FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1765, 270 aa 1>>>pF1KE1765 270 - 270 aa - 270 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3621+/-0.000389; mu= 14.6749+/- 0.024 mean_var=65.2726+/-13.085, 0's: 0 Z-trim(112.3): 37 B-trim: 1268 in 1/52 Lambda= 0.158748 statistics sampled from 21075 (21111) to 21075 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.623), E-opt: 0.2 (0.248), width: 16 Scan time: 6.190 The best scores are: opt bits E(85289) NP_001300973 (OMIM: 608678) interleukin-33 isoform ( 270) 1797 420.3 1.8e-117 NP_254274 (OMIM: 608678) interleukin-33 isoform a ( 270) 1797 420.3 1.8e-117 NP_001300974 (OMIM: 608678) interleukin-33 isoform ( 270) 1797 420.3 1.8e-117 XP_016870774 (OMIM: 608678) PREDICTED: interleukin ( 264) 1737 406.6 2.5e-113 NP_001300975 (OMIM: 608678) interleukin-33 isoform ( 264) 1737 406.6 2.5e-113 NP_001300976 (OMIM: 608678) interleukin-33 isoform ( 264) 1737 406.6 2.5e-113 XP_011516363 (OMIM: 608678) PREDICTED: interleukin ( 229) 1523 357.5 1.2e-98 NP_001300977 (OMIM: 608678) interleukin-33 isoform ( 228) 1044 247.8 1.3e-65 NP_001186569 (OMIM: 608678) interleukin-33 isoform ( 228) 789 189.4 5e-48 NP_001186570 (OMIM: 608678) interleukin-33 isoform ( 144) 774 185.9 3.6e-47 >>NP_001300973 (OMIM: 608678) interleukin-33 isoform a p (270 aa) initn: 1797 init1: 1797 opt: 1797 Z-score: 2229.8 bits: 420.3 E(85289): 1.8e-117 Smith-Waterman score: 1797; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 190 200 210 220 230 240 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: NP_001 GVKDNHLALIKVDSSENLCTENILFKLSET 250 260 270 >>NP_254274 (OMIM: 608678) interleukin-33 isoform a prec (270 aa) initn: 1797 init1: 1797 opt: 1797 Z-score: 2229.8 bits: 420.3 E(85289): 1.8e-117 Smith-Waterman score: 1797; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_254 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_254 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_254 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_254 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 190 200 210 220 230 240 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: NP_254 GVKDNHLALIKVDSSENLCTENILFKLSET 250 260 270 >>NP_001300974 (OMIM: 608678) interleukin-33 isoform a p (270 aa) initn: 1797 init1: 1797 opt: 1797 Z-score: 2229.8 bits: 420.3 E(85289): 1.8e-117 Smith-Waterman score: 1797; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 190 200 210 220 230 240 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: NP_001 GVKDNHLALIKVDSSENLCTENILFKLSET 250 260 270 >>XP_016870774 (OMIM: 608678) PREDICTED: interleukin-33 (264 aa) initn: 1015 init1: 1015 opt: 1737 Z-score: 2155.7 bits: 406.6 E(85289): 2.5e-113 Smith-Waterman score: 1737; 97.8% identity (97.8% similar) in 270 aa overlap (1-270:1-264) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT :::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSS------IT 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 180 190 200 210 220 230 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: XP_016 GVKDNHLALIKVDSSENLCTENILFKLSET 240 250 260 >>NP_001300975 (OMIM: 608678) interleukin-33 isoform d [ (264 aa) initn: 1015 init1: 1015 opt: 1737 Z-score: 2155.7 bits: 406.6 E(85289): 2.5e-113 Smith-Waterman score: 1737; 97.8% identity (97.8% similar) in 270 aa overlap (1-270:1-264) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT :::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_001 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSS------IT 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 180 190 200 210 220 230 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: NP_001 GVKDNHLALIKVDSSENLCTENILFKLSET 240 250 260 >>NP_001300976 (OMIM: 608678) interleukin-33 isoform d [ (264 aa) initn: 1015 init1: 1015 opt: 1737 Z-score: 2155.7 bits: 406.6 E(85289): 2.5e-113 Smith-Waterman score: 1737; 97.8% identity (97.8% similar) in 270 aa overlap (1-270:1-264) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT :::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_001 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSS------IT 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 180 190 200 210 220 230 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: NP_001 GVKDNHLALIKVDSSENLCTENILFKLSET 240 250 260 >>XP_011516363 (OMIM: 608678) PREDICTED: interleukin-33 (229 aa) initn: 1523 init1: 1523 opt: 1523 Z-score: 1891.8 bits: 357.5 E(85289): 1.2e-98 Smith-Waterman score: 1523; 100.0% identity (100.0% similar) in 229 aa overlap (42-270:1-229) 20 30 40 50 60 70 pF1KE1 ISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLK :::::::::::::::::::::::::::::: XP_011 MYFMKLRSGLMIKKEACYFRRETTKRPSLK 10 20 30 80 90 100 110 120 130 pF1KE1 TGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYND 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE1 QSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKD 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE1 FWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIK 160 170 180 190 200 210 260 270 pF1KE1 VDSSENLCTENILFKLSET ::::::::::::::::::: XP_011 VDSSENLCTENILFKLSET 220 >>NP_001300977 (OMIM: 608678) interleukin-33 isoform e [ (228 aa) initn: 1044 init1: 1044 opt: 1044 Z-score: 1298.9 bits: 247.8 E(85289): 1.3e-65 Smith-Waterman score: 1423; 84.4% identity (84.4% similar) in 270 aa overlap (1-270:1-228) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT ::::::::::::: ::::: NP_001 RRETTKRPSLKTG------------------------------------------ISPIT 70 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 140 150 160 170 180 190 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: NP_001 GVKDNHLALIKVDSSENLCTENILFKLSET 200 210 220 >>NP_001186569 (OMIM: 608678) interleukin-33 isoform b [ (228 aa) initn: 789 init1: 789 opt: 789 Z-score: 983.3 bits: 189.4 E(85289): 5e-48 Smith-Waterman score: 1444; 84.4% identity (84.4% similar) in 270 aa overlap (1-270:1-228) 10 20 30 40 50 60 pF1KE1 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSIT------ 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK :::::::::::::::::::::::: NP_001 ------------------------------------DKVLLSYYESQHPSNESGDGVDGK 120 130 190 200 210 220 230 240 pF1KE1 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI 140 150 160 170 180 190 250 260 270 pF1KE1 GVKDNHLALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::::::::: NP_001 GVKDNHLALIKVDSSENLCTENILFKLSET 200 210 220 >>NP_001186570 (OMIM: 608678) interleukin-33 isoform c [ (144 aa) initn: 958 init1: 774 opt: 774 Z-score: 967.8 bits: 185.9 E(85289): 3.6e-47 Smith-Waterman score: 774; 99.1% identity (100.0% similar) in 114 aa overlap (157-270:31-144) 130 140 150 160 170 180 pF1KE1 STYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTL .::::::::::::::::::::::::::::: NP_001 MKPKMKYSTNKISTAKWKNTASKALCFKLGNKVLLSYYESQHPSNESGDGVDGKMLMVTL 10 20 30 40 50 60 190 200 210 220 230 240 pF1KE1 SPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNH 70 80 90 100 110 120 250 260 270 pF1KE1 LALIKVDSSENLCTENILFKLSET :::::::::::::::::::::::: NP_001 LALIKVDSSENLCTENILFKLSET 130 140 270 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:51:47 2016 done: Sun Nov 6 15:51:47 2016 Total Scan time: 6.190 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]