FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3994, 421 aa 1>>>pF1KE3994 421 - 421 aa - 421 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1278+/-0.000534; mu= 7.6449+/- 0.033 mean_var=190.3190+/-38.481, 0's: 0 Z-trim(114.3): 289 B-trim: 36 in 1/50 Lambda= 0.092968 statistics sampled from 23669 (24059) to 23669 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.282), width: 16 Scan time: 8.140 The best scores are: opt bits E(85289) NP_060343 (OMIM: 615051) ankyrin repeat and SOCS b ( 421) 2820 391.5 2.1e-108 NP_001189332 (OMIM: 615051) ankyrin repeat and SOC ( 392) 1576 224.6 3.4e-58 NP_821066 (OMIM: 615051) ankyrin repeat and SOCS b ( 197) 873 130.0 5.2e-30 NP_065082 (OMIM: 610734) ankyrin repeat domain-con ( 360) 226 43.5 0.001 NP_001278147 (OMIM: 610734) ankyrin repeat domain- ( 446) 226 43.6 0.0012 XP_005254586 (OMIM: 612516) PREDICTED: uveal autoa (1392) 221 43.5 0.004 XP_016877884 (OMIM: 612516) PREDICTED: uveal autoa (1399) 221 43.5 0.004 NP_001008225 (OMIM: 612516) uveal autoantigen with (1403) 221 43.5 0.004 XP_016877883 (OMIM: 612516) PREDICTED: uveal autoa (1405) 221 43.5 0.004 NP_060473 (OMIM: 612516) uveal autoantigen with co (1416) 221 43.5 0.004 XP_011520055 (OMIM: 612516) PREDICTED: uveal autoa (1425) 221 43.5 0.004 XP_011520054 (OMIM: 612516) PREDICTED: uveal autoa (1436) 221 43.5 0.0041 XP_005251814 (OMIM: 600831) PREDICTED: death-assoc ( 839) 214 42.3 0.0054 >>NP_060343 (OMIM: 615051) ankyrin repeat and SOCS box p (421 aa) initn: 2820 init1: 2820 opt: 2820 Z-score: 2067.2 bits: 391.5 E(85289): 2.1e-108 Smith-Waterman score: 2820; 100.0% identity (100.0% similar) in 421 aa overlap (1-421:1-421) 10 20 30 40 50 60 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD 370 380 390 400 410 420 pF1KE3 I : NP_060 I >>NP_001189332 (OMIM: 615051) ankyrin repeat and SOCS bo (392 aa) initn: 1528 init1: 1528 opt: 1576 Z-score: 1165.9 bits: 224.6 E(85289): 3.4e-58 Smith-Waterman score: 2574; 93.1% identity (93.1% similar) in 421 aa overlap (1-421:1-392) 10 20 30 40 50 60 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHG--------- 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF :::::::::::::::::::::::::::::::::::::::: NP_001 --------------------ADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF 180 190 200 210 250 260 270 280 290 300 pF1KE3 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE3 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE3 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD 340 350 360 370 380 390 pF1KE3 I : NP_001 I >>NP_821066 (OMIM: 615051) ankyrin repeat and SOCS box p (197 aa) initn: 915 init1: 873 opt: 873 Z-score: 659.8 bits: 130.0 E(85289): 5.2e-30 Smith-Waterman score: 873; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA :::::::::::::: NP_821 LLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPA 130 140 150 160 170 180 >>NP_065082 (OMIM: 610734) ankyrin repeat domain-contain (360 aa) initn: 194 init1: 85 opt: 226 Z-score: 187.7 bits: 43.5 E(85289): 0.001 Smith-Waterman score: 226; 30.5% identity (62.6% similar) in 187 aa overlap (30-212:138-315) 10 20 30 40 50 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQE---SLDRPSYV-ASEESRILVLTEL :: .: .:. ... :. :... :. .. NP_065 DVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKF 110 120 130 140 150 160 60 70 80 90 100 110 pF1KE3 LERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQ : . . .. .:: . . : . . :: .::...:.: . ::.: : .. NP_065 LADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC-TAMHWACRGGH 170 180 190 200 210 220 120 130 140 150 160 170 pF1KE3 PDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTAL ..:.:: ::::.: ::.. :.:: .: . . . ....:.:: ..:: :..: ::: NP_065 LEVVKLLQSHGADTNVRDKLL-STPLHVAVRTGQ-VEIVEHFLSLGLEINARDREGDTAL 230 240 250 260 270 280 180 190 200 210 220 230 pF1KE3 LHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMI : :.:... . :.::: :::. . . : : NP_065 -H-----DAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGA 290 300 310 320 330 240 250 260 270 280 290 pF1KE3 NRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGAS NP_065 EHNGLEGPNDSGRETPQPVPAQ 340 350 360 >>NP_001278147 (OMIM: 610734) ankyrin repeat domain-cont (446 aa) initn: 194 init1: 85 opt: 226 Z-score: 186.6 bits: 43.6 E(85289): 0.0012 Smith-Waterman score: 226; 30.5% identity (62.6% similar) in 187 aa overlap (30-212:224-401) 10 20 30 40 50 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQE---SLDRPSYV-ASEESRILVLTEL :: .: .:. ... :. :... :. .. NP_001 DVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKF 200 210 220 230 240 250 60 70 80 90 100 110 pF1KE3 LERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQ : . . .. .:: . . : . . :: .::...:.: . ::.: : .. NP_001 LADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC-TAMHWACRGGH 260 270 280 290 300 310 120 130 140 150 160 170 pF1KE3 PDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTAL ..:.:: ::::.: ::.. :.:: .: . . . ....:.:: ..:: :..: ::: NP_001 LEVVKLLQSHGADTNVRDKLL-STPLHVAVRTGQ-VEIVEHFLSLGLEINARDREGDTAL 320 330 340 350 360 370 180 190 200 210 220 230 pF1KE3 LHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMI : :.:... . :.::: :::. . . : : NP_001 -H-----DAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGA 380 390 400 410 420 240 250 260 270 280 290 pF1KE3 NRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGAS NP_001 EHNGLEGPNDSGRETPQPVPAQ 430 440 >>XP_005254586 (OMIM: 612516) PREDICTED: uveal autoantig (1392 aa) initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004 Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:37-277) 10 20 30 40 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE : .::.. :. .: . . : . :.. . XP_005 SCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA . . :. .: . . . . ::: :. : . . ::... . : . :: XP_005 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA :: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::. XP_005 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG ::...:::. . . :.:. :.: .: :: : : . .. ::.. :. : XP_005 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE .:.. . .... . . .. . :.: : . .:. XP_005 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL XP_005 IQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGS 300 310 320 330 340 350 >>XP_016877884 (OMIM: 612516) PREDICTED: uveal autoantig (1399 aa) initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004 Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:33-273) 10 20 30 40 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE : .::.. :. .: . . : . :.. . XP_016 MREKTYKHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA . . :. .: . . . . ::: :. : . . ::... . : . :: XP_016 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA :: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::. XP_016 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG ::...:::. . . :.:. :.: .: :: : : . .. ::.. :. : XP_016 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE .:.. . .... . . .. . :.: : . .:. XP_016 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL XP_016 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNR 300 310 320 330 340 350 >>NP_001008225 (OMIM: 612516) uveal autoantigen with coi (1403 aa) initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004 Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:37-277) 10 20 30 40 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE : .::.. :. .: . . : . :.. . NP_001 SCTPKNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA . . :. .: . . . . ::: :. : . . ::... . : . :: NP_001 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA :: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::. NP_001 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG ::...:::. . . :.:. :.: .: :: : : . .. ::.. :. : NP_001 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE .:.. . .... . . .. . :.: : . .:. NP_001 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL NP_001 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNR 300 310 320 330 340 350 >>XP_016877883 (OMIM: 612516) PREDICTED: uveal autoantig (1405 aa) initn: 236 init1: 92 opt: 221 Z-score: 177.1 bits: 43.5 E(85289): 0.004 Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:50-290) 10 20 30 40 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE : .::.. :. .: . . : . :.. . XP_016 GAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA . . :. .: . . . . ::: :. : . . ::... . : . :: XP_016 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA :: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::. XP_016 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG ::...:::. . . :.:. :.: .: :: : : . .. ::.. :. : XP_016 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE .:.. . .... . . .. . :.: : . .:. XP_016 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL XP_016 IQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGS 320 330 340 350 360 370 >>NP_060473 (OMIM: 612516) uveal autoantigen with coiled (1416 aa) initn: 236 init1: 92 opt: 221 Z-score: 177.0 bits: 43.5 E(85289): 0.004 Smith-Waterman score: 221; 27.0% identity (57.3% similar) in 248 aa overlap (18-260:50-290) 10 20 30 40 pF1KE3 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSY-VASEE : .::.. :. .: . . : . :.. . NP_060 GAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGV-NPGKLDVEGRSVFHVVTSK 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE3 SRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTA . . :. .: . . . . ::: :. : . . ::... . : . :: NP_060 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTA 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE3 LHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA :: :.. . :. ..:: :::.:: .: . .:: ::.. . : : :.: :::::. NP_060 LHDAAMADCPSSIQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNS 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE3 ADKHGKTALLHA--LASSDGVQ--IHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG ::...:::. . . :.:. :.: .: :: : : . .. ::.. :. : NP_060 RDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNL---DILTLL 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE3 ETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE .:.. . .... . . .. . :.: : . .:. NP_060 KTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRK 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE3 SGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQL NP_060 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNR 320 330 340 350 360 370 421 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:09:43 2016 done: Sun Nov 6 08:09:44 2016 Total Scan time: 8.140 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]