---LAVRIG- ::::..:::. .:: :... : ..:. . :.. . :.: .. ::.. . CCDS33 VCGGNGSTCKKISGSVTSAKPG-YHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD 720 730 740 750 760 770 610 620 630 640 650 660 pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR : :.. : ...: : ... : : : . . ::.:: ..::.: ::: CCDS33 GTYILNGDYTLS--TLEQDIMYKGVV-LRYSGSS---AALERIRSFSPLKEPLTIQVLT- 780 790 800 810 820 670 680 690 700 pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQ---------AWV---WAAVRGPCSVSCGAGLRWVNY :: :: : .::: : .. ::: : : :: :: : . CCDS33 ----VGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEW----GECSKSCELGWQRRLV 830 840 850 860 870 710 720 730 740 750 760 pF1KE6 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVR : : . : : ... :: . :. .::: : .:... :: .:: : ..: .. CCDS33 ECRDINGQPASE---C-AKEVKPASTRPCADHPCPQ-WQLGEWSSCSKTCGKGYKKRSLK 880 890 900 910 920 930 770 780 790 800 810 820 pF1KE6 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALEN :. .:..:. : ..: .. :. : CCDS33 CLSHDGGVLSH---ESCDP-LKKPKHFIDFCTMAECS 940 950 960 830 840 850 860 870 880 pF1KE6 ETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIR >>CCDS41732.1 ADAMTS8 gene_id:11095|Hs108|chr11 (889 aa) initn: 946 init1: 290 opt: 1029 Z-score: 863.9 bits: 171.7 E(32554): 8.5e-42 Smith-Waterman score: 1103; 28.9% identity (53.7% similar) in 765 aa overlap (60-805:201-888) 30 40 50 60 70 80 pF1KE6 PSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVG :: : .: .: .. .: :... CCDS41 TGEGQRQERGDHQEDSEEESQEEEAEGASEPPPP--LGATSRTKRFVSEARFVETLLVAD 180 190 200 210 220 90 100 110 120 130 140 pF1KE6 PDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTS .. . : . ..:: ....:.. . ::. .. . .::..:. . . .:... : CCDS41 ASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGL 230 240 250 260 270 280 150 160 170 180 190 200 pF1KE6 SLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCL .: . :.:.. .: .: : : : .. .:: .. .: .. ::...: :.:. :: CCDS41 TLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCS 290 300 310 320 330 340 210 220 230 240 250 260 pF1KE6 ITEDTGFDLGVTIAHEIGHSFGLEHDGA-PGSGC-GPSG--HVMASDGAAPRAGLAWSPC . :: :.. . :.:::.:: ... :: . : . :: : :::: . : :::: CCDS41 VIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPC 350 360 370 380 390 400 270 280 290 300 310 320 pF1KE6 SRRQLLSLLSAGRARCVWDPPRPQPGSAGHP-PDAQPGLY--YSANEQCRVAFGPKAVAC : : ::..:.. :. : : .:. : : . :: . :. ..::: ::: : CCDS41 SAMYLTELLDGGHGDCLLDAP-----AAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHC 410 420 430 440 450 460 330 340 350 360 370 pF1KE6 TFAREHLDMCQALSCHTD---PLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELT- . . :.: : :::: :: ... . : : ::: :: . ::.: : :. CCDS41 PNTSAQ-DVCAQLWCHTDGAEPLCHTKNGSL--PWADGTPCGPGHLCSEGSCLPEEEVER 470 480 490 500 510 520 380 390 400 410 420 430 pF1KE6 PIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQAC : .. : :. ::: . :::.::::: .:.:..:.: ::: :.: . . :.:. : CCDS41 PKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEEC 530 540 550 560 570 580 440 450 460 470 480 490 pF1KE6 EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA---LCRHMCRAIGESFI : ::: . .. . : .. .: ::. : . :. .::: :.: . CCDS41 PPDGKSFREQQCEKYNAYNYTDMDG--NLLQW---VPKYAGVSPRDRCKLFCRARGRSEF 590 600 610 620 630 500 510 520 530 540 550 pF1KE6 MKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC . .::: : ::. ::..:: :.: ::: .:: . :.: :::: ...: CCDS41 KVFEAKVIDGTLC---GPE---TLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSC 640 650 660 670 680 560 570 580 590 600 610 pF1KE6 SPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVA----GKMSI .::.: : ..:. . :.. . .. .: .:. : :.. :.. . CCDS41 RKVSGSLTP-TNYGYNDIVTIPAGATNIDVKQR----SHPGVQNDGNYLALKTADGQYLL 690 700 710 720 730 740 620 630 640 650 660 670 pF1KE6 SPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRP . : . .. .: :. . . ::... . :: : .:. :: . : CCDS41 NGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFP----P 750 760 770 780 790 800 680 690 700 710 720 730 pF1KE6 DITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPP . .:.: :. :..: :. :: . : CCDS41 KVKYTFFVPND-----------------------VDFSM--QSSKERATT---------- 810 820 740 750 760 770 780 790 pF1KE6 AWPEACVLEPC-PPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ ...: :..::.. ::..::.: ..: :.: . .:. : : : CCDS41 -----NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQ-----ASATCNK-AL 830 840 850 860 870 800 810 820 830 840 850 pF1KE6 QPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVD .: : . :. : :: CCDS41 KPEDA-KPCESQLCPL 880 >>CCDS1223.1 ADAMTS4 gene_id:9507|Hs108|chr1 (837 aa) initn: 843 init1: 204 opt: 1016 Z-score: 853.3 bits: 169.7 E(32554): 3.3e-41 Smith-Waterman score: 1034; 31.1% identity (54.9% similar) in 679 aa overlap (38-682:162-805) 10 20 30 40 50 60 pF1KE6 ARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGA-------PLKGRP :: :: . .: .::: : .:. CCDS12 INGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQG 140 150 160 170 180 190 70 80 90 100 110 pF1KE6 P-----SP-GFQRQRQRQ-RRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAE : .: : : :. .: :. .: ::.. . : .::.:: . .:. CCDS12 PMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAK 200 210 220 230 240 250 120 130 140 150 160 170 pF1KE6 LLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHAD .. ::. . ....::: : .:.. . ...: : :.:.. .: .:.:: : : CCDS12 AFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFD 260 270 280 290 300 310 180 190 200 210 220 230 pF1KE6 LVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLE .. .:: :: .. .. :....: .:.:. :: :.:: :.. . : :::.:: :.. CCDS12 TAILFTRQDL-CGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 320 330 340 350 360 370 240 250 260 270 280 pF1KE6 HDGAPG--SGCGP---SGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRP ::.. : :: : :::: : ::::: : . ..:. : ..:. : CCDS12 HDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLD---- 380 390 400 410 420 290 300 310 320 330 340 pF1KE6 QPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCS .: . : : . :: :.:..::...::: . : . : :: : .. :. CCDS12 KPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCP---QLPPPCAALWCSGHLNGHAMCQ 430 440 450 460 470 480 350 360 370 380 390 400 pF1KE6 RLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVH-GRWSSWGPRSPCSRSCGGGVVTR : ::: :: . : ::: . .: . . : :. ::: . :::.::::: CCDS12 TKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFS 490 500 510 520 530 540 410 420 430 440 450 460 pF1KE6 RRQCNNPRPAFGGRACVGADLQAEMCNTQACEK-TQLEFMSQQCA----RTDGQPLRSSP :.:. : : ::. : : . . :::. : . : : .::: ::: ..: : CCDS12 SRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDL--FKSFP 550 560 570 580 590 600 470 480 490 500 510 pF1KE6 GGASFY-HWGAAVPHSQGDALCRHMCRA--IGESFIMKRGDSFLDGTRCMPSGPREDGTL : .. .. ...:..: :. :.: .: .... .::: : : :.. CCDS12 GPMDWVPRYTGVAPQDQ----CKLTCQAQALGYYYVLE--PRVVDGTPCSP-----DSS- 610 620 630 640 520 530 540 550 560 570 pF1KE6 SLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPN :.::.: : ::: . :.. .:.:.:::::.: :: ..::: : : . .:. . CCDS12 SVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-YGYNNVVTIPAG 650 660 670 680 690 700 580 590 600 610 620 630 pF1KE6 LTSVYI-----ANHRPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALT : . . .:: .. ::... : :.. :.... :. : ... : : : . CCDS12 ATHILVRQQGNPGHRSIY--LALKLPDGSYALNGEYTLMPSPT--DVVLPGAVSLRYS-- 710 720 730 740 750 760 640 650 660 670 680 690 pF1KE6 EDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRG : . ::: . .:: :: . ...: :.: CCDS12 -GATAASETLSGHGPLAQPLTLQVLVA-----GNPQDTRLRYSFFVPRPTPSTPRPTPQD 770 780 790 800 810 700 710 720 730 740 750 pF1KE6 PCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP CCDS12 WLHRRAQILEILRRRPWAGRK 820 830 >>CCDS7307.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1226 aa) initn: 1077 init1: 298 opt: 997 Z-score: 835.5 bits: 166.9 E(32554): 3.2e-40 Smith-Waterman score: 1313; 29.5% identity (55.5% similar) in 892 aa overlap (70-933:248-1092) 40 50 60 70 80 90 pF1KE6 ALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRR-AAGGILHLELLVAVGPDVFQAH-Q .:.:: : : .:.:..: .: . : . CCDS73 EPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGK 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE6 EDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNIT-ANLTSSLLSVCG : .. :::: .:: :. .: :::... . ::..... .. : .: . :: .:: CCDS73 EHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCR 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE6 WSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGF :... . .: . : : :...:: :. :.: ..: . . : : : :: .... :: CCDS73 WAHSQQRQDPSHAEHHDHVVFLTRQDFG-PSG---MQGYAPVTGMCHPLRSCALNHEDGF 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE6 DLGVTIAHEIGHSFGLEHDGAPGSGCGPS---GHVMASDGAAPRAGLAWSPCSRRQLLSL . . .:::: :: .:.:::: :.::. : ::: : . :: ::. .: CCDS73 SSAFVIAHETGHVLGMEHDGQ-GNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 400 410 420 430 440 450 280 290 300 310 320 330 pF1KE6 LSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQ : . :. : : .: . .::. ::. :: .:::: :: .: .: . .. :. CCDS73 LPS--YDCLLDDPF-DP-AWPQPPEL-PGINYSMDEQCRFDFGSGYQTC-LAFRTFEPCK 460 470 480 490 500 340 350 360 370 380 390 pF1KE6 ALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAV--HGRWSSWG : : . : . :. : ::::::. ::: ::.: . .: . : :::: CCDS73 QLWC-SHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---IWKSPEQTYGQDGGWSSWT 510 520 530 540 550 560 400 410 420 430 440 450 pF1KE6 PRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA . ::::::::: .: :.:::: ::.::: :.: .. ..::.. : : .: .:::: CCDS73 KFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCA 570 580 590 600 610 620 460 470 480 490 500 pF1KE6 RTDGQPLRSSPGGASFYHWGAAVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCM . .. .... . : ::. : :. .:.. . .. .. ::::: CCDS73 KRNSYYVHQNAK----HSW---VPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 630 640 650 660 670 510 520 530 540 550 560 pF1KE6 PSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSF-TAGRAR : :.:. : : ::: .. :... :.: ::::::: : ::.. :.. CCDS73 YRDPY-----SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQA 680 690 700 710 720 730 570 580 590 600 610 620 pF1KE6 EYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGGRYVVAGKMSISPNTTYPSL---LED . .. . . . : . ...:. . : ... : . . . :. .. :: CCDS73 GALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWED 740 750 760 770 780 790 630 640 650 660 670 680 pF1KE6 GRVEYRVAL-TEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP . . . .: : ::. : : . .. .: . : : : . . CCDS73 AVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLL--PLIGSNNVLLEE 800 810 820 830 840 690 700 710 720 730 740 pF1KE6 RQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP ... :: .::: .::.:.....:.: . ...:. :. ...: . : .: CCDS73 MDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHP 850 860 870 880 890 900 750 760 770 780 790 pF1KE6 CP-PYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC : : :.. ..: :: ::: :.. : ..:. .. . . ::. :: ..: : . : CCDS73 CSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPE-ARRPC 910 920 930 940 950 960 800 810 820 830 840 850 pF1KE6 NPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPC ::::.:... :.:... : :. .. .: .:..: . : .: . : CCDS73 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTV-------QVC 970 980 990 1000 1010 860 870 880 890 900 910 pF1KE6 VGMSCPPGWGHLDATSAGE--KAPSPWGSIRTGAQAAHVWT------PAAGSCSVSCGRG .: : .: ..: .. . .: :. .. : . : .:. :: : CCDS73 SLPAC--GGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQ-- 1020 1030 1040 1050 1060 1070 920 930 940 950 960 970 pF1KE6 LMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVV ::. .: .: ..:: CCDS73 -MEV----LDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDP 1080 1090 1100 1110 1120 1130 >>CCDS13579.1 ADAMTS5 gene_id:11096|Hs108|chr21 (930 aa) initn: 539 init1: 238 opt: 986 Z-score: 827.7 bits: 165.1 E(32554): 8.8e-40 Smith-Waterman score: 1050; 29.5% identity (54.4% similar) in 743 aa overlap (30-742:223-930) 10 20 30 40 50 pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVS-SYLSPGAPLKG :.: . : :: : .. : :::.. : CCDS13 YTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAG---G 200 210 220 230 240 60 70 80 90 100 110 pF1KE6 RPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDP :. ..:.:. :: ..:::... .. . . . ..:.:: .:. .: CCDS13 SGPQTWWRRRRRSISRAR----QVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHA 250 260 270 280 290 300 120 130 140 150 160 170 pF1KE6 SLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYI :. ..:. .::.:.: . . . ... : ...: . : :.. : : : : .. . CCDS13 SIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILF 310 320 330 340 350 360 180 190 200 210 220 230 pF1KE6 TRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAP :: :: . .. :....: ::: :: . :: :. . :.:::::: .:: :: . CCDS13 TREDL-CGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSK 370 380 390 400 410 420 240 250 260 270 280 290 pF1KE6 GS----GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG : . ..:.: .. :. :: :. . .:. :.. :. : :: : : CCDS13 FCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI--LG 430 440 450 460 470 480 300 310 320 330 340 350 pF1KE6 HPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPL :. :: :.:..:: ..:::. .: .:.: : : . : : .: CCDS13 --PEELPGQTYDATQQCNLTFGPEYSVCP----GMDVCARLWCAVVRQGQMVCLTKKLPA 490 500 510 520 530 360 370 380 390 400 410 pF1KE6 LDGTECGVEKWCSKGRCRSLVELTPIA-AVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNN ..:: :: . : .:.: . .. . . :: :.::: . ::::::::: :.::: CCDS13 VEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNN 540 550 560 570 580 590 420 430 440 450 460 470 pF1KE6 PRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAA : : .:: :.: . :. . : . : .:: .: .. : .: .: CCDS13 PAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQ-SDAKGVKTFVEW--- 600 610 620 630 640 650 480 490 500 510 520 530 pF1KE6 VPHSQG---DALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTF ::. : .:. ::: : .. . . . :::.: : .. :.:: :.: CCDS13 VPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTEC-----RLYSN-SVCVRGKCVRT 660 670 680 690 700 540 550 560 570 580 pF1KE6 GCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYI----A :::: . :. .:.: :::::::.:. :.:. ... :. . . . : . . : CCDS13 GCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK-KSKGYTDVVRIPEGATHIKVRQFKA 710 720 730 740 750 760 590 600 610 620 630 640 pF1KE6 NHRPLFT-HLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALT--EDRLPRL-- . . :: .::.. .:.:.. ::. :: . : .. .: : . . .: : . CCDS13 KDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDI--NGTVMNYSGWSHRDDFLHGMGY 770 780 790 800 810 820 650 660 670 680 690 pF1KE6 ---EEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPR-----QAWVWAAVR .:: : : : . ::. . . : .. . . . . . : : CCDS13 SATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQW--VT 830 840 850 860 870 880 700 710 720 730 740 pF1KE6 GP---CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG :: :: .: .: . . .: : :: :.. : ::.: :. . :.:. : CCDS13 GPWLACSRTCDTGWHTRTVQCQDGNRK-LAKG--CPLSQRPSAFKQ-CLLKKC 890 900 910 920 930 750 760 770 780 790 800 pF1KE6 DFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWE >>CCDS7306.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1223 aa) initn: 941 init1: 298 opt: 979 Z-score: 820.5 bits: 164.1 E(32554): 2.2e-39 Smith-Waterman score: 1301; 29.5% identity (55.2% similar) in 892 aa overlap (70-933:248-1089) 40 50 60 70 80 90 pF1KE6 ALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRR-AAGGILHLELLVAVGPDVFQAH-Q .:.:: : : .:.:..: .: . : . CCDS73 EPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGK 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE6 EDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNIT-ANLTSSLLSVCG : .. :::: .:: :. .: :::... . ::..... .. : .: . :: .:: CCDS73 EHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCR 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE6 WSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGF :... . .: . : : :...:: :. :.: : :. : : :: .... :: CCDS73 WAHSQQRQDPSHAEHHDHVVFLTRQDFG-PSGYAPVTGM------CHPLRSCALNHEDGF 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE6 DLGVTIAHEIGHSFGLEHDGAPGSGCGPS---GHVMASDGAAPRAGLAWSPCSRRQLLSL . . .:::: :: .:.:::: :.::. : ::: : . :: ::. .: CCDS73 SSAFVIAHETGHVLGMEHDGQ-GNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY 400 410 420 430 440 280 290 300 310 320 330 pF1KE6 LSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQ : . :. : : .: . .::. ::. :: .:::: :: .: .: . .. :. CCDS73 LPS--YDCLLDDPF-DP-AWPQPPEL-PGINYSMDEQCRFDFGSGYQTC-LAFRTFEPCK 450 460 470 480 490 500 340 350 360 370 380 390 pF1KE6 ALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAV--HGRWSSWG : : . : . :. : ::::::. ::: ::.: . .: . : :::: CCDS73 QLWC-SHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---IWKSPEQTYGQDGGWSSWT 510 520 530 540 550 400 410 420 430 440 450 pF1KE6 PRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA . ::::::::: .: :.:::: ::.::: :.: .. ..::.. : : .: .:::: CCDS73 KFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCA 560 570 580 590 600 610 460 470 480 490 500 pF1KE6 RTDGQPLRSSPGGASFYHWGAAVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCM . .. .... . : ::. : :. .:.. . .. .. ::::: CCDS73 KRNSYYVHQNAK----HSW---VPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 620 630 640 650 660 670 510 520 530 540 550 560 pF1KE6 PSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSF-TAGRAR : :.:. : : ::: .. :... :.: ::::::: : ::.. :.. CCDS73 YRDPY-----SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQA 680 690 700 710 720 570 580 590 600 610 620 pF1KE6 EYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGGRYVVAGKMSISPNTTYPSL---LED . .. . . . : . ...:. . : ... : . . . :. .. :: CCDS73 GALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWED 730 740 750 760 770 780 630 640 650 660 670 680 pF1KE6 GRVEYRVAL-TEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP . . . .: : ::. : : . .. .: . : : : . . CCDS73 AVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLL--PLIGSNNVLLEE 790 800 810 820 830 840 690 700 710 720 730 740 pF1KE6 RQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP ... :: .::: .::.:.....:.: . ...:. :. ...: . : .: CCDS73 MDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHP 850 860 870 880 890 900 750 760 770 780 790 pF1KE6 CP-PYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC : : :.. ..: :: ::: :.. : ..:. .. . . ::. :: ..: : . : CCDS73 CSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPE-ARRPC 910 920 930 940 950 960 800 810 820 830 840 850 pF1KE6 NPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPC ::::.:... :.:... : :. .. .: .:..: . : .: . : CCDS73 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTV-------QVC 970 980 990 1000 1010 860 870 880 890 900 910 pF1KE6 VGMSCPPGWGHLDATSAGE--KAPSPWGSIRTGAQAAHVWT------PAAGSCSVSCGRG .: : .: ..: .. . .: :. .. : . : .:. :: : CCDS73 SLPAC--GGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQ-- 1020 1030 1040 1050 1060 1070 920 930 940 950 960 970 pF1KE6 LMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVV ::. .: .: ..:: CCDS73 -MEV----LDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDP 1080 1090 1100 1110 1120 >>CCDS31778.2 ADAMTS20 gene_id:80070|Hs108|chr12 (1910 aa) initn: 981 init1: 384 opt: 937 Z-score: 783.1 bits: 157.9 E(32554): 2.7e-37 Smith-Waterman score: 1640; 27.0% identity (52.4% similar) in 1321 aa overlap (46-1325:232-1433) 20 30 40 50 60 70 pF1KE6 AGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRA : .. : ..::: .:...:..: CCDS31 SVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKD-------ERRHSRKKRL 210 220 230 240 250 80 90 100 110 120 130 pF1KE6 AGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILT . ..:..:.. : .:: . . :.:: ..: : . .:::.: ... .::.:.. CCDS31 ISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIH 260 270 280 290 300 310 140 150 160 170 180 190 pF1KE6 EPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGV . : .: :. . ...: . :.:.:: : ::. :.: : .. ::: :. . .. :. CCDS31 REEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGL 320 330 340 350 360 370 200 210 220 230 240 250 pF1KE6 TQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGP----SGHVMAS . :: :.: ::.:.:. :. . :::::.::..:..:: : : . :::: CCDS31 SYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNP--RCKEMKVTKYHVMAP 380 390 400 410 420 430 260 270 280 290 300 310 pF1KE6 DGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQC . . .:: :::. . .:..: ..:. : : . . :. :: :..:.:: CCDS31 ALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEE---IYNLPSELPGSRYDGNKQC 440 450 460 470 480 320 330 340 350 360 370 pF1KE6 RVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC ..:::: . : :...:. : : . ...: :: :::.:: : .: : CCDS31 ELAFGPGSQMCP----HINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLC 490 500 510 520 530 540 380 390 400 410 420 430 pF1KE6 RSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAE . . : :.:.:. : : : :::.::::. . :.:: :.: :: ::: .. . CCDS31 VN--KETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFR 550 560 570 580 590 600 440 450 460 470 480 pF1KE6 MCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL---CRHMCR :::..: : .: .::. .:. : : : : .: .:. .: . :. .:. CCDS31 SCNTDSCPKGTQDFREKQCSDFNGKHLDIS-GIPSNVRW---LPRYSGIGTKDRCKLYCQ 610 620 630 640 650 490 500 510 520 530 540 pF1KE6 AIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVC . : .... : ::: : : . : ..::.:.: . ::: ..:. :.: :: CCDS31 VAGTNYFYLLKDMVEDGTPC---GTE---THDICVQGQCMAAGCDHVLNSSAKIDKCGVC 660 670 680 690 700 710 550 560 570 580 590 600 pF1KE6 GGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANH----RPLFTHLAVRIG-GRY :::::.:. : :.... : . . . . :.: : .. .: ..::. . : . CCDS31 GGDNSSCKTITGVFNSSH-YGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNF 720 730 740 750 760 770 610 620 630 640 650 660 pF1KE6 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE . :.. .: . .. . :. . . ... . :.. . ... .:: CCDS31 LFNGNFLLSTSKKEINV-QGTRTVIEYSGSNNAVERINST---NRQEKELILQVL----- 780 790 800 810 820 670 680 690 700 710 pF1KE6 EYGNLTRPDITFTYFQPKPRQA--WVWAAVRGP---CSVSCGAGLRWVNYSCLDQARKEL ::: ::. ... : ... ..: :: :. : ::. : .:. .. . . CCDS31 CVGNLYNPDVHYSFNIPLEERSDMFTWDPY-GPWEGCTKMC-QGLQRRNITCIHKSDHSV 830 840 850 860 870 880 720 730 740 750 760 770 pF1KE6 VETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLK : .:. : ..: . : : : . ::..:: : : ..:.. . . CCDS31 VSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQ 890 900 910 920 930 940 780 790 800 810 820 830 pF1KE6 TLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGL :. : : . : :. . .::. :: :.:. . :.: .. :. ... CCDS31 TVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCM---NNF 950 960 970 980 990 840 850 860 870 880 890 pF1KE6 EAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWT .... . .. : : .::: .: : : :. CCDS31 GHRLADNECQELSRVTR-ENCNEFSCP-SW-----------AASEWSE------------ 1000 1010 1020 1030 900 910 920 930 940 950 pF1KE6 PAAGSCSVSCGRGLMELRFLCMDSALRVP-VQEELCGLASKPGSRREVCQAVPCPARWQY : :.::.: . . :. : : ... .:. ..:: : :. : : :: CCDS31 -----CLVTCGKGTKQRQVWCQ---LNVDHLSDGFCNSSTKPESLSP-CELHTC-ASWQV 1040 1050 1060 1070 1080 960 970 980 990 1000 1010 pF1KE6 -KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP--- . :...::.: : . :. .. . .: ::.:. :: ...: : :: CCDS31 GPWGPCTTTCGHGYQMRDVKCV----NELASAVLEDTECHEASRPSDRQSCVLTPCSFIS 1090 1100 1110 1120 1130 1020 1030 1040 1050 pF1KE6 -------P--------RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAAL : .:. : :::.::: :: : :.: .. : .::. :: : CCDS31 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC---RDALDRIADESYCAHL 1140 1150 1160 1170 1180 1190 1060 1070 1080 1090 1100 1110 pF1KE6 VRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK :: :. . : .:..: : ::.::: : :. :. . . :. ..:. . CCDS31 PRPAEIWDCF-TPCG-EWQAGDWSPCSASCGHGKTTRQVLCM--NYHQPIDENYCDPEVR 1200 1210 1220 1230 1240 1250 1120 1130 1140 1150 1160 1170 pF1KE6 PVTVRGCWAGPCVGQGTPSLVPHEEAAAPGR--TTATPAGASLEWSQARGLLFSPAPQPR :. . : . : . : : . :. .: : .:: .. . . :. . CCDS31 PLMEQECSLAAC--PPAHSHFPSSPVQ-PSYYLSTNLPLTQKLEDNENQ--VVHPSVRGN 1260 1270 1280 1290 1300 1180 1190 1200 1210 1220 1230 pF1KE6 RLLPGPQENSVQSSACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNC . :: . .: . : :: . . : : . . : .: : :. .: CCDS31 QWRTGPWGSCSSSCSGGLQH-RAVVCQDENGQSASYCDAASKPP-----ELQ------QC 1310 1320 1330 1340 1350 1240 1250 1260 1270 1280 1290 pF1KE6 SAGDMLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLA--PET . : :. .: . : . ..:. ::. : :.: .: .. ... : . CCDS31 GPGPCPQ-WNYGNWGE-CSQTCGGGIKSR---LVI---CQFPNGQILEDHNCEIVNKPPS 1360 1370 1380 1390 1400 1300 1310 1320 1330 1340 1350 pF1KE6 FYRECDMQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGAN .: :. : :: : :: ...: CCDS31 VI-QCHMHAC-PAD--VSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQK 1410 1420 1430 1440 1450 1460 1360 1370 1380 1390 1400 1410 pF1KE6 ASYILIRDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPE CCDS31 PPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQ 1470 1480 1490 1500 1510 1520 1427 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:55:36 2016 done: Tue Nov 8 15:55:37 2016 Total Scan time: 4.420 Total Display time: 0.410 Function used was FASTA [36.3.4 Apr, 2011]