FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6461, 475 aa 1>>>pF1KE6461 475 - 475 aa - 475 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5110+/-0.000368; mu= 17.0849+/- 0.023 mean_var=70.7876+/-14.774, 0's: 0 Z-trim(113.4): 36 B-trim: 97 in 1/53 Lambda= 0.152439 statistics sampled from 22699 (22733) to 22699 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.267), width: 16 Scan time: 8.890 The best scores are: opt bits E(85289) NP_149040 (OMIM: 608956) thymic stromal cotranspor ( 475) 3075 685.6 8.1e-197 NP_861450 (OMIM: 616764) solute carrier family 46 ( 461) 399 97.0 1.1e-19 XP_005266418 (OMIM: 616764) PREDICTED: solute carr ( 463) 399 97.0 1.2e-19 NP_001129391 (OMIM: 616764) solute carrier family ( 463) 399 97.0 1.2e-19 XP_016879599 (OMIM: 229050,611672) PREDICTED: prot ( 385) 284 71.7 4e-12 NP_542400 (OMIM: 229050,611672) proton-coupled fol ( 459) 284 71.7 4.7e-12 XP_005277843 (OMIM: 229050,611672) PREDICTED: prot ( 415) 170 46.7 0.00015 NP_001229295 (OMIM: 229050,611672) proton-coupled ( 431) 170 46.7 0.00016 >>NP_149040 (OMIM: 608956) thymic stromal cotransporter (475 aa) initn: 3075 init1: 3075 opt: 3075 Z-score: 3654.5 bits: 685.6 E(85289): 8.1e-197 Smith-Waterman score: 3075; 99.8% identity (100.0% similar) in 475 aa overlap (1-475:1-475) 10 20 30 40 50 60 pF1KE6 MSPEVTCPRRGHLPRFHPRTWVEPVMASSQVAASLYDAGLLLVVKASYGTGGSSNHSASP :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: NP_149 MSPEVTCPRRGHLPRFHPRTWVEPVVASSQVAASLYDAGLLLVVKASYGTGGSSNHSASP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SPRGALEDQQQRAISNFYIIYNLVVGLSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 SPRGALEDQQQRAISNFYIIYNLVVGLSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 LGLLLKVLLDWPVEVLYGAAALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 LGLLLKVLLDWPVEVLYGAAALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLML 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GLAGFCGSMASGHLFKQMAGHSGQGLILTACSVSCASFALLYSLLVLKVPESVAKPSQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 GLAGFCGSMASGHLFKQMAGHSGQGLILTACSVSCASFALLYSLLVLKVPESVAKPSQEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 PAVDTVSGTVGTYRTLDPDQLDQQYAVGHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 PAVDTVSGTVGTYRTLDPDQLDQQYAVGHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 VDVIPLFVLREPLGWNQVQVGYGMAAGYTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 VDVIPLFVLREPLGWNQVQVGYGMAAGYTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 GALLLAFVKETYMFYIARAVMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLALTGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 GALLLAFVKETYMFYIARAVMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLALTGV 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 VTSTLYNKIYQLTMDMFVGSCFALSSFLSFLAIIPISIVAYKQVPLSPYGDIIEK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 VTSTLYNKIYQLTMDMFVGSCFALSSFLSFLAIIPISIVAYKQVPLSPYGDIIEK 430 440 450 460 470 >>NP_861450 (OMIM: 616764) solute carrier family 46 memb (461 aa) initn: 433 init1: 358 opt: 399 Z-score: 474.1 bits: 97.0 E(85289): 1.1e-19 Smith-Waterman score: 577; 30.3% identity (64.2% similar) in 402 aa overlap (61-459:56-436) 40 50 60 70 80 pF1KE6 VAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYIIYNLVVGLSP- :: :.... :. .: : . .. . :: : NP_861 QYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMD-ISGLIPG 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE6 LLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGAAALNGLFGGF :.:.. : .::.: ::. . .: .: : . . : : . .: ..: ... .... :.. NP_861 LVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNY 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE6 SAFWSGVMALGSLGSSEGR-RSVRLILIDLMLGLA-GFCGSMASGHLFKQMAGHSGQGLI ..::.. .: .: . ...:. .::..:::. :. : ..::...... : . :: NP_861 TTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTG-LSSGYFIREL-GFEWSFLI 150 160 170 180 190 200 210 220 230 240 250 260 pF1KE6 LTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPDQLDQQYAV . .:: : :.: :. : : . . ::.. :.: . : ...: . . : . NP_861 I---AVSLA-VNLIYILFFLGDPVKECS-SQNV----TMSCSEG-FKNL----FYRTYML 210 220 230 240 270 280 290 300 310 320 pF1KE6 GHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAG . : :: .. . ::. .: : ..:.: . .. :. : :: ::.: .::: : : NP_861 FKNAS-GK---RRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALG 250 260 270 280 290 300 330 340 350 360 370 380 pF1KE6 YTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAVMLFALIP . :.:::::. .:: :..: : .::. . .: . ::.. : :...::. .::...: NP_861 SASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVP 310 320 330 340 350 360 390 400 410 420 430 440 pF1KE6 VTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSF ...:: .::..... : .:. . . .: ::.. . .: ::. :. . : : ::. NP_861 FSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAG 370 380 390 400 410 420 450 460 470 pF1KE6 LSFLAIIPISIVAYKQVPLSPYGDIIEK : .: : . .: NP_861 LLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDR 430 440 450 460 >>XP_005266418 (OMIM: 616764) PREDICTED: solute carrier (463 aa) initn: 433 init1: 358 opt: 399 Z-score: 474.0 bits: 97.0 E(85289): 1.2e-19 Smith-Waterman score: 577; 30.3% identity (64.2% similar) in 402 aa overlap (61-459:56-436) 40 50 60 70 80 pF1KE6 VAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYIIYNLVVGLSP- :: :.... :. .: : . .. . :: : XP_005 QYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMD-ISGLIPG 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE6 LLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGAAALNGLFGGF :.:.. : .::.: ::. . .: .: : . . : : . .: ..: ... .... :.. XP_005 LVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNY 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE6 SAFWSGVMALGSLGSSEGR-RSVRLILIDLMLGLA-GFCGSMASGHLFKQMAGHSGQGLI ..::.. .: .: . ...:. .::..:::. :. : ..::...... : . :: XP_005 TTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTG-LSSGYFIREL-GFEWSFLI 150 160 170 180 190 200 210 220 230 240 250 260 pF1KE6 LTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPDQLDQQYAV . .:: : :.: :. : : . . ::.. :.: . : ...: . . : . XP_005 I---AVSLA-VNLIYILFFLGDPVKECS-SQNV----TMSCSEG-FKNL----FYRTYML 210 220 230 240 270 280 290 300 310 320 pF1KE6 GHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAG . : :: .. . ::. .: : ..:.: . .. :. : :: ::.: .::: : : XP_005 FKNAS-GK---RRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALG 250 260 270 280 290 300 330 340 350 360 370 380 pF1KE6 YTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAVMLFALIP . :.:::::. .:: :..: : .::. . .: . ::.. : :...::. .::...: XP_005 SASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVP 310 320 330 340 350 360 390 400 410 420 430 440 pF1KE6 VTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSF ...:: .::..... : .:. . . .: ::.. . .: ::. :. . : : ::. XP_005 FSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAG 370 380 390 400 410 420 450 460 470 pF1KE6 LSFLAIIPISIVAYKQVPLSPYGDIIEK : .: : . .: XP_005 LLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDRAC 430 440 450 460 >>NP_001129391 (OMIM: 616764) solute carrier family 46 m (463 aa) initn: 433 init1: 358 opt: 399 Z-score: 474.0 bits: 97.0 E(85289): 1.2e-19 Smith-Waterman score: 577; 30.3% identity (64.2% similar) in 402 aa overlap (61-459:56-436) 40 50 60 70 80 pF1KE6 VAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYIIYNLVVGLSP- :: :.... :. .: : . .. . :: : NP_001 QYVYRRIWEETGNYTFSSDSNISECEKNKSSPIFAFQEEVQKKVSRFNLQMD-ISGLIPG 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE6 LLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGAAALNGLFGGF :.:.. : .::.: ::. . .: .: : . . : : . .: ..: ... .... :.. NP_001 LVSTFILLSISDHYGRKFPMILSSVGALATSVWLCLLCYFAFPFQLLIASTFIGAFCGNY 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE6 SAFWSGVMALGSLGSSEGR-RSVRLILIDLMLGLA-GFCGSMASGHLFKQMAGHSGQGLI ..::.. .: .: . ...:. .::..:::. :. : ..::...... : . :: NP_001 TTFWGACFAYIVDQCKEHKQKTIRIAIIDFLLGLVTGLTG-LSSGYFIREL-GFEWSFLI 150 160 170 180 190 200 210 220 230 240 250 260 pF1KE6 LTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPDQLDQQYAV . .:: : :.: :. : : . . ::.. :.: . : ...: . . : . NP_001 I---AVSLA-VNLIYILFFLGDPVKECS-SQNV----TMSCSEG-FKNL----FYRTYML 210 220 230 240 270 280 290 300 310 320 pF1KE6 GHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAG . : :: .. . ::. .: : ..:.: . .. :. : :: ::.: .::: : : NP_001 FKNAS-GK---RRFLLCLLLFTVITYFFVVIGIAPIFILYELDSPLCWNEVFIGYGSALG 250 260 270 280 290 300 330 340 350 360 370 380 pF1KE6 YTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAVMLFALIP . :.:::::. .:: :..: : .::. . .: . ::.. : :...::. .::...: NP_001 SASFLTSFLGIWLFSYCMEDIHMAFIGIFTTMTGMAMTAFASTTLMMFLARVPFLFTIVP 310 320 330 340 350 360 390 400 410 420 430 440 pF1KE6 VTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSF ...:: .::..... : .:. . . .: ::.. . .: ::. :. . : : ::. NP_001 FSVLRSMLSKVVRSTEQGTLFACIAFLETLGGVTAVSTFNGIYSATVAWYPGFTFLLSAG 370 380 390 400 410 420 450 460 470 pF1KE6 LSFLAIIPISIVAYKQVPLSPYGDIIEK : .: : . .: NP_001 LLLLPAISLCVVKCTSWNEGSYELLIQEESSEDASDRAC 430 440 450 460 >>XP_016879599 (OMIM: 229050,611672) PREDICTED: proton-c (385 aa) initn: 329 init1: 182 opt: 284 Z-score: 338.6 bits: 71.7 E(85289): 4e-12 Smith-Waterman score: 388; 24.2% identity (57.7% similar) in 409 aa overlap (69-468:2-385) 40 50 60 70 80 90 pF1KE6 GLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYIIYNLVVG-LSPLLSAYGLG :. ..... . .: : : : :.:. :: XP_016 MQEVETLTSHWTLYMNVGGFLVGLFSSTLLG 10 20 30 100 110 120 130 140 150 pF1KE6 WLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGAAALNGLFGGFSAFWSGVM :: :. . .. ::.::. : .. : :. : . . : .:.: :... .. . XP_016 AWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE6 ALGSLGSSEGRRSVRLILIDLMLGLAGFCGSMASGHLFKQMAGHSGQGLILTACSVSCAS : . :: :. :. :.. .:.::. .:. .:: .. . :... . : .. . XP_016 ASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQ-GYANPFWLALALLIAMTL 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE6 FALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPDQLDQQYAVGHPPSPGKAK .: . .:: :.:. . :.: .. : :.. :.: :.. XP_016 YAAFCFGETLKEPKST---------------RLFTFR--HHRSIVQLYVA---PAPEKSR 160 170 180 190 280 290 300 310 320 330 pF1KE6 PHKTTIAL-LFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAGYTIFITSFL : . .: .:: .. :. :.. :. : :: :.. .::: :: . ..::.: XP_016 KHLALYSLAIFVVITVH----FGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLL 200 210 220 230 240 340 350 360 370 380 390 pF1KE6 GVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAVMLFALIPVTTIRSAMS .. ... :. :. . ::.. : ...::. : ... . ......:. . .::. .: XP_016 ALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLS 250 260 270 280 290 300 400 410 420 430 440 450 pF1KE6 KLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSFLSFLAIIPI ::.. . : .: . .:. ...: ..:..: :.... : : :.. : .. . : XP_016 KLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLI 310 320 330 340 350 360 460 470 pF1KE6 SIVA-------YKQVPLSPYGDIIEK ... ..: : :: XP_016 GMLEKADPHLEFQQFPQSP 370 380 >>NP_542400 (OMIM: 229050,611672) proton-coupled folate (459 aa) initn: 379 init1: 182 opt: 284 Z-score: 337.4 bits: 71.7 E(85289): 4.7e-12 Smith-Waterman score: 412; 24.6% identity (57.7% similar) in 426 aa overlap (51-468:64-459) 30 40 50 60 70 80 pF1KE6 WVEPVMASSQVAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYII :: ::.::.:. :. ..... . . NP_542 FALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTM------QEVETLTSHWTL 40 50 60 70 80 90 100 110 120 130 pF1KE6 YNLVVG-LSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGA : : : : :.:. :: :: :. . .. ::.::. : .. : :. : . . NP_542 YMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLG 90 100 110 120 130 140 140 150 160 170 180 190 pF1KE6 AALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLMLGLAGFCGSMASGHLFKQMA : .:.: :... .. .: . :: :. :. :.. .:.::. .:. .:: .. . NP_542 RILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQ- 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE6 GHSGQGLILTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPD :... . : .. . .: . .:: :.:. . :.: NP_542 GYANPFWLALALLIAMTLYAAFCFGETLKEPKST---------------RLFTFR--HHR 210 220 230 240 260 270 280 290 300 310 pF1KE6 QLDQQYAVGHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQ .. : :.. :.: :.. : .:: .. .. . :. :.. :. : :: :.. NP_542 SIVQLYVA---PAPEKSRKH---LALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKL 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE6 VGYGMAAGYTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARA .::: :: . ..::.:.. ... :. :. . ::.. : ...::. : ... . . NP_542 IGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYG 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE6 VMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVG .....:. . .::. .:::.. . : .: . .:. ...: ..:..: :.... : NP_542 LLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKG 370 380 390 400 410 420 440 450 460 470 pF1KE6 SCFALSSFLSFLAIIPISIVA-------YKQVPLSPYGDIIEK : :.. : .. . :... ..: : :: NP_542 FPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP 430 440 450 >>XP_005277843 (OMIM: 229050,611672) PREDICTED: proton-c (415 aa) initn: 341 init1: 144 opt: 170 Z-score: 202.6 bits: 46.7 E(85289): 0.00015 Smith-Waterman score: 298; 25.7% identity (56.3% similar) in 327 aa overlap (51-375:64-359) 30 40 50 60 70 80 pF1KE6 WVEPVMASSQVAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYII :: ::.::.:. :. ..... . . XP_005 FALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTM------QEVETLTSHWTL 40 50 60 70 80 90 100 110 120 130 pF1KE6 YNLVVG-LSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGA : : : : :.:. :: :: :. . .. ::.::. : .. : :. : . . XP_005 YMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLG 90 100 110 120 130 140 140 150 160 170 180 190 pF1KE6 AALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLMLGLAGFCGSMASGHLFKQMA : .:.: :... .. .: . :: :. :. :.. .:.::. .:. .:: .. . XP_005 RILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQ- 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE6 GHSGQGLILTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPD :... . : .. . .: . .:: :.:. . :.: XP_005 GYANPFWLALALLIAMTLYAAFCFGETLKEPKST---------------RLFTFR--HHR 210 220 230 240 260 270 280 290 300 310 pF1KE6 QLDQQYAVGHPPSPGKAKPHKTTIAL-LFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQV .. : :.. :.: :.. : . .: .:: .. :. :.. :. : :: :.. XP_005 SIVQLYVA---PAPEKSRKHLALYSLAIFVVITVH----FGAQDILTLYELSTPLCWDSK 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE6 QVGYGMAAGYTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIAR .::: :: . ..::.:.. ... :. :. . ::.. : ...::. : ... XP_005 LIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGC 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE6 AVMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFV XP_005 WKRLILTSSSSSFPRAPDLPGPEDRGQEEQSEHQATGGLQLEAQPTAGQATLV 370 380 390 400 410 >>NP_001229295 (OMIM: 229050,611672) proton-coupled fola (431 aa) initn: 341 init1: 144 opt: 170 Z-score: 202.3 bits: 46.7 E(85289): 0.00016 Smith-Waterman score: 305; 23.7% identity (54.7% similar) in 426 aa overlap (51-468:64-431) 30 40 50 60 70 80 pF1KE6 WVEPVMASSQVAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYII :: ::.::.:. :. ..... . . NP_001 FALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTM------QEVETLTSHWTL 40 50 60 70 80 90 100 110 120 130 pF1KE6 YNLVVG-LSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGA : : : : :.:. :: :: :. . .. ::.::. : .. : :. : . . NP_001 YMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLG 90 100 110 120 130 140 140 150 160 170 180 190 pF1KE6 AALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLMLGLAGFCGSMASGHLFKQMA : .:.: :... .. .: . :: :. :. :.. .:.::. .:. .:: .. . NP_001 RILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQ- 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE6 GHSGQGLILTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPD :... . : .. . .: . .:: :.:. . :.: NP_001 GYANPFWLALALLIAMTLYAAFCFGETLKEPKST---------------RLFTFR--HHR 210 220 230 240 260 270 280 290 300 310 pF1KE6 QLDQQYAVGHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQ .. : :.. :.: :.. : .:: .. .. . :. :.. :. : :: :.. NP_001 SIVQLYVA---PAPEKSRKH---LALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKL 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE6 VGYGMAAGYTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARA .::: :: . ..::.:.. ... :. :. . ::. .:. .:..: NP_001 IGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGL-AFN----ILGMV----------- 310 320 330 340 380 390 400 410 420 430 pF1KE6 VMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVG .::. .: . .. :. .. : . .:.. ...: ..:..: :.... : NP_001 --VFAFATITPL------MFTGALFSAVACVNSLAM----LTASGIFNSLYPATLNFMKG 350 360 370 380 390 440 450 460 470 pF1KE6 SCFALSSFLSFLAIIPISIVA-------YKQVPLSPYGDIIEK : :.. : .. . :... ..: : :: NP_001 FPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP 400 410 420 430 475 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:31:13 2016 done: Tue Nov 8 13:31:15 2016 Total Scan time: 8.890 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]